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This meeting took place in 2011



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The Evolution of Protein Phosphorylation (F1)


Organizer(s) Tony Hunter and Tony Pawson
January 23—28, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 27, 2010
Late Abstract Deadline: Oct 28, 2010
Scholarship Deadline: Sep 27, 2010
Early Registration Deadline: Nov 29, 2010

Supported by the Directors’ Fund

Summary of Meeting:
Major progress has been made in defining the basis of signaling in eukaryotic cells both with respect to the function and structure of protein modules that are involved in signaling and how these proteins are organized into pathways and networks that are used to regulate cellular responses to extracellular and intracellular stimuli. Through intensive studies over the past 40 years protein phosphorylation has become one of the best understood signaling mechanisms. Most of what has been learned has been derived from studies of a few model organisms, which have taught us that several major signal transduction pathways are conserved in evolution. The recent flood of new eukaryotic genome sequences has engendered significant interest in understanding the evolution of the protein kinases and phosphatases and other signaling proteins involved in protein phosphorylation (e.g. where did tyrosine kinases come from?). In addition, the explosion of phosphoproteomic data from multiple organisms (including prokaryotes) indicates that the majority of proteins in the cell may be phosphorylated, leading to questions such as whether all the detected phosphorylation events are functional, and how this can be addressed, especially for highly phosphorylated proteins. Our increasingly systems-based understanding of the genes involved in phosphorylation signaling and the identification of the full spectrum of proteins that are reversibly phosphorylated now makes it possible to ask to what extent phosphorylation of specific sites or regions is conserved during evolution, which may provide important functional insights. In addition to these topics, the meeting will cover the evolution of protein kinases and phosphatases and key signaling modules, such as the SH2 and SH3 domains, and the evolution of protein phosphorylation in prokaryotes and plants and how their systems differ from those in animals. A number of other topics, such as the functional conservation of orthologous proteins involved in phosphorylation, whether phosphorylation network architecture has been conserved, and the evolutionary function of conserved pseudokinases, will be discussed. Clearly for this topic it is particularly important to have as broad a representation as possible from the different areas of protein phosphorylation, we have selected speakers working on a wide range of eukaryotic and prokaryotic organisms in order to emphasize the evolution and conservation of protein phosphorylation.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 23

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
Tony Hunter, The Salk Institute for Biological Studies, USA
Why did Nature Choose Phosphate and Use it to Modify Proteins?

Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Evolution of Phosphotyrosine and Methylarginine Signaling


MONDAY, JANUARY 24

07:00—08:00
Breakfast

Longs Peak
08:00—11:15
Bioinformatics of Protein Phosphorylation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Tony Hunter, The Salk Institute for Biological Studies, USA

Gerard Manning, Genentech, Inc., USA
Kinome Evolution

Rune Linding, University of Copenhagen, Denmark
Evolution of Complex Regulatory Systems - Signaling Fidelity and Disease

Alex N. Nguyen Ba, University of Toronto, Canada
Short Talk: Evolution of Characterized Phosphorylation Sites in Budding Yeast

James E. Ferrell Jr., Stanford University, USA
A Mechanism for the Evolution of Phosohrylation Sites

Matthew P. Jacobson, University of California, San Francisco, USA
Short Talk: Computational Studies of Protein Regulation by Post-Translational Phosphorylation

Nicholas K. Tonks, Cold Spring Harbor Laboratory, USA
Signal Transduction from a Protein Tyrosine Phosphatase Perspective

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Phosphoproteomics
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada

Steven P. Gygi, Harvard Medical School, USA
A Comprehensive Strategy to Study Phosphorylation Dynamics Shows Partial Redundancy between MAPK Pathways in Yeast

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Kinase-Substrate Networks

Judit Villen, University of Washington, USA
Short Talk: Evolution of Phosphoregulation in the Cell Cycle

Anton Iliuk, Tymora Analytical, USA
Short Talk: Developing Novel Technologies for Phosphoproteomic Analyses

Philip A. Cole, Johns Hopkins University School of Medicine, USA
Chemical Approaches to Sorting out Protein Signaling Pathways

19:15—20:15
Social Hour with Lite Bites

Longs Peak
19:30—22:00
Poster Session 1

Longs Peak

TUESDAY, JANUARY 25

07:00—08:00
Breakfast

Longs Peak
08:00—11:15
Phosphorylation Networks
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Wendell A. Lim, University of California, San Francisco, USA

Nevan J. Krogan, University of California, San Francisco, USA
Evolutionary Dynamics of Phosphorylation

Stephen W. Michnick, Université de Montréal, Canada
Causality and Contingency in Protein Interaction (Signaling) Networks

Michael Tyers, University of Montreal, Canada
Kinase/Phosphatase Interaction Networks

Brenda J. Andrews, University of Toronto, Canada
Short Talk: Phosphorylation Networks: A Comprehensive Genetic Interaction Map of a Eukaryotic Kinase

Luca Freschi, Institut de Biologie Intégrative et des Systèmes, Canada
Short Talk: Regulatory Network Rewiring by Gene Duplication

Michael B. Yaffe, Massachusetts Institute of Technology, USA
Integration of Mitotic Kinases, MAP Kinases and DNA Damage Signaling Networks

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Evolution of Tyrosine Phosphorylation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Tony Hunter, The Salk Institute for Biological Studies, USA

Wendell A. Lim, University of California, San Francisco, USA
Evolution of the Phosphor-Tyrosine Signaling Toolkit

Piers Nash, University of Chicago, USA
Short Talk: SH2 Domain Linguistics and the Evolution of Selective Interactions

Shohei Koide, New York University Langone Medical Center, USA
Short Talk: Dissecting and Controlling SH2-Mediated Regulation with Designer Binding Proteins

Bruce J. Mayer, University of Connecticut Health Center, USA
Profiling Global Tyrosine Phosphorylation Patterns: Implications for the Evolution and Design of Tyrosine Kinase Signaling Networks

Joel P. Wagner, Massachusetts Institute of Technology, USA
Short Talk: Confronting Complexity: Analysis of Six Evolutionary Diverse RTK Networks

19:00—20:00
Social Hour with Lite Bites

Longs Peak
19:30—22:00
Poster Session 2

Longs Peak

WEDNESDAY, JANUARY 26

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Evolution of Prokaryotic Protein Kinases
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Susan S. Taylor, University of California, San Diego, USA

Tom Alber, University of California, Berkeley, USA
Ser/Thr Phosphosignaling in Tuberculosis

Christophe Grangeasse, CNRS - University of Lyon, France
Short Talk: Bacterial Tyrosine-Kinases

Sylvie Nessler, Laboratoire d'Enzymologie et Biochimie Structurales, France
Short Talk: Structure Function Analysis of Bacterial P-Loop Protein Kinases Characterized by a Walker A Motif BY Kinase and HPrK/P

Ann M. Stock, University of Medicine and Dentistry of New Jersey, USA
Mechanistic Diversity in Bacterial Two-Component Signaling Systems

Michael T. Laub, Massachusetts Institute of Technology, USA
Specificity and Evolution of Two-Component Signaling Pathways

Andrew Xiao, Yale University, USA
Short Talk: The Function of WSTF in DNA Damage Response and Development

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Protein Kinase Medley
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Bruce J. Mayer, University of Connecticut Health Center, USA

Shin-Han Shiu, Michigan State University, USA
Why Does this Thing has >1000 Receptor-like Kinases?

Christian Doerig, Monash University, Australia
The Plasmodium Kinome: An Untapped Source of Potential Targets for Antimalarial Drug Discovery

Edward Y. Skolnik, New York University Medical Center, USA
Short Talk: Regulation of the Potassium Channel KCa3.1

Nicole LaRonde-LeBlanc, University of Maryland, USA
Short Talk: The RIO Kinases: An Ancient Protein Kinase Family with Influence in Cellular Proliferation and Motility

Natalie G. Ahn, University of Colorado, USA
A New Role to Cell Polarity by Wnt5a Signaling

19:15—20:15
Social Hour with Lite Bites

Longs Peak
19:30—22:00
Poster Session 3

Longs Peak

THURSDAY, JANUARY 27

07:00—08:00
Breakfast

Longs Peak
08:00—11:15
Evolution of Protein Structures Used in Phosphorylation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Ann M. Stock, University of Medicine and Dentistry of New Jersey, USA

Susan S. Taylor, University of California, San Diego, USA
PKA: Evolution of a Dynamic Allosteric Macromolecular Signaling Complex

Louise N. Johnson, University of Oxford, UK
The Structural Basis for Control by Phosphorylation and Protein Kinase Inhibitors

Natarajan Kannan, University of Georgia, USA
Short Talk: Delineating Protein Kinase Design Principles using Sequence Data

Zongchao Jia, Queen's University, Canada
Short Talk: Structures of E. coli Bifunctional Isocitrate Dehydrogenase Kinase/ Phosphatase and its Complex with Isocitrate Dehydrogenase

Andrei V. Karginov, University of Illinois at Chicago, USA
Short Talk: Engineered Allosteric Regulation of Kinases in Living Cells

Fernando Correa, University of Texas Southwestern Medical Center, USA
Short Talk: Light-Dependent Two-Component Signaling Systems: Enzymatic and Functional Characterization of a LOV-Histidine Kinase

Stefan Knapp, University of Oxford, UK
Lessons Learned from Wide-Scale Protein Kinase Structure Determination

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Phosphatase Evolution
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Tony Hunter, The Salk Institute for Biological Studies, USA

Tricia Cohen, University of Dundee, UK
Structural and Functional Evolution of Protein Phosphatases in PPP Family

Daniel L. Fisher, Institute of Molecular Genetics of Montpellier, France
Short Talk: PP2A Sharpens the Cell Cycle Oscillator

Carolyn A. Worby, University of California, San Diego, USA
Highly Conserved Phosphatases: Studies on Laforin and PTPMT1

Mark Chen, Genentech, USA
Short Talk: Evolution of Protein Phosphatases from Yeast to Human

Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Networking Kinases and Phosphatases: A High Density Interaction Network Reveals a Link between PP2A, Ste20 Kinases and Angioma

19:15—20:15
Social Hour with Lite Bites

Longs Peak
20:00—23:00
Entertainment

Longs Peak

FRIDAY, JANUARY 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


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We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

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