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This meeting took place in 2010



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Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3)


Organizer(s) Luke A.J. O'Neill, Kate A. Fitzgerald and Averil I. Ma
June 7—12, 2010
Trinity College Dublin • Dublin, Ireland
Abstract Deadline: Feb 24, 2010
Late Abstract Deadline: Feb 24, 2010
Scholarship Deadline: Feb 24, 2010
Early Registration Deadline: Apr 7, 2010

Organized in Collaboration with Science Foundation Ireland

Summary of Meeting:
In the past 5 years there have been remarkable advances in our understanding of the molecular basis of innate immunity. We now have considerable detail on the major classes of innate immune receptors that sense pathogens and provoke immune and inflammatory responses. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). The role these receptors play in host defense against microbes has been studied, their signaling pathways elucidated, and their roles in infectious and inflammatory diseases examined in detail. As well as stimulating innate immunity via induction of various effector mechanisms, these receptors also participate in the establishment of adaptive immunity. This occurs via the induction of key cytokines to promote T and B cell development and activation, and also via the induction of co-stimulatory molecules on the surface of dendritic cells, notably CD80 and CD86. A final aspect concerns adjuvancy – microbial or synthetic agents that activate these receptors act as powerful adjuvants required for the establishment of memory responses. This conference will bring together scientists working on innate immune mechanisms activated by these receptors, and will have as a key focus the ability of these receptors and the responses they elicit to promote adaptive immunity. The conference will therefore be of interest to many investigators interested in immunity and the role the immune system plays in disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JUNE 7

15:00—19:30
Registration

Lower Concourse
18:30—19:30
Refreshments

Lower Concourse
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Innate Control of Adaptive Immunity


TUESDAY, JUNE 8

07:30—08:30
Breakfast

At Lodging Location
07:30—08:30
Poster Setup

Beckett Rooms/Lower Concourse
08:30—15:00
Poster Viewing

Beckett Rooms/Lower Concourse
08:30—11:45
The Modulation of Innate and Adaptive Immune Responses by Innate Receptors
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
Shizuo Akira, Osaka University, Japan
Functional Analysis of TLR Inducible Genes by Gene Targeting

* Alberto Mantovani, Humanitas University, Italy
The Interplay between Cellular and Humoral Innate Immunity: The Long Pentraxin PTX3 as a Paradigm

Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Phagosomes and Adaptive Immunity

* Mihai G. Netea, Radboud University, Netherlands
Modulation of Antifungal Immune Responses by Innate Receptors

Michael C. Abt, Sloan Kettering Institute, USA
Short Talk: Signals Derived from Intestinal Microbial Communities Regulate Anti-Viral Immunity

Anna M. Hansen, Medimmune, USA
Short Talk: An Innate, Non-NK T Cell with Memory-Like Phenotype Produces Large Amounts of IL-17 Independently of IL-6 and IL-21

09:40—10:00
Coffee Break

Lower Concourse
11:45—12:45
Lunch

Dining Hall/Atrium/Java Vaults
12:00—14:30
Poster Session 1

Beckett Rooms/Lower Concourse
14:30—15:00
Coffee Available

Lower Concourse
15:00—17:00
Autoimmunity as a Consequence of Innate Immunity Defects
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
Robert L. Coffman, Dynavax Technologies, USA
Targeting TLR7 and TLR9 in Autoimmune Disease

* Jos van der Meer, Nijmegen Institute for Infection, Netherlands
The auto-inflammatory syndromes

* Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and Innate Immunity

Dominik Schenten, Yale University, USA
Short Talk: The Role of TLR-Induced IL-6 and IL-1 in the Control of Adaptive Immunity

17:00
On Own for Dinner


WEDNESDAY, JUNE 9

07:30—08:30
Breakfast

At Lodging Location
08:30—11:45
Evolution of Innate and Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Max D. Cooper, Emory University, USA
Evolution of the Adaptive Immune System

* Gary W. Litman, University of South Florida, USA
The Evolution of Immune Receptor Diversity

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLR Proteins: From Plants to Animals

Neal Silverman, University of Massachusetts Medical School, USA
What the Fly has Taught us about Innate Immunity: New Lessons for NF-kappaB Signaling?

A. Neil Barclay, University of Oxford, UK
Short Talk: The Evolution and Ligands of Macrophage Paired Receptors

Gregory Ian Vladimer, CeMM, Center for Molecular Medicine, Austria
Short Talk: NLRP12 and Other Inflammasome Components Participate in the Resistance to Yersinia pestis Producing a Potent LPS

09:40—10:00
Coffee Break

Lower Concourse
11:45—12:45
Lunch

Dining Hall/Atrium/Java Vaults
11:45—12:45
Poster Setup

Beckett Rooms/Lower Concourse
12:45—14:45
Workshop

Burke Theatre/Beckett Rooms
* Averil I. Ma, University of California, San Francisco, USA

Amy Grace Hise, Case Western Reserve University, USA
Innate Immune Host Defense to Fungal Pathogens

Clare E. Bryant, University of Cambridge, UK
Allergen Lipid Binding Proteins (Alps) Sensitise Ligand Induced Activation of TLR4: A Common Mechanism of Allergen Recognition?

Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Regulation of Mucosal Immunity by a New Interferon (IFNepsilon) with Unusual Properties Evolved to Protect Reproductive Tract from Bacterial and Viral Infection

Mirjam Kool, Erasmus MC, Netherlands
An Unexpected Role for Uric Acid as an Inflammatory Mediator of Allergic Asthma

Susan B. Carpenter, University of California, Santa Cruz, USA
TRIL: A Novel Modulator of TLR4 Signaling is also Required for TLR3 Mediated Immune Responses

Shruti Sharma, University of Massachusetts Medical School, USA
Innate Immune Recognition of a Novel AT-rich DNA Motif in the P. falciparum Genome.

14:45—15:00
Coffee Available

Lower Concourse
15:00—17:00
The Role of Innate Receptors in Adjuvancy
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Kingston H.G. Mills, Trinity College Dublin, Ireland
Activation and Manipulation of TLR and NLR Signalling Pathways in Dendritic Cells for Selective Induction of T Cell Responses

Alan Sher, NIAID, National Institutes of Health, USA
Critical Role for IL-1R Signaling and the Inflammasome in the Th1/Th17 cell Adjuvant Activity of Mycobacteria

* Bart N. Lambrecht, VIB, Ghent University, Belgium
Molecular Basis for Alum Adjuvancy

Sheri Dubey, Merck & Co., Inc., USA
Short Talk: Novel TLR9 Agonists Combined with Alum for Use as Vaccine Adjuvants

17:00—18:00
Social Hour with Lite Bites

Lower Concourse
17:30—20:00
Poster Session 2

Beckett Rooms/Lower Concourse

THURSDAY, JUNE 10

07:30—08:30
Breakfast

At Lodging Location
07:30—08:30
Poster Setup

Beckett Rooms/Lower Concourse
08:30—15:00
Poster Viewing

Beckett Rooms/Lower Concourse
08:30—11:45
Control of T Cell Subsets by Innate Immune Signals
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

* Laurence A. Turka, Massachusetts General Hospital, USA
Regulation of T Lymphocytes by "Innate Immune Pathways"

Shimon Sakaguchi, Osaka University, Japan
Regulatory T Cells in Innate and Adaptive Immunity

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Omitting Felony by Switching Fate: TGF-beta and Retinoic Acid Mediate Lineage Conversion of CD4 Th Cells to CD8 CTLs

Ed C. Lavelle, Trinity College Dublin, Ireland

Aisling Dunne, Trinity College Dublin, Ireland
Short Talk: Inflammasome Activation by Adenylate Cyclase Toxin Directs TH17 Responses and Protection Against Bordetella Pertussis

Mattias Enoksson, Mabtech AB, Sweden
Short Talk: Mast Cells as Novel Sensors of Cell Injury through Interleukin-33 Recognition

09:40—10:00
Coffee Break

Lower Concourse
11:45—12:45
Lunch

Dining Hall/Atrium/Java Vaults
12:00—14:30
Poster Session 3

Beckett Rooms/Lower Concourse
14:30—15:00
Coffee Available

Lower Concourse
15:00—17:00
Innate Immune Mechanisms: Molecular and Structural Aspects
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Novel Components in Innate Immune Signaling

* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Inflammasomes and Anti-Viral Responses

Eicke Latz, University of Bonn, Germany
Regulation of NLRP3 and AIM2 Inflammasome Signaling

Tilmann Bürckstümmer, Haplogen Genomics, Austria
Short Talk: Functional Dissection of the TBK1 Molecular Machine

17:00
On Own for Dinner


FRIDAY, JUNE 11

07:30—08:30
Breakfast

At Lodging Location
07:30—20:30
Poster Setup

Beckett Rooms/Lower Concourse
08:30—15:00
Poster Viewing

Beckett Rooms/Lower Concourse
08:30—11:30
Therapeutic Manipulation of Innate Immunity in Inflammatory Diseases
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Anthony J. Coyle, Pfizer, USA
Role of Type I Interferons in Autoimmune Disease

Carla V. Rothlin, Yale University, USA
TAMing Inflammation in vivo

Nicola La Monica, Janssen Pharmaceutical, USA
Synthetic Agonists and Antagonists of Toll-like Receptor 7, 8, and 9

* Andrew Parker, GeNeuro SA, Switzerland
Targeting TLR2 in Ischemic Organ Damage

Greg CA Elson, NovImmune SA, Switzerland
Short Talk: Mechanistic Studies Reveal the Mode of Action of Highly Potent TLR4 Neutralizing MAbs

Alison A. Humbles, MedImmune, LLC, USA
Short Talk: RAGE Deficiency Protects Mice from RSV Infection

09:40—10:00
Coffee Break

Lower Concourse
11:30—12:30
Lunch

Lower Concourse
12:00—14:30
Poster Session 4

Beckett Rooms/Lower Concourse
16:30—17:00
Coffee Available

Lower Concourse
17:00—19:15
Pathogen-Specific Responses
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
* Tracy Hussell, University of Manchester, UK
The Role of Innate Immunity in Host Defence against Respiratory Pathogens

Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Sensing Bacterial Virulence

Stefanie N. Vogel, University of Maryland, USA
Distinct Roles of Alternatively Activated Macrophages in the Host Response to Bacterial and Viral Infection

* Andrew G. Bowie, Trinity College Dublin, Ireland
Novel Components of Anti-Viral Pattern Recognition Receptor Pathways

19:15—19:30
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Burke Theatre/Beckett Rooms
Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Closing Remarks

19:30—20:00
Social Hour

Grand Dining Hall
20:00—21:00
Dinner

Grand Dining Hall
19:30—21:00
Entertainment

Grand Dining Hall

SATURDAY, JUNE 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI088869-01




We gratefully acknowledge additional support for this conference from:

AbD Serotec Fáilte Ireland
JDRF Science Foundation Ireland

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Opsona Therapeutics Ltd


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Pubget Inc. SAGE Publications

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676