Snowbird Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2010



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Toward Defining the Pathophysiology of Autistic Behavior (Z4)


Organizer(s) Pat Levitt and Joseph Piven
April 11—15, 2010
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 10, 2009
Late Abstract Deadline: Jan 6, 2010
Scholarship Deadline: Dec 10, 2009
Early Registration Deadline: Feb 11, 2010

Sponsored by Simons Foundation


Summary of Meeting:
Autism is a neurodevelopmental disorder defined by the co-occurrence of a set of characteristic behavioral features. One of the most common neurodevelopmental disorders, autism is recognized as heterogeneous in etiology, phenotype, behavioral trajectory and response to treatment. While the etiology and specific pathogenetic mechanisms underlying autism are unknown, those mechanisms which underlie a small subset of etiologically-defined neurodevelopmental disorders (e.g., Fragile X Syndrome, tuberous sclerosis), that are associated with autism and autistic behaviors, have been well described. The overarching aim of this Keystone Symposia meeting will be to take advantage of our knowledge of etiologic heterogeneity by examining the phenomenology and pathophysiology of etiologically-defined autistic syndromes, and contrasting this with what is known about idiopathic autism, in order to ultimately shape the development of treatment approaches informed by knowledge of the underlying pathophysiology. This conference will bring together clinical and basic scientists from various disciplines to expand on the success of an earlier Keystone Symposia meeting on this topic by additionally: 1) covering a broader number of etiologically-defined autistic syndromes; 2) comparing and contrasting the phenomenology (including physical features, behavior and neural circuitry) of autistic syndromes, to refine ideas regarding etiologically-meaningful aspects of the autism phenotype; 3) examining the role of the environment (epigenetic influences) in contributing to the etiology and underlying mechanisms of autism (including idiopathic autism and autistic syndromes), with the aim of elucidating a more comprehensive understanding of the pathophysiology of autistic behavior; and 4) examining how gene-by-environment (GxE) factors impact synaptic function and plasticity that may lie at the heart of autism syndromes. Goals: 1. Define more precisely the common and unique clinical features of syndromic and idiopathic autism. The field needs a realistic view of autism heterogeneity with regard to phenotype expression, longitudinal course and diversity in response to treatment. What are key differences in the social and communication domains between individuals with Rett, Fragile X, Angelman Syndromes compared to idiopathic autisms? To what extent is the heterogeneity in single gene disorders similar or different than in idiopathic autisms, for example, in relation to mental health issues? 2. Provide novel insight into the role of complex genetic mechanisms in autism. To what extent do we understand how different genetic etiologies (CNVs, syndromic disorders common variants) contribute to the autism? Can we better understand the role of specific genetic modifiers that result in expression of the core clinical and other symptoms in distinct syndromic and idiopathic autism? 3. Provide a basic understanding of and define the roles for epigenetics in understanding the causes of the autism. How are specific gene X environment interactions relevant to the study of the autisms? How can studies of cancer and other common diseases inform those working on the autisms regarding the roles of gene modification in the disorder process? Are there ways in which clinical and basic studies can integrate efforts to define epistatic and epigenetic factors in the autisms? 4. Examine the common cellular mechanisms that underlie the autisms. Re-examine the disconnection-synapse hypothesis of the autisms through a new perspective of factors that influence synapse formation and maturation. Is the synapse most vulnerable in most brain disorders in general due to the magnitude of the molecular machinery that goes into making, breaking and stabilizing synapses?

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 11

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Lobby
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Matthew B. Dalva, Thomas Jefferson University, USA

Michael E. Greenberg, Harvard Medical School, USA
Signaling Networks that Control Synapse Development and Cognitive Function


MONDAY, APRIL 12

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
The Autism Phenotype
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Pat Levitt, Keck School of Medicine, USA

Joseph Piven, University of North Carolina at Chapel Hill, USA
The Syndrome of Autism: Phenomenology

Patrick Bolton, King's College, London, UK
Overview of Medical Conditions Associated with the Autistic Phenotype

Genevieve Konopka, UCLA, USA
Genetics of Autism

Elizabeth M. Berry-Kravis, RUSH University Medical Center, USA
Autism Phenotype in Fragile X Syndrome: A Door to Molecular Pathways and New Targeted Treatment Strategies

Thomas Portmann, Stanford University, USA
Short Talk: Analysis of a Patient-Derived Cellular Model System for Autism Spectrum Disorders

08:00—11:15
Circuit Formation
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Yishi Jin, University of California, San Diego, USA

Anirvan Ghosh, Biogen, USA
On the Emergence of Synaptic Specificity in Developing Neural Circuits

Kang Shen, Stanford University, USA
Intrinsic and Extrinsic Factors Pattern Synaptic Circuit Assembly in C. elegans

Silvia Arber, Biozentrum, University of Basel & Friedrich Miescher Institute, Switzerland
Mechanisms Controlling Synaptic Specificity in the Motor System

Hitoshi Sakano, University of Tokyo, Japan
Autonomous Topographic Map Formation by Olfactory Axons in Mouse

Fatiha Boukhtouche, Biozentrum, University of Basel, Switzerland
Short Talk: Trans-Synaptic BMP Signaling in the Ponto-Cerebellar Projection System

Beatriz Rico, Instituto de Neurociencias de Alicante, Spain
Short Talk: Control of Cortical GABAergic Circuitry Development by Nrg1/ErbB4 Signalling

09:20—09:40
Coffee Break

Ballroom Lobby
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
FXS
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Joseph Piven, University of North Carolina at Chapel Hill, USA

Randi J. Hagerman, University of California, Davis Health System, USA
Molecular Mechanisms of ASD in the Premutation and the Full Mutation

Mark F. Bear, Massachusetts Institute of Technology, USA
Pathogenisis & Treatment of FXS

Claudia Bagni, KU Leuven, Belgium
Molecular Aspects of Mental Retardation: Insights from the Fragile X Syndrome

17:00—19:00
Synaptic Adhesion and Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Philip E. Washbourne, University of Oregon, USA

Matthew B. Dalva, Thomas Jefferson University, USA
Postsynaptic Mechanisms Guiding Synapse Development

Nils Brose, Max Planck Institute of Experimental Medicine, Germany
Genetic Dissection of Neuroligin Function: From Synaptogenesis to Autism

Lisa M. Boulanger, Princeton University, USA
Regulation of Synaptic Transmission and Synaptic Plasticity by MHC Class I

Robby M. Weimer, Genentech, inc., USA
Short Talk: Death Receptor 6 (DR6) Regulates Synapse Stability in vivo

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch/Maybird

TUESDAY, APRIL 13

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
15q, CNV and Rare Syndromes
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Ben D. Philpot, University of North Carolina, Chapel Hill, USA

Carolyn Schanen, A.I. duPont Hospital for Children, USA
International Rett Syndrome Foundation Speaker: Increasing Molecular and Phenotypic Complexities of the Chromosome 15q11.2-q13.3 Duplication Syndromes in Autism Spectrum Disorders

Elisabeth Dykens, Vanderbilt University, USA
Prader-Willi Syndrome and Other Disorders

Matthew W. State, Yale Child Study Center, USA
Rare Structural and Sequence Variation in Autism Spectrum Disorders

Toru Takumi, Hiroshima University, Japan
Neurobiology of Chromosome 15 Copy Variants in Mice

Michael J. Ronemus, Cold Spring Harbor Laboratory, USA
Short Talk: Rare and de novo Mutations in the Simons Simplex Collection

08:00—11:15
Transynaptic Mechanisms
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Elva Diaz, University of California, Davis, School of Medicine, USA

Hisashi Umemori, University of Michigan, USA
Wiring the Functional Brain

Thomas Biederer, Tufts University, USA
Synaptic Adhesion Complexes Organize Synapse Development

Michisuke Yuzaki, School of Medicine, Keio University, Japan
Cbln1 and its Receptor: A Unique and Essential Bidirectional Synaptic Organizer Complex

Vivian Budnik, University of Massachusetts Medical School, USA
Trans-Synaptic Transport of a Vesicular Wnt Signal

Brian D. McCabe, Columbia University, USA
Short Talk: Retrograde Robo Signaling Coordinates Synaptic Maturation

Matthew J. Kennedy, University of Colorado Denver, USA
Short Talk: A Domain for Activity-Triggered Postsynaptic Exocytosis in Dendritic Spines

09:20—09:40
Coffee Break

Ballroom Lobby
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
PI3 Kinase Dysfunction
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Matthew W. State, Yale Child Study Center, USA

Alcino J. Silva, University of California, Los Angeles, USA
Involvement of mTOR Signaling & Neuropsychiatric Disorders tsc & disc1

Pat Levitt, Keck School of Medicine, USA
MET Receptor Tyrosine Kinase and Social-Emotional Circuit Wiring Relevant to Autism Spectrum Disorder

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Mouse Models as Translational Tools to Discover Treatments for Autism Spectrum Disorders: Focus on Rapamycin

17:00—19:00
Glia Cells and Synapse Formation
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Christopher W. Cowan, University of Texas-Southwestern Medical School, USA

Cagla Eroglu, Duke University Medical Center, USA
How do Astrocytes Induce Central Nervous System Synaptogenesis?

Philip G. Haydon, Tufts University, USA
Glia: Listening and Talking to the Synapse

Dwight E. Bergles, Johns Hopkins University School of Medicine, USA
Synaptic Communication between Neurons and Glial Cells in the Mammalian Brain

Suzanne Paradis, Brandeis University, USA
Short Talk: Elucidating the Function of Semaphorin 4D in GABAergic Synapse Formation

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch/Maybird

WEDNESDAY, APRIL 14

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Synaptic and Circuit Function in Neurodevelopmental Disorders (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Peter Scheiffele, Biozentrum, University Basel, Switzerland

Jennifer Darnell, Rockefeller University, USA
HITS-CLIP Identifies Specific Neuronal mRNA Targets of Translational Repression by the Fragile X Mental Retardation Protein, FMRP

Kimberly M. Huber, University of Texas Southwestern Medical Center, USA
Regulation of Synapse Number by Fragile X Mental Retardation Protein

Ben D. Philpot, University of North Carolina, Chapel Hill, USA
Angelman Syndrome and Synaptic Plasticity

Ann Marie Craig, University of British Columbia, Canada
Molecular Assembly of Hippocampal Synapses

Jeremy M. Veenstra-VanderWeele, Columbia University and New York State Psychiatric Institute, USA
Short Talk: Hyperserotonemia, Enhanced Brain Serotonin Clearance, and Altered Behavior Accompany Knock-In of the Autism-Associated SERT Ala56 Variant

Kristen J. Brennand, The Salk Institute for Biological Studies, USA
Short Talk: Modeling Schizophrenia Using hiPS-Derived Neurons

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Epigenetic Modifiers of Neurodevelopmental Disorders
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Alcino J. Silva, University of California, Los Angeles, USA

Moshe Szyf, McGill University, Canada
How Early Life Experience Modifies the Epigenome and Affects Mental Health

Lisa M. Monteggia, University of Texas Southwestern Medical Center, USA
International Rett Syndrome Foundation Speaker: Role of MeCP2 and HDACs in Regulating Synapse Function and Behavior

Courtney A. Miller, The Scripps Research Institute, USA
Epigenetics and Memory

17:00—19:00
Technology
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Erik M. Ullian, University of California, San Francisco, USA

Ed Callaway, The Salk Institute, USA
New Rabies-Based Tools for Studies of the Structure and Function of Neural Circuits

Feng Zhang, Broad Institute of MIT and Harvard University, USA
Neural Engineering: Molecular and Optical Axis of Control

Alexander Egner, Max Planck Institute for Biophysical Chemistry, Germany
Nanoscopy with Focused Light

Jun Ding, Harvard Medical School, USA
Short Talk: Deep Tissue Supraresolution Imaging of Neurons Using Stimulated-Emission Depletion 2-Photon Laser Scanning Microscopy

19:00—20:00
Social Hour with Lite Bites

Ballroom 1-2
20:00—23:00
Entertainment

Ballroom 1-2

THURSDAY, APRIL 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Institute of Mental Health (NIMH)

Grant No. 1R13MH090651-01




We gratefully acknowledge additional support for this conference from:

International Rett Syndrome Foundation Simons Foundation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Organization for Autism Research Pubget Inc.

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676