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This meeting took place in 2010



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RNA Silencing: Mechanism, Biology and Application (A7)


Organizer(s) Phillip D. Zamore and Beverly L. Davidson
January 14—19, 2010
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 17, 2009
Late Abstract Deadline: Oct 15, 2009
Scholarship Deadline: Sep 17, 2009
Early Registration Deadline: Nov 16, 2009

Sponsored by Alnylam Pharmaceuticals, Inc., Isis Pharmaceuticals, Inc., Regulus Therapeutics, Inc. and Santaris Pharma A/S

Summary of Meeting:
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA classes have been identified, including microRNAs, various types of siRNAs and piRNAs. These classes differ in their biogenesis, modes of target regulation and in the biological pathways they regulate. However, there is also a growing realization that these distinct small RNA pathways are interconnected. These pathways functions in RNA-based immunity, developmental gene regulation, transcriptional silencing, and genomic stability. The aim of this meeting is to explore the similarities and differences between RNA silencing pathways, to probe their underlying molecular mechanisms, to learn—by illustrative examples—the logic behind RNA-guided regulation of gene expression, and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 14

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
James C. Carrington, Donald Danforth Plant Science Center, USA
Small RNA-Directed Silencing Pathways in Plants

V. Narry Kim, Seoul National University, South Korea
The Making of a MicroRNA


FRIDAY, JANUARY 15

07:00—08:00
Breakfast

Grays/Torreys Peaks
08:00—11:00
Structure and Regulation of Small RNAs
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Dicer and Beyond: Mechanisms of Regulatory RNA Processing and Targeting

Rachel J. Senturia, University of California, Los Angeles, USA
Short Talk: Crystallographic and Cellular Studies of the DGCR8 Dimerization Domain: A Platform for Interaction with Heme

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
A Structural Perspective of Recognition and Cleavage Events in RNA Silencing

Nina Schürmann, University of Heidelberg, Germany
Short Talk: Directed Molecular Evolution of Chimeric Argonaute Proteins as Potent New Approach to Elucidate Structure-Function Relationships of Human RISC

Martijn Kedde, Netherlands Cancer Institute, Netherlands
Short Talk: A Pumilio-Induced RNA Structure Switch in p27-3’UTR Controls miR-221&222 Accessibility

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Shavano/Torreys Peaks
13:00—22:00
Poster Viewing

Shavano/Torreys Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Regulation of Small RNA Pathways
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Brenda L. Bass, University of Utah, USA
A Role for Dicer's Helicase Domain

Brandi N. Davis, Tufts Medical Center, USA
Short Talk: Smad Proteins Bind a Conserved RNA Sequence to Promote microRNA Maturation by Drosha

Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
Function and Regulation of miRNA Pathways in Plants

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Genetic Analysis Reveals the Complexity of the C. elegans RNA Silencing Pathways

Guillaume Jannot, Laval University Cancer Research Centre, Canada
Short Talk: Conserved Function of a Ribosomal Protein RACK1 in the microRNA Pathway

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys Peaks
19:30—22:00
Poster Session 1

Shavano/Torreys Peaks

SATURDAY, JANUARY 16

07:00—08:00
Breakfast

Grays/Torreys Peaks
08:00—11:15
miRNA Biogenesis and Function
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Xuemei Chen, University of California, Riverside, USA
Three Polymerases in siRNA-Directed Transcriptional Gene Silencing

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
The silencing domain of GW182 interact with PABPC1 to prompt silencing of miRNA targets

Demian E. Cazalla, University of Utah, USA
Short Talk: Herpesvirus saimiri U RNAs Affect the Expression of Cellular microRNAs in Latently Infected T Cells

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
MicroRNAs: Genomics, Targets, and the Molecular Consequences of Targeting

Victor R. Ambros, University of Massachusetts, USA
Modulators of microRNA Activity

Catherine A. Reinke, Northwestern University, USA
Short Talk: Elucidation of the miRNA Pathway through the Identification and Characterization of Genes Identified in a Forward Genetics Study of miRNA Function in Drosophila melanogaster

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Shavano/Torreys Peaks
13:00—22:00
Poster Viewing

Shavano/Torreys Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:30
Small RNA Therapeutics
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Priti Kumar, Yale School of Medicine, USA
Targeting siRNAs to T-Cells for Anti-Viral Therapy

Daniel G. Anderson, Massachusetts Institute of Technology, USA
Combinatorial Development of Synthetic siRNA Delivery Systems

Mark A. Kay, Stanford University, USA
Mechanism of MicroRNA Mediated Transgene Silencing

Lukas Jeker, University Hospital and University of Basel, Switzerland
Short Talk: miR-10a in Regulatory T Cells

Sakari Kauppinen, Aalborg University, Denmark
Targeting of microRNAs for Therapeutics

19:30—20:30
Social Hour with Lite Bites

Shavano/Torreys Peaks
19:30—22:00
Poster Session 2

Shavano/Torreys Peaks

SUNDAY, JANUARY 17

07:00—08:00
Breakfast

Grays/Torreys Peaks
08:00—11:15
Small RNAs and RNAi I
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Attila Molnar, University of Cambridge, UK
Small RNAs are Mobile and Trigger DNA Methylation in Distant Tissue

Sarah C.R. Elgin, Washington University, USA
Targeting Heterochromatin Formation in Drosophila

Hanbang Zhang, Stanford University, USA
Short Talk: Antisense Small RNAs with 5’-Polyphosphate Termini Regulate Gene Expression in the Deep Branching Eukaryote Entamoeba Histolytica

Phillip A. Sharp, Massachusetts Institute of Technology, USA
MicroRNAs in mammalian cells---robustness

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Regulation in skin stem cell: Fine tuning by miRNA profile

Shouhong Guang, University of Science and Technology of China, China
Short Talk: Small RNAs Mediate Transcription Termination

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Grays/Torreys Peaks
13:00—22:00
Poster Viewing

Grays/Torreys Peaks
14:30—16:30
Workshop: piRNA Biogenesis and Function

Longs/Quandary Peaks
Craig C. Mello, University of Massachusetts Medical School, USA
piRNAs in Worms: The Same, but Different

Mikiko C. Siomi, University of Tokyo, Japan
piRNAs in the Fly Germ Line

Gregory J. Hannon, University of Cambridge, UK
Why is Ago catalysis conserved in vertebrate?

Phillip D. Zamore, University of Massachusetts Medical School, USA
Target directed destruction of small silencing RNAs

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Small RNAs and RNAi II
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
René F. Ketting, Institute for Molecular Biology, Germany
Piwi biology in Zebrafish

Danesh Moazed, Harvard Medical School, USA
Small RNAs that Trigger Heterochromatin Assembly and RNAi

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi and Heterochromatin Factors Suppress Antisense RNAs

Stephan Emmerth, Friedrich Miescher Institute, Switzerland
Short Talk: Nuclear Retention of Fission Yeast Dicer Ensures Accurate Gene Expression and Heterochromatin Assembly

19:00—20:00
Social Hour with Lite Bites

Grays/Torreys Peaks
19:30—22:00
Poster Session 3

Grays/Torreys Peaks

MONDAY, JANUARY 18

07:00—08:00
Breakfast

Grays/Torreys Peaks
08:00—11:00
Small RNAs, Disease and Development
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Role of miRNAs in T-Cell Function

Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA
Small RNAs and Huntington’s disease

Mark P. Boldin, City of Hope, USA
Short Talk: Myeloproliferative Disease, Autoimmunity and Cancer in Mice with Targeted Deletion of miR-146a Gene

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
microRNA Regulation of Cardiac Cell Fate, Morphogenesis and Function

Magnus Blø, University of Bergen, Norway
Short Talk: Flow Cytometric-Based Functional Selection of RNA Interference Triggers for epi-allelic Analysis

Tudor A. Fulga, University of Oxford, UK
Short Talk: Defining microRNA Function with Precise Spatiotemporal Resolution in Intact Organisms

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Small RNAs in Stem Cells and Germ Cells
Meeting has ended...abstracts no longer viewable online.

Longs/Quandary Peaks
Gene W. Yeo, University of California, San Diego, USA
Pinning down microRNA and Targeting in C. elegants and Humans

Dasaradhi Palakodeti, Institute for Stem cell Biology and Regenerative Medicine, India
Small RNAs in the Planarian Schmidtea mediterranea

Colin C. Conine, University of Massachusetts Medical School, USA
Short Talk: The Ago-Class Argonautes TZK-1 and TZK-2 Bind 26G-RNAs to Promote Male Fertility in C. elegans

Alex Bortvin, Carnegie Institution of Washington, USA
Short Talk: Maelstrom and Mammalian Meiosis

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys Peaks
20:00—23:00
Entertainment

Shavano/Torreys Peaks

TUESDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD063228-01




We gratefully acknowledge additional support for this conference from:

Alnylam Pharmaceuticals, Inc. Integrated DNA Technologies
Isis Pharmaceuticals, Inc. Promega Corporation
Regulus Therapeutics Inc. Santa Cruz Biotechnology, Inc.
Santaris Pharma A/S Thermo Fisher Scientific, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676