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This meeting took place in 2010



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Synapses: Formation, Function and Misfunction (Z3)


Organizer(s) Matthew B. Dalva, Peter Scheiffele and Yishi Jin
April 11—15, 2010
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 10, 2009
Late Abstract Deadline: Jan 6, 2010
Scholarship Deadline: Dec 10, 2009
Early Registration Deadline: Feb 11, 2010

Supported by The Directors' Fund


Summary of Meeting:
During the last half-decade, a host of cellular mechanisms guiding synapse development have been identified. Exciting new links are being forged between our growing understanding of the basic processes and certain diseases. A major driving force in current research of synapses is new technologies. We propose to develop a meeting that would focus on these areas. Our meeting will bring together scientists working on the basic biological questions of how synapses form in model organisms, the development of new technology, and those with interests in understanding the links to human diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 11

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Lobby
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Matthew B. Dalva, Thomas Jefferson University, USA

Michael E. Greenberg, Harvard Medical School, USA
Signaling Networks that Control Synapse Development and Cognitive Function


MONDAY, APRIL 12

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Circuit Formation
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Yishi Jin, University of California, San Diego, USA

Anirvan Ghosh, Biogen, USA
On the Emergence of Synaptic Specificity in Developing Neural Circuits

Kang Shen, Stanford University, USA
Intrinsic and Extrinsic Factors Pattern Synaptic Circuit Assembly in C. elegans

Silvia Arber, Biozentrum, University of Basel & Friedrich Miescher Institute, Switzerland
Mechanisms Controlling Synaptic Specificity in the Motor System

Hitoshi Sakano, University of Tokyo, Japan
Autonomous Topographic Map Formation by Olfactory Axons in Mouse

Fatiha Boukhtouche, Biozentrum, University of Basel, Switzerland
Short Talk: Trans-Synaptic BMP Signaling in the Ponto-Cerebellar Projection System

Beatriz Rico, Instituto de Neurociencias de Alicante, Spain
Short Talk: Control of Cortical GABAergic Circuitry Development by Nrg1/ErbB4 Signalling

08:00—11:00
The Autism Phenotype
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Pat Levitt, Keck School of Medicine, USA

Joseph Piven, University of North Carolina at Chapel Hill, USA
The Syndrome of Autism: Phenomenology

Patrick Bolton, King's College, London, UK
Overview of Medical Conditions Associated with the Autistic Phenotype

Genevieve Konopka, UCLA, USA
Genetics of Autism

Elizabeth M. Berry-Kravis, RUSH University Medical Center, USA
Autism Phenotype in Fragile X Syndrome: A Door to Molecular Pathways and New Targeted Treatment Strategies

Thomas Portmann, Stanford University, USA
Short Talk: Analysis of a Patient-Derived Cellular Model System for Autism Spectrum Disorders

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Synaptic Adhesion and Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Philip E. Washbourne, University of Oregon, USA

Matthew B. Dalva, Thomas Jefferson University, USA
Postsynaptic Mechanisms Guiding Synapse Development

Nils Brose, Max Planck Institute of Experimental Medicine, Germany
Genetic Dissection of Neuroligin Function: From Synaptogenesis to Autism

Lisa M. Boulanger, Princeton University, USA
Regulation of Synaptic Transmission and Synaptic Plasticity by MHC Class I

Robby M. Weimer, Genentech, inc., USA
Short Talk: Death Receptor 6 (DR6) Regulates Synapse Stability in vivo

17:00—19:00
FXS
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Joseph Piven, University of North Carolina at Chapel Hill, USA

Randi J. Hagerman, University of California, Davis Health System, USA
Molecular Mechanisms of ASD in the Premutation and the Full Mutation

Mark F. Bear, Massachusetts Institute of Technology, USA
Pathogenisis & Treatment of FXS

Claudia Bagni, KU Leuven, Belgium
Molecular Aspects of Mental Retardation: Insights from the Fragile X Syndrome

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch/Maybird

TUESDAY, APRIL 13

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Transynaptic Mechanisms
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Elva Diaz, University of California, Davis, School of Medicine, USA

Hisashi Umemori, University of Michigan, USA
Wiring the Functional Brain

Thomas Biederer, Tufts University, USA
Synaptic Adhesion Complexes Organize Synapse Development

Michisuke Yuzaki, School of Medicine, Keio University, Japan
Cbln1 and its Receptor: A Unique and Essential Bidirectional Synaptic Organizer Complex

Vivian Budnik, University of Massachusetts Medical School, USA
Trans-Synaptic Transport of a Vesicular Wnt Signal

Brian D. McCabe, Columbia University, USA
Short Talk: Retrograde Robo Signaling Coordinates Synaptic Maturation

Matthew J. Kennedy, University of Colorado Denver, USA
Short Talk: A Domain for Activity-Triggered Postsynaptic Exocytosis in Dendritic Spines

08:00—11:00
15q, CNV and Rare Syndromes
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Ben D. Philpot, University of North Carolina, Chapel Hill, USA

Carolyn Schanen, A.I. duPont Hospital for Children, USA
International Rett Syndrome Foundation Speaker: Increasing Molecular and Phenotypic Complexities of the Chromosome 15q11.2-q13.3 Duplication Syndromes in Autism Spectrum Disorders

Elisabeth Dykens, Vanderbilt University, USA
Prader-Willi Syndrome and Other Disorders

Matthew W. State, Yale Child Study Center, USA
Rare Structural and Sequence Variation in Autism Spectrum Disorders

Toru Takumi, Hiroshima University, Japan
Neurobiology of Chromosome 15 Copy Variants in Mice

Michael J. Ronemus, Cold Spring Harbor Laboratory, USA
Short Talk: Rare and de novo Mutations in the Simons Simplex Collection

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch/Maybird
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Glia Cells and Synapse Formation
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Christopher W. Cowan, University of Texas-Southwestern Medical School, USA

Cagla Eroglu, Duke University Medical Center, USA
How do Astrocytes Induce Central Nervous System Synaptogenesis?

Philip G. Haydon, Tufts University, USA
Glia: Listening and Talking to the Synapse

Dwight E. Bergles, Johns Hopkins University School of Medicine, USA
Synaptic Communication between Neurons and Glial Cells in the Mammalian Brain

Suzanne Paradis, Brandeis University, USA
Short Talk: Elucidating the Function of Semaphorin 4D in GABAergic Synapse Formation

17:00—19:00
PI3 Kinase Dysfunction
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Matthew W. State, Yale Child Study Center, USA

Alcino J. Silva, University of California, Los Angeles, USA
Involvement of mTOR Signaling & Neuropsychiatric Disorders tsc & disc1

Pat Levitt, Keck School of Medicine, USA
MET Receptor Tyrosine Kinase and Social-Emotional Circuit Wiring Relevant to Autism Spectrum Disorder

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Mouse Models as Translational Tools to Discover Treatments for Autism Spectrum Disorders: Focus on Rapamycin

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Wasatch/Maybird
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch/Maybird

WEDNESDAY, APRIL 14

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Synaptic and Circuit Function in Neurodevelopmental Disorders (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Peter Scheiffele, Biozentrum, University Basel, Switzerland

Jennifer Darnell, Rockefeller University, USA
HITS-CLIP Identifies Specific Neuronal mRNA Targets of Translational Repression by the Fragile X Mental Retardation Protein, FMRP

Kimberly M. Huber, University of Texas Southwestern Medical Center, USA
Regulation of Synapse Number by Fragile X Mental Retardation Protein

Ben D. Philpot, University of North Carolina, Chapel Hill, USA
Angelman Syndrome and Synaptic Plasticity

Ann Marie Craig, University of British Columbia, Canada
Molecular Assembly of Hippocampal Synapses

Jeremy M. Veenstra-VanderWeele, Columbia University and New York State Psychiatric Institute, USA
Short Talk: Hyperserotonemia, Enhanced Brain Serotonin Clearance, and Altered Behavior Accompany Knock-In of the Autism-Associated SERT Ala56 Variant

Kristen J. Brennand, The Salk Institute for Biological Studies, USA
Short Talk: Modeling Schizophrenia Using hiPS-Derived Neurons

09:20—09:40
Coffee Break

Ballroom Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Technology
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Erik M. Ullian, University of California, San Francisco, USA

Ed Callaway, The Salk Institute, USA
New Rabies-Based Tools for Studies of the Structure and Function of Neural Circuits

Feng Zhang, Broad Institute of MIT and Harvard University, USA
Neural Engineering: Molecular and Optical Axis of Control

Alexander Egner, Max Planck Institute for Biophysical Chemistry, Germany
Nanoscopy with Focused Light

Jun Ding, Harvard Medical School, USA
Short Talk: Deep Tissue Supraresolution Imaging of Neurons Using Stimulated-Emission Depletion 2-Photon Laser Scanning Microscopy

17:00—19:00
Epigenetic Modifiers of Neurodevelopmental Disorders
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Alcino J. Silva, University of California, Los Angeles, USA

Moshe Szyf, McGill University, Canada
How Early Life Experience Modifies the Epigenome and Affects Mental Health

Lisa M. Monteggia, University of Texas Southwestern Medical Center, USA
International Rett Syndrome Foundation Speaker: Role of MeCP2 and HDACs in Regulating Synapse Function and Behavior

Courtney A. Miller, The Scripps Research Institute, USA
Epigenetics and Memory

19:00—20:00
Social Hour with Lite Bites

Ballroom 1-2
20:00—23:00
Entertainment

Ballroom 1-2

THURSDAY, APRIL 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS070362-01




We gratefully acknowledge additional support for this conference from:


EMD Millipore


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676