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This meeting took place in 2011


Here are the related meetings in 2018:
Chromatin Architecture and Chromosome Organization (X5)

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Histone Code: Fact or Fiction? (A6)


Organizer(s) Karolin Luger, James Davie and Joanna Wysocka
January 10—15, 2011
Zermatt Resort & Spa - Utah • Midway, Utah USA
Abstract Deadline: Sep 16, 2010
Late Abstract Deadline: Oct 13, 2010
Scholarship Deadline: Sep 16, 2010
Early Registration Deadline: Nov 10, 2010

Sponsored by Pfizer Inc.

Summary of Meeting:
It has become customary to refer to posttranslational histone modifications in all contexts as “epigenetic”, and to refer to a histone ‘code’. In certain contexts, histone modifications contribute to the epigenetic maintenance, whereas in others, they don’t. Similarly, some of the phenomena attributed to the posttranslational modification of histones do not fall into the strict definition of a ‘histone code’. This meeting strives to bring together scientists from different ‘camps’, to illuminate the effects of posttranslational modifications from many viewpoints. The emphasis here is on the effect of PTMs on the structure and readout of the genome, and less on the enzymatic activities and their regulation. Speakers will be encouraged to engage in rigorous discussion, as is obvious in the format for the opening and closing session which will be held in discussion format. In particular, we plan to • Investigate how histone modifications participate in the maintenance of epigenetic information • Elaborate on recent findings that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities that involves feedback loops, and talk about ‘epigenetic memory’ • How do histone modifications affect nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? • Discuss the responsiveness of the epigenetic process, and the 3-D interplay in the nuclear environment that ultimately decides which gene will be fired up. • Have a workshop highlighting newest approaches / technologies to study histone modification states. • Have a final round table discussion to perhaps re-define and tighten up terminology, and to consolidate viewpoints where possible.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 10

15:00—19:30
Registration

Matterhorn Foyer
18:15—19:15
Refreshments

Matterhorn Foyer/Mtn Rosa
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.
Discuss ‘histone code’ and give a historic perspective.

Matterhorn Ballroom
Bryan M. Turner, University of Birmingham, UK
Evolution of the Histone Code “Historical Perspective”

C. David Allis, Rockefeller University, USA
A Historical Journey towards and beyond the “Histone Code” hypothesis


TUESDAY, JANUARY 11

06:30—08:00
Breakfast

Bernese Event Center
08:00—11:15
Relationship between Epigenetics and Histone Modifications
Meeting has ended...abstracts no longer viewable online.
Highlight the most recent evidence that histone modifications participate in the maintenance of epigenetic information: (i) Discuss how histone modifications contribute to the maintenance of gene expression patterns (ii) Show recent evidence on how epigenetic states can be reversed (e.g. during reprogramming) (iii) Highlight progress that has been made on the mechanisms of transmission of histone modifications during replication

Matterhorn Ballroom
* Siavash K. Kurdistani, University of California, Los Angeles, USA

Danesh Moazed, Harvard Medical School, USA
Histone Modifications in Heterochromatin Assembly and Propagation

Nicole J. Francis, Institut de Recherches Cliniques de Montreal, Canada
Investigating the Mechanism and Maintenance of Polycomb Group proteins proteins on Chromatin through DNA Replication

Barbara Panning, University of California, San Francisco, USA
Epigenetic Regulation of Embryonic Stem Cell Self-Renewal

Stavros Lomvardas, Columbia University, USA
Short Talk: The Histone Thingy as a Postal Code

Bharat D. Reddy, bluebird bio, USA
Short Talk: DeMYSTifying Heterochromatin

Joanna Wysocka, Stanford University School of Medicine, USA
A Unique Chromatin Signature Identifies Early Developmental Enhancers in Humans

09:20—09:40
Coffee Break

Matterhorn Foyer
11:15—13:00
Poster Setup

Bernese Event Center
13:00—22:00
Poster Viewing

Bernese Event Center
13:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Matterhorn Foyer
17:00—19:00
Re-Programming Epigenetic States
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Joanna Wysocka, Stanford University School of Medicine, USA

Azim Surani, University of Cambridge, UK
Role of Epigenetic Mechanisms in the Establishment and Regulation of Mouse Germ Cells

Siavash K. Kurdistani, University of California, Los Angeles, USA
Regulating Global Levels of Histone Modifications

Yehudit Bergman, Hebrew University Medical School, Israel
Short Talk: Epigenetic Control of Immunoglobulin Allelic Exclusion

Chengran Xu, Peking University, China
Short Talk: Chromatin Modifiers in Embryonic Endoderm Cells Promote Differential Induction of Liver or Pancreas

Emily Bernstein, Mount Sinai School of Medicine, USA
Short Talk: The Histone Variant macroH2A Suppresses Progression of Malignant Melanoma

19:00—20:00
Social Hour with Lite Bites

Bernese Event Center
19:30—22:00
Poster Session 1

Bernese Event Center

WEDNESDAY, JANUARY 12

06:30—08:00
Breakfast

Bernese Event Center
08:00—11:15
Mechanistic Nature of Epigenetic Memory
Meeting has ended...abstracts no longer viewable online.
Understood as propagation of gene expression patterns over many cell generations. A static model of epigenetic memory that relies on the stability of modification mark on a given nucleosome is dead. Instead, it becomes increasingly clear that epigenetic states are likely conveyed as a dynamic equilibrium of opposing modifying activities such as methyltransferases and demethylases that involves feedback loops. Note that to some extent the preceding session has covered some of these topics. There is recent theoretical work (e.g. Dodd et al., Cell 2007) that propose a dynamic model of epigenetic memory based on bistability. This model has some fascinating predictions. Unfortunately, it seems it received less attention from the field than it should (as someone put it, “biologists are a fearful bunch”). Topics to be covered: (i) To have a theoretical biology component, hopefully presented in a way that is accessible to biologists (ii) To discuss existing evidence on feedback loops involving histone modifications and their integration with transcriptional networks; also discussion what is the role of transcription factors in epigenetic memory (iii) Experimental models of epigenetic memory (iv) Role of chromatin in dampening transcriptional noise

Matterhorn Ballroom
* Laurie A. Boyer, Massachusetts Institute of Technology, USA

Ian Dodd, University of Adelaide, Australia
Modeling Cell Memory by Nucleosome Modification Containment – Defining Chromatin Regions

Jürg Müller, Max Planck Institute of Biochemistry, Germany
Molecular Mechanisms of the Polycomb/Trithorax System

Ziyang Ma, Stanford University, USA
Short Talk: Prdm14 is a Sequence-Specific Transcriptional Regulator Promoting ESC Gene Expression Programs

Tasuku Kitada, Massachusetts Institute of Technology, USA
Short Talk: Deciphering the "Epigenetic Switch" for Budding Yeast Telomere Position Effect

Yohei Hayashi, Tohoku University, Japan
Short Talk: Network-Based Histone “Modification Web” Theory and “DESS” Strategy for Elucidating the Physiological Significance of Histone Modifications

William H. Light, Northwestern University, USA
Short Talk: Interaction of a DNA Zip Code with the Nuclear Pore Complex Promotes H2A.Z Incorporation and Transcriptional Memory

Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Histone Variant Dynamics and Epigenetics

09:20—09:40
Coffee Break

Matterhorn Foyer
11:15—13:00
Poster Setup

Bernese Event Center
13:00—22:00
Poster Viewing

Bernese Event Center
13:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Hot Topics

Matterhorn Ballroom
* James R. Davie, University of Manitoba, Canada

Samuel G. Cox, University of Southern California, USA
A Dominant Variant Histone H3.3 Mutant Reveals a Unique Epigenetic Remodeling Event in the Specification of the Multipotent Cranial Neural Crest

Alexander M. Erkine, Butler University, USA
Activator - Histone Interactions: Fact or Fiction?

Alea A. Mills, Cold Spring Harbor Laboratory, USA
PHD-mediated H3K4me0 Binding is Essential for the Tumor Suppressive Function of CHD5

Mekonnen Lemma Dechassa, Colorado State University, USA
Structure and Scm3 Mediated Assembly of Budding Yeast Centromeric Nucleosomes

Yamini Dalal, NCI, National Institutes of Health, USA
Centromeric Histone H3 Dynamics in Human Disease, Differentiation and Repair

Jun Liu, Indiana University Bloomington, USA
Is there a Histone Code for Origins of DNA Replication?

Vamsi Gangaraju, Medical University of South Carolina, USA
Drosophila Piwi Functions in Hsp90-Mediated Suppression of Phenotypic Variation

16:30—17:00
Coffee Available

Matterhorn Foyer
17:00—19:00
Epigenomics and Roadmaps
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Yang Shi, Children's Hospital Boston, Harvard Medical School, USA

Laurie A. Boyer, Massachusetts Institute of Technology, USA
Chromatin States and Cell Fate: A Role for H2A.Z

James R. Davie, University of Manitoba, Canada
Nucleosomal Response and Immediate-Early Gene Expression

B. Franklin Pugh, Pennsylvania State University, USA
Nucleosome Organization, Modifications States, and Gene Regulation during a Yeast Developmental Pathway

Zhanxin Wang, Beijing Normal University, China
Short Talk: Structural Insights into a PHD-Bromo Double “Reader” Domain in Recognizing Histone Modifications

19:00—20:00
Social Hour with Lite Bites

Bernese Event Center
19:30—22:00
Poster Session 2

Bernese Event Center

THURSDAY, JANUARY 13

06:30—08:00
Breakfast

Bernese Event Center
08:00—11:15
Histone Modifications and Chromatin Structural Impact
Meeting has ended...abstracts no longer viewable online.
Up to now we have heard about epigenetic processes, their reversibility, epigenetic mechanisms and epigenomic roadmaps, now it is time to see how this information plays out. (i) What do histone modifications really do to nucleosome / chromatin structure and stability / interaction with chromatin architectural proteins? (ii) Code readers, emphasis on recognition and perhaps its combinatorial aspects

Matterhorn Ballroom
* Danesh Moazed, Harvard Medical School, USA

Michael Guy Poirier, Ohio State University, USA
Unlocking Nucleosome Dynamics and Remodeling with Histone Post-Translational Modifications

David John Tremethick, Australian National University, Australia
The Nucleosome Surface Regulates Chromatin Compaction and Couples it with Unique Functions

Job Dekker, University of Massachusetts Medical School, USA
Three-Dimensional Organization of Chromosomes

Judith B. Zaugg, EMBL-EBI, UK
Short Talk: A Four State Model of Promoter-Nucleosome Architecture

Steven M. Johnson, Brigham Young University, USA
Short Talk: Nucleosome Organization in Primary Human Cells

Karolin Luger, Colorado State University, USA
Intrinsic and Extrinsic Modulators of Chromatin Structure

09:20—09:40
Coffee Break

Matterhorn Foyer
11:15—13:00
Poster Setup

Bernese Event Center
13:00—22:00
Poster Viewing

Bernese Event Center
13:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Matterhorn Foyer
17:00—19:00
Combinatorial Readout of Histone PTMs
Meeting has ended...abstracts no longer viewable online.

Matterhorn Ballroom
* Karolin Luger, Colorado State University, USA

Michael A. Shogren-Knaak, Iowa State University, USA
Writing and Reading SAGA Autoacetylation in the Context of Nucleosome Acetylation

Or P. Gozani, Stanford University, USA
Role of NSD2/MMSET in Chromatin Regulation and Oncogenic Programming

Tatiana G. Kutateladze, University of Colorado School of Medicine, USA
Structural Insights into Histone Code Recognition by PHD Fingers

Brian D. Strahl, University of North Carolina at Chapel Hill, USA
Short Talk: Targeting the Histone Code Hypothesis via Peptide Arrays

19:00—20:00
Social Hour with Lite Bites

Bernese Event Center
19:30—22:00
Poster Session 3

Bernese Event Center

FRIDAY, JANUARY 14

06:30—08:00
Breakfast

Bernese Event Center
08:00—11:15
Dynamics of Histone Modifications and Chromosomal Organization
Meeting has ended...abstracts no longer viewable online.
Discuss how responsive the epigenetic process is and how we need to think in three dimensional terms when considering the interplay in the nuclear environment that ultimately decides which gene will be fired up. This will be important to consider as ChIP, ChIP-seq or any other high powered ChIP protocol is dealing with averaging information from multiple alleles (in the case of cancer cells) and lots of cells. This illustrates the limitation of our current approaches and how we are missing the richness and diversity of how each cell configures both or single alleles.

Matterhorn Ballroom
* Nicole J. Francis, Institut de Recherches Cliniques de Montreal, Canada

Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Histone Demethylation

Dimitris Thanos, Foundation for Biomedical Research, Academy of Athens, Greece
Mechanisms of Stochastic Gene Expression

Scott D. Briggs, Purdue University, USA
Small Protein Motifs Required for Histone Methylation

Paolo Sassone-Corsi, University of California, Irvine, USA
Joining the Dots: Epigenetics, Metabolism and the Circadian Clock

William J. Belden, Rutgers, State University of New Jersey, USA
Short Talk: Examining the Role of Histone Crosstalk in Circadian Regulated Gene Expression

Ali Shilatifard, Northwestern University, USA
Short Talk: Histone H3K79 Methylation as an Epigenetic code for Telomere-Associated Gene Silencing

09:20—09:40
Coffee Break

Matterhorn Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Navigating Epigenetic Landscapes

Matterhorn Ballroom
* Tatiana G. Kutateladze, University of Colorado School of Medicine, USA

Alf Herzig, Max-Planck Institute for Infection Biology, Germany
A Genetic System to Assess Functions of Higher Eukaryote Histones and Histone Modifications in vivo

Duy P. Nguyen, MRC Laboratory of Molecular Biology, UK
Genetically Encoding Post-Translational Modifications in Recombinant Histones

Shohei Koide, New York University Langone Medical Center, USA
Designer Affinity Reagents for Histone Marks

Peter Kharchenko, Harvard Medical School, USA
Characterization of D. melanogaster Chromatin Landscape

Peter J. Brown, University of Toronto, Canada
Discovery of Epigenetic Chemical Probes

Menzies Chen, Illumina, Inc., USA
A Systematic Position-Effect Screen for Interrogating Epigenetic-Genetic Interactions

Paul D. Soloway, Cornell University, USA
Single Molecule Chromatin Analysis

16:30—17:00
Coffee Available

Matterhorn Foyer
17:00—19:00
Histone Code: Fact or Fiction? - The Debate

Matterhorn Ballroom
* Barbara Panning, University of California, San Francisco, USA

* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA

* Ali Shilatifard, Northwestern University, USA

* Alexander J. Ruthenburg, University of Chicago, USA

* Bryan M. Turner, University of Birmingham, UK

19:00—20:00
Social Hour with Lite Bites

Bernese Event Center
20:00—23:00
Entertainment

Bernese Event Center

SATURDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-02




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Novus Biologicals, Inc.
Pfizer Inc.
 

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