Sagebrush Inn & Suites Floorplan

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This meeting took place in 2010


Here are the related meetings in 2018:
Chromatin Architecture and Chromosome Organization (X5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Basis for Chromatin Structure and Regulation (A8)


Organizer(s) Jonathan Widom, Geeta Narlikar and Dinshaw J. Patel
January 17—22, 2010
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 18, 2009
Late Abstract Deadline: Oct 21, 2009
Scholarship Deadline: Sep 18, 2009
Early Registration Deadline: Nov 17, 2009

Supported by The Directors' Fund

Summary of Meeting:
Chromatin structure and dynamics underlie every aspect of genome function. The past several years have seen an exponential growth in our knowledge of facts, ranging from catalogs of histone protein posttranslational modifications to complete genome sequences of many organisms to atomic resolution structures of many key molecular players. But our mechanistic understanding lags far behind. New reagents, methodologies and concepts are needed. This meeting will bring together leading experts in diverse areas of chromatin biology who are developing and applying new approaches to develop a concrete mechanistic link between chromatin structure and chromatin function. The topics covered include: fundamental in vivo physical chemical studies of transcription factor binding; real-time single molecule in vivo imaging; state-of-the-art methods for discovery, characterization, and manipulation of histone- and nucleosome-modifying enzymes and for the synthesis and characterization of their specifically-modified histone and nucleosome substrates; single molecule biophysics studies of molecular mechanisms; atomic resolution structural studies; and locus- and chromosome-wide phenomena such as heterochromatin formation and dosage compensation.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 17

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jonathan Widom, Northwestern University, USA

Roger D. Kornberg, Stanford University, USA
Chromatin Structure and Transcription

C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Writing and Reading the Histone Code


MONDAY, JANUARY 18

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Transcription Factor and Chromatin Dynamics in vivo
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Timothy J. Stasevich, National Institutes of Health, USA
Dissecting the Binding Mechanism of the Linker Histone in Live Cells: An Integrated FRAP Analysis

John T. Lis, Cornell University, USA
Very Rapid and Locus-Wide Changes in Chromatin Caused by Activation of a Potentiated Gene

X. Sunney Xie, Harvard University, USA
Transcription Factor and Chromatin Dynamics in vivo

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
The Role of Nucleosome Remodelers in the Positioning and Dynamics of DNA during Expression and Repair

Hinrich Boeger, University of California, Santa Cruz, USA
Short Talk: The Kinetics of Stochastic Fluctuations in Chromatin Structure and Gene Expression

Maya M. Kasowski, Howard Hughes Medical Institute, USA
Short Talk: Analyzing Variation in Gene Regulation in Humans: Global Analysis of NF-kappaB and Polii Binding using CHIP-SEQ

Alexander Tarakhovsky, Rockefeller University, USA
Short Talk: Histone Mimicry by Pathogens

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
15:30—16:30
Workshop Panel
To be geared toward helping women (and men, if interested) graduate students, postdocs, and junior faculty address the challenges of balancing an academic career and family.

Chamisa Ballroom 1
* Geeta J. Narlikar, University of California, San Francisco, USA

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Functional Elements
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Insulators and Enhancer Blockers

Stavros Lomvardas, Columbia University, USA
Molecular Mechanisms of Olfactory Receptor Choice

Robert E. Kingston, Massachusetts General Hospital, USA
Nucleosome Occupancy and Transcriptional Regulation

J.J. Miranda, Gladstone Institutes and University of California, San Francisco, USA
Short Talk: Molecular Architecture of CTCF and the Insulatosome

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, JANUARY 19

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Chromatin Assembly and Modification
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Karolin Luger, Colorado State University, USA
Histone Chaperone Mechanisms in Chromatin Assembly and Disassembly

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Histone Chaperones, Chromatin Assembly and the Challenges of Cell Cycle

James T. Kadonaga, University of California, San Diego, USA
Chromatin Assembly and DNA Dynamics

Shelley L. Berger, University of Pennsylvania, USA
Histone Covalent Modifications in Genome Regulation

Song Tan, Pennsylvania State University, USA
Short Talk: Structural Basis for Nucleosome Recognition by the RCC1 Chromatin Factor

Michael A. Shogren-Knaak, Iowa State University, USA
Short Talk: Acetylation-Dependent Multimerization of the Yeast SAGA Coactivator Complex in Inducible Gene Transcription

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Histone Code Modules and Enzyme Mechanism
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA

Or P. Gozani, Stanford University, USA
Role of Protein Lysine Methylation Signaling in Health and Disease

Cheryl Arrowsmith, University of Toronto, Canada
Structural and Chemical Biology of Histone Code Modules

Philip A. Cole, Johns Hopkins University School of Medicine, USA
Chemical Approaches to Mechanisms of Histone Modifying Enzymes

Alexander J. Ruthenburg, University of Chicago, USA
Short Talk: Multivalent Interactions Interpret the Histone Code at the Nucleosome Level

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, JANUARY 20

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Dynamic Transitions and ATP-Dependent Remodeling
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Bradley R. Cairns, HHMI/University of Utah, USA
DNA Translocation by the RSC Chromatin Remodeler in ‘Tethered’ Formats

Geeta J. Narlikar, University of California, San Francisco, USA
Structure and Mechanisms of ATP-Dependent Chromatin Remodeling Motors

Michelle D. Wang, Cornell University, USA
The Dynamics of Accessing DNA

Xiaowei Zhuang, Harvard University, USA
Single Molecule Studies of Chromatin Remodeling Enzymes

Gregory D. Bowman, Johns Hopkins University, USA
Short Talk: Crystal Structure of the Chd1 Remodeler Reveals that Chromodomains can Directly Regulate the ATPase Motor

Hua-Ying Fan, Fox Chase Cancer Center, USA
Short Talk: UV-Induced Association of the CSB Remodeling Protein with Chromatin Requires ATP-Dependent Relief of N-Terminal Autorepression

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Chromatin Structure
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Geeta J. Narlikar, University of California, San Francisco, USA

Timothy J. Richmond, ETH Zürich, Switzerland
Structure and Interactions of the Chromatin Remodeling Factor ISW1a

Eran Segal, Weizmann Institute of Science, Israel
EMBO Young Investigator Lecture: Toward Understanding the Code of Chromatin Regulation

John van Noort, BF/ LION, Leiden University, Netherlands
Unraveling Chromatin Higher Order Structure with Magnetic Tweezers

Yvonne N. Fondufe-Mittendorf, Northwestern University, USA
Short Talk: Nucleosome Positioning and Dynamic Nucleosome Repositioning in Transcription Regulation

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, JANUARY 21

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Silencing and Dosage Compensation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Danesh Moazed, Harvard Medical School, USA
In Vitro Reconstitution of Heterochromatin-Dependent Transcriptional Gene Silencing

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Mediated Epigenetic Control of the Genome

Barbara J. Meyer, University of California, Berkeley, USA
X-Chromosome-Wide Gene Regulation

Jeannie T. Lee, Massachusetts General Hospital, USA
Separating Repressive and Activating Chromatin Domains at the X-Inactivation Center

Joanna Wysocka, Stanford University School of Medicine, USA
Short Talk: Coordinated Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

Yali Dou, University of Michigan, USA
Short Talk: The Heterodimer of Non-SET Domain Proteins Ash2L and RbBP5 has Intrinsic Histone Methyltransferase Activity that Synergizes with the MLL1 SET Domain in H3 K4 Methylation

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Protein Chemistry
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Tom W. Muir, Princeton University, USA
A Synthetic ‘Kiss of Death’

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
A Structural Perspective of How Chromatin-Binding Modules Interpret Histone Modifications

Jennifer J. Ottesen, Ohio State University, USA
Short Talk: Ligation Strategies to Probe Histone Modifications in the Nucleosome Core

Benjamin A. Garcia, University of Pennsylvania, USA
Short Talk: Next Generation Quantitative Proteomic Tools for Analyzing Histone Modifications

Daniele Canzio, University of California, San Francisco, USA
Short Talk: Polymerizable Chromodomain "Sticky Ends" in HP1 Couple H3K9me3 Recognition to Nucleosome Arrangement in Heterochromatin Assembly

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

FRIDAY, JANUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Integrated DNA Technologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676