Whistler Conference Centre Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2011



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Autophagy (D1)


Organizer(s) Ana Maria Cuervo, David C. Rubinsztein and Thomas P. Neufeld
March 27—April 1, 2011
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 29, 2010
Late Abstract Deadline: Dec 30, 2010
Scholarship Deadline: Nov 29, 2010
Early Registration Deadline: Jan 27, 2011

Supported by the Directors’ Fund

Summary of Meeting:
Autophagy is an essential cellular process that mediates continuous recycling of intracellular components and becomes an alternative source of energy when nutrients are scarce. Novel roles of autophagy in embryogenesis, development, cellular defense and cell death have emerged from recent studies, along with growing evidence of associations between autophagic dysfunction and disease. However, a deeper understanding of the molecular effectors and regulators of autophagy is still required if we are to effectively repair, restore or modulate autophagy in whole organisms for therapeutic purposes. This meeting will bring together experts in different areas of cell biology, genetics, cellular pathophysiology and metabolism to foster multidisciplinary discussions intended to advance our knowledge about the different autophagic mechanisms, their regulation and their contribution to normal cell functioning and to disease.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 27

15:00—19:30
Registration

Coat Check Area
18:15—19:15
Refreshments

Grand Foyer/Mountainview
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

* David C. Rubinsztein, Cambridge Institute for Medical Research, UK

* Thomas P. Neufeld, University of Minnesota, USA

Aaron J. Ciechanover, Technion-Israel Institute of Technology, Israel
Proteolysis: From the Lysosome to Ubiquitin and the Proteasome

Yoshinori Ohsumi, Tokyo Institute of Technology, Japan
Autophagy in Yeast: Looking Back on the Past Two Decades and Future Perspective


MONDAY, MARCH 28

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
Genetics of Autophagy: Novel Players
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Thomas P. Neufeld, University of Minnesota, USA

Daniel J. Klionsky, University of Michigan, USA
The Regulation of Macroautophagy

Noboru Mizushima, University of Tokyo, Japan
(Part I) Hierarchical Relationships among Mammalian Atg Proteins (PartII) Parkin-Dependent Selective Degradation of Mitochondria (Mitophagy)

Roland L. Knorr, Max Planck Institute of Colloids and Interfaces, Germany
Short Talk: How Phagophores Bend into Autophagic Vesicles

Roland L. Knorr, Max Planck Institute of Colloids and Interfaces, Germany
Short Talk: How Phagophores Bend into Autophagic Vesicles

Jeannette S. Messer, University of Chicago, USA
Short Talk: ATG16L1 Mediates Lipidation of the mATG8 Family Members GABARAP, GATE-16, and LC3

Sharon A. Tooze, Francis Crick Institute, UK
Exploring the Role of the Autophagy Specific PI3P Binding Protein, WIPI2

Zvulun Elazar, Weizmann Institute of Science, Israel
Atg8s and Autophagosome Biogenesis

09:20—09:40
Coffee Break

Grand Foyer/Mountainview
11:15—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:15
On Own for Lunch

13:30—14:45
Workshop 1: Novel Techniques to Track Autophagy

Sea to Sky C
* Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA

* Sharon A. Tooze, Francis Crick Institute, UK

Ana Joaquina Jimenez, Institut Curie, France
Selective Recruitment of Autophagic Machineries upon Targeted Damage of Trafficking Organelles

Jason S. King, Beatson Institute for Cancer Research, UK
Autophagy and Cellular Adaptation to Mechanical Stress in Dictyostelium and Mammalian Cells

Anders Overbye, Institute for Cancer Research, Norway
Autophagic-Lysosomal Processing of Betaine:Homocysteine Methyltransferase (BHMT): Role of Asparaginyl Endopeptidase (Legumain)

Steven V. Rødkær, University of Southern Denmark, Denmark
Mapping out Starvation Responses in Yeast by Proteomics

Sebastian Schuck, HHMI/University of California, San Francisco, USA
Selective Autophagy of the Endoplasmic Reticulum by a Novel Microautophagic Mechanism

14:45—15:15
Discussion: Novel Techniques to Track Autophagy
Discussants: Leon Murphy, Tamotsu Yoshimori, Zvulun Elazar

15:15—16:00
Workshop 2: Autophagy and Disease: A Clinical Point of View

Sea to Sky C
* Beth Levine, University of Texas Southwestern Medical Center, USA

* Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA

Andrey A. Parkhitko, Brigham and Women's Hospital Harvard Medical School, USA
Role of Autophagy in the Pathogenesis of Tuberous Sclerosis Complex

Katja Simon, University of Oxford, UK
The Autophagy Protein Atg7 is Essential for Hematopoietic Stem Cell Maintenance and Leukemia Prevention

Louis R. Lapierre, Brown University, USA
Autophagy Links Lipid Metabolism to Longevity in C. elegans

16:00—16:30
Discussion: Autophagy and Disease: A Clinical Point of View
Discussants: Vojo Deretic, Noboru Mizushima, David Rubinsztein, Ana Maria Cuervo

16:30—17:00
Coffee Available

Grand Foyer/Mountainview
17:00—19:00
Genetics of Autophagy: Novel Regulators
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Daniel J. Klionsky, University of Michigan, USA

Leon O. Murphy, Third Rock Ventures, USA
mTOR and Autophagy

Xuejun Jiang, Memorial Sloan Kettering Cancer Center, USA
From ULK1 Complex-Mediated Autophagy Induction to Distinct Mechanism Governing Autophagosomal-Lysosomal Fusion

Elaine Dunlop, Cardiff University, UK
Short Talk: ULK1 Inhibits mTORC1 through Multisite Raptor Phosphorylation and Hindrance of Substrate Binding

Tamotsu Yoshimori, Osaka University, Japan
Mechanistic Insight into Membrane Dynamics in Mammalian Autophagy

19:00—20:00
Social Hour with Lite Bites

Grand Foyer/Mountainview
19:30—22:00
Poster Session 1

Sea to Sky A/Grand Foyer

TUESDAY, MARCH 29

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:00
Autophagy in Cell Biology and Cell Function
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Patrice Codogno, INSERM, France

Thomas P. Neufeld, University of Minnesota, USA
Intersections between Autophagy and the Cell Growth Machinery

Richard J. Youle, NINDS, National Institutes of Health, USA
Damage control: How the Pink-1/Parkin Pathway can Regulate the Removal of Damaged Mitochondria by Autophagy

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy in Aging Pathophysiology

Marc D. Meneghini, University of Toronto, Canada
Short Talk: Sporophagy: Developmentally Programmed Autophagic Destruction of Whole Nuclei during Yeast Gametogenesis

Ivan Dikic, Goethe University Medical School, Germany
Regulation of Selective Autophagy by Receptor Phosphorylation

09:20—09:40
Coffee Break

Grand Foyer/Mountainview
11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:00
On Own for Lunch

13:30—14:45
Workshop 3: Non-Mammalian Autophagy: Advantages/Limitations

Sea to Sky C
* Daniel J. Klionsky, University of Michigan, USA

* Thomas P. Neufeld, University of Minnesota, USA

Takahiko Akematsu, York University, Canada
Gigantic Macroautophagy in Programmed Nuclear Death of Tetrahymena Thermophila

Diane C. Bassham, Iowa State University, USA
Degradation of the Endoplasmic Reticulum by Autophagy during ER Stress in Plants

Guang-Chao Chen, Academia Sinica, Taiwan
Atg1-Mediated Myosin-II Activation Regulates Autophagy in Drosophila and Mammalian Cells

Amy Kiger, University of California, San Diego, USA
Class II PI3-Kinase and Regulators of Membrane Trafficking Coordinately Regulate Autophagy

Dennis Pultz, University of Southern Denmark, Denmark
Investigating Temporal Changes in the Yeast Phosphoproteome upon Fatty Acid Starvation

14:45—15:00
Discussion: Non-Mammalian Autophagy: Advantages/Limitations
Discussants: Malene Hansen, Sharon Gorski, Daniel Klionsky

15:00—16:00
Workshop 4: Large Screening and Omics in Autophagy

Sea to Sky C
* David C. Rubinsztein, Cambridge Institute for Medical Research, UK

Benoît Pasquier, Sanofi Aventis, France
High throughput Screening for Autophagy Inhibitors

Chih-Wen Shu, Kaohsiung Veterans General Hospital, Taiwan
High-Throughput Screening for Small Molecule Inhibitors of Autophagins/Atg4

Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA
Image-Based Genome-Wide siRNA Screen Identifies Host Factors Involved in Selective Autophagy

* Eileen P. White, Rutgers University, USA
PROS and CONS of the Major Metabolomics Technics

16:00—16:30
Discussion: Large Screening and Omics in Autophagy
Discussants: Eileen P. White, Robert Abraham

16:30—17:00
Coffee Available

Grand Foyer/Mountainview
17:00—19:00
Autophagy in Response to Stress and Injury
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Noboru Mizushima, University of Tokyo, Japan

Beth Levine, University of Texas Southwestern Medical Center, USA
Bcl-2 Regulated Autophagy in Exercise and Resistance

Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Short Talk: Autophagy Promotes Survival of Retinal Ganglion Cells after Optic Nerve Axotomy in Mice

Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Short Talk: Autophagy Promotes Survival of Retinal Ganglion Cells after Optic Nerve Axotomy in Mice

Claudio A. Hetz, University of Chile, Chile
Homeostatic Connection between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

N. Tony Eissa, Baylor College of Medicine, USA
Short Talk: p62 Mediates a Novel Cytosolic Response to Unfolded Proteins Linking Inflammation, ER Stress and Metabolic Syndrome

Conrad C. Weihl, Washington University School of Medicine, USA
Short Talk: VCP Coordinates the Degradation of Ubiquitinated Substrates via Multiple Pathways

19:00—20:00
Social Hour with Lite Bites

Grand Foyer/Mountainview
19:30—22:00
Poster Session 2

Sea to Sky A/Grand Foyer

WEDNESDAY, MARCH 30

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
Autophagy in Disease I
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Francesco Cecconi, Danish Cancer Society Research Center, Denmark
Physiological and Pathological Regulation of the Pro-Autophagic Factor Ambra1

Daniela Laura Papademetrio, University of Buenos Aires, Argentina
Short Talk: Autophagy Prevents Apoptotic Death in Pancreatic Tumor

Andrea Ballabio, Telethon Institute of Genetics and Medicine, Italy
TFEB Links Autophagy to Lysosomal Biogenesis

Nivetha Ramachandran, SickKids, Canada
X-Linked Myopathy with Excessive Autophagy

Ralph A. Nixon, New York University, Langone Medical Center, USA
Autophagy in the Alzheimer's Brain

Shengkan V. Jin, Rutgers University-Robert Wood Johnson Medical School, USA
Short Talk: Autophagy in Differentiation and Mitochondrial Homeostasis Control of White Adipose Tissue: Implications in Obesity and Type II Diabetes

09:20—09:40
Coffee Break

Grand Foyer/Mountainview
11:15—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Grand Foyer/Mountainview
17:00—19:00
Autophagy in Disease II
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Herbert (Skip) W. Virgin†, Washington University School of Medicine, USA

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy: An Emerging Immunological Paradigm

Marija Cemma, Hospital for Sick Children, Canada
Short Talk: The Ubiquitin-Binding Adaptor Proteins p62/SQSTM1 and NDP52 are Recruited Independently to Bacteria-Associated Microdomains to Target Salmonella to the Autophagy Pathway

Iryna Monastyrska, Utrecht University, Netherlands
Short Talk: LC3-I is Abused by Positive-Stranded RNA Viruses for Replication on ER-Derived Vesicles

Seungmin Hwang, University of Chicago, USA
Short Talk: ATG5 is Required for Interferon-gamma to Control Murine Norovirus Replication

Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA
Integrative Genomics Approaches to Gene Discovery in Autophagy and Disease

19:00—20:00
Social Hour with Lite Bites

Grand Foyer/Mountainview
19:30—22:00
Poster Session 3

Sea to Sky A/Grand Foyer

THURSDAY, MARCH 31

07:00—08:00
Breakfast

Sea to Sky A
08:00—11:15
Autophagy, Cell Death and Cancer
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Beth Levine, University of Texas Southwestern Medical Center, USA

Kevin M. Ryan, Beatson Institute for Cancer Research, UK
Autophagy in Cancer Development and Tumor Cell Death

Guido Kroemer, Cordeliers Research Center, France
Autophagy: A Cytoprotective Mechanism that Shapes Anticancer Immune Responses

Robert T. Abraham, Pfizer Worldwide Research and Development, USA
mTOR at the Crossroads of Cancer Metabolism and Cancer Therapy

Maryam Mehrpour, INSERM, France
Short Talk: Self Renewal of Breast Cancer Stem Cells is Dependent on Beclin 1

Alec Kimmelman, New York University Langone Medical Center, USA
Short Talk: Pancreatic Cancers are Addicted to Autophagy for Tumor Maintenance

Eileen P. White, Rutgers University, USA
Targeting Autophagy in Cancer

09:20—09:40
Coffee Break

Grand Foyer/Mountainview
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Grand Foyer/Mountainview
17:00—18:15
Autophagy: Hot and Controversial Topics
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Sharon A. Tooze, Francis Crick Institute, UK

* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Autophagy Regulation by Mitochondria after Starvation

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
The Plasma Membrane Contributes to Pre-Autophagosomal Structures

18:15—19:00
Round Table Discussion: Mitophagy

* Richard J. Youle, NINDS, National Institutes of Health, USA

Sih-han Wang, University of Texas MD Anderson Cancer Center, USA
Short Talk: A Tale of Two Mitophagies: Parkin-Dependent and -Independent Pathways

Kristi Lynn Norris, Duke University Medical Center, USA
Short Talk: Parkin Maintains Mitochondrial Quality by Promoting Stress-Induced Mitochondrial Fusion and Mitophagy

Wim Vandenberghe, University Hospitals Leuven, Belgium
Short Talk: Parkin Interacts with Ambra1 to Induce Mitophagy

19:00—20:00
Social Hour with Lite Bites

Grand Foyer/Mountainview
20:00—23:00
Entertainment

Sea to Sky A

FRIDAY, APRIL 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA159718-01




National Institutes of Health

Grant No. 5R13DK084688-02




We gratefully acknowledge additional support for this conference from:

BioMarin Pharmaceutical Inc. Boston Biochem, an R&D Systems Company
Cell Signaling Technology, Inc. Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company
Landes Bioscience Novus Biologicals, Inc.
Pfizer Oncology Seahorse Bioscience, Inc.

Biosensis Pty Ltd

 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Pfizer Biopharmaceuticals


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Cell Therapy News

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676