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This meeting took place in 2011



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Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics (X4)


Organizer(s) Joseph M. Metzger, Leslie A. Leinwand and Jeffery D. Molkentin
February 22—27, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 21, 2010
Late Abstract Deadline: Nov 23, 2010
Scholarship Deadline: Oct 21, 2010
Early Registration Deadline: Dec 22, 2010

Sponsored by Bayer USA Foundation


Summary of Meeting:
Human health and wellness are advanced, both nationally and globally, by new mechanistic insights emanating from the field of molecular cardiology and its application to experimental cardiovascular therapeutics. This meeting is designed to attract leading laboratories, investigators, students and trainees in the field to address gaps in fundamental pathways in human heart functionality and how, when they become dysfunctional, they contribute to cardiac disease. The significance and impact of this meeting is further amplified by aligning in joint format with the parallel Keystone Symposia meeting on Mechanisms of Cardiac Growth, Death and Regeneration. Collectively, these meetings will address the fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human heart disease. Another unique feature of this joint meeting stems from implementing and highlighting an Early Independent Career Research Competition and a dedicated Graduate Student and Postdoc Research Competition. Specific Objectives feature: 1) insights and controversies in the genetics, epigenetics and the biochemistry and physiology of cardiac cell growth; 2) emerging concepts in cardiac calcium handling and how new mechanistic insights are informing novel experimental therapeutics; and 3) mechanisms of inter- and intra-cellular cardiac communication in health and disease. The concurrent meeting format also aims to accomplish the following: 4) stimulate interactions among stem cell biologists and individuals studying cardiac growth, death and cardiac physiology; and 5) provide trainees with a significant learning experience through several mechanisms in addition to the usual lectures and poster presentations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 22

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Richard N. Kitsis, Albert Einstein College of Medicine, USA

* Joseph M. Metzger, University of Minnesota Medical School, USA

Joanna Wysocka, Stanford University School of Medicine, USA
Chromatin, Enhancers and Emergence of Epigenomes in Development

Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
Pleiotropic Signaling from G Protein-Coupled Receptors


WEDNESDAY, FEBRUARY 23

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
Genetic and Epigenetic Specification of Cardiac Structure and Function (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA

Christine E. Seidman, Harvard Medical School, USA
Finding Missing Mutations in DCM

Elizabeth M. McNally, Northwestern University, USA
Genetic Modifiers for Heart and Muscle Disease

Stuart A. Cook, Duke-NUS Graduate Medical School Singapore, Singapore
Systems Genetics Studies of Heart Disease

Jean E. Schaffer, Washington University School of Medicine, USA
Unexpected Regulators of Metabolic Stress

Roger Foo, Genome Institute of Singapore, Singapore
Short Talk: Distinct Epigenomic Features of Human Heart Failure

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:00
On Own for Lunch and Recreation

15:30—16:30
Workshop 1: Early Independent Career Research Competition (Joint)
The Early Independent Career Research Competition will be for independent faculty (Independent Junior Research Faculty/Assistant Professors (not tenured)). There will be no reference to age. Abstracts submitted to this competition will be rated by the organizers. The top submissions will be selected for oral presentation in these sessions in addition to poster sessions. The referees will select a winner from the presenters. The winners from the two competitions will be announced on the final night of the meeting.

Longs/Grays Peak
* Ivor J. Benjamin, University of Utah, USA

* Leslie A. Leinwand, University of Colorado Boulder, USA

* Richard N. Kitsis, Albert Einstein College of Medicine, USA

* Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA

* Charles E. Murry, University of Washington, USA

Ching-Pin Chang, Indiana University, USA
Chromatin Remodeling by Brg1 Regulates Cardiac Growth, Differentiation and Hypertrophy

Maria I. Kontaridis, Beth Israel Deaconess Medical Center, USA
Rapamycin Normalizes Hypertrophic Cardiomyopathy in a Mouse Model of LEOPARD Syndrome-Associated PTPN11 Mutation

Sharlene M. Day, University of Michigan, USA
Disrupted Sarcomere Stoichiometry and Heterogeneous Expression of Mutant Sarcomere Proteins in Human Hypertrophic Cardiomyopathy

Zoltan P. Arany, University of Pennsylvania, USA
PGC-1alpha Regulates Cardiac Vascularity and Protects from Post-Partum Cardiomyopathy

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Regulation of Cardiac Function
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Eric N. Olson, University of Texas Southwestern Medical Center, USA

Howard A. Rockman, Duke University Medical Center, USA
Beta-Arrestin Signaling and Cardiac Function

Walter J. Koch, Temple University School of Medicine, USA
Novel Roles of GRKs in Cardiac Injury and Repair

David A. Kass, Johns Hopkins Hospital, USA
Cyclic GMP/PKG Modulation of Heart Disease

Ralph Knöll, AstraZeneca and Karolinska Institutet, Sweden
Short Talk: Novel MLP-Interacting Proteins and Their Potential Role in Cardiomyopathy

17:00—19:00
Cardiac Stress Responses
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA

Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Choices of a Stressed Cardiomyocyte: Necrosis, Apoptosis or Autophagy?

Ivor J. Benjamin, University of Utah, USA
Mammalian HSP-HSF Regulatory Network For Pretein Quality Control

Issei Komuro, Tokyo University Graduate School, Japan
p53 as a Mediator of Cardiovascular Diseases

Jill Rafael-Fortney, Ohio State University College of Medicine, USA
Short Talk: Claudin-5 Prevents Functional and Histological Indicators of Cardiomyopathy, and Represents a Novel Treatment Strategy for Heart Failure

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

THURSDAY, FEBRUARY 24

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
New Insights into Cardiac Hypertrophy
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Howard A. Rockman, Duke University Medical Center, USA

Anthony Rosenzweig, Massachusetts General Hospital, USA
SGK1 in Pathological Cardiac Hypertrophy, Failure, and Arrhythmias

Meredith Bond, University of Maryland School of Medicine, USA
AKAPs in Healthy and Failing Heart

Eric N. Olson, University of Texas Southwestern Medical Center, USA
MicroRNA Control of Cardiovascular Development and Disease

Joan Heller Brown, University of California, San Diego, USA
Ca++/calmodulin-Dependent Protein Kinase II in Heart Failure Development

Zhi-Ping Liu, University of Texas Southwestern Medical Center, USA
Short Talk: The Histone Trimethyl Demethylase, JMJD2A, Promotes Pressure Overload-Induced Cardiac Hypertrophy

08:00—11:00
Directed Differentiation of Cardiac Progenitors
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Gordon M. Keller, University Health Network, MaRS Centre, Canada

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Reprogramming Approaches to Cardiac Disease

Michael D. Schneider, Imperial College London, UK
Cardiopoiesis: Genetic Circuits for Cardiac Myocyte Creation by Stem Cells

Christine L. Mummery, Leiden University Medical Center, Netherlands
Cardiomyocytes from Pleuripotent Stem Cells in Drug Discovery and Disease

Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA
Epigenetic Regulation of Heart Development

Robert J. Schwartz, Texas A&M University, USA
Short Talk: Trans-differentiation of Noncardiogenic Fibroblast into Cardiac Progenitors

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Ca++ Dynamics and Heart Failure
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Roger J. Hajjar, Mount Sinai School of Medicine, USA

W. Jonathan Lederer, University of Maryland Baltimore, USA
Stretch-dependent Ca2+ signaling in rat and mouse cardiac ventricular myocytes

Joseph M. Metzger, University of Minnesota Medical School, USA
New Delayed Ca2+ Buffer for the Failing Heart

Evangelia G. Kranias, University of Cincinnati College of Medicine, USA
Ca-Cycling Circuits in Heart Failure

17:00—19:00
Cardiac Death Programs
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Richard N. Kitsis, Albert Einstein College of Medicine, USA

Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Thrombosponin-4 as a Platform for the Adaptive ER Stress Response

Lorrie A. Kirshenbaum, University of Manitoba, Canada
Novel Alternative Splicing of Death Gene Bnip3 Promotes Cell Survival of Post-Natal Ventricular Myocytes

Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Signaling Mechanism of Autophagy in the Heart

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

FRIDAY, FEBRUARY 25

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
“Wntch” Signaling in Cardiogenesis and Repair (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Charles E. Murry, University of Washington, USA

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Induction and Specification of Cardiac Mesoderm from Human Pluripotent Stem Cells

Jonathan A. Epstein, University of Pennsylvania, USA
Notch…and other Stories

Kenneth R. Chien, Karolinska Institutet, Sweden
Engineering Ventriculogenesis: Epigenetic and Modified RNA Pathway and Technology

Edward E. Morrisey, University of Pennsylvania, USA
Wnt Signaling, Cardiac Development and iPSCs

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:00
On Own for Lunch and Recreation

15:30—16:30
Workshop 2: Graduate Student and Postdoc Research Competition (Joint)
The postdoc/graduate student competition is open to all postdocs/graduate students. There will be no reference to age. Abstracts submitted to this competition will be rated by the organizers. The top submissions will be selected for oral presentation in these sessions in addition to poster sessions.

Longs/Grays Peak
* Ivor J. Benjamin, University of Utah, USA

* Richard N. Kitsis, Albert Einstein College of Medicine, USA

* Leslie A. Leinwand, University of Colorado Boulder, USA

* Charles E. Murry, University of Washington, USA

Pontus Boström, Dana Farber Cancer Institute, Harvard Medical School, USA
C/EBPbeta Controls Exercise-Induced Cardiac Growth and Protects Against Pathological Cardiac Remodeling

Oscar Abilez, Stanford University, USA
In Vitro and In Silico Optogenetic Control of Differentiated Human Pluripotent Stem Cell-Derived Cardiomyocytes

Stacey L. Rentschler, Washington University School of Medicine, USA
Notch Signaling Regulates Murine Atrioventricular Conduction and Formation of Accessory Pathways

Jennifer M. Davis, Cincinnati Children's Hospital Medical Center, USA
TRPC6 Promotes the Fibroblast to Myofibroblast Transition in Cardiac Fibroblasts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Nutrition, Energetics, and Signaling
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Evangelia G. Kranias, University of Cincinnati College of Medicine, USA

Leslie A. Leinwand, University of Colorado Boulder, USA
Gender, Diet, and Cardiac Function

David D. Thomas, University of Minnesota Medical School, USA
Biophysical Assault on Heart Failure

Daniel P. Kelly, University of Pennsylvania, USA
Transcriptional Regulation of Cardiac Energetics

DeWayne Townsend, University of Minnesota Medical School, USA
Short Talk: Loss of Dystrobrevin Markedly Weakens the Interaction between Dystrophin and beta-Dystroglycan, but Cardiac Function is Maintained

17:00—19:00
Translating the (Pluri)Potential into Therapy
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Doris A. Taylor, Texas Heart Institute, USA

Bernd K. Fleischmann, Bonn University, Germany
The Physiological Basis for Cardiac Repair by Stem Cells

Gordana V. Vunjak-Novakovic, Columbia University, USA
Tissue Engineered Cardiac patch

Joseph Gold, Beckman Research Institute, City of Hope, USA
Development Human Embryonic Stem Cell-Derived Therapies for the Treatment of Human Disease: Applications in Spinal Cord Injury and Heart Failure

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Short Talk: Mending the Broken Heart: Better Living Through Chemistry

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 3

Quandary Peak

SATURDAY, FEBRUARY 26

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
Intercellular and Intracellular Communication
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Joseph M. Metzger, University of Minnesota Medical School, USA

Kenneth Walsh, Boston University School of Medicine, USA
Signaling between Cardiac Myocytes and Endothelial Cells

Richard T. Lee, Harvard University, USA
Paracrine Signaling Between Fibroblasts and Myocytes

Gerald W. Dorn, II, Washington University School of Medicine, USA
Cross-Talk between ER and Mitochondria

Yibin Wang, University of California, Los Angeles, David Geffen School of Medicine, USA
A Mitochondrial Protein Phosphatase in Cardiac Regulation

Daniela C. Tirziu, Yale University School of Medicine, USA
Short Talk: Role of Nitric Oxide-G Protein Axis in Endothelium to Cardiomyocyte Crosstalk

08:00—11:00
Identification and Manipulation of Progenitor Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA

Charles E. Murry, University of Washington, USA
Human Cardiogenesis: Lessons on Growing Cardiomyocytes and Myocardium from Pluripotent Cells

Daniel J. Garry, University of Minnesota, USA
Nkx2-5 Transcriptional Networks and Cardiogenesis

Bernhard Kühn, Children's Hospital of Pittsburgh, USA
Inducing Myocardial Regeneration to Hreat Heart Disease

William T. Pu, Children's Hospital, Harvard Medical School, USA
More than a Cover: Epicardial Function in Heart Development and Disease

Paul H. Goldspink, Medical College of Wisconsin, USA
Short Talk: The E-Domain of MGF Preserves Cardiac Function and Mobilizes Cardiac Progenitor Cell Populations following Myocardial Infarction

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Bench to Bedside: Experimental Therapeutics
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Anthony Rosenzweig, Massachusetts General Hospital, USA

Eva van Rooij, Hubrecht Institute, Netherlands
Oligo-Based Modulation of miRNAs to Control Cardiovascular Disease

Roger J. Hajjar, Mount Sinai School of Medicine, USA
Manipulating SERCA2a in Heart Failure: Basic Mechanisms to Clinical Applications

Bruce E. Markham, Phrixus Pharmaceuticals, USA
Membrane Repair, Triblock Co-Polymers and Heart Failure

Yang Xiang, University of California, Davis, USA
Short Talk: Spatiotemporal Regulation of beta Adrenergic Receptor Signaling in Cardiac Myocytes

17:00—19:00
Cardiac Rebirth and Renewal
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jonathan A. Epstein, University of Pennsylvania, USA

Loren J. Field, Indiana University, School of Medicine, USA
Cell Cycle Induction and Stem Cell Mobilization for Cardiomyocyte Repopulation

Michael A. Laflamme, University of Washington, USA
Human Embryonic Stem Cell-Derived Cardiomyocytes and the Risk of Graft-Related Arrhythmias

Doris A. Taylor, Texas Heart Institute, USA
Cells, Molecules and Matrix: New Tools for Regeneration

Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Short Talk: Heart Regeneration in Neonatal Mice

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

SUNDAY, FEBRUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL106856-01




We gratefully acknowledge additional support for this conference from:

Bayer USA Foundation
American Heart Association's Council on Basic Cardiovascular Sciences


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676