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This meeting took place in 2011



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Transmembrane Signaling by GPCRs and Channels (B1)


Organizer(s) Oliver P. Ernst and U. Benjamin Kaupp
January 23—28, 2011
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 23, 2010
Late Abstract Deadline: Oct 25, 2010
Scholarship Deadline: Sep 23, 2010
Early Registration Deadline: Nov 23, 2010

Sponsored by Takeda Pharmaceutical Company Limited

Summary of Meeting:
Cellular membranes present natural borders for signal transduction between cells and their environment. Nature developed different strategies to enable signals to cross the membrane barrier. The goal of this meeting is to discuss the molecular mechanisms of transmembrane signaling on the basis of three protein classes, i.e. G protein-coupled receptors, ion channels and transporters. Available protein structures together with biophysical and functional approaches will provide guidance to explore similarities and differences of the underlying mechanisms. Exemplified will be receptors and channels as well as proteins with dual or modified functions, such as channelrhodopsin. A comparative view is thought to bring researchers from diverse fields together and to stimulate further development of transmembrane signaling proteins in drug discovery and fighting disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 23

15:00—19:30
Registration

Chamisa Lobby
18:15—19:15
Refreshments

Chamisa Ballroom 2
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Brian K. Kobilka, Stanford University School of Medicine, USA
Structure and Dynamics of G Protein Coupled Receptors: Insights From the Human Beta 2 Adrenoceptor

Francisco Bezanilla, University of Chicago, USA
From Conductance to Structure


MONDAY, JANUARY 24

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
GPCR Structure and Intramolecular Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Krzysztof Palczewski, Case Western Reserve University, USA

Oliver P. Ernst, University of Toronto, Canada
Structure and Dynamics of Rhodopsin

Steven O. Smith, Stony Brook University, USA
Activation of Rhodopsin: Insights from Solid-State NMR Spectroscopy

Jörg Standfuss, Paul Scherrer Institut, Switzerland
Short Talk: Crystal Structure of Constitutively Active Rhodopsins: How an Agonist can Activate its GPCR

Fiona H. Marshall, Heptares Therapeutics Ltd., UK
Stabilization of GPCRs for Structural Studies

Philippe Rondard, Institut de Génomique Fonctionnelle, France
Short Talk: Intramolecular Signal Transduction in Metabotropic Glutamate Receptors

William P. Clarke, University of Texas Health Science Center, USA
Short Talk: Functional Selectivity of Ligands at 7-TMs Receptors: Evidence for Multiple Active Receptor Conformations

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

16:00—16:30
Data Blitz Session 1

Chamisa Ballroom 1
Sviatoslav N. Bagriantsev, University of California, San Francisco, USA
Protons, Heat, and Mechanical Force Converge to Gate Two-Pore Potassium Channels

Jana Brejchova, Academy of Sciences of the Czech Republic, Czech Republic
FLIM, TCSPC and Laurdan Generalized Polarization Studies of the Effect of Cholesterol Depletion on Hydrophobic Interior and Polar-Head Group Region of the Cell Membrane

Steve Briddon, University of Nottingham, UK
Evidence for Pathway-Specific Active Conformations of the Adenosine-A3 Receptor

Moritz Bünemann, Phillips University Marburg, Germany
Dynamics of Gq Protein Interactions with PLCbeta3 Studied by TIRF Microscopy

Ines Claudia Heinrich, Max Planck Institute of Molecular Physiology, Germany
Signal Transduction in Chemo- and Photoreceptor Arrays

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Interaction of GPCRs with Signaling Proteins
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Thomas P. Sakmar, Rockefeller University, USA

Wayne L. Hubbell, University of California, Los Angeles, USA
Structural and Dynamical Orgins of G Protein Activation as Revealed by Site Directed Spin Labeling

Vsevolod V. Gurevich, Vanderbilt University, USA
Structural Determinants of Receptor Binding and the Conformation of Active Receptor-Bound Arrestin

John J.G. Tesmer, University of Michigan, USA
Molecular Basis for the Activation of G Protein-Coupled Receptor Kinases by GPCRs

Oleg G. Kisselev, St. Louis University, USA
Short Talk: Role of Transducin beta-gamma Complex in Rod Phototransduction Pathway

Daniel Fourmy, INSERM U858, France
Short Talk: A Unique Conformation of the CCK2R Recruits beta-Arrestin2

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, JANUARY 25

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Signal Transduction by Microbial Rhodopsins
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Ulrike Alexiev†, Freie Universitaet Berlin, Germany

Martin Engelhard, Max Planck Institute for Molecular Physiology, Germany
Sensory Rhodopsins: Transmembrane Signal Transfer

Hideki Kandori, Nagoya Institute of Technology, Japan
Active Internal Waters in Visual and Microbial Rhodopsins

Peter Hegemann, Humboldt-Universität zu Berlin, Germany
Channelrhodopsin: The Light-Gating Problem

Karl Deisseroth, Stanford University, USA
Retinal Proteins as Neural State Switches

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:00
On Own for Lunch and Recreation

16:00—16:30
Data Blitz Session 2

Chamisa Ballroom 1
Gerd Krause, Leibniz-Institut für Molekulare Pharmakologie, Germany
From Transmembrane Interactions in the Thyroptropin Receptor to General Aspects of Intramolecular Signal Transduction in GPCRs

Christophe J.W. Moreau, Structural Biology Institute, France
Engineering of GPCR-Ion Channel Fusion Proteins for Direct Characterization of Ligand Binding and Gating Regulation

Sven Schünke, Institute of Complex Systems, Research Centre Jülich, Germany
Structural Insights into Conformational Changes of a Cyclic Nucleotide-Binding Domain in Solution from a Bacterial CNG Channel (MloK1)

Peter Nollert, Bio Data Bridges, USA
Expanded Sampling of Membrane Protein Crystallization Experiments with Plugs and Lipid Matrices

Gregory M. Pask, Vanderbilt University, USA
A Novel Characterization of an Insect Odorant Receptor as an Ion Channel

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Role of Lipids in Transmembrane Signaling
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Brian K. Kobilka, Stanford University School of Medicine, USA

Roger K. Sunahara, University of California, San Diego, USA
Structure and Function of the G-Protein Coupled Receptor Cascade

Marc Baldus, Utrecht University, Netherlands
Membrane Protein Structure in a Cellular(-Like) environment

Pontus Gourdon, Aarhus University, Denmark
Crystal Structure of the Copper Pump

Vladimir Ladizhansky, University of Guelph, Canada
Short Talk: Conformation of a Seven-Helical Transmembrane Photosensor in the Lipid Environment

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, JANUARY 26

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Novel Approaches
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Steven O. Smith, Stony Brook University, USA

Thomas P. Sakmar, Rockefeller University, USA
Using Genetically Encoded Non-Natural Amino Acids to Examine the GPCR Signalosome

Krzysztof Palczewski, Case Western Reserve University, USA
Role of Integral Waters in GPCR Activation

Helmut Grubmüller, Max Planck Institute for Biophysical Chemistry, Germany
Forces and Non-Equilibrium-Dynamics in Biological Macromolecules

Kenneth E. Carlson, Ironwood Pharmaceuticals, USA
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure based Drug Discovery

Klaus Gawrisch, NIAAA, National Institutes of Health, USA
Short Talk: Global Fold of Human Peripheral Cannabinoid Receptor CB2 probed by Solid-State 13C,15N-MAS NMR and Molecular Dynamics Simulations

Irina Kufareva, University of California, San Diego, USA
Short Talk: GPCR Ligand Binding Prediction Assessment for CXCR4 and D3 and Implications for Structure Based Drug Discovery

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:00
On Own for Lunch and Recreation

16:00—16:30
Data Blitz Session 3

Chamisa Ballroom 1
Steffen Wolf, Partner Institute for Computational Biology, China
Directional Proton-Transfer in Membrane Proteins Via Protein-Bound Internal Water Molecules: A Proton-Diode

David M. Thal, Monash Institute of Pharmaceutical Sciences, Australia
Molecular Mechanism of Selectivity Among G Protein-Coupled Receptor Kinase 2 Inhibitors

Kalyan C. Tirupula, University of Pittsburgh, USA
Role of Conserved Transmembrane Domain Cysteines in Activation of Metabotropic Glutamate Receptor Type 6

Friederike Winkhaus, Center of Advanced European Studies and Research (CAESAR), Germany
HCN2 Channels: Cyclic Nucleotide Binding and Oligomerization

Elsa Yan, Yale University, USA
Purification of G-Protein Coupled Receptor Using Nanodiscs

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Late-Breaking News
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Francisco Bezanilla, University of Chicago, USA

Luis G. Cuello, Texas Tech University Health Science Center, USA
Structural Mechanism of C-Type Inactivation in Potassium Channels

Vadim Cherezov, The Scripps Research Institute, USA
New GPCR Structures

Wayne A. Hendrickson, Columbia University, USA
Structural Analysis of SLAC1-Family Anion Channel Activity

Polina V. Lishko, University of California, San Francisco, USA
Short Talk: Female Sex Hormone Progesterone and Sperm Specific Calcium Channel CatSper: An Intimate Relationship

Normann Goodwin, Center of Advanced European Studies and Research (CAESAR), Germany
Short Talk: The Chemoattractant Progesterone Activates CatSper Channels in Human Sperm

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, JANUARY 27

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Ion Channel Structure and Function
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Wayne A. Hendrickson, Columbia University, USA

Leslie B. Vosshall, Rockefeller University, USA
Structure-Function Analysis of the Insect Odorant Receptors: Odor-Gated Ion Channels Modulated by Insect Repellents

Uhtaek Oh, Seoul National University, South Korea
Anoctamin 1, A Cloned Calcium-Activated Chloride Channel and its Physiological Implications

U. Benjamin Kaupp, Center of Advanced European Studies and Research (CAESAR), Germany
Novel Cyclic Nucleotide-Gated Channels

Crina M. Nimigean, Weill Cornell Medical College, USA
Mechanism of Proton Sensing in KcsA Potassium Channels

Elena Gracheva, Yale University, School of Medicine, USA
Short Talk: Molecular Basis of Infrared Sensation by Snakes

09:20—09:40
Coffee Break

Chamisa Lobby
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Mechanisms of Channels and Transporters
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Crina M. Nimigean, Weill Cornell Medical College, USA

Pierre-Jean Corringer, Institut Pasteur - CNRS, France
Allosteric Transition and Regulation of Bacterial Pentameric Channel- Receptors

Hassane S. Mchaourab, Vanderbilt University, USA
Structural Dynamics of the Leucine Transporter: Spin Labeling and EPR Spectroscopy

Olga Boudker, Weill Cornell Medical College, USA
Conformational Ensemble and Molecular Mechanism of Glutamate Transporters

Eitan Reuveny, Weizmann Institute of Science, Israel
Short Talk: Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

FRIDAY, JANUARY 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM094985-01




We gratefully acknowledge additional support for this conference from:

Affymetrix, Inc. Boehringer Ingelheim Stiftung
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Heptares Therapeutics Ltd


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