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This meeting took place in 2010



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Cell Biology of Virus Entry, Replication and Pathogenesis (B5)


Organizer(s) Margaret Kielian, Peter Sarnow, Terence S. Dermody and Paul D. Bieniasz
February 16—21, 2010
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 19, 2009
Late Abstract Deadline: Nov 16, 2009
Scholarship Deadline: Oct 19, 2009
Early Registration Deadline: Dec 16, 2009

Sponsored by Santaris Pharma A/S

Summary of Meeting:
The Keystone Symposia meeting on the Cell Biology of Virus Entry, Replication and Pathogenesis emphasizes key aspects of virus infection pathways and cellular responses. A central goal is the identification of critical virus-cell crosstalk during these processes. Rather than dividing viruses into separate “categories” such as positive-sense RNA viruses and DNA viruses, the meeting highlights common aspects of virus lifecycles among different virus groups. The multi-disciplinary nature of the proposed meeting is important in bringing together investigators using structural, molecular, cell biological, immunological and epidemiological methods. This emphasis on shared themes and multiple experimental approaches will continue to be critical to future advances in virology. While there has been spectacular recent progress in our understanding of virus lifecycles, we are still very far from being able to design antiviral strategies, and unexpected novel aspects of virus cell biology are constantly being discovered. Plenary sessions will cover the most important aspects of virus interactions with cells. Day 1 will include cutting-edge structural virology studies and imaging methods to follow single virus particles during entry. Day 2 will focus on the entry mechanisms of enveloped and non-enveloped viruses and the roles of cellular proteins in virus infection. Day 3 will cover viral and cellular aspects of virus replication and cellular antiviral responses. The last day will focus on the important areas of virus assembly and pathogenesis. Late-breaking exciting developments in this fast-moving field will be incorporated by short presentations and afternoon workshop sessions drawn from the submitted abstracts.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 16

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Francis V. Chisari, The Scripps Research Institute, USA
Induction and Evasion of the Innate Host Response to HCV

20:30—20:45
Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.

Chamisa Ballroom 1

WEDNESDAY, FEBRUARY 17

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Advances in Understanding Virus Structure and Function
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Margaret Kielian, Albert Einstein College of Medicine, USA
Virus-Membrane Fusion: Mechanisms of the Alphavirus and Flavivirus Fusion Proteins

* Kay Grünewald, University of Oxford, UK
Probing Membrane Interactions of Herpesvirus Glycoproteins by Cryo Electron Tomography

* Erica Ollmann Saphire, The Scripps Research Institute, USA
Crystal Structures Reveal a Shared Immunological Solution for Neutralizing Ebolaviruses

Richard J. Kuhn, Purdue University, USA
Dengue Virus Structure and Function during Assembly, Maturation and Entry

Manidipa Banerjee, Indian Institute of Technology, Delhi, India
Short Talk: Entry of a Non-Enveloped Virus Depends on Metal-Mediated pH Control of the Delivery of a Lytic Peptide to the Endosomal Membrane

Gaya Amarasinghe, Washington University School of Medicine, USA
Short Talk: Structural Basis for Innate Immune Evasion by Ebola VP35

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: Virus Entry and Assembly

Chamisa Ballroom 1
* Colin R. Parrish, Cornell University, USA

* Ted C. Pierson, NIAID, National Institutes of Health, USA

Christopher A. Davis, University of Birmingham, UK
Claudin Association with CD81 Defines Hepatitis C Virus Entry

Julia Bitzegeio, TWINCORE, Germany
Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Factors

Walther Mothes, Yale University School of Medicine, USA
Mechanism of Cell-to-Cell Transmission of Retroviruses

Jason Laliberte, NIAID, National Institutes of Health, USA
The Membrane Fusion Step of Vaccinia Virus Entry is Cooperatively Mediated by Twelve Viral Membrane Proteins

Kai Xu, National Institutes of Health, USA
Structural Studies on the Henipavirus G Attachment Glycoprotein and a Cross-Reactive Neutralizing Human Monoclonal Antibody

Rebecca Dutch, , USA
Paramyxovirus Fusion Protein Transmembrane Domain Interactions: Potential Roles in Protein Folding, Membrane Fusion and Intracellular Trafficking

Joshua Matthew Costin, Florida Gulf Coast University, USA
Peptide-Induced Ejection of the Dengue Virus Genome

Andrew M. Lee, The Scripps Research Institute, USA
Probing Arenavirus Fusion Using Unique Small Molecules

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Approaches to Visualizing Virus Entry
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Robert W. Doms, University of Pennsylvania School of Medicine, USA

Xiaowei Zhuang, Harvard University, USA
Zooming in on Virus-Cell Interactions – By Single Particle Tracking and Sub-Diffraction Limit Imaging

Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
Single Virus Tracking of HIV in vivo

Sean P. Whelan, Harvard Medical School, USA
Approaches to Characterizing the Entry of Vesicular Stomatitis Virus into Host Cells

Carolyn B. Coyne, University of Pittsburgh, USA
Short Talk: Coxsackievirus B3 Internalization into Polarized Endothelial Cells Requires DAF-Mediated Release of ER-Derived Calcium Stores

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, FEBRUARY 18

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Virus Entry Pathways
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Glen R. Nemerow, The Scripps Research Institute, USA

Terence S. Dermody, Vanderbilt University School of Medicine, USA
Reovirus Internalization and Proteolytic Disassembly

Matthew J. Evans, Icahn School of Medicine at Mount Sinai, USA
Hepatitis C Virus Cell Entry Factors And Pathways

Kartik Chandran, Albert Einstein College of Medicine, USA
Proteolysis and the Membrane Fusion Mechanism of Ebolavirus

* Billy Tsai, University of Michigan Medical School, USA
Polyomavirus Entry Pathway

Daniel C. DiMaio, Yale University School of Medicine, USA
Short Talk: Cellular DNAJ Proteins are Required for Efficient SV40 Infection

Megan Shaw, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Human Host Factors Required for Influenza Virus Replication

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Cellular Genes and Virus Infection
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Karla A. Kirkegaard, Stanford University School of Medicine, USA
Autophagy and Virus Infection

* Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Identification of Factors Involved in Virus Replication using RNAi Screens

* Susana Lopez, Instituto de Biotecnologia, Mexico
Rotavirus Strategies to Control the Cell Protein Synthesis Apparatus

Matthew D. Weitzman, Children's Hospital of Philadelphia, USA
Short Talk: A Viral Ubiquitin Ligase Targets RNF8 and RNF168 to Modulate Histone Ubiquitination and the Cellular DNA Damage Response

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, FEBRUARY 19

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Virus Replication
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Robert F. Kalejta, University of Wisconsin-Madison, USA

Peter Sarnow, Stanford University School of Medicine, USA
Modulation of Hepatitis C Virus RNA Abundance by MicroRNA 122 and Residents of Processing Bodies

Ian J. Mohr, New York University School of Medicine, USA
Regulation of Translation during Virus Infection

Peter D. Nagy, University of Kentucky, USA
A Systems Biology Approach to Dissect the Roles of Host Proteins in Tombusvirus RNA Replication

Andrea Gamarnik, Fundación Instituto Leloir, Argentina
Dengue Virus Capsid Protein Localization in Lipid Droplets and its Interplay with Viral RNA Synthesis

Sunnie R. Thompson, University of Alabama, Birmingham, USA
Short Talk: A Genetic Approach to Understanding how Viral Internal Ribosome Sites Recruit Host Ribosomes

Oren Kobiler, Princeton University, USA
Short Talk: A “Brainbow” Herpesvirus, Able to Switch Fluorophores, Suggests a Limited Number of Viral Genomes Express and Replicate in a Newly Infected Cell

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 2: Viral Pathogenesis and Host Interactions

Chamisa Ballroom 1
* Jaisri R. Lingappa, University of Washington, USA

* Daniel C. DiMaio, Yale University School of Medicine, USA

Daniel Popkin, The Scripps Research Institute, USA
Mapping the Chronic Viral Infection Resistome

Jan E. Carette, Stanford University, USA
Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

Shane D. Trask, NIAID, National Institutes of Health, USA
Engineering Rotavirus Reassortants by Reverse Genetics

Ivo Lorenz, Tri-Institutional Therapeutics Discovery Institute, USA
Insertion of the HIV-1 gp41 Epitopes 2F5 and 4E10 into the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein

Svetlana M. Atasheva, University of Alabama at Birmingham, USA
Venezuelan Equine Encephalitis Virus Capsid Forms a Tetrameric Complex with CRM1 and Importin-alphabeta that Obstructs Nuclear Pore Complex Function

Sarah Cohen, University of British Columbia, Canada
Caspase-Mediated Nuclear Envelope Disruption is Important for the Parvovirus Replication Cycle

Eric Chi-Wang Yu, Sanford-Burnham Medical Research Institute, USA
A Bcl-2-like, Vaccinia Viral Protein, F1L is a Caspase-9 Inhibitor

Andrew Mehle, University of Wisconsin, Madison, USA
Adaptive Strategies of the Influenza Virus Polymerase for Replication in Humans

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Immune Responses and Viral Evasion
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Molecular Arms Races between Viruses and Primate Genomes

Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy in Mammalian Alphavirus Host Defense

Shou-Wei Ding, University of California, Riverside, USA
siRNAs and piRNAs in Viral Immunity

Julie K. Pfeiffer, University of Texas Southwestern Medical Center, USA
Short Talk: The Gut Microbiota Influence Enteric Virus Shedding, Replication, and Pathogenesis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, FEBRUARY 20

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Virus Assembly and Exit
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Heinrich Gottlinger, University of Massachusetts Medical School, USA

Paul D. Bieniasz, Aaron Diamond AIDS Research Center, USA
Retrovirus Particle Assembly and Release

Juan Martin-Serrano, King's College London School of Medicine, UK
Parallels between Viral Budding and Cytokinesis

Thomas C. Mettenleiter, Friedrich-Loeffler-Institut, Germany
Assembly and Exit Pathway of Herpesvirus

Anette Schneemann, The Scripps Research Institute, USA
Molecular and Cell Biological Requirements for Specific Packaging of a Multipartite Viral Genome

Jeremy Rossman, Northwestern University, USA
Short Talk: The Influenza Virus M2 Ion Channel Protein Mediates the ESCRT-Independent Budding of Filamentous Virions

Brett D. Lindenbach, Yale University School of Medicine, USA
Short Talk: Hepatitis C Virus NS2 Protein Mediates Distinct, Early Steps in Virus Particle Assembly

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Viral Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Barbara Sherry, North Carolina State University, USA

Nancy C. Reich, Stony Brook University, USA
Activation of Cellular Transcription Factors in Innate Host Defense

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Pathogenesis of Influenza Virus

Raul Andino, University of California, San Francisco, USA
Short Talk: The Structure of the Viral Quasispecies and its Evolvability

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, FEBRUARY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI085778-01




We gratefully acknowledge additional support for this conference from:

Burroughs Wellcome Fund Landes Bioscience
Santaris Pharma A/S
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676