Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2010



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Tolerance and Autoimmunity (B7)


Organizer(s) Betty Diamond and Diane J. Mathis
February 21—26, 2010
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 21, 2009
Late Abstract Deadline: Nov 20, 2009
Scholarship Deadline: Oct 21, 2009
Early Registration Deadline: Dec 21, 2009

Sponsored by Novo Nordisk A/S

Summary of Meeting:
Elegant studies of central T and B cell tolerance have been performed, leading to the identification of multiple mechanisms that remove or silence autoreactive cells during their maturation, but also reminding us that some autoreactive cells do mature to immunocompetence in all individuals. Furthermore, studies of the B cell response to antigen have clearly demonstrated that autoreactivity can arise de novo in antigen-activated cells, which also requires silencing. Finally, it has now been established in studies of multiple autoimmune diseases that a critical checkpoint exists between autoreactivity and tissue injury, one of the issues about which we remain most ignorant. Understanding peripheral mechanisms for maintaining self-tolerance offers promise for better therapies for autoimmune disease. The proper implementation of this new knowledge requires an understanding of similarities and differences between animal models and human disease. Specific Issues: • Translating results from studies of animal models to human studies • Peripheral and central tolerance • T cells and B cells • The relationship between autoimmunity and immunodeficiency • The role of dendritic cells in autoimmunity • What dictates generation of autoreactive antibody in one individual and not in another? • How much autoreactivity must occur in order to progress to disease and what governs this? • What exactly is "pathogenic autoreactivity", i.e, are all investigators talking about the same thing? • How much of pathogenesis is due to autoreacting antibodies per se versus the tissue's response to antibody? • What role is innate immunity playing in all of this?

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 21

15:00—19:30
Registration

Rio Grande A
18:30—19:30
Refreshments

Rio Grande A
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bataan
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
T cells in the framework of immunological tolerance


MONDAY, FEBRUARY 22

07:00—08:00
Breakfast

Rio Grande B,C,D
08:00—11:00
Signaling Negative Selection of Autoreactive Lymphocytes
Meeting has ended...abstracts no longer viewable online.

Bataan
Chang-Zheng Chen, Stanford University, USA
Immune Modulation: Lessons and Puzzles from the miR81 Family of Genes

* Eric M. Verdin, University of California, San Francisco, USA
HDAC7 and Autoimmunity

Philippe Bouillet, Walter and Eliza Hall Institute of Medical Research, Australia
Bim Kills Cells Mostly by Inhibiting the Bcl-2 Pro-Survival Proteins

Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
Blunted BCR Signaling, a Source of Lost Tolerance in Autoimmunity

Maria A. Gutierrez, University of Texas Southwestern Medical Center, USA
Short Talk: Separate Checkpoints Regulate Plasma Cell Accumulation and IgG Autoantibody Production in Lyn-/- Mice

09:20—09:40
Coffee Break

Rio Grande B,C
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Rio Grande A,B,C
13:00—22:00
Poster Viewing

Rio Grande A,B,C
14:30—16:30
Workshop 1

Bataan
* Kristin V. Tarbell, NIDDK, National Institutes of Health, USA

* Zhibin Chen, University of Miami, USA

Hsin-Jung Wu, University of Arizona, USA
Gut-Residing Segmented Filamentous Bacteria can Trigger Autoimmune Arthritis via T Helper 17 Cells

Yong Fan, University of Pittsburgh, USA
Autoimmune Diabetes Induced by Thymic Medullary Epithelium-Specific Deletion of Insulin

Brandy Lynn Houser, Harvard University, USA
Two Distinct Subsets of Macrophages at the Human Maternal-Fetal Interface: Neither Proinflammatory nor Immunosuppressive

Siamak Jabbarzadeh Tabrizi, Kyushu University, Japan
BCR Signaling Regulates the Expression of IRAK Proteins in Human B Cell Subsets

Scott M. Lieberman, Children's Hospital of Philadelphia, USA
Characterizing Natural CD4+Foxp3+ Regulatory T Cells by Anatomical Location

Heather Niederer, University of Cambridge, UK
Copy Number, Linkage Disequilibrium and Disease Association in the FCGR Locus

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Early Moments in Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Bataan
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Tolerogenic and Immunogenic DCs

* Teresa P. DiLorenzo, Albert Einstein College of Medicine, USA
Autoimmunity and Tolerance in Type 1 Diabetes

Partha S. Biswas, University of Pittsburgh, USA
Short Talk: ROCK2 and IRF4: A Novel Interaction Regulating IL-17 and IL-21 Production and the Development of Autoimmunity

Lars Rönnblom, Uppsala Universitet, Sweden
Controls of the Unfolding of Lupus

19:00—20:00
Social Hour with Lite Bites

Rio Grande A,B,C
19:30—22:00
Poster Session 1

Rio Grande A,B,C

TUESDAY, FEBRUARY 23

07:00—08:00
Breakfast

Rio Grande B,C,D
08:00—11:00
B Cell Effectors and Regulators
Meeting has ended...abstracts no longer viewable online.

Bataan
Robert Brink, Garvan Institute of Medical Research, Australia
Early B cell differentiation and the germinal centre response

* Betty Diamond, Feinstein Institute for Medical Research, USA
Regulation of GC-matured B cells

Claudia Mauri, University College London, UK
Regulatory B Cells in Health and in Patients with SLE

Gregg J. Silverman, New York University Langone Medical Center, USA
Regulatory Natural Antibodies Control Inflammatory Responses and Protect From Autoimmune Disease

Tomabu G. Adjobimey, Institute for Medical Immunology Microbiology and Parasitology, Germany
Short Talk: Regulatory T Cells Induce IgG4 Production by B Cells through GITR/GITR-L Interaction, IL-10 and TGF-beta

09:20—09:40
Coffee Break

Rio Grande B,C
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Rio Grande A,B,C
13:00—22:00
Poster Viewing

Rio Grande A,B,C
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Braking Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Bataan
* Diane Mathis, Harvard Medical School, USA
Molecular Pathways Controlling Autoimmunity

Shohei Hori, RIKEN Research Center for Allergy and Immunology, Japan
Stability and Plasticity in Regulatory T Cell Differentiation

Juan J. Lafaille, New York University School of Medicine, USA
Anergy and Tolerance

Anneleen Bosma, University College London, UK
Short Talk: Lipid Antigen Presentation by B Cells is Important to Trigger iNKT Cell Expansion for Mediation of an Anti-Inflammatory Response

19:00—20:00
Social Hour with Lite Bites

Rio Grande A,B,C
19:30—22:00
Poster Session 2

Rio Grande A,B,C

WEDNESDAY, FEBRUARY 24

07:00—08:00
Breakfast

Rio Grande B,C,D
08:00—11:00
Regulating Thresholds for Activation and Tolerance I
Meeting has ended...abstracts no longer viewable online.

Bataan
Bruce Compton Richardson, University of Michigan, USA
Chromatin Structure and Immune Activation in Autoimmunity

Ian R. Rifkin, Boston University, USA
Toll-like Receptor Signaling Pathways and Lupus Pathogenesis

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
The Adipocyte and the Monocyte

* Jeffrey V. Ravetch, Rockefeller University, USA
The Up- and Down-Side of Immune Complexes

09:20—09:40
Coffee Break

Rio Grande B,C
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Rio Grande A,B,C
13:00—22:00
Poster Viewing

Rio Grande A,B,C
14:30—16:30
Workshop 2

Bataan
* William M. Ridgway, University of Cincinnati College of Medicine, USA

* Alessandra Pernis, Hospital for Special Surgery, USA

Donald M. Simons, AbbVie Bioresearch Center, USA
Inflammatory Monocytes from Arthritic Mice Induce Th17 Cell Differentiation

Reiko Takahashi, Keio University School of Medicine, Japan
SOCS1 Mediates Stabilization of Foxp3 Expression in Treg Cells

Charis E. Teh, John Curtin School of Medical Research, Australia
Combinatorial Defects in Central and Peripheral Tolerance Checkpoints Precipitate Autoimmune Pancreatitis and Sialadenitis

Falk Weih, Leibniz-Institute for Age Research, Germany
Role of RelA and RelB in Medullary Thymic Epithelial Cells in the Establishment of Immunological Self-Tolerance

Duane R. Wesemann, Brigham and Women's Hospital, Harvard Medical School, USA
Peripheral B Cell Receptor Editing

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Tissue Response: Turning the Other Cheek (Or Not)
Meeting has ended...abstracts no longer viewable online.

Bataan
Bryce A. Binstadt, University of Minnesota, USA
Effector Pathways in Multi-Organ Autoimmunity

Matthias Kretzler, University of Michigan, USA
A Systems View of Regulatory Networks in Lupus Nephritis

* William M. Ridgway, University of Cincinnati College of Medicine, USA
Why Some Tissues are Targeted for Damage

Javier Ochoa-Repáraz, Eastern Washington University, USA
Short Talk: Oral Treatment with Purified Polysaccharide A (PSA) of Human Commensal Bacteroides Fragilis Protects Against Experimental CNS Demyelinating Disease

19:00—20:00
Social Hour with Lite Bites

Rio Grande A,B,C
19:30—22:00
Poster Session 3

Rio Grande A,B,C

THURSDAY, FEBRUARY 25

07:00—08:00
Breakfast

Rio Grande B,C,D
08:00—11:00
Regulating Thresholds for Activation and Tolerance II
Meeting has ended...abstracts no longer viewable online.

Bataan
Charlotte Cunningham-Rundles, Mount Sinai Medical Center, USA
Immunodeficiency and Autoimmunity in Man

Roberta Pelanda, University of Colorado Denver, USA
Antigen and BAFF Receptors Guide the Selection and Differentiation of Immature B Cells

* Carola G. Vinuesa, Australian National University, Australia
T Follicular Helper Cells in the Control of Autoimmune Disease

Jarish N. Cohen, University of Virginia Health Systems, USA
Short Talk: Lymphatic Endothelial Cells Mediate CD8+ T Cell Peripheral Tolerance by Direct Antigen Presentation that is Independent of Aire

Norihito Kawasaki, The Scripps Research Institute, USA
Short Talk: CD22 is a Potent Negative Regulator of TLRs in B Cells

09:20—09:40
Coffee Break

Rio Grande B,C
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Novel Insights and Novel Therapeutics
Meeting has ended...abstracts no longer viewable online.

Bataan
Antonio Uccelli, IRCCS A.O.U. San Martino IST Istituto Nazionale per la Ricerca sul Cancro, Italy
Mesenchymal Stem Cells: A New Cell Therapy for Autoimmune Diseases

* Kevin J. Tracey, Feinstein Institute for Medical Research, USA
Reflexive Control of Autoinflammation and Immunity

Marijke Niens, The Jackson Laboratory, USA
Short Talk: Prevention of Type 1 Diabetes in “HLA Humanized” NOD Mice by a Multi-Peptide Coupled-Cell Approach

19:00—20:00
Social Hour with Lite Bites

Rio Grande A,B,C
20:00—23:00
Entertainment

Rio Grande

FRIDAY, FEBRUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI085738-01




We gratefully acknowledge additional support for this conference from:

JDRF Novo Nordisk A/S

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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