Alpbach Congress Centrum Floorplan

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This meeting took place in 2011



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Omics Meets Cell Biology (E1)


Organizer(s) Anne-Claude Gavin and Charlie M. Boone
May 8—13, 2011
Alpbach Congress Centrum • Alpbach, Austria
Abstract Deadline: Jan 6, 2011
Late Abstract Deadline: Feb 10, 2011
Scholarship Deadline: Jan 6, 2011
Early Registration Deadline: Mar 8, 2011

Supported by the Directors’ Fund

Summary of Meeting:
Whole genome sequencing has become widespread and modern biologists currently access exponentially growing lists of genomes from organisms covering all three domains of life. This has fundamentally changed the way scientists address biological questions. A spectacular flourishing of technologies allows for global interrogation of gene activity and function and ever more comprehensive measurement of cellular macromolecules. These Omics approaches are still in full expansion but already increasingly contribute to the editing and annotation of systems-level networks charting physical and functional links between all cellular components. Nevertheless, an important challenge resides in the interpretation and integration of the data within the context of the whole physiology of a cell. We are for example, still learning and developing the bioinformatic tools to store and integrate different types of datasets. Emerging biochemical and chemical approaches contribute chemical tools and affinity reagents to systematically interrogate or perturb macromolecules within a cell. Live-cell imaging and quantitative microscopy have also moved large-scale allowing unprecedented phenotypic analysis. This conference will bring together the leading experts representing Omics technologies, cell biology, chemical-genetics, and bioinformatics to discuss and present these latest developments.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MAY 8

15:00—19:30
Registration

Otto Molden Foyer
18:15—19:15
Refreshments

Otto Molden Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
Lucas Pelkmans, University of Zürich, Switzerland
Origins of Regulated Cell-to-Cell Variability


MONDAY, MAY 9

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:15
Proteome Visualization: Toward a Molecular Anatomy of the Cell
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Matthias Mann†, Max Planck Institute of Biochemistry, Germany

Martin Beck, European Molecular Biology Laboratory, Germany
Molecular Anatomy of the Human Pathogen Leptospira interrogans

Robert B. Russell, University of Heidelberg, Germany
Predicting Protein-Peptide and Protein-Chemical Interactions within Biological Networks

Carol V. Robinson, University of Oxford, UK
Dehydrated but Unharmed? - The Mass Spectrometry of Protein Complexes

Frank Sobott, University of Antwerp, Belgium
Short Talk: Stoichiometry and Architecture of Protein-DNA/RNA Complexes by Native Mass Spectrometry Combined with Ion Mobility

Sarah Teichmann, Wellcome Trust Sanger Institute, UK
Evolution and Assembly of Protein Complexes

Jennifer L. Greene, University of Pennsylvania, USA
Short Talk: Global Proteomic Approaches Reveal Structural Diversity of Cysteines Endogenously Targeted for S-Nitrosylation

09:20—09:40
Coffee Break

Otto Molden Foyer
11:15—13:00
Poster Setup

Otto Molden Foyer
13:00—22:00
Poster Viewing

Otto Molden Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Available Bioinformatic Resources for Cell Biologists

Erwin Schrödinger Hall
* Lydie Lane, Swiss Institute of Bioinformatics, Switzerland
neXtProt, a Novel Human Protein Knowledge Platform in the Era of Omics Techologies

Misha Savitski, Cellzome GmbH, Germany
C-score, a Confidence Score for Reliable Protein Complex Determination from Orthogonal, High-Precision Quantitative Mass Spectrometry Experiments

Jean M. Peccoud, Virginia Tech, USA
Cyber-Infrastructures for Genetic Design Automation

Paul A. Jensen, University of Virginia, USA
Automatic Thresholding of Expression Data Captures Functional Responses in Genome-Scale Metabolic Models

Noor Jailkhani, International Centre for Genetic Engineering and Biotechnology, India
Delineating Points of Vulnerability in Mitogen Activated Signaling Networks

Olga Vitek, Purdue University, USA
Statistical Methods and Tools for Protein Quantification in Mass Spectrometry-Based Proteomics

Benoît Robisson, INSERM PACA, France
Detection of Multifunctional Proteins in Protein-Protein Interaction Networks

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:00
Omics of Complex Systems
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Brenda J. Andrews, University of Toronto, Canada

Jeff Hasty, University of California, San Diego, USA
Genetic Clocks from Engineered Oscillators

Norbert Perrimon, Harvard Medical School, USA
Large-Scale Analyses of Signaling Networks

Mikko Taipale, Whitehead Institute, USA
Short Talk: High-Throughput in vivo Profiling of Kinase/HSP90 Interactions and Kinase Inhibitor Specificities

Joachim Wittbrodt, Heidelberg University, Germany
Seeing is Believing: From the Digital Embryo to Refined Stem Cells (and more)

19:00—20:00
Social Hour with Lite Bites

Otto Molden Foyer
19:30—22:00
Poster Session 1

Otto Molden Foyer

TUESDAY, MAY 10

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:00
Omics and Signaling
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Norbert Perrimon, Harvard Medical School, USA

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Mass Spectrometric Collection of Proteomic and Phosphoproteomic Data for Systems Biology

Rochelle C. J. D'Souza, Max Planck Institute of Biochemistry, Germany
Short Talk: Studying TGF-beta Signaling using a High Resolution, Quantitative Mass Spectrometric Approach

Andy Fraser, University of Toronto, Canada
Short Talk: Measuring Fitness in an Animal Model

Matthias Mann, Max Planck Institute of Biochemistry, Germany
Technologies for Comprehensive Proteome Quantification

Anne-Claude Gavin, European Molecular Biology Laboratory, Germany
Molecular Networks from Proteins to Metabolites

Julian Mintseris, Harvard Medical School, USA
Short Talk: The Drosophila Melanogaster Protein Interaction Map

09:20—09:40
Coffee Break

Otto Molden Foyer
11:15—13:00
Poster Setup

Otto Molden Foyer
13:00—22:00
Poster Viewing

Otto Molden Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:00
Omics of Metabolic Networks
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Lucas Pelkmans, University of Zürich, Switzerland

Nick M. Luscombe, EMBL-European Bioinformatics Institute, UK
Models to Predict Gene Regulation in Three Dimensions

Uwe Sauer, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Unraveling Active Metabolic Regulation Networks by Omics Methods

Igor Stagljar, University of Toronto, Canada
Protein Interaction Networks Regulating Cell Signaling in Human Health and Disease

Nicola Zamboni, Institute of Molecular Systems Biology, Switzerland
Short Talk: Metabotyping of Breast Cancer by High throughput Metabolomics

19:00—20:00
Social Hour with Lite Bites

Otto Molden Foyer
19:30—22:00
Poster Session 2

Otto Molden Foyer

WEDNESDAY, MAY 11

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:15
From Omics to Phenomes I
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Yoshikazu Ohya, University of Tokyo, Japan

Brenda J. Andrews, University of Toronto, Canada
Global Protein Abundance and Localization Maps Define Subcellular Flux Networks in Yeast

Fabio Piano, New York University, USA
Toward a Comprehensive Molecular Description of Early Embryogenesis in C. elegans

Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Protein Phosphatase Networks

Susann Lehmann, University of Nottingham, UK
Short Talk: Identification of Kinases and Phosphatases Regulating Muscle Protein Degradation and Dystrophies in C. elegans by a Genome-Wide RNAi Screen

Lorey K. Smith, Peter MacCallum Cancer Centre, Australia
Short Talk: A Large Scale RNAi Screen Identifies an Extensive Network of Mammalian Cell Polarity Regulators as Key Modifiers of the Oncogenic Properties of Sustained RAS-MAPK Signaling

Nils Johnsson, Ulm University, Germany
Short Talk: Constructing and Exploiting Constraint Interaction Networks for Understanding Cellular Processes

Thomas Kislinger, University of Toronto, Canada
Short Talk: Identification of Cell-Surface Proteins Enables Isolation of Viable Lineage-Specific Cells from Blastocysts by Flow Cytometry

09:20—09:40
Coffee Break

Otto Molden Foyer
11:15—13:00
Poster Setup

Otto Molden Foyer
13:00—22:00
Poster Viewing

Otto Molden Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:15
From Omics to Phenomes II
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Joseph Lehár, Novartis Institutes for BioMedical Research, USA

Yoshikazu Ohya, University of Tokyo, Japan
Hi-Content and Quantitative Morphological Screening for the Drug Targets in Yeast

A.J. Marian Walhout, University of Massachusetts Medical School, USA
Gene-Centered Regulatory Networks

Jan Ellenberg, European Molecular Biology Laboratory, Germany
Automating Fluorescence Microscopy for Systems Biology: From Genome-Wide Profiling to the Analysis of Protein Complexes

Alexander S. Mikheyev, Okinawa Institute of Science and Technology, Japan
Short Talk: Evolutionary Fate of Alien Genes in Bdelloid Rotifers

Rekha G. Panchal, USAMRIID, USA
Short Talk: Systems Cell Biology to Profile Cellular and Pathogen Responses to Bioactive Probes based on High Content Screening

19:15—20:15
Social Hour with Lite Bites

Otto Molden Foyer
19:30—22:00
Poster Session 3

Otto Molden Foyer

THURSDAY, MAY 12

07:00—08:00
Breakfast

Your Lodging Location
08:00—11:15
Omics Meets Chemistry and Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* Marie Evangelista, Genentech, Inc., USA

Gitte Neubauer, Cellzome AG, Germany
Interrogating Drugs, their Targets and their Complexes: Chemical Proteomics in Drug Discovery

Minoru Yoshida, RIKEN, Japan
Reverse Proteomics Approaches for Discovery and Target Identification of Novel Bioactive Compounds

Joseph Lehár, Novartis Institutes for BioMedical Research, USA
Approaching Cancer Therapy via a Genomic, Phenotypic and Combination Campaign

Denis V. Yashin, Institute of Gene Biology RAS, Russia
Short Talk: Interplay of Three Proteins (PGRP S, Hsp70, and S100A4) in Host vs. Cancer Combat

Herbert Waldmann, Max Planck Institute for Molecular Physiology, Germany
From Molecular to Dynamic Biological Systems

Christoph Schaab, Kinaxo Biotechnologies, Germany
Short Talk: Comprehensive Phosphoproteomic Mode of Action Analysis in Cultured Cell Lines and Xenograft Models

09:20—09:40
Coffee Break

Otto Molden Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Otto Molden Foyer
17:00—19:15
Omics Meets Genetics and Gene Expression
Meeting has ended...abstracts no longer viewable online.

Erwin Schrödinger Hall
* A.J. Marian Walhout, University of Massachusetts Medical School, USA

Charlie M. Boone, University of Toronto, Canada
The Genetic Landscape of a Cell

Martin Fussenegger, ETH Zürich, Switzerland
Engineering Synthetic Mammalian Gene Networks: From Tools to Therapies

Marie Evangelista, Genentech, Inc., USA
Integration of Genomic Strategies to Predict Combination Benefit in the Clinic

Christian Feller, ETH Zurich, Switzerland
Short Talk: MOF Associated Cofactors Confer Different Modes of Transcriptional Activation

Florian Grebien, CeMM - Research Center for Molecular Medicine, Austria
Short Talk: Genomic and Proteomic Characterization of Normal and Oncogenic CEBPA Variants in Myeloid Cells

19:15—20:15
Social Hour with Lite Bites

Otto Molden Foyer
20:00—23:00
Entertainment

Otto Molden Foyer

FRIDAY, MAY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Science Foundation (NSF)

Grant No. MCB-1110372




We gratefully acknowledge additional support for this conference from:

Boehringer Ingelheim Pharmaceuticals, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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