Keystone Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2011



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Stem Cells, Cancer and Metastasis (C4)


Organizer(s) Richard J. Gilbertson and Daniel A. Haber
March 6—11, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 4, 2010
Late Abstract Deadline: Dec 9, 2010
Scholarship Deadline: Nov 4, 2010
Early Registration Deadline: Jan 6, 2011

Sponsored by Astellas Pharma Inc., Celgene Corporation and Takeda Pharmaceutical Company Limited

Summary of Meeting:
Several concepts regarding the origins of cancer and metastasis have converged in recent years. In particular, special interest has focused on the possibility that tissue specific stem cells and cancer cells displaying the properties of these cells play fundamental roles in the malignant process. These concepts have been supported by studies of mouse models in which predictable patterns of tumor spread and access to both primary and metastatic lesions has allowed molecular analyses. With regard to primary tumors, emerging evidence suggests that important cancers, including those in the colon and brain, may arise directly from mutated progenitor cells that display deviant differentiation within "stem cell-niches". Tumors appear also to contain stem-like cancer cells that are both necessary and required to propagate the disease. These findings overlap with observations of metastasis that suggest tumor dissemination may be driven by critical changes in tumor cell differentiation, including epithelial to mesenchymal transition (EMT), and the migration of malignant stem cells to "pre-metastatic niches". We believe the time is ripe for a joint conference that will bring together scientists and clinicians with interests in stem cell biology, cancer and metastasis. The meeting will provide a forum for exchange of information and insights between these rapidly moving fields. In addition to increasing the sharing of key scientific approaches we believe this conference will galvanize collaborative efforts among disparate research communities to address several key outstanding questions: (i) What is the relationship between normal and malignant tissue stem cells? (ii) What is the relationship between cancer stem cells and the so-called "metastatic precursor", that is capable of indefinite proliferation at the new metastatic site? (iii) What are the interactions between stromal and stem-like cancer cells in primary and metastatic disease sites? How do these interactions facilitate disease propagation and metastatic spread? (iv) How should we monitor in vivo the biology of stem-like cells in primary tumors and metastasis? (v) What are the optimal approaches to target therapeutically stem-like cancer cells in primary and metastatic disease? By focusing on these questions, we aim to elicit exciting fundamental biological discussions with significant translational application.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 6

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Richard J. Gilbertson, University of Cambridge, UK

Robert A. Weinberg, Massachusetts Institute of Technology, USA
Cancer Stem Cells and the Epithelial-Mesenchymal Transition


MONDAY, MARCH 7

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Stem Cells in Cancer Pathogenesis I: The Controversy of Cancer Origins
Meeting has ended...abstracts no longer viewable online.
Aim: To discuss the controversy surrounding the candidate cell of origin of cancer and the relation to stem cells.

Longs/Grays Peak
* David Lyden, Weill Cornell Medical College, USA

John E. Dick, Princess Margaret Cancer Centre, Canada
Stem Cells in Leukemia: Do They Matter?

Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Stem Cells Behaving Badly: The Origins of Anaplastic Medulloblastoma

Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA
Mature Cells: A Hotbed of Cancer Susceptibility?

Richard J. Gilbertson, University of Cambridge, UK
Do Normal Tissue Stem Cells Drive Cancer Heterogeneity?

Jonathan P. Robson, Institute for Molecular Bioscience, Australia
Short Talk: A Stem-Like Cell as the Cell of Origin for Medulloblastoma

Jungwoo Lee, University of Massachusetts, USA
Short Talk: Implantable Humanized Stem Cell Niches

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Stem Cells in Cancer Pathogenesis II: Niches and the Metastatic Cascade
Meeting has ended...abstracts no longer viewable online.
Aim: To discuss the connection between stem cells, niches and metastases.

Longs/Grays Peak
* Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Stem Cells and Cancer in the Skin

Dorothy A. Sipkins, University of Chicago, USA
The Leukemic Stem Cell Niche

David Lyden, Weill Cornell Medical College, USA
Priming the Soil: The Pre-Metastatic Niche

Jonathan Chou, University of California, San Francisco, USA
Short Talk: GATA3 Suppresses Metastasis and Induces MicroRNAs that Regulate the Tumor Microenvironment

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, MARCH 8

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Genomic Analyses: Reading the Genome in Cancer Stem Cells and Metastatic Precursors
Meeting has ended...abstracts no longer viewable online.
Aim: To highlight how high-end genomic technologies are being used to inform regarding the deregulation of stem cells in cancer.

Longs/Grays Peak
* Frederic J. de Sauvage, Genentech, Inc., USA

Charles G. Mullighan, St. Jude Children's Research Hospital, USA
Unmasking the Origins of Leukemia with Genomics

Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Regulation of Stem Cells and Cancer

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Cancer Stem Cell Viability in the Metastatic Niche

Sridhar Ramaswamy, TESARO, Inc., USA
Spontaneous Cancer Cell Quiescence

Nicolo Riggi, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland
Short Talk: EWS-FLI-1 Modulates miRNA145 and SOX2 Expression to Initiate Mesenchymal Stem Cell Reprogramming Toward Ewing Sarcoma Cancer Stem Cells

Fabio Petrocca, Boston University School of Medicine, USA
Short Talk: A Genome-Wide siRNA Screen Identifies Selective Inhibitors of Triple-Negative Breast Tumor-Initiating Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Breast Cancer
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Sridhar Ramaswamy, TESARO, Inc., USA

Jane E. Visvader, Walter and Eliza Hall Institute of Medical Research, Australia
The Mammary Epithelial Hierarchy and its Implications for Identifying Cells of Origin of Breast Cancer

Rama Khokha, Ontario Cancer Institute, Canada
Regulation of the Mammary Stem Cell Niche

Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA
Genetic and Epigenetic Plasticity of Stem Cells in Breast Cancer

Casey A. Frankenberger, University of Chicago, USA
Short Talk: A Let-7 Signaling Pathway Targets Metastatic Genes Enriched in Tumor Initiating Cells

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, MARCH 9

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
Cancer Stem Cells, Metastasis and Cancer Therapy
Meeting has ended...abstracts no longer viewable online.
Aim: To discuss current and ongoing efforts to develop new therapies against cancer stem cells and metastatic disease.

Longs/Grays Peak
* Charlotte Kuperwasser, Tufts University School of Medicine, New England, USA

Max S. Wicha, University of Michigan, USA
Therapeutic Implications of Stem Cells in Breast Cancer

Margaret A. Read, Infinity Pharmaceuticals, Inc., USA
Rationale for Smo Inhibition as Therapeutic Intervention in Minimal Residual Disease

Frederic J. de Sauvage, Genentech, Inc., USA
Development of Hedgehog Pathway Inhibitors for the Treatment of Cancer

Richard O. Hynes, Massachusetts Institute of Technology, USA
Extracellular Matrix Effects in Cancer Progression

Johannes Tsung-han Yeh, Harvard Medical School, USA
Short Talk: Drugging the Undruggable: Direct Targeting of beta-catenin in Cancer Stem Cells by Novel Designed Stapled Peptides

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Imaging and Tracking Cancer Stem Cells and Metastatic Precursors
Meeting has ended...abstracts no longer viewable online.
Aim: To bring highlight technological advances in stem cell tracking, isolation and imaging.

Longs/Grays Peak
* Richard O. Hynes, Massachusetts Institute of Technology, USA

Peter Kuhn, The Scripps Research Institute, USA
High Definition Circulating Tumor Cells in Carcinoma Patients

Daniel A. Haber, Massachusetts General Hospital, USA
Molecular Characterization of Circulating Tumor Cells

Michael R.H. White, University of Manchester, UK
Systems Analysis in Single Cells

Irène Baccelli, DKFZ (Deutsches Krebsforschungszentrum), Germany
Short Talk: Towards the Functional Analysis of Human Disseminating Tumor Cells (DgTCs)

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 3

Quandary Peak

THURSDAY, MARCH 10

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Epithelial Cancers and Stem Cells
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA

Marc van de Wetering, Netherlands Institute for Developmental Biology, Netherlands
Wnt Signaling, Lgr5 Stem Cells and Cancer

Joan S. Brugge, Harvard Medical School, USA
Genes that Regulate Migration and Invasion

Carla F. Kim, Boston Children's Hospital, USA
Stem Cells in Normal Lung and Lung Cancer

Courtney W. Houchen, University of Oklahoma Health Sciences Centers, USA
Pancreatic Cancer Stem Cell Marker DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism

JoAnne M. Montalbano, University of Virginia, USA
Short Talk: The Polarity Protein Par3 Acts as a Tumor Growth and Invasion Suppressor, through Stat3-Dependent Mechanisms

Andrew D. Rhim, University of Michigan Medical School, USA
Short Talk: Genetic Lineage Labeling Identifies New Populations of Circulating Tumor Cells in a Mouse Model of Spontaneous Pancreatic Ductal Adenocarcinoma (PDAC)

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—17:45
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Daniel A. Haber, Massachusetts General Hospital, USA

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cells and Cancer: Where Are We Now?

17:45—19:00
Roundtable: Cancer Stem Cells in Metastasis: Insights and Controversies

Longs/Grays Peak
* Richard J. Gilbertson, University of Cambridge, UK

* Daniel A. Haber, Massachusetts General Hospital, USA

Sean J. Morrison, University of Texas Southwestern Medical Center, USA

Robert A. Weinberg, Massachusetts Institute of Technology, USA

Marc van de Wetering, Netherlands Institute for Developmental Biology, Netherlands

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

FRIDAY, MARCH 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Astellas Pharma Inc. Celgene Corporation
Cell Signaling Technology, Inc. Cephalon
Chroma Technology Corporation OncoMed Pharmaceuticals, Inc.
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

The Rockefeller University Press - The Journal of Cell Biology The Rockefeller University Press - The Journal of Experimental Medicine

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676