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This meeting took place in 2011



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MicroRNAs and Non-Coding RNAs and Cancer (J5)


Organizer(s) Gregory J. Hannon, Curtis C. Harris and Martine F. Roussel
February 11—16, 2011
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 12, 2010
Late Abstract Deadline: Nov 16, 2010
Scholarship Deadline: Oct 12, 2010
Early Registration Deadline: Dec 10, 2010

Sponsored by Astellas Pharma Inc. and Regulus Therapeutics Inc.


Summary of Meeting:
Studies of tumor-associated genetic alterations and expression profiling normal and tumor cells, disease-associated stroma, and immune cells increasingly point to non-coding RNAs as key players in cancer biology. Since strategies that intervene in non-coding RNA pathways for therapeutic purposes are moving rapidly into the clinic, it is critical to deepen our understanding of the biology of small RNAs in the context of cancer. The goal of the proposed meeting is to bring together biologists studying the basic principles of non-coding RNA-based regulation and those studying the roles of non-coding RNAs in cancer with both industrial and clinical researchers focused on translating non-coding RNA-based therapies into the clinic. It is our hope that the resulting synergy will create both a deeper understanding of gene regulatory mechanisms and how they are altered in cancer and new opportunities to exploit this understanding for the benefit of cancer patients.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 11

15:00—19:30
Registration

Van Horne Foyer
18:15—19:15
Refreshments

Van Horne Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Eric N. Olson, University of Texas Southwestern Medical Center, USA

Victor R. Ambros, University of Massachusetts, USA
MicroRNA Pathways in C. elegans

* Gregory J. Hannon, University of Cambridge, UK

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Identifying Tumor Suppressor and Tumor Maintenance Genes using Mouse Models and RNAi


SATURDAY, FEBRUARY 12

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
MicroRNA Mechanisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany

Stefan L. Ameres, Institute of Molecular Biotechnology, Austria
Mehanism and Application of Small RNAi Mediated Decay

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Structural and Mechanistic Insights into Silencing Pathways

Gunter Meister, University of Regensburg, Germany
Argonaute Function in Glioblastoma

John L. Rinn, University of Colorado, Boulder, USA
Some Missing lincRNAs in Chromatin, Cancer, and Cellular Identity

Aaron J. Arvey, Gilead, USA
Short Talk: Target mRNA Abundance Dilutes MicroRNA and siRNA Activity

Steven G. Chaulk, University of Alberta, Canada
Short Talk: pri-miRNA Tertiary Structure Modulation of miRNA Biogenesis

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:15
MicroRNA Targets and Polymorphisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Phillip A. Sharp, Massachusetts Institute of Technology, USA

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Post-Transcriptional Gene Regulation by small RNAs and RNA Binding Proteins

Robert B. Darnell, HHMI/Rockefeller University, USA
Decoding protein-RNA regulation with HITS-CLIP maps

Karen P. Steel, Wellcome Trust Sanger Institute, UK
miR-96 Regulates the Maturation of Mammalian Hair Cells

Danilo Allegra, University Hospital of Ulm, Germany
Short Talk: A Drosha Processing Defect Contributes to Down-Regulation of miR-15a/-16 in a Subset of CLL Patients

Pieter Mestdagh, Ghent University Hospital, Belgium
Short Talk: The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 1

Mezzanine 2

SUNDAY, FEBRUARY 13

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:15
MicroRNAs as Oncogenes and Tumor Suppressors I
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
Phillip A. Sharp, Massachusetts Institute of Technology, USA
MicroRNA Activity and Cancer

Mark E. Hatley, St. Jude Children's Research Hospital, USA
Modulation of K-ras-Dependent Lung Tumorigenesis by microRNA-21

* Martine F. Roussel, St. Jude Children's Research Hospital, USA
MicroRNAs during Cerebellum Development and in Pediatric Medulloblastoma

Varda Rotter, Weizmann Institute of Science, Israel
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

Jean-Christophe W. Marine, Vlaams Interuniversitair Instituut, Katholieke Universiteit Leuven, Belgium
Short Talk: Dicer1 is a Synthetic Lethal Partner of Tumor Suppressor p53 and is Required for Retinoblastoma Formation

Kalpana Ghoshal, Ohio State University, USA
Short Talk: Loss of microRNA-122 Affects Lipid Metabolism and Promotes Hepatocarcinogenesis in Mice


Following Session is for MicroRNAs and Human Disease (J6)

08:00—11:15
MicroRNAs in Muscle Development and Disease
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Eva van Rooij, Hubrecht Institute, Netherlands

Eric N. Olson, University of Texas Southwestern Medical Center, USA
MicroRNA Control of Cardiovascular Development and Disease

Gerald W. Dorn, II, Washington University School of Medicine, USA
Genetic Variation and microRNA Targeting of Cardiac mRNAs

Thomas Thum, Medical School Hannover, Germany
A microRNA Involved in Cardiac Remodeling

Da-Zhi Wang, Children's Hospital Boston, USA
microRNAs in Cardiac and Skeletal Muscle

Francisco J. Naya, Boston University, USA
Short Talk: MEF2A Regulation of a miRNA Mega-Cluster is Required for Proper Skeletal Muscle Regeneration

Kasey C. Vickers, National Institutes of Health, USA
Short Talk: High-Density Lipoproteins Transport and Delivery of MicroRNA: A Novel Intercellular Communication Pathway in Cardiovascular Disease

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
MicroRNAs as Oncogenes and Tumor Suppressors II
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
MicroRNA Reprogramming by Oncogenic and Tumor Suppressor Pathways

Andrea Ventura, Memorial Sloan Kettering Cancer Center, USA
MicroRNA Oncogenes

Carlo M. Croce, Ohio State University, USA
Causes and Consequences of microRNA Dysregulation in Cancer


Following Session is for MicroRNAs and Human Disease (J6)

17:00—19:00
MicroRNAs and Vascular Disease
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA

Stefanie Dimmeler, University of Frankfurt, Germany
Control of Angiogenesis by MicroRNA

Thomas Braun, , Germany
The Role of miRNAs and RNA Binding Proteins in Post-Transcriptional Regulation of the Cardiovascular System

Anne Yaël Nossent, Leiden University Medical Center, Netherlands
Short Talk: Insulin Receptor Substrate 1 is a Direct Target of MicroRNA-487b, which is Up-Regulated in the Aortic Wall under Chronic Angiotensin II Induced Hypertension in Rats

Greg M. LaMonte, Duke University, USA
Short Talk: Erythrocytic microRNA as Potential Genetic Determinants of Malaria Resistance in Sickle Cell Diseases

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 2

Mezzanine 2

MONDAY, FEBRUARY 14

07:00—08:00
Breakfast

Mezzanine 2
08:00—11:00
MicroRNAs in the Immune Response, Angiogenesis and Metastasis
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* David Baltimore, California Institute of Technology, USA
MicroRNAs in the Immune System

Sohail F. Tavazoie, Rockefeller University, USA
Regulation of Cancer Metastasis by Human microRNAs

Elsa R. Flores, University of Texas MD Anderson Cancer Center, USA
TAp63 Suppresses Metastasis through Coordinate Regulation of Dicer and miRNAs

Gemma E.M. Bridge, University College London Cancer Institute, UK
Short Talk: MicroRNA-Mediated Regulation of DLL4 Influences Endothelial Cell Behavior and Vascular Integrity during Developmental Angiogenesis

Desire Bonci, Istituto Superiore di Sanità, Italy
Short Talk: Control of Tumor and Microenvironment Crosstalk by miR-15a and miR-16 in Prostate Cancer


Following Session is for MicroRNAs and Human Disease (J6)

08:00—11:15
MicroRNAs in CNS Disorders
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Robert B. Darnell, HHMI/Rockefeller University, USA

Gerhard Schratt, Philipps-University-Marburg, Germany
Activity-Dependent Regulation of Neuronal microRNAs

Bart De Strooper, University College London, UK
miRNA Deregulation in the Pathogenesis of Alzheimer's Disease

Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA
Noncoding RNAs and Huntington's Disease

Claes Wahlestedt, University of Miami, Miller School of Medicine, USA
Regulatory Natural Antisense Transcripts

Angela Anderegg, Northwestern University, USA
Short Talk: The Role of MicroRNAs in Midbrain Dopaminergic Neurogenesis

Eva Maria Jimenez-Mateos, Royal College of Surgeons in Ireland, Ireland
Short Talk: MicroRNA Regulation in Hippocampus Following Status Epilepticus in Mice

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Mezzanine 2
13:00—22:00
Poster Viewing

Mezzanine 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
MicroRNAs as Cancer Biomarkers
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Curtis C. Harris, NCI, National Institutes of Health, USA
Inflammation and Cancer: Microenvironment, Cytokines, MicroRNA and p53

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
MicroRNAs as Diagnostics and Therapeutics in Cancer

Xin Wei Wang, NCI, National Institutes of Health, USA
MicroRNA and Hepatocellular Carcinoma: Biology and Prognostic Significance

Jason D. Arroyo, Pfizer, USA
Short Talk: Circulating MicroRNAs Are Carried by Argonaute2 Complexes in Human Plasma


Following Session is for MicroRNAs and Human Disease (J6)

17:00—19:15
MicroRNAs in the Immune Response and Viral Infections
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Sakari Kauppinen, Aalborg University, Denmark

Peter Sarnow, Stanford University School of Medicine, USA
Modulation of Hepatitis C Virus and Insig1 RNA Abundances by MicroRNA 122

Stephane Heymans, Maastricht University, Netherlands
Inflammation-MicroRNAs Mediate Cardiac Failure

Bryan R. Cullen, Duke University Medical Center, USA
Viruses and MicroRNAs

Emma-Kate Loveday, University of British Columbia, Canada
Short Talk: Strain Specific Modulation of the Host Cell MicroRNA-ome by High Pathogenic H5N1, H7N7, and Swine-Origin 2009 H1N1 Influenza A Viruses

Joseph Luna, Rockefeller University, USA
Short Talk: Argonaute HiTS-CLIP Defines a Dynamic miRNA:mRNA Interaction Map for Hepatitis C Virus Infection

19:00—20:00
Social Hour with Lite Bites

Mezzanine 2
19:30—22:00
Poster Session 3

Mezzanine 2

TUESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Mezzanine 2
07:30—08:00
Poster Setup

Mezzanine 2
08:00—17:00
Poster Viewing

Mezzanine 2
08:00—11:15
MicroRNAs and Stem Cells (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Stefanie Dimmeler, University of Frankfurt, Germany

Gregory J. Hannon, University of Cambridge, UK
DNA Methylation in the Germ Line

Scott M. Hammond, University of North Carolina at Chapel Hill, USA
Regulation of miRNA Production

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
MicroRNA Regulation of Cardiac Cell Fate, Morphogenesis and Function

Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Regulation of Induced Pluripotency

Emily K. Pugach, University of Colorado, USA
Short Talk: The Role of miR-205 in Embryonic Skin Development and Stem Cells

Edward E. Morrisey, University of Pennsylvania, USA
Short Talk: Highly Efficient and Hdac2 Regulated Pluripotential Stem Cell Reprogramming by miR302/367

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—12:15
Lunch

Mezzanine 2
12:00—14:30
Poster Session 4

Mezzanine 2
14:30—16:30
Workshop: MicroRNA Therapeutics: Medicinal Chemistry and Delivery (Joint)

Van Horne A - B
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Muthiah Manoharan, Alnylam Pharmaceuticals, Inc., USA
Medicinal Chemistry and Delivery of siRNAs and Antagomirs

David R. Corey, University of Texas Southwestern Medical Center, USA
Unusual Targets for Duplex RNAs

Sarah-Louise Gill, Royal College of Surgeons in Ireland (RCSI), Ireland
Short Talk: Delivery of MicroRNA Mimics to Cardiomyocytes using Ultrasound Responsive Microbubbles

Eric Marcusson, Providence Therapeutics, USA
Short Talk: microRNA-21 as a Novel Therapeutic Target in Hepatocellular Carcinoma

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:15
MicroRNA Therapeutics: Applications (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A - B
* Eric N. Olson, University of Texas Southwestern Medical Center, USA

Sakari Kauppinen, Aalborg University, Denmark
Targeting microRNAs for Therapeutics

Eva van Rooij, Hubrecht Institute, Netherlands
Therapeutic Regulation of MiRNAs to Treat Cardiovascular Disease

Anders M. Näär, Harvard Medical School, USA
Therapeutic Targeting of MicroRNAs to Control Cholesterol/Lipid Homeostasis

Shelly Adi-Harel, Weizmann Institute of Science, Israel
Short Talk: Epigenetic Silencing of p53-Regulated microRNAs in Lung Cancer

David M. Patrick, University of Texas Southwestern Medical Center, USA
Short Talk: Regulation of Erythroid Differentiation and Disease by MicroRNA-451

19:15—20:15
Social Hour with Lite Bites

Mezzanine 2
20:00—23:00
Entertainment

Mezzanine 2

WEDNESDAY, FEBRUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Astellas Pharma Inc. Integrated DNA Technologies
Regulus Therapeutics Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Santaris Pharma A/S


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676