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This meeting took place in 2010


Here are the related meetings in 2018:
Gene Control in Development and Disease (X6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Dynamics of Eukaryotic Transcription during Development (C4)


Organizer(s) Karen Adelman and Marc Timmers
April 7—12, 2010
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Dec 7, 2009
Late Abstract Deadline: Jan 5, 2010
Scholarship Deadline: Dec 7, 2009
Early Registration Deadline: Feb 5, 2010

Supported by The Directors' Fund

Summary of Meeting:
Gene expression in eukaryotes is regulated primarily at the level of transcription. Although much is known about the basic building blocks required to recruit RNA polymerase II to a gene promoter and establish a pre-initiation complex, recent data reveals that a great deal of regulation occurs during transcription elongation, and involves dynamic interactions between the transcription machinery and chromatin structure. This meeting is intended to explore these recently appreciated mechanisms for gene regulation and to showcase the novel techniques that have permitted these advances. Of particular interest are the use of comprehensive, genomic approaches, and their use towards understanding the different patterns of gene expression in different model systems, including stem cells and developing tissues, as well as the application of novel molecular probing and cell imaging techniques to investigate the global nuclear architecture and its impact on gene expression.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 7

15:00—19:30
Registration

Lower Atrium
18:30—19:30
Refreshments

Lower Atrium
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Karen Adelman, Harvard Medical School, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Programming Embryonic Stem Cell State


THURSDAY, APRIL 8

07:00—08:00
Breakfast

Jefferson/Madison
08:00—11:00
Genomic Approaches to Understanding Gene Expression
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Marc Timmers, University Medical Centre Utrecht, Netherlands

Jonathan Widom, Northwestern University, USA
DNA-Encoded Nucleosome Organization of Eukaryotic Genomes

Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Mapping Genome-Wide Nucleosome Dynamics

B. Franklin Pugh, Pennsylvania State University, USA
Global Interplay between the Transcription Machinery and Chromatin

Frank C.P. Holstege, University Medical Center, Utrecht, Netherlands
Understanding Regulatory Circuitry through Expression-Profile Phenotypes

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Short Talk: Exploring the Direct Estrogen-Regulated Transcriptome in Breast Cancer Cells Using GRO-Seq

09:20—09:40
Coffee Break

Lower Atrium
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Jefferson/Madison
13:00—22:00
Poster Viewing

Jefferson/Madison
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Transcription Regulation in Stem Cells and during Development
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Michael S. Levine, Princeton University, USA
Gene Activation during Development and Differentiation in Drosophila

Fiona M. Watt, King's College London School of Medicine, UK
Proliferation and Differentiation of Epidermal Stem Cells

Kenneth S. Zaret, University of Pennsylvania, USA
Pioneer Transcription Factors in Programming of Liver and Pancreas Progenitors: Lessons for Stem Cell Differentiation

X. Shirley Liu, Dana-Farber Cancer Institute, Harvard School of Public Health, USA
Short Talk: Using Histone Mark Dynamics to Infer the Transcription Regulatory Network in Intestine Development

19:00—20:00
Social Hour with Lite Bites

Jefferson/Madison
19:30—22:00
Poster Session 1

Jefferson/Madison

FRIDAY, APRIL 9

07:00—08:00
Breakfast

Jefferson/Madison
08:00—11:00
Transcription Regulation - From Pol II Recruitment to Early Elongation
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Kenneth S. Zaret, University of Pennsylvania, USA

Robert G. Roeder, Rockefeller University, USA
Function of Diverse Transcriptional Coactivators in Animal Cells

Marc Timmers, University Medical Centre Utrecht, Netherlands
Dynamic Regulation of the Basal Transcription Machinery

Jennifer F. Kugel, University of Colorado Boulder, USA
Regulation of Early Steps of Transcription by ncRNAs

Bijan Sobhian, Institute of Human Genetics, France
Short Talk: HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

Laszlo Tora, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
TBP2 is Essential for Germ Cell Development by Regulating Transcription and Chromatin Condensation in the Oocyte

09:20—09:40
Coffee Break

Lower Atrium
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Jefferson/Madison
13:00—22:00
Poster Viewing

Jefferson/Madison
14:30—16:30
Workshop 1: Genomic Approaches: Discovery of Transcription Modulators as Drug Targets and High-Throughput Techniques for Investigating Changes in Gene Expression
This workshop is designed to engage members of pharmaceutical industry using new techniques to identify transcription inhibitors, as well as companies that do high-throughput sequencing.

Gallatin
* Laszlo Tora, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France

James E. Bradner, Novartis Institutes for BioMedical Research, USA
Direct Inhibition of the Notch Transcription Factor Complex

Jun Zhu, NHLBI, National Institutes of Health, USA
The Landscape of Transcription Initiation in the Drosophila melanogaster Embryo

Tae-Kyung Kim, University of Texas Southwestern Medical Center, USA
Widespread Transcription at Thousands of Enhancers during Activity-Dependent Gene Expression in Neurons

Marta Radman-Livaja, University of Massachusetts Medical School, USA
Gene Inactivation and Epigenetic Inheritance

Michael P. Schnetz, Case Western Reserve University, USA
CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene Expression

Michael D. Wilson, Cambridge Research Institute, UK
Five Vertebrate ChIP-seq Reveals the Genetic Mechanisms of Rapid Transcription Factor Binding Divergence

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Regulation of Transcription Elongation
Meeting has ended...abstracts no longer viewable online.

Gallatin
* John T. Lis, Cornell University, USA

Hiroshi Handa, Tokyo Institute of Technology, Japan
The Role of Transcription Elongation Factors in Genome Expression

Karen Adelman, Harvard Medical School, USA
Pol II Stalling Across the Genome

David S. Gilmour, Pennsylvania State University, USA
Biochemical and in vivo Analysis of Promoter Proximal Pausing

L. Ryan Baugh, Duke University, USA
Short Talk: Nutritional Control of Pol II Pausing during C. elegans Development

19:00—20:00
Social Hour with Lite Bites

Jefferson/Madison
19:30—22:00
Poster Session 2

Jefferson/Madison

SATURDAY, APRIL 10

07:00—08:00
Breakfast

Jefferson/Madison
08:00—11:00
The Interplay between Transcription and Chromatin
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA

Jane Mellor, University of Oxford, UK
Histone Modifications, Transcription Factors, ncRNA and Gene Loops in Transcription

Marc D. Meneghini, University of Toronto, Canada
Short Talk: Global Histone Demethylation Controls Spore Differentiation Timing during Budding Yeast Gametogenesis

Olivier Cuvier, LBME- CNRS, France
Deciphering the Discrete Stages of Insulator-encoded Nucleosome-Positioning: The Road toward Transcriptional Competence

Ali Shilatifard, Northwestern University, USA
Transcriptional Elongation Control and Human Leukemia

David H. Price, University of Iowa, USA
Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by HIV Tat and the Chromatin Binding Protein, Brd4

09:20—09:40
Coffee Break

Lower Atrium
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Jefferson/Madison
13:00—22:00
Poster Viewing

Jefferson/Madison
14:30—16:30
Workshop 2: New and Noteworthy

Gallatin
* Joan W. Conaway, Stowers Institute for Medical Research, USA

Maria Ciofani, Skirball Institute of Biomolecular Medicine, USA
Transcriptional Regulatory Network Underlying CD4+ T Helper 17 (Th17) Lineage Specification

Suming Huang, University of Florida, USA
Serine Phosphorylation on TAL1 Regulates its Interaction with Histone Demethylase LSD1 during Hematopoiesis

Miguel Garcia-Diaz, Stony Brook University, USA
A Unique DNA Binding Mode Enables Human mterf1 to Regulate Mitochondrial Transcription

Akihiko Yokoyama, Kyoto University, Japan
Mechanisms of MLL-Dependent Transcriptional Maintenance in Normal and Cancer Cells

Madeline M. Wong, National Cancer Institute, NIH, USA
Promoter Bound p300 Complexes Facilitate Transmission of Molecular Memory Across the Cell Cycle

Ines de Santiago, Medical Research Council - Clinical Sciences Centre, UK
Genome-Wide Mapping of RNA Polymerase II Phosphorylation Elucidates the CTD Code in Embryonic Stem Cells

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Activators and Co-Regulatory Complexes
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Katherine A. Jones†, The Salk Institute, USA

Barbara Panning, University of California, San Francisco, USA
Tip60-p400 as a Regulator of Embryonic Stem Cell Identity

Joan W. Conaway, Stowers Institute for Medical Research, USA
Mechanisms for Recruiting Chromatin Remodeling Complexes to Their Targets

Susan E. Mango, Harvard University, USA
Investigating the Transcriptional Mechanisms that Govern the Progression of C. elegans Development

Michael Meisterernst, Institute of Molecular Tumor Biology, Germany
Short Talk: Transcription Cofactor PC4 is Critical for Cellular Proliferation and Early Development of Mammals

19:00—20:00
Social Hour with Lite Bites

Jefferson/Madison
19:30—22:00
Poster Session 3

Jefferson/Madison

SUNDAY, APRIL 11

07:00—08:00
Breakfast

Jefferson/Madison
08:00—11:00
Co-Transcriptional RNA Processing and Non-Coding RNAs
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Wendy A. Bickmore, University of Edinburgh, UK

Stephen Buratowski, Harvard Medical School, USA
Connecting Transcription to Chromatin and mRNA Processing

Katherine A. Jones, The Salk Institute, USA
SKIP, a Cell Survival Factor that Controls Elongation and Gene-Specific Splicing

Sukesh R. Bhaumik, Southern Illinois University School of Medicine, USA
Short Talk: A Novel Regulatory Pathway of Eukaryotic Transcriptional Activation by mRNA Cap-Binding Complex in vivo

Ramin Shiekhattar, University of Miami, USA
Elucidating the Function of Long Non-Coding RNAs

09:20—09:40
Coffee Break

Lower Atrium
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Imaging and Probing Global Nuclear Architecture
Meeting has ended...abstracts no longer viewable online.

Gallatin
* Stephen Buratowski, Harvard Medical School, USA

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Architecture and Function of Genome - Nuclear Lamina Interactions

Wendy A. Bickmore, University of Edinburgh, UK
Ring1B Compacts Chromatin Structure, and Represses Gene Expression, Independent of Histone Ubiquitination

Jie Yao, Yale University School of Medicine, USA
Short Talk: Coordinate Re-Positioning of Genes and Core Promoter Selectivity Factors during Myogenesis

John T. Lis, Cornell University, USA
New Views of Local and Genome-Wide Transcription Activation in Vivo

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Marc Timmers, University Medical Centre Utrecht, Netherlands
Closing Remarks

19:15—20:15
Social Hour with Lite Bites

Jefferson/Madison
20:00—23:00
Entertainment

Jefferson/Madison

MONDAY, APRIL 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA150313-01




We gratefully acknowledge additional support for this conference from:

Development, The Company of Biologists Ltd Integrated DNA Technologies

National Institute of Environmental Health Sciences

National Institute of General Medical Sciences (NIGMS)

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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