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This meeting took place in 2010



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HIV Biology and Pathogenesis (A6)


Organizer(s) Thomas J. Hope, Katherine A. Jones and Daniel C. Douek
January 12—17, 2010
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: Sep 16, 2009
Late Abstract Deadline: Oct 15, 2009
Scholarship Deadline: Sep 16, 2009
Early Registration Deadline: Nov 12, 2009

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Gilead Sciences, Inc. and Sangamo BioSciences, Inc.

Summary of Meeting:
The Keystone Symposia Meeting on HIV Biology and Pathogenesis emphasizes key aspects of the basic virological, cell and molecular biological, and disease aspects of HIV. The focus will be to highlight recent advances in our understanding of HIV/AIDS ranging from the earliest events of transmission, to treatments for infected individuals, to interventions to prevent viral transmission. The goal of the meeting is to emphasize the basic mechanisms of viral replication and the interplay of the virus with the immune system leading to the development of AIDS.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 12

15:00—19:30
Registration

Sweeney Ballroom Foyer
18:30—19:30
Refreshments

Sweeney Ballroom A-D
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
Stephen P. Goff, Columbia University, USA
HIV-1 Interactions with Host Proteins

20:30—20:45
Orientation for New Attendees and New Investigators
Meeting Organizer, Dr. Thomas Hope, to lead discussion in a "What to Expect during your Attendance" for interested delegates.

Sweeney Ballroom E-F

WEDNESDAY, JANUARY 13

07:00—08:00
Breakfast

Sweeney Ballroom A-D
08:00—11:00
HIV Transmission and Early Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* John P. Moore, Weill Medical College of Cornell University, USA

Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
Defining the Mechanisms of HIV Entry and Interactions with the Female Genital Tract

Beatrice H. Hahn, University of Pennsylvania, USA
Natural History of SIVcpz in Wild Chimpanzees

Daniel C. Douek, NIAID, National Institutes of Health, USA
Immune Aspects of HIV Disease Pathogenesis

Guido Silvestri, Emory University School of Medicine, USA
SIV Infection of Sooty Mangabeys

Jan Münch, University Clinic of Ulm, Germany
Short Talk: Testing the Effect of Semen on HIV Infection

09:20—09:40
Coffee Break

Sweeney Ballroom A-D
11:00—13:00
Poster Setup

Sweeney Ballroom A-D
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney Ballroom A-D
14:30—16:30
Workshop 1: Interplay of Viral and Cellular Proteins

Sweeney Ballroom E-F
* Paula M. Cannon, University of Southern California, Keck School of Medicine, USA

* David McDonald, Case Western Reserve University, USA

Hillel Haim, University of Iowa, USA
An Inherent ‘Ligand-Reactivity’ Property of the HIV-1 Envelope Glycoproteins Determines both Fusion Capacity and General Inhibitor Sensitivity

Brian P. Doehle, University of Washington, USA
HIV-1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells

Edward M. Campbell, Loyola University, Stritch School of Medicine, USA
p62/Sequestosome1 Associates with and Stabilizes the Expression of TRIM5alpha Proteins

Jonathan Richard, Centre de Recherche du CHUM, Canada
HIV-1 Vpr Promotes NK Cell-Mediated Killing by Upregulating Expression of Ligands for the Activating NKG2D Receptor

Amy J. Andrew, NIAID, National Institutes of Health, USA
Functional Analysis of Bst-2/Tetherin Imposed Inhibition of HIV-1 Virus Release

Elena Chertova, NCI, National Institutes of Health, USA
Denying the Denialists: Purification of SIV Particles from Highly Viremic Monkey Plasma

Vincent Dussupt, Walter Reed Army Institute of Research, USA
Mutations of Basic Residues in the Nucleocapsid Region of HIV-1 Gag cause Budding Arrests

16:30—17:00
Coffee Available

Sweeney Ballroom A-D
17:00—19:15
HIV Entry
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Jeremy Luban, University of Massachusetts Medical School, USA

Gregory B. Melikian, Emory University, USA
Biophysics of HIV Entry

David McDonald, Case Western Reserve University, USA
Cell Biology of HIV Trans-Infection

Anna Cereseto, Scuola Normale Superiore, Italy
Visualization of the Pre-Integration Complex

Benjamin Dale, Mount Sinai School of Medicine, USA
Short Talk: The Virological Synapse Promotes HIV Entry into Fusion-Permissive Compartments

Andrea Polacchini-Oliveira Jordan, University of Pennsylvania School of Medicine, USA
Short Talk: Pathological Correlates of Attenuation for SIVmac239 Containing a Mutation in a Tyr-Dependent Trafficking Motif in the Envelope Transmembrane Cytoplasmic Tail

19:15—20:15
Social Hour with Lite Bites

Sweeney Ballroom A-D
19:30—22:00
Poster Session 1

Sweeney Ballroom A-D

THURSDAY, JANUARY 14

07:00—08:00
Breakfast

Sweeney Ballroom A-D
08:00—11:00
Innate Restriction of HIV Infection
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Wesley I. Sundquist, University of Utah School of Medicine, USA

Michael H. Malim, King's College London, UK
APOBEC3G and HIV-1 Vif

Jeremy Luban, University of Massachusetts Medical School, USA
TRIM5 is a Receptor for Retroviral Capsid that Contributes to the Antiviral State

Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Tetherin Restriction and its Ablation by Diverse Viral Proteins

Mark Yeager, University of Virginia School of Medicine, USA
Structural Studies of HIV Capsid and TRIM5 alpha

Robert A. Barnitz, NIAID, National Institutes of Health, USA
Short Talk: Protein Kinase A Phosphorylation Activates Vpr-induced Cell Cycle Arrest during HIV-1 Infection

09:20—09:40
Coffee Break

Sweeney Ballroom A-D
11:00—13:00
Poster Setup

Sweeney Ballroom A-D
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney Ballroom A-D
14:30—16:30
Workshop 2: Towards Understanding How HIV Causes AIDS

Sweeney Ballroom E-F
* Richard A. Koup, NIAID, National Institutes of Health, USA

* Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA

Boris Dominik Julg, Ragon Institute, Massachusetts General Hospital, USA
Strong Antiviral CD8 T Cell Function in-vitro Correlates with Better Disease Outcome in HIV Elite Controllers Lacking Protective HLA Class I Alleles

Benjamin C. Chaon, University of Iowa, USA
Simultaneous ex vivo Expression of the PD-1/PD-L1 Axis, a Potential Mediator of T-T Cell Interactions, Characterizes HIV-Specific CD4+ T Cells

Donald L. Sodora, Center for Infectious Disease Research, USA
Double Negative T Cells (CD3+/CD4-/CD8-) with Potential CD4 T Cell Function during Natural SIV Infection of Sooty Mangabeys

Lena Al-Harthi, Rush University, USA
CD4dimCD8bright T-Cells have Potent Anti-HIV-Specific Responses and their Phenotype is Induced in a beta-Catenin-Dependent Manner

Kelly M. Fahrbach, Northwestern University, USA
Enhanced Cellular Responses and Environmental Sampling in Inner Foreskin Explants: Evidence for the Foreskin's Role in HIV Transmission

Victor H. Ferreira, McMaster University, Canada
The Effect of Co-Infection on HIV-1 Replication in the Female Genital Tract

Tara Edmonds, University of Alabama, Birmingham, USA
Infectious Molecular Clones of Transmitted/Founder HIV-1 Infect Monocyte-Derived Macrophages Less Efficiently Than Highly Macrophage Tropic Viruses

Steven E. Bosinger, Emory University, USA
Global Genomic Analysis Reveals Rapid Control of a Robust Innate Response in SIV-Infected Sooty Mangabeys

16:30—17:00
Coffee Available

Sweeney Ballroom A-D
17:00—19:15
Immune Responses to HIV Infection
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
NK Cells in HIV Infection

Richard A. Koup, NIAID, National Institutes of Health, USA
Interplay of HIV and the Immune Response

Timothy W. Schacker, University of Minnesota, USA
Mechanisms of Lymphoid Tissue Fibrosis and he Subsequrnt Impact on in HIV Infection

Judith Angeline Briant, NIAID, National Institutes of Health, USA
Short Talk: Are Infant African Green Monkeys Resistant to SIVagm Infection?

Leonid Margolis, NICHD, National Institutes of Health, USA
Short Talk: HIV Interactions with Other Viruses: And How to Exploit Them

19:15—20:00
Social Hour with Lite Bites

Sweeney Ballroom A-D
19:30—22:00
Poster Session 2

Sweeney Ballroom A-D

FRIDAY, JANUARY 15

07:00—08:00
Breakfast

Sweeney Ballroom A-D
08:00—11:00
Regulation of HIV Integration and Gene Expression
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Anna Cereseto, Scuola Normale Superiore, Italy

Frederic D. Bushman, University of Pennsylvania, USA
HIV DNA Integration: Mechanism and Consequences

Peter P. Cherepanov, Imperial College London, UK
Structural Basis for Retroviral PIC Assembly and Strand Transfer Inhibitor Action

Katherine A. Jones, The Salk Institute, USA
Tat and Cellular Stress Induce the HIV-1 Core Promoter via Distinct Mechanisms

Qiang Zhou, University of California, Berkeley, USA
Novel Cellular Cofactors and Mechanism for Tat-Activation of HIV-1 Transcription

Ivan D'Orso, UT Southwestern Medical Center, USA
Short Talk: Proteomic Study of HIV-host Transcription Complexes

09:20—09:40
Coffee Break

Sweeney Ballroom A-D
11:00—13:00
Poster Setup

Sweeney Ballroom A-D
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sweeney Ballroom A-D
13:30—16:30
NIAID Workshop: The Next Challenge: Elimination of HIV Reservoirs

Sweeney Ballroom E-F
Janet Siliciano, Johns Hopkins University School of Medicine, USA
Issues in HIV-1 Persistence and Latency

Carl H. June, University of Pennsylvania, USA
Exploring the Potential of Gene Modified CD4 T Cells to Target the HIV-1 Reservoir

Olaf Kutsch, University of Alabama at Birmingham, USA
HIV-1 Latency – Does Site of Integration Matter?

Vicente Planelles, University of Utah, USA
The Role of NFAT in HIV-1 Latency: New Insights from a Central Memory T-Cell Model

Javier Martinez-Picado, ICREA and irsiCaixa Foundation, Spain
HIV-1 Replication and Immune Dynamics are Impacted by Raltegravir Intensification of HAART-Suppressed Patients

Sarah E. Palmer, University of Sydney, Australia
Characterizing Persistent HIV Viremia

Jeffrey C. Laurence, Weill Cornell Medical College, USA
Proving the Concept: The First Well-Documented Functional, and Probably Complete, Case of HIV Eradication

* Diana Finzi, NIAID, National Institutes of Health, USA
Wrap-Up and Discussion

* Janet Siliciano, Johns Hopkins University School of Medicine, USA
Wrap Up and Discussion

14:45—15:15
Coffee Break

Sweeney Ballroom A-D
16:30—17:00
Coffee Available

Sweeney Ballroom A-D
17:00—19:00
Treatment and Prevention of HIV Infection
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Dana H. Gabuzda, Dana Farber Cancer Institute, USA

Steven G. Deeks, University of California, San Francisco, USA
HIV-Association Inflammation as a Cause of Accelerated Aging

John P. Moore, Weill Medical College of Cornell University, USA
Studying Entry Inhibitor-based Vaginal Microbicides in the Rhesus Macaque

Jerome H. Kim, International Vaccine Institute, South Korea
Understanding the Results of the Thai Vaccine Trial

Christopher Aiken, Vanderbilt University School of Medicine, USA
Short Talk: Inhibition of HIV-1 Infection by Small Molecule Destabilization of the Viral Capsid

19:00—20:00
Social Hour with Lite Bites

Sweeney Ballroom A-D
19:30—22:00
Poster Session 3

Sweeney Ballroom A-D

SATURDAY, JANUARY 16

07:00—08:00
Breakfast

Sweeney Ballroom A-D
08:00—11:00
HIV Latency and Reservoirs
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Vineet N. KewalRamani, NCI, National Institutes of Health, USA

Eric M. Verdin, University of California, San Francisco, USA
Epigenetic Regulation of HIV Latency

Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
Tat-mediated Gene Modulation in HIV Target Cells

Dana H. Gabuzda, Dana Farber Cancer Institute, USA
NeuroAIDS and HIV Reservoirs

Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Transmission of HIV-1 and Dynamics of Early Escape from Cytotoxic T-Cells: with an Ultradeep View

Wendy A. Burgers, University of Cape Town, South Africa
Short Talk: Immune Activation during Early HIV Infection Associates with the Rate of Disease Progression

09:20—09:40
Coffee Break

Sweeney Ballroom A-D
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney Ballroom A-D
17:00—19:15
HIV Interactions with the Cell and Host
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom E-F
* Michael H. Malim, King's College London, UK

Frank Kirchhoff, University of Ulm, Germany
Role of Nef and Vpu in Primate Lentiviral Pathogenesis and Transmission

Wesley I. Sundquist, University of Utah School of Medicine, USA
Hexameric Assemblies of a Restricting TRIM5Ą Protein: Implications for Molecular Recognition of Viral Capsids

Vineet N. KewalRamani, NCI, National Institutes of Health, USA
Postentry Restriction of HIV-1 by a Capsid Interacting Factor

Marc C. Johnson, University of Missouri, Columbia, USA
Short Talk: The Minimal Requirements for Viral Pseudotyping

Greg J. Towers, University College London, UK
Short Talk: A Role for the Nuclear Pore Protein Nup358 (RANBP2) in Capsid Dependent Nuclear Entry of Lentiviruses

19:15—20:15
Social Hour with Lite Bites

Sweeney Ballroom A-D
20:00—23:00
Entertainment

Sweeney Ballroom A-D

SUNDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI087256-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Gilead Sciences, Inc.
Office of AIDS Research, NIH Sangamo BioSciences, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676