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This meeting took place in 2011



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NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses (A4)


Organizer(s) James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg
January 9—14, 2011
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 15, 2010
Late Abstract Deadline: Oct 12, 2010
Scholarship Deadline: Sep 15, 2010
Early Registration Deadline: Nov 9, 2010

Supported by the Directors’ Fund

Summary of Meeting:
Our knowledge base in innate immunity has exploded over the past decade, and our understanding of innate immune mechanisms will soon impact in the clinics. Nevertheless, we still have much to learn about how NK cells and NKT cells shape innate and adaptive immune responses. This meeting will address issues related to the biological roles of these two specialized innate lymphocyte populations by bringing together NK and NKT cell experts to discuss their latest cutting-edge results on topics including NK/NKT development, NK/NKT cell ligand recognition, NK/NKT activation and “crosstalk”, and roles for NK/NKT cells as both effectors and regulators of the immune response in inflammatory disease, infection and cancer. This ‘confrontation’ between NK cell and NKT cell biologists should promote a lively forum for discussion and debate about the specificity and redundancy of NK/NKT cell responses, and can hopefully lead to new collaborations to help advance our understanding of the biological roles of these important innate mediators.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 9

15:00—19:30
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Jürg Tschopp, University of Lausanne, Switzerland
The Inflammasome in Health and Disease


MONDAY, JANUARY 10

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Development of NK and NKT Cells
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Hugh J.M. Brady, Imperial College London, UK
E4bp4 in NK Cell development

Molly Thomas, University of California, San Francisco, USA
Short Talk: Eri1 Modulates Small RNAs in Lymphocytes and is Required for Natural Killer Cell Homeostasis

Cheong-Hee Chang, University of Michigan, USA
Unique Properties of Innate CD4 T Cells Selected by Thymocytes

* Derek B. Sant'Angelo, Robert Wood Johnson Medical School, USA
The Transcription Factor PLZF Controls the Development of Mouse and Human Innate T Cells

Louise M. D'Cruz, University of Pittsburgh, USA
Short Talk: E and Id Proteins in Development and Homeostasis of iNKT Cells

Maria do Carmo Leite-de-Moraes, CNRS, University Paris 5, France
iNKT17

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Recognition by NK/NKT Receptors

Peaks 4-5
* Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA

* Laurent Gapin, University of Colorado and National Jewish Medical and Research Center, USA
The Crystal Structure of the Invariant NK TCR: A Molecular Basis for iNKT Cell Autoreactivity and Recognition of CD1d-self antigen

Sandeep K. Tripathy, Washington University School of Medicine, USA
Activation Receptor-Mediated Modulation of Natural Killer Cell Tolerance in vivo

Carsten Watzl, IfADo, Germany
2B4-Mediated Co-Activation of NK Cells Induces Rapid LFA-1-Dependent Adhesion to Tumor Cells as Measured by Single Cell Force Spectroscopy

Erin J. Adams, University of Chicago, USA
Molecular Studies of NKT Cell Recognition of CD1d Presenting the Self Lipid, Lysophosphatidylcholine

Susanna Cardell, Göteborg University, Sweden
A Search for Endogenous Glycolipid Ligands Activating Autoreactive Type II NKT Cells

Peter van den Elzen, University of British Columbia, Canada
Autoimmune Recognition of Sulfatide bz Human Invariant NKT Cells

16:30—17:00
Coffee Available

Foyer
17:00—19:00
NK and NKT Cell Activation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Andre Veillette, Institut de Recherches Cliniques de Montreal, Canada
NK Cell Regulation by the SLAM and SAP Families

Subramaniam Malarkannan, Blood Center of Wisconsin, USA
Short Talk: Rap1b Facilitates NK Cell Functions via IQGAP1-Mediated Signalosomes

Jamie Rossjohn, Monash University, Australia
Recent Insights into NKT TCR Recognition

Taishan Hu, Oklahoma Medical Research Foundation, USA
Short Talk: The RAS/MAPK Signaling Cascade is Critically Required for iNKT Cell Development

* Lewis L. Lanier, University of California, San Francisco, USA
How do NK Cells Sense their Environment and Respond?

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

TUESDAY, JANUARY 11

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Dissecting NK and NKT
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Christian Münz, University of Zurich, Switzerland
Human NK Cell Compartments and Their Activation by Dendritic Cells

Peggy Riese, Helmholtz Center for Infection Research, Germany
Immune Intervention against HCV Infection Utilizing a Pegylated Derivative of the NKT Aganoist alphaGalCer

Pooja Arora, Albert Einstein College of Medicine, USA
Short talk: Tuning of iNKT Cell Responses: How Ligand Structure Directs Cytokine Secretion

Daniel M. Davis, Imperial College London, UK
Imaging NK Cell Interactions

Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK
Short Talk: Inflammatory Monocytes are the Major Cell Infiltrate to the Lungs during Lethal Influenza A Virus Infection, and can be Controlled by iNKT Cells

* Michael B. Brenner, Harvard Medical School, USA
Mechanisms that Drive NKT Activation

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Studying NK and NKT Cells in situ

Peaks 4-5
* Eleanor M. Riley, Roslin Institute, UK

* James P. Di Santo, Institut Pasteur, France

Zacarias Garcia†, Pasteur Institute, France
Dynamics of NK Cell Activation Following Administration of an MVA-Based HIV Vaccine

Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Inhibitory Receptor Signaling Dynamics in NK Cells

James C. Whisstock, Monash University, Australia
The Structure of Lymphocyte Perforin and Pore Formation by Perforin

Klaas P.J.M. Van Gisbergen, Sanquin Research, Netherlands
Hobit is an NKT Cell Specific Transcription Factor that Regulates Cytotoxicity

Ernesto Merino Plaza, Memorial Sloan-Kettering Cancer Center, USA
PKC-theta Regulatory Domain is Necessary for Protein Cluster Formation in Response to ITAM-Mediated NK Cell Activation

Rupali Das, Children's Hospital of Philadelphia, USA
Dichotomous Roles for SAP in Mature NKT Cell Functions

Patricia Barral, Cancer Research UK. London Research Institute, UK
CD169+ Macrophages Present Lipid Antigens to Mediate Early Activation of Invariant NKT Cells in Lymph Nodes

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Mucosal NK and NKT Cells
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Marco Colonna, Washington University School of Medicine, USA
Human NK22 Cells un Mucosal Immunity

Olivier Lantz, Institut Curie, France
Anti-Microbial Activity of MAIT Cells

Magdalena Sips, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Significant Alterations in Natural Killer Cells in the Gastrointestinal Tract Following HIV Infection

Andreas Diefenbach, University of Mainz, Germany
Development and Function of Innate Lymphocytes at Mucosal Surfaces

Laurent Brossay, Brown University, USA
Short Talk: Salivary Gland NK Cells are Phenotypically and Functionally Unique

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

WEDNESDAY, JANUARY 12

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
NK and NKT Cells in Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Bana Jabri, University of Chicago, USA
NKG2D and Stress-Specific Killing of Tissue Target Cells: Role in Autoimmunity

Masaru Taniguchi, RIKEN RCAI, Japan
iPS-Derived NKT Cells and their Adjuvant Effects

Ling-Pei Ho, Weatherall Institute of Molecular Medicine, UK
Short talk: iNKT Cells Improve Outcome in EAE Mice by Promoting the Differetiation of Inflammatory CD11b+Gr1mid Monocytes into Anti-Inflammatory Alternatively Activated Macrophages in the CNS

Joel Linden, La Jolla Institute for Allergy and Immunology, USA
Induction of Anti-Inflammatory Adenosine A2A and A2B Receptor Transcripts, CD39 and CD73 on NKT, NK and T Cells in Response to alpha-GalCer or Ischemia-Reperfusion Injury

Ofer Mandelboim, Hebrew University, Israel
Cellular and Viral mircoRNAs Controlling the Immune Response to Stress

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
NK and NKT Cells in Bacterial and Parasitic Infection
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Eleanor M. Riley, Roslin Institute, UK
Natural Killer Cells as Effectors of Vaccine-Induced Immunity?

Daniela S. Herzig, University of Texas Medical Branch, USA
Short Talk: Regulation of NK Cell Function during Acute Bacterial Peritonitis by CXCR3

* Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
NKT Antigens from the Elements: Earth, Water, and Air

Nadia Cohen, Harvard University, USA
Short talk: The Anti-Fungal NKT Cell Response

James P. Di Santo, Institut Pasteur, France
An Emerging Family of Immune Effectors

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

THURSDAY, JANUARY 13

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
NK and NKT Cells in the Anti-Tumor Response
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* David H. Raulet, University of California, Berkeley, USA
NK Cells and NKG2D in Tumor Surveillance

Jay A. Berzofsky, NCI, National Institutes of Health, USA
Short Talk: Novel Agonist of Mouse and Human iNKT Cells Reveals a New Mechanism of Tumor Immunity

Michael Nowak, University of Bonn, Germany
Short Talk: Defective NKT Cell Activation by CD1d+ TRAMP Prostate Tumor Cells is Corrected by Interleukin-12 with alpha-Galactosylceramide

Philippe Bousso, Institute Pasteur, France
NK Cell Interactions during Activation and Killing: Lessons from in vivo Imaging

Leonid Metelitsa, Baylor College of Medicine, USA
Anti-tumor Potential of Type-I NKT Cells Against CD1d-Positive and CD1d-Negative Tumors in Humans

François Romagné, Innate Pharma, France
Pharmacological Aspects of the Development of Anti-KIR Antibodies

09:20—09:40
Coffee Break

Foyer
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
NK and NKT Cells in Viral Infection
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Mary Carrington, Frederick National Laboratory for Cancer Research, USA
Immunogenetic Variation Characterizing Exceptional Control of HIV

* Hans-Gustaf Ljunggren, Karolinska Institutet, Sweden
Short Talk: The Human NK Cell Response to Puumala Hantavirus Infection

Sandra L. Lopez-Verges, University of California, San Francisco, USA
Short Talk: A New Subset of CD57+NKG2Chi NK Cells is Observed after HCMV Infection

Agnès C. Lehuen, Institut Cochin, France
Role of iNKT Cells from Infection to Type 1 Diabetes

Moriya Tsuji, Aaron Diamond AIDS Research Center, Rockefeller University, USA
Clinical Development of 7DW8-5 – A Novel Glycolipid Vaccine Adjuvant

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

FRIDAY, JANUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI091292-01




We gratefully acknowledge additional support for this conference from:

STEMCELL Technologies, Inc.

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