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This meeting took place in 2010



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Nuclear Receptors: Development, Physiology and Disease (X8)


Organizer(s) Carl S. Thummel, David D. Moore and Joyce J. Repa
March 21—26, 2010
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 23, 2009
Late Abstract Deadline: Dec 28, 2009
Scholarship Deadline: Nov 23, 2009
Early Registration Deadline: Jan 22, 2010

Supported by The Directors' Fund


Summary of Meeting:
Nuclear receptors represent a family of ligand-regulated transcription factors that play central roles in development, physiology, and metabolism. Upon binding small lipophilic hormones and metabolites, such as steroids, fatty acids, and bile acids, nuclear receptors switch their regulatory status, reprogramming gene expression in target tissues. Current research is aimed at defining roles for these receptors in normal development and metabolism as well as better understanding how nuclear receptor dysfunction contributes to diabetes, cancer, cardiovascular disease, obesity, and neuronal disorders. Nuclear receptors are also a major target for drug development, with many compounds on the market and several in ongoing human trials. This meeting will highlight recent breakthroughs in nuclear receptor research, promote interactions between scientists from industry and academia, and provide opportunities for senior scientists to interact with younger researchers and trainees.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 21

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA
RNA-Protein Complexes (RNPs): The Instruments of Post-Transcriptional Gene Regulation


MONDAY, MARCH 22

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Nuclear Receptors in Development and Disease
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Carl S. Thummel, University of Utah School of Medicine, USA

Peter Tontonoz, University of California, Los Angeles, USA
Liver X Receptors in Metabolism, Inflammation and Disease

Carlie J. M. de Vries, University of Amsterdam, Netherlands
NR4A Orphan Nuclear Receptors in Vascular Disease

Joe Thornton, University of Chicago, USA
Evolution of Nuclear Receptors

Henry M. Krause, University of Toronto, Canada
Coordination of Developmental Check Points and Metabolism

Jason M. Tennessen, Indiana University, USA
Short Talk: The Drosophila Estrogen-Related Receptor Coordinates Carbohydrate Metabolism with Cell Growth

Marc R. Van Gilst, Fred Hutchinson Cancer Research Center, USA
Short Talk: From the Nematode Nuclear Receptor Milieu, C. elegans NHR-49 Emerges as a Casanova

08:00—11:00
Signaling and Physiology
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA

Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Mechanisms in Progesterone Receptor Regulation of Inflammatory Signaling in Pregnancy and Labor

Sheue-Yann Cheng, NCI, National Institutes of Health, USA
Novel Signaling of Mutant Thyroid Hormone Receptors in Carcinogenesis

John A. Cidlowski, NIEHS, National Institutes of Health, USA
Talk Title to be Determined

Iris Z. Jaffe, Tufts-New England Medical Center, USA
Mineralocorticoid Receptor Regulation of Vascular Gene Expression: Role in Vascular Function and Disease

Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA
Short Talk: MicroRNAs Differentially Expressed in Luminal versus Triple Negative Breast Cancer Control Estrogen Receptor alpha and Growth Factor Receptor Expression and Aspects of Tumor Metabolism

Mark G. Obukowicz, Pfizer Inc., USA
Short Talk: Dissociated Agonist of the Glucocorticoid Receptor (DAGR): 60 Years in the Making (and of Waiting)

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop 1: Hot Topics: Nuclear Receptors in Development and Disease

Longs Peak
Lilach Gilboa, Weizmann Institute of Science, Israel
Hormonal Coordination of Niche Formation and Germ Line Stem Cell Establishment

Chris R. Gissendanner, University of Louisiana at Monroe, USA
The C. elegans NR4A Nuclear Receptor: Conserved Functions in Cell Proliferation and Cell Differentiation during Organ Morphogenesis

Wen Xie, University of Pittsburgh, USA
Unexpected Hepatotoxicity and Inflammatory Gene Activation in FXR Transgenic Mice

Wendong Huang, Beckman Research Institute of City of Hope, USA
FXR, Liver Repair and Aging

* Li Wang, University of Connecticut, USA
Nuclear Receptor SHP-dependent Mitochondrial Targeting in Apoptosis Signaling and Tumor Growth

14:30—16:30
Workshop 1: Hot Topics: Physiology

Grays Peak
* Carolyn L. Smith, Baylor College of Medicine, USA

Michihisa Umetani, University of Houston, USA
LXRbeta Promotes Vascular Reendothelialization via a Novel Mechanism Involving non-Nuclear Signaling in Endothelium

Terry D. Hinds, University of Toledo, USA
Discovery of Glucocorticoid Receptor beta in Mice and its Role in Insulin Signaling and Metabolism

Ronni Nielsen, University of Southern Denmark, Denmark

Brian Sandri, University of Minnesota, USA
Evidence for a Global Role of the Estrogen- Regulated ZEB1 Transcription Factor in Modulating Adiposity through Regulation of FGF-21

Jens Tiefenbach, University of Toronto, Canada
A live Zebrafish-based Screening System for Human Nuclear Receptors Allows for Tissue Selective Drug Discovery

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mechanisms of Nuclear Receptor Signaling (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
* Donald P. McDonnell, Duke University School of Medicine, USA

Christopher K. Glass, University of California, San Diego, USA
Lineage-Determining Transcription Factors Prime Cis-regulatory Elements Required for Ligand-dependent Gene Expression

Keith R. Yamamoto, University of California, San Francisco, USA
Cell and Gene Selectivity of Glucocorticoid Action: DNA Sequences as Specific GR Ligands

Gordon L. Hager, NCI, National Institutes of Health, USA
Global Regulation of Chromatin Structure and Gene Expression by Glucocorticoid Receptors

Jason S. Carroll, Cancer Research UK, University of Cambridge, UK
Short Talk: FoxA1 is the Critical Determinant of ER Binding and Activity in Breast Cancer Cells

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, MARCH 23

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Metabolic Control and Circadian Rhythms
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Susanne Mandrup, University of Southern Denmark, Denmark

Urs Albrecht, University of Fribourg, Switzerland
The Clock Component Per2 Coordinates Circadian Output by Interaction with Nuclear Receptors

Ueli Schibler, University of Geneva, Switzerland
The Regulation of Circadian Gene Expression in Peripheral Cell Types

David D. Moore, Baylor College of Medicine, USA
Gut Feelings

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Integrating Metabolic Control by NAD+ Sensors

Pavlos Pissios, Beth Israel Deaconess Medical Center, USA
Short Talk: Regulation of Glucose and Lipid Metabolism by Nicotinamide N-Methyltransferase

Thomas P. Burris, Saint Louis University School of Medicine, USA
Short Talk: Characterization of Synthetic REV-ERB ligands

08:00—11:15
Ligands, Cofactors, and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Donald P. McDonnell, Duke University School of Medicine, USA
The ERRalpha/PGC-1 Complex Links HER2/IGF1 Initiated Signaling Events to the Expression of Target Genes that Impact Breast Cancer Pathogenesis

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Epigenetics: Life, Death, and Tumor Translocations

Carol A. Lange, University of Minnesota, USA
Mechanisms of PR Coupling to MAP Kinases

Geoffrey L. Greene, University of Chicago, USA
Structural Basis of ER Ligand Selectivity

Kendall W. Nettles, The Scripps Research Institute, USA
Short Talk: Coupling of Estrogen Receptor Conformation and Ligand Orientation Determine Graded Signaling Activity

Wei Xu, University of Wisconsin-Madison, USA
Short Talk: “Yin-Yang” Principle for Estrogen Receptor Heterodimers in Breast Cancer: A Targeted Molecular Approach for Therapeutic Development

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop 2: Hot Topics: Co-Regulators and Post-Transcriptional Control

Longs Peak
Inna I. Astapova, Beth Israel Deaconess Medical Center, USA
The Nuclear Corepressor, NCoR, Controls the Set Point of the Thyroid Axis In vivo

Karine C. Gauthier, Université de Lyon, France
The Thyroid Hormone Receptor TRalpha Protects Against Atherosclerosis Development

Atul Chopra, Baylor College of Medicine, USA
Hepatic SRC-2 Regulates Energy Balance by Coordinating Bile Secretion and Dietary Fat Absorption

Nan Wu, University of Pennsylvania, USA
Arf-bp1 and Pam are Novel Regulators of Circadian Rhythm that Target Rev-erbalpha for Degradation

William Bourguet, Centre de Biochimie Structurale, France
A Unique Secondary Structure Switch Controls Constitutive Gene Silencing by Retinoic Acid Receptor

* Patrick R. Griffin, The Scripps Research Institute, USA
HDX of Intact VDR/RXR Heterodimer Reveals Agonist and DNA-Induced Conformational Changes Important for Coactivator Interaction

14:30—16:30
Workshop 2: Hot Topics: Gene Regulation

Grays Peak
* Steven K. Nordeen, University of Colorado Health Sciences Center, USA

Katherine Anne Burns, University of Cincinnati College of Medicine, USA
Selective Mutations in the D-domain of Mouse ERalpha Alters Nuclear Translocation and ERalpha’s Non-ERE Gene Regulatory Mechanism

Nasun Hah, The Salk Institute for Biological Studies, USA
Exploring the Direct Estrogen-Regulated Transcriptome in Breast Cancer Cells Using GRO-Seq

Moray J. Campbell, Roswell Park Cancer Institute, USA
VDR Regulation of Histone Modifications and miRNA Combine to Fine-Tune Transcriptional Cycling of Target Genes

Robert H. Oakley, NIEHS, National Institutes of Health, USA
Crosstalk between Glucocorticoid and G Protein-Coupled Receptor Signaling Pathways Mediated by Arrestins

Joshua D. Stender, University of California, San Diego, USA
Control of Pro-Inflammatory Gene Programs by Active Histone Methylation and Demethylation

Daniel G. Gioeli, University of Virginia, USA
CDK9 Regulates AR Activity and Cell Growth through Serine 81 Phosphorylation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Physiology and Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
* David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Regulation of Adipogenesis and Energy Homeostasis

Deborah Clegg, Cedars-Sinai Medical Center, USA
Estrogen, Adipose Tissue, and The Metabolic Syndrome

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
PPARs in Metabolism and Disease

Austin J. Cooney, Baylor College of Medicine, USA
Short Talk: Regulation of ES Cells and iPS by Nuclear Receptors

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, MARCH 24

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Cell Fate and Tissue Homeostasis
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Joyce J. Repa, University of Texas Southwestern Medical Center, USA

Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
NR4A Orphan Nuclear Receptors Trigger a Neuroprotective Pathway Induced by Elevated Cyclic AMP

Gary D. Hammer, University of Michigan, USA
SF-1/DAX: Adrenocortical Stem/Progenitor Cell Fate and Multipotency

Frances M. Sladek, University of California, Riverside, USA
HNF4alpha Function and Regulation -- New Insights into an Old Receptor

Erin G. Schuetz, St. Jude Children's Research Hospital, USA
Cis and Trans Genetic Variation Affecting Hepatic Nuclear Hormone Receptor Expression

Jae W. Lee, Oregon Health and Science University, USA
Short Talk: Histone H3-lysine 4 Methyltransferases Specialized for Nuclear Receptor-Mediated Metabolic Homeostasis

Kai Ge, NIDDK, National Institutes of Health, USA
Short Talk: Epigenetic Regulation of PPARgamma and Adipogenesis

08:00—11:15
Chromatin and Transcription
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Dean P. Edwards, Baylor College of Medicine, USA

Roland Schüle, Universitaetsklinikum Freiburg, Germany
Androgen Receptor Function is Regulated by Histone Demethylases: Implication for Prostate Cancer

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Genomic Analyses of Estrogen-Regulated Transcription Reveal New Facets of the Estrogen Signaling Pathway

Raphael Metivier, Université de Rennes I, France
Estrogen Receptor Transcriptional Activity: A Dynamic Integration of Multi-Leveled Information

Shigeaki Kato, University of Tokyo, Japan
Epigenetic Regulators Supporting Nuclear Receptor Function

Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: The Role of GRIP1 in Type I Interferon Signaling and Glucocorticoid-Induced Immunosuppression

Catharine L. Smith, University of Arizona, USA
Short Talk: Histone Deacetylases Function as Glucocorticoid Receptor Coactivators

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop 3: Hot Topics: Nuclear Receptors in Metabolism

Longs Peak
* Carolyn L. Cummins, University of Toronto, Canada

Kari T. Chambers, Washington University School of Medicine, USA
PGC-1beta Regulates Hepatic Energy Metabolism Under ad Libitum Fed Conditions

Philipp M. Kulozik, German Cancer Research Center, Germany
Lack of Hepatic TBL1/TBLR1 Transcriptional Co-Activator Function Promotes Obesity-Related Dyslipidemia

Hong Soon Kang, NIEHS, National Institutes of Health, USA
Retinoid-Related Orphan Receptor alpha (RORalpha) Positively Regulates Obesity, Hepatic Steatosis, and Inflammation

Yanqiao Zhang, Northeastern Ohio Universities College of Medicine, USA
Identification of Novel Pathways that Control FXR-mediated Hypocholesterolemia

Katja A. Lamia, The Scripps Research Institute, USA
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

14:30—16:30
Workshop 3: Hot Topics: Signaling and Cancer

Grays Peak
* Jonna Frasor†, University of Illinois, Chicago, USA

Shannon T. Bailey, Dana-Farber Cancer Institute, USA
Loss of ER-Regulated microRNAs is Fundamental to Hormone-Independent Breast Cancer Cells

Ruby Dhar, University of Chicago, USA
Genome Wide RNAi Screen to Identify Novel Targets for Estrogen Signaling in Breast Cancer

Zeynep Madak-Erdogan, University of Illinois at Urbana-Champaign, USA
Critical Role of ERK2 in Estrogen Receptor alpha (ERalpha)-mediated Regulation of Gene Expression and Proliferation of Breast Cancer Cells

Lillian J. Eichner, The Salk Institute, USA
miR-378 Induces Metabolic Shift in Breast Cancer Cells via the ERRgamma Transcriptional Pathway

Jun Qin, Baylor College of Medicine, USA
COUP-TFII Regulates Angiogenesis to Promote Tumor Growth and Metastasis

Matthew J. Schiewer, Thomas Jefferson University, USA
Impact of PARP1 on AR Signaling and Therapeutic Response in Prostate Cancer

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Coregulators and Gene Expression (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Bert W. O'Malley, Baylor College of Medicine, USA
NR Coactivators: Physiology and Disease

Catherine C. Thompson, Pfizer, USA
LXR is a Therapeutic Target for Skin Aging and Dermal Inflammatory Indications

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Epigenetic Regulation of Nuclear Receptor Expression, Cistromes, and Function

Ralf Kittler, University of Texas Southwestern Medical Center, USA
Short Talk: A cis-Regulatory Map for Nuclear Receptors in Breast Cancer

Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: dkCOIN: A BIG Solution to Data Integration

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, MARCH 25

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Nuclear Receptors in Metabolism
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Pancreatic Beta Cells

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
Regulation of Metabolism by Nuclear Receptor-FGF Pathways

Anastasia Kralli, Johns Hopkins Medical School, USA
ERR Function in Energy Metabolism and Cancer

* Vincent Giguère, McGill University, Canada
Metabolic Gene Networks in Normal and Cancer Cells: One Nuclear Receptor Subfamily to Rule them All

Carolyn L. Cummins, University of Toronto, Canada
Short Talk: LXRbeta is Required for Glucocorticoid-Induced Hyperglycemia and Hepatosteatosis

Yihong Wan, University of Texas Southwestern Medical Center, USA
Short Talk: PGC1beta Mediates PPARgamma Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

08:00—11:15
Steroid Receptors, Signaling and Cancer
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* John A. Cidlowski, NIEHS, National Institutes of Health, USA

Kathryn B. Horwitz, University of Colorado Health Sciences Center, USA
Women’s Hormones, Breast Cancer Metastasis and Cancer Stem Cells

Jan-Åke Gustafsson, University of Houston, USA
Novel Biological Roles of LXRs

Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
New Paradigms in Tumor Suppression: The RB-E2F Axis and Nuclear Receptor Regulation in Cancer

Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
Overcoming Resistance to Anti-Androgen Therapy in Prostate Cancer

Yun Qiu, University of Maryland School of Medicine, USA
Short Talk: Androgen Receptor Splicing Variants and Castration Resistance in Prostate Cancer

Suzanne D. Conzen, University of Chicago, USA
Short Talk: Identification of a Glucocorticoid Receptor Signature in Primary Human Breast Cancers

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Nuclear Receptors, Signaling, and Gene Regulation (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peaks
* Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nutrient-Sensing and Metabolic Control by Nuclear Receptors

Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Genomics of Estrogen Receptor Signaling in Breast Cancer and Endocrine Resistance

Myles Brown, Dana-Farber Cancer Institute, USA
Nuclear Receptor Cistromes and Epigenomes

Edwin Cheung, University of Macau, Macau
Short Talk: Global and Funcational Analyses of ER-Mediated Long-Range Chromatin Interactions

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

FRIDAY, MARCH 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK084688-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck & Co., Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676