Beaver Run Resort Floorplan

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This meeting took place in 2010


Here are the related meetings in 2018:
Lymphocytes and their Roles in Cancer (R1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Lymphocyte Activation and Gene Expression (B8)


Organizer(s) Leslie J. Berg, Lawrence E. Samelson and Facundo D. Batista
February 27—March 4, 2010
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Oct 27, 2009
Late Abstract Deadline: Nov 30, 2009
Scholarship Deadline: Oct 27, 2009
Early Registration Deadline: Dec 28, 2009

Sponsored by Amgen Inc., Genzyme Corporation and Novo Nordisk A/S

Summary of Meeting:
Lymphocytes mediate the adaptive immune responses to antigens derived from infectious agents, transformed cells, transplanted organs and, in the setting of autoimmunity, ones own cells. The study of lymphocyte activation and gene expression is central to understanding the complex biology of these cells and offers hope for regulating these cells in different clinical settings. Much has been learned in the past several decades in this field. Receptors, enzymes and adapter molecules have been identified, signaling cascades and networks have been defined, and the complex regulation of gene expression has been explored. Nonetheless many basic questions remain to be elucidated. Among several contentious areas of research that will be presented by experts at this meeting are the actual means by which antigen receptors initiate the activation process, how activation induces changes in signaling pathways, intracellular organelles and the cytoskeleton, and how changes in chromatin and transcriptional factors determine gene expression.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 27

15:00—19:30
Registration

Foyer
06:30—07:30
Refreshments

Foyer
19:30—20:30
Keynote Address: The TCR
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Lawrence E. Samelson, National Institutes of Health, USA

Mark M. Davis, Stanford University, USA
T-Cell Receptor Signaling


SUNDAY, FEBRUARY 28

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Initiation of Antigen Receptor Signaling
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Molecular Mechanisms Underlying the Initiation of BCR Signaling

Phillip Anton van der Merwe, University of Oxford, UK
Molecular Mechanism of TCR Triggering

Balbino Alarcón, CSIC-Universidad Autonoma de Madrid, Spain
Intramolecular Mechanism for Transmission of the Conformational Change in the TCR

Arup K. Chakraborty, Massachusetts Institute of Technology, USA
How T Cells “See” Antigen

Nina G. Caculitan, Genentech, Inc., USA
Short Talk: The Regulation of Protein Spatial Sorting and its Effect on T Cell Signaling in the Immunological Synapse

Mira Barda-Saad, Bar Ilan University, Israel
Short Talk: THE NEGATIVE REGULATION MECHANISM OF THE WISKOTT-ALDRICH SYNDROME PROTEIN

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Peaks 1-4
13:00—22:00
Poster Viewing

Peaks 1-4
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cell Biology of Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Peak 5
Facundo D. Batista, Ragon Institute of MGH, MIT and Harvard, USA
Interplay between the BCR and Cytoskeleton: A Mechanism to Regulate Lymphocyte Activation and Tonic Signaling?

* Gillian Griffiths, Cambridge Institute for Medical Research, UK
The Immunological Synapse: A Focal Point for Exocytosis and Endocytosis

Matthew F. Krummel, University of California, San Francisco, USA
The Interplay of T Motility and Signaling

Sarah Russell, Swinburne University of Technology, Australia
Short Talk: Orchestratation of Lymphocyte Fate by the Polarity Network

19:00—20:00
Social Hour with Lite Bites

Peaks 1-4
19:30—22:00
Poster Session 1

Peaks 1-4

MONDAY, MARCH 1

07:00—08:00
Poster Setup

Peaks 1-4
07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Transcriptional Regulation and Chromatin Remodeling during Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Ca Signaling and Transcription Regulation in Lymphocytes

Steven L. Reiner, Columbia University, USA
Specifying the T Cell Fates Required for Immunity

Joonsoo Kang, University of Massachusetts Medical School, USA
Transcriptional Regulation of alpha-beta vs. gamma-delta T Cell Lineage Commitment

Casey T. Weaver, University of Alabama at Birmingham, USA
Gene Expression and the TH17 Response

Michael J. Pazin, National Human Genome Research Institute, National Institutes of Health, USA
Short Talk: The Chromatin Remodeling Landscape of T Helper Cell Differentiation

Robert J. Johnston, La Jolla Institute for Allergy & Immunology, USA
Short Talk: Bcl6 and Blimp-1 are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

08:00—17:00
Poster Viewing

Peaks 1-4
09:20—09:40
Coffee Break

Foyer
11:30—12:30
Lunch

12:30—14:30
Poster Session 2

Peaks 1-4
14:30—16:30
Workshop 1: Early Events in Lymphocyte Activation

Peak 5
* Arthur Weiss, University of California, San Francisco, USA

Melania Capasso, Barts Cancer Institute, UK
Control of B Cell Activation and Metabolism by the Voltage-Gated Proton Channel HVCN1

Olga Anna Ksionda, University of California, San Francisco, USA
The Role of the Localization of Vav1 during T Cell Activation

Aaron J. Marshall, University of Manitoba, Canada
The Phosphoinositide 3-Kinase Effector Molecule Bam32/DAPP1 Promotes B Cell Adhesion and Formation of Polarized Conjugates with T Cells

David Oh, Stanford University, USA
Ca2+ Signaling and the Regulation of Thymocyte Mobility during Negative Selection in Thymic Slices

Hanne L. Ostergaard, University of Alberta, Canada
Regulation of the Tyrosine Kinase Pyk2 By Calcium in Cytotoxic T Lymphocytes

Bruno Silva-Santos, University of Lisbon, Portugal
Differential Requirements on TCR/ CD27 versus TLR Signaling for Activation of Discrete Pro-Inflammatory gamma-delta T Cell Subsets

Neetu Gupta, Cleveland Clinic, USA
Regulation of Antigen-Dependent B Cell Activation by Tyrosine and Threonine Phosphorylation of the ERM Family Protein Ezrin

Steve R. Roffler, Academia Sinica, Taiwan
Mechanical Forces Acting on the T Cell Receptor Complex Can Trigger TCR Signaling

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Downstream Pathways of Antigen Receptor Signaling I
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Doreen A. Cantrell, University of Dundee, UK
The Function of Protein Kinase B/Akt in Peripheral T Cells

Pamela L. Schwartzberg, NHGRI, National Institutes of Health, USA
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Th2 Lymphoproliferative Disorders Resulting from Defective LAT Signalosomes

Debbie A. Yablonski, Technion - Israel Institute of Technology, Israel
Short Talk: Regulatory Interactions within the SLP-76-Nucleated Complex

Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Probing Inhibitory Signaling Dynamics in NK Cells by Photostimulation

Michelle Krogsgaard, New York University School of Medicine, USA
Short Talk:

19:00
On Own for Dinner

Peaks 1-4

TUESDAY, MARCH 2

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Downstream Pathways of Antigen Receptor Signaling II
Meeting has ended...abstracts no longer viewable online.

Peak 5
Arthur Weiss, University of California, San Francisco, USA
Turning T Cells Off and On with Small Molecule Inhibitors of Tyrosine Kinases

Andrey S. Shaw, Washington University School of Medicine, USA
Imaging T Cell Activation

Jürgen Wienands, Georg August University of Goettingen, Germany
Short Talk: Composition and Dynamic Assembly of B Cell Signalosomes as Revealed by Functional Proteomics

* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Role of SLP-76 in Immune Cell Development and Function

Bridget S. Wilson, University of New Mexico Health Science Center, USA
High Resolution Imaging of Fc[epislon]RI Organization and Receptor Dynamics: Immobilization is not a Requirement for Signal Initiation

Stephen C. Bunnell, Tufts University School of Medicine, USA
Short Talk: VLA-4 Inhibits the Centralization of SLP-76 Microclusters by Resisting the Contraction of Myosin IIA Filaments

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-4
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Peaks 1-4
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Downstream Pathways of Antigen Receptor Signaling III
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Leslie J. Berg, University of Massachusetts Medical Center, USA
Tec Kinases in T Cell Differentiation

Lawrence E. Samelson, National Institutes of Health, USA
Signaling at the TCR

Richard S. Lewis, Stanford University School of Medicine, USA
Molecular Mechanisms for Activation and Inactivation of Calcium Channels in T Cells

Patrick G. Hogan, La Jolla Institute of Allergy and Immunology, USA
Short Talk: Minimal Requirement for Store-Operated Calcium Entry: STIM1 Gates ORAI1 Channels in vitro

19:00—20:00
Social Hour with Lite Bites

Peaks 1-4
19:30—22:00
Poster Session 3

Peaks 1-4

WEDNESDAY, MARCH 3

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Visualization of Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Ellen A. Robey, University of California, Berkeley, USA
Visualizing Thymic Selection in situ

Michael L. Dustin, University of Oxford, UK
Immunological Synapse Formation in Normal and Pathological Immune Responses

Ronald N. Germain, NIAID, National Institutes of Health, USA
Cell Dynamics during the Initiation and Effector Phases of Adaptive Immune Responses

Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Molecular Dynamics for T-Cell Activation and Co-stimulation

Daniel M. Davis, Imperial College London, UK
Short Talk: Membrane Nanotubes Support Sub-Micron Scale Immune Synapses and Aid Cytolysis of Distant Target Cells

Philippe Bousso, Institute Pasteur, France
Short Talk: Intravital Imaging Reveals Distinct Dynamics of NK Cells and CD8+ T Cells during Effector Function in Solid Tumors

09:20—09:40
Coffee Break

Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Late Events in Lymphocyte Activation

Peak 5
* Pamela L. Schwartzberg, NHGRI, National Institutes of Health, USA

Mark R. Boothby, Vanderbilt University Medical Center, USA
Stage-Specific Essential Roles of Rictor, a Mammalian Target of Rapamycin Complex 2 (mTORC2) Subunit, in T Cell Differentiation Define a Bifurcation in the Signal Relay

Jennifer L. Cannons, National Institutes of Health, USA
A Multi-Stage T:B Lymphocyte Adhesion Process is Required for Germinal Centre Responses

Greg M. Delgoffe, University of Pittsburgh, USA
The mTOR Signaling Complexes TORC1 and TORC2 Selectively Regulate CD4+ T Cell Differentiation

Guo Fu, The Scripps Research Institute, USA
Themis Regulates Thymocyte Signaling

Katrina L. Randall, Canberra Hospital, Australia
DOCK8 Mutations Cripple B Cell Immune Synapse Formation, Germinal Centers and Long-Lived Antibody Production

Yuri K. Sykulev, Thomas Jefferson University, USA
Kinetics of Early TCR Signaling Influences the Path of Granule Delivery by CTL

Bazarragchaa Damdinsuren, National Institute on Aging, National Institutes of Health, USA
Single-Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help

Vanessa Marie Hubbard-Lucey, New York University School of Medicine, USA
Macroautophagy Regulates CD4+ T Cell Function

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regulation of the Immune Response by microRNA
Meeting has ended...abstracts no longer viewable online.
Session supported in part by the Juvenile Diabetes Research Foundation

Peak 5
* Matthias Merkenschlager, Imperial College London, UK
Cohesins and Gene Expression: From Proof-of-Principle Towards Cell Lineage- and Developmental Stage-Specific Regulation

Carola G. Vinuesa, Australian National University, Australia
Role of Bcl-6 in Specializing the Function of T Follicular Helper Cells

Li-Fan Lu, University of California, San Diego, USA
Short Talk: Function of miR-146a in Controlling Treg Cell-Mediated Regulation of TH1 Responses

Anna Barbara Stittrich, German Arthritis Research Center, Germany
Short Talk: MicroRNA-182 Promotes Clonal Expansion of Activated T Helper Cells

19:00—20:00
Social Hour with Lite Bites

Peaks 1-4
20:00—23:00
Entertainment

Peaks 1-4

THURSDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI085592-01




We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Genzyme Corporation
Invitrogen Corporation JDRF
Novo Nordisk A/S Rigel Pharmaceuticals, Inc.

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