Whistler Conference Centre Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2010



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Diabetes (Z6)


Organizer(s) Juleen R. Zierath, Philippe Froguel, Nancy A. Thornberry and Michael P. Czech
April 12—17, 2010
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Dec 14, 2009
Late Abstract Deadline: Jan 15, 2010
Scholarship Deadline: Dec 14, 2009
Early Registration Deadline: Feb 12, 2010

Sponsored by Eli Lilly and Company and Hoffmann-La Roche, Inc.

Joint Meeting: Islet Biology (Z5)

Summary of Meeting:
The increased incidence of Type 2 diabetes mellitus is a growing threat to global health. This chronic and progressive metabolic disease is characterized by insulin resistance and beta cell defects, arising from environmental and genetic factors. Multi-disciplinary approaches that capitalize on genetic, genomic and physiological disciplines are required to gain insight into Type 2 diabetes pathogenesis through an increased understanding of the complicated biology that contributes to the development of insulin resistance and beta cell failure. The meeting will focus on latest advancements in our understanding of the molecular pathogenesis of Type 2 diabetes to accelerate the translation of experimental and clinical discoveries to link phenotype to genotype. Particular emphasis will be placed on 1) epigenetics, genetics and pharmacogenomics of metabolic responses, 2) links between pathways linking obesity, inflammation, and insulin resistance and 3) Type 2 diabetes in children and adolescents. A key goal for the meeting will be to facilitate collaborative interactions between basic and clinical scientists focused on prediction, prevention, and treatment of insulin resistance and diabetes.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, APRIL 12

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* Juleen R. Zierath, Karolinska Institutet, Sweden

Victor R. Ambros, University of Massachusetts, USA
MicroRNAs in Model Systems and Human Disease

* Markus Stoffel, ETH Zürich, Switzerland

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Mitochondrial Role in Cell Cycle Control and Autophagy


TUESDAY, APRIL 13

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
Genetics of Diabetes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Simeon Taylor, University of Maryland School of Medicine, USA

Philippe Froguel, Imperial College of London, UK
Genome Structure and Point DNA Variation: The Power of the Extreme in Diabesity

Mark I. McCarthy, University of Oxford, UK
Type 2 Diabetes: Susceptibility Variants across the Allele Frequency Spectrum

Jose C. Florez, Massachusetts General Hospital, USA
Genetic Epidemiology of Type 2 Diabetes and Related Traits in General Populations

Eric Schadt, Mount Sinai School of Medicine, USA
Multi-Tissue Networks Elucidate Type 2 Diabetes Circuits

Jussi A. Pihlajamäki, Kuopio University Hospital, Finland
Short Talk: Alternative Splicing is Regulated by Weight Loss and Differs between Fat Depots in Humans

Jeremy B.M. Jowett, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Expression Profiling Identifies Biomarkers for Progression to Type 2 Diabetes


Following Session is for Islet Biology (Z5)

08:00—11:00
From Stem Cell Development to Transplantation
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Catherine Lee May, University of Pennsylvania, USA

Bernhard J. Hering, University of Minnesota, USA
Islet Transplantation: Today and Tomorrow

Anne Grapin-Botton, University of Copenhagen, Denmark
Role of Pancreas 3D Architecture in Endocrine Cell Development

Lori Sussel, University of Colorado, USA
Regulation of Pancreatic Islet Cell Fates

Maike Sander, University of California, San Diego, USA
Control of Cell Fate Choice in the Pancreas

Dina Fomina-Yadlin, Harvard University, USA
Short Talk: Altering Pancreatic Cell State with Small Molecules

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
13:00—22:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cell and Tissue Signaling Mechanisms in Diabetes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Adria Giacca, University of Toronto, Canada

Claire C. Bastie, Albert Einstein College of Medicine, USA
Fyn Kinase and LKB1: A Novel Pathway Regulating Lipid Utilization and Energy Expenditure

Robert E. Lewis, University of Nebraska Medical Center, USA
Molecular Scaffolds as Energy Sensors

Bei B. Zhang, Pfizer Inc., USA
Modulation of Glucose, Amino Acid and Lipid Metabolism Pathways with Pharmacological Agents

Philipp Gut, Nestlé Institute of Health Sciences, Switzerland
Short Talk: In vivo Drug Discovery of New Regulators of Glucose Metabolism using Transgenic “Gluconeogenesis Reporter” Zebrafish


Following Session is for Islet Biology (Z5)

17:00—19:00
Signaling in Pancreatic B-Cells
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany
Role of Blood Vessels in Pancreatic Islet Development and Function

Marc Prentki, , Canada
Beta Cell Metabolic Signaling and Dysfunction in Type 2 Diabetes

Ingo B. Leibiger, Karolinska Institutet, Sweden
Insulin Signaling in the Pancreatic Beta Cell

Jocelyn E. Manning Fox, University of Alberta, Canada
Short Talk: Small Ubiquitin-Like Modifier 1 (SUMO1) Directly and Acutely Regulates Insulin Exocytosis from Human beta-Cells

19:00—20:00
Social Hour with Lite Bites

Foyer/Mountain View/Sea to Sky Ballroom A
19:30—22:00
Poster Session 1

Foyer/Mountain View/Sea to Sky Ballroom A

WEDNESDAY, APRIL 14

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
Intertissue Communication
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Jeffrey S. Elmendorf, Indiana University School of Medicine, USA

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
A Novel Pathway in Adipose Tissue and Liver that Regulates Adiposity

Kenneth Walsh, Boston University School of Medicine, USA
Discovery of Novel Myokines

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Discovery of Novel Adipokines

Fatima Bosch, Universitat Autonoma Barcelona, Spain
Gene Therapy and Diabetes

Tsu-Shuen Tsao, University of Arizona, USA
Short Talk: Inhibition of Adiponectin Oligomerization under Oxidizing Conditions and Induction of an Oxidizing Redox Environment in Endoplasmic Reticulum of 3T3-L1 Adipocytes Exposed to High Concentrations of Palmitate

Marianna Sadagurski, Wayne State University, USA
Short Talk: Inactivation of Foxo1 in Leptin Receptor (LepRb)-Expressing Neurons Reverses Obesity and Diabetes, Caused by Deletion of Insulin Receptor Substrate 2 (Irs2)


Following Session is for Islet Biology (Z5)

08:00—11:00
Transcriptional Networks Signaling
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Maike Sander, University of California, San Diego, USA

Catherine Lee May, University of Pennsylvania, USA
Islet-1 and its Cofactor Ldb1 in the Endocrine Pancreas

Markus Stoffel, ETH Zürich, Switzerland
MicroRNA Networks

Roland W. Stein, Vanderbilt University Medical Center, USA

Alan D. Attie, University of Wisconsin-Madison, USA
Networks of QTLs, mRNAs, and microRNAs in Beta Cell Growth and Function

Melissa K. Thomas, Massachusetts General Hospital, USA
Short Talk: TCF7L2 Deficiency Alters Mouse Metabolic and Islet Cell Functions with Aging

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
13:00—22:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Molecular Mechanisms in Insulin Secretion and Action (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Insulin Signaling and Insulin Resistance: The Ultimate Systems Biology Problem

Per-Olof Berggren, Karolinska Institutet, Sweden
Systems Biology Approach to Study Beta Cell Function and Survival

Morris J. Birnbaum, Pfizer Inc., USA
The Role of Akt in the Regulation of Hepatic Metabolism by Insulin

Weiping Han, Singapore Bioimaging Consortium, Singapore
Short Talk: Molecular Regulation of Calcium-Dependent Insulin Secretion

Jennifer L. Estall, Institut de Recherches Cliniques de Montréal, Canada
Short Talk: PGC-1alpha Negatively Regulates Hepatic FGF21 Expression by Modulating the Heme/Rev-Erbalpha Axis

19:15—20:15
Social Hour with Lite Bites

Foyer/Mountain View/Sea to Sky Ballroom A
19:30—22:00
Poster Session 2

Foyer/Mountain View/Sea to Sky Ballroom A

THURSDAY, APRIL 15

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
07:00—11:00
Poster Setup

Foyer/Mountain View/Sea to Sky Ballroom A
08:00—11:15
Inflammatory Mechanisms and Insulin Resistance
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Nancy A. Thornberry, Kallyope, Inc., USA

Diane Mathis, Harvard Medical School, USA
Lymphocyte Regulation of Adipose Tissue Inflammation

Roger J. Davis, HHMI/University of Massachusetts Medical School, USA
Pathogenesis Mechanisms of the JNK Pathway

Rémy G. Burcelin, Institute of Molecular Medicine, France
Intestinal Microflora, Inflammation, and Metabolic Diseases

Michael P. Czech, University of Massachusetts Medical School, USA
RNAi-Based Strategies to Address Metabolic Dysfunction

Birgitte Lindegaard, Rigshospitalet, Denmark
Short Talk: IL-18 Increases Intramuscular Fat Oxidation by Activating AMPK

Heather C. Denroche, Child & Family Research Institute, Canada
Short Talk: Leptin Therapy Reverses Fasting Hyperglycemia and Enhances Insulin Sensitivity in Diabetic Mice, Independent of Hepatic Leptin Signaling


Following Session is for Islet Biology (Z5)

08:00—11:15
Control of Insulin Secretory Machinery in Diabetes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Per-Olof Berggren, Karolinska Institutet, Sweden

Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Calcium Channels and Insulin Exocytosis

Michele Solimena, Dresden University of Technology, Germany
Signaling from the Insulin Granule to the Nucleus

Gerard Karsenty, Columbia University Medical Center, USA
Regulation of Glucose Homeostasis by Osteocalcin

Herbert Y. Gaisano, University of Toronto, Canada
Molecular Mechanism of Insulin Granule-Granule Fusion Contributing to Biphasic Insulin Secretion

Ja-Young Kim-Muller, Merck & Co., USA
Short Talk: Abnormal Regulation of Basal Insulin Secretion in Mice Homozygous for a Constitutively Deacetylated FoxO1 Allele

Hail Kim, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Serotonin Regulates Pancreatic beta-Cell Mass during Pregnancy

09:20—09:40
Coffee Break

Foyer
11:00—17:00
Poster Viewing

Foyer/Mountain View/Sea to Sky Ballroom A
11:30—12:30
Lunch

Foyer/Mountain View/Sea to Sky Ballroom A
12:30—14:30
Poster Session 3

Foyer/Mountain View/Sea to Sky Ballroom A
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Emerging Targets for Improving Insulin Action and Secretion (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA

Richard D. DiMarchi, Indiana University, USA
Novel Glucagon-Like Chimera Peptides – Virtues of Combinatorial Pharmacology

David E. Moller, Eli Lilly and Company, USA
Challenges and Opportunities for Diabetes Drug Discovery

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Integrating Metabolic Control by NAD+ Sensors

Tian-Qiang Sun, Rigel Pharmaceuticals, Inc., USA
Short Talk: Small Molecule Adiponectin Mimetics Improve Hepatic Steatosis and Insulin Sensitivity in Diabetic Mouse Models

Christine Esau, Arcturus Therapeutics, USA
Short Talk: Inhibition of Let-7 with Anti-miR Oligonucleotides Improves Insulin Resistance in DIO Mice

19:15
On Own for Dinner


FRIDAY, APRIL 16

07:00—08:00
Breakfast

Sea to Sky Ballroom A, Lower Level
08:00—11:15
Insulin Secretion and Action in Humans (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B,C
* Michael P. Czech, University of Massachusetts Medical School, USA

Andrew Hattersley, Peninsula Medical School, UK
Learning from Genetic Beta Cell Defects in Man

Anna Moore, Massachusetts General Hospital, USA
Imaging Pancreatic Islets in vivo: Current Status

Juleen R. Zierath, Karolinska Institutet, Sweden
Gene/Environment Influence on Skeletal Muscle Insulin Sensitivity in Type 2 Diabetic Patients

Peter Arner, Karolinska Institutet, Sweden
Dysfunction in Human Adipose Tissue and Insulin Resistance

Michael Ristow, ETH Zürich, Switzerland
Short Talk: Impaired Insulin Signaling Extends Life Span by Increasing Oxidative Stress

Mary Armanios, Johns Hopkins University School of Medicine, USA
Short Talk: Short Telomeres Lead to beta-cell Dysfunction and Impair Glucose Tolerance

09:20—09:40
Coffee Break

Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Type 2 Diabetes in Children and Adolescents
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom C
* Philippe Froguel, Imperial College of London, UK

Rebecca Anne Simmons, University of Pennsylvania School of Medicine, USA
Epigenetic Mechanisms in the Development of Type 2 Diabetes

Susan Ozanne, University of Cambridge, UK
Early Life Programming of Type 2 Diabetes

Phil Zeitler, University of Colorado, Denver, USA
Type 2 Diabetes in Children and Adolescents: Epidemiology, Pathophysiology, and Comorbidities

Kasper Rud, University of Copenhagen, Denmark
Short Talk: Effects of Gestational Low Protein Diet Followed by Postnatal High Fat or High Sucrose Diet on the Interplay between Fat and Carbohydrate Metabolism in Rat Mitochondria


Following Session is for Islet Biology (Z5)

17:00—19:00
Beta Cell Stress in Diabetes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky Ballroom B
* Marc Prentki, , Canada

Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation in Type 2 Diabetes: Novel Mechanisms and Treatment

Thomas Mandrup-Poulsen, Hagedorn Research Institute, Denmark
Cytokine Signaling in Inflammatory beta-Cell Destruction

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Insulin/IGF-I Signaling, Mitochondrial Function and Endoplasmic Stress in Pancreatic beta-Cells

Raghavendra G. Mirmira, Indiana University School of Medicine, USA
Short Talk: The Unique Hypusine Modification of eIF5A Promotes Islet Inflammation and Dysfunction during the Development of Diabetes

19:00—20:00
Social Hour with Lite Bites

Foyer/Mountain View/Sea to Sky Ballroom A
20:00—23:00
Entertainment

Foyer/Mountain View/Sea to Sky Ballroom A

SATURDAY, APRIL 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK084688-01




We gratefully acknowledge additional support for this conference from:

AdipoGen International ALPCO Diagnostics
CEDARLANE CovX Research LLC (Pfizer)
Educational grant from Lilly USA, LLC Hoffmann-La Roche, Inc.
Landes Bioscience Rigel Pharmaceuticals, Inc.
Seahorse Bioscience, Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck & Co., Inc.


Merck Research Laboratories


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676