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This meeting took place in 2011



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Hematopoiesis (D2)


Organizer(s) David Traver, Amy J. Wagers and Emmanuelle Passegué
March 27—April 1, 2011
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Nov 29, 2010
Late Abstract Deadline: Dec 30, 2010
Scholarship Deadline: Nov 29, 2010
Early Registration Deadline: Jan 27, 2011

Sponsored by Onyx Pharmaceuticals, Inc.

Summary of Meeting:
As a paradigmatic model of developmental and regenerative biology, studies of the hematopoietic system have been critical in establishing fundamental principles in growth factor signaling, transcriptional regulation, organ patterning and stem cell biology. Now, with new and emerging knowledge, we are beginning to develop a true molecular understanding of the mechanisms by which blood cells are created and maintained, and how their function may be perturbed in the context of hematopoietic deficiency and malignancy. In addition, sophisticated embryological studies have finally documented the existence of bipotential hemogenic endothelium in developing organisms, and striking technological advances in in vivo imaging and cell identification strategies have provided our first direct visualization of blood cell formation in situ, and indicated the key importance of cell migration and interaction with discrete niches in the direction of cell fate and function. Finally, when turned to the study of blood diseases, these tools have provided unexpected insights into the microenvironmental controls that regulate hematopoietic (dys)function during aging and malignancy. In light of these exciting developments, it is clear that the time has come to again bring together hematopoiesis researchers to facilitate and accelerate the exchange of new knowledge and ideas. Our meeting will include a diverse group of scientists studying hematopoiesis with new technologies and complementary model systems. Speakers have been included from all career stages, and talks will focus on current findings, emerging opportunities, and immediate challenges within the field. We expect this meeting to serve as a catalyst to develop new ideas and collaborations, and to enhance and encourage the creative and interactive science that will continue to push forward discoveries in this important area of research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 27

15:00—19:30
Registration

Lower Atrium
18:15—19:15
Refreshments

Lower Atrium
19:15—20:30
Welcome and Keynote Address I
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Amy J. Wagers, Harvard University, USA
Welcome, Introductory Remarks and Update of Major Breakthroughs

* Emmanuelle Passegué, Columbia University, USA
How to Attend a Keystone Symposium

* David Traver, University of California, San Diego, USA
Acknowledgements and Introduction to Keynote Address

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Signaling Pathways and Transcriptional Control of Hematopoiesis


MONDAY, MARCH 28

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:15
Developmental Hematopoiesis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Marella F.T.R. De Bruijn, University of Oxford, UK

Utpal Banerjee, University of California, Los Angeles, USA
Development of Blood Cells in the Fly

David Traver, University of California, San Diego, USA
Wnt16 Specifies Hematopoietic Stem Cells through Environmental Regulation of Notch Signaling

Hanna K.A. Mikkola, University of California, Los Angeles, USA
Mechanisms Regulating Hematopoietic Stem Cell Development

Nancy A. Speck, University of Pennsylvania, USA
Temporal and Spatial Requirements for Runx1-CBFbeta in Hemogenic Endothelium

Yachao Liu, Genome Institute of Singapore, Singapore
Short Talk: Primary Yolk Sac Extraembryonic Endoderm Cells Serve as Stromal Cells for Supporting Hematopoietic Stem Cells

Katja Brückner, University of California, San Francisco, USA
Short Talk: Blood Cell Homing and Self-Renewal in the Larval Hematopoietic System of Drosophila

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Madison/Gallatin
13:00—22:00
Poster Viewing

Madison/Gallatin
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Hemogenic Endothelium. Sponsored by BD Biosciences.

Jefferson
* Thierry Jaffredo, University Pierre and Marie Curie, CNRS UMR7622, France

Julien Y. Bertrand, University of Geneva, School of Medicine, Switzerland
EMP versus HSC Origin: Venous versus Aortic Hemogenic Endothelium

Andrea Ditadi, SR-TIGET, Italy
Notch Signaling Defines Two Distinct Hematopoietic Programs in Mouse Embryonic Stem Cell Differentiation Cultures

Joanna M. Tober, University of Pennsylvania, USA
Runx1 is Temporally Required for Progenitor Emergence from Hemogenic Endothelium

Elizabeth S. Ng, Monash University, Australia
BMP4 Stimulates Hematopoietic Blast Colony Formation from Human Embryonic Stem Cells

Brandoch D. Cook, Weill Cornell Medical College, USA
SMAD1 Restricts Hematopoietic Potential after Promoting Hemangioblast Expansion

Andrew Jarratt, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Distinct Runx1 Enhancers Direct Transcription to Discrete Stages of Developmental Hematopoiesis

16:30—17:00
Coffee Available

Lower Atrium
17:00—18:30
Adult Hematopoietic Stem and Progenitor Cells
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Amy J. Wagers, Harvard University, USA

Hiromitsu Nakauchi, Stanford University, USA
Non-Myelinating Schwann Cells in the Mouse Bone Marrow Niche Maintain Hematopoietic Stem Cell Hibernation through TGF-beta Signaling

Emmanuelle Passegué, Columbia University, USA
Molecular and Cellular Understanding of Normal and Malignant Hematopoiesis

Patricia Ernst, University of Colorado Anschutz Medical Center, USA
Short Talk: Control of HSC Self-Renewal by Mll-Dependent Pathways

18:30—19:30
Keynote Address II
Meeting has ended...abstracts no longer viewable online.

Jefferson
Irving L. Weissman, Stanford University, USA
Biology of Hematopoietic Stem and Progenitor Cells

19:30—20:30
Social Hour with Lite Bites

Madison/Gallatin
19:30—22:00
Poster Session 1

Madison/Gallatin

TUESDAY, MARCH 29

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:15
Myelopoiesis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Timm Schroeder, ETH Zürich, Switzerland

James Palis, University of Rochester, USA
Ontogeny of Erythropoiesis in the Mammalian Embryo

Constanze Bonifer, University of Birmingham, UK
Molecular Dissection of Gene Activation Processes in the Hematopoietic System Using ES Cell Differentiation as Model

Daniel G. Tenen, Cancer Science Institute, Singapore
Myeloid Transcriptional Factors in Stem Cell Lineage Commitment and Leukemia

Margaret A. Goodell, Baylor College of Medicine, USA
Stress Regulation of Hematopoietic Stem Cells

Minh-Ha T. Do, aTyr Pharma, USA
Short Talk: Novel Protein Agonist of Thrombopoiesis Acts via a Physiocrine Pathway Distinct from that of Thrombopoietin

Kate C. MacNamara, Albany Medical College, USA
Short Talk: Interferon gamma Signaling Activates Hematopoietic Stem Cells during Acute Intracellular Bacterial Infection

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Madison/Gallatin
13:00—22:00
Poster Viewing

Madison/Gallatin
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Lymphopoiesis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Rachel Golub, Pasteur Institute, France

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Control of Lymphoid Development by Chemokines and Lipid Cues

Rudolf Grosschedl, Max Planck Institute of Immunobiology and Epigenetics, Germany
Regulation of B Lymphopoiesis by Transcription Factor Ebf1

Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada
Human T Cell Progenitors, from in vitro Generation to in vivo Function

Lisa K. Denzin, Robert Wood Johnson Medical School, UMDNJ, USA
Short Talk: The Paf Oncogene is Essential for Hematopoietic Stem Cell Function and Development

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
19:30—22:00
Poster Session 2

Madison/Gallatin

WEDNESDAY, MARCH 30

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:15
The Microenvironmental Niche
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Gregor B. Adams, University of Southern California, USA

Amy J. Wagers, Harvard University, USA
Dynamic Niches: Implications of Stem Cell Trafficking for Hematopoietic Function

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Niche Initiated Oncogenesis

Timm Schroeder, ETH Zürich, Switzerland
In vitro Imaging of Mammalian Hematopoiesis

Paul S. Frenette, Albert Einstein College of Medicine, USA
Neural Control of the Stem Cell Niche

E. Camilla Forsberg, University of California, Santa Cruz, USA
Short Talk: Cooperative Cues in Hematopoietic Stem Cell Localization

Jason Butler, Weill Medical College of Cornell University, USA
Short Talk: Inhibition of NF-kappaB Signaling in Endothelial Cells Regulates Hematopoietic Stem Cell Self-Renewal and Expansion

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Madison/Gallatin
13:00—22:00
Poster Viewing

Madison/Gallatin
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: The Leukemic Niche. Sponsored by BD Biosciences.

Jefferson
* Rick Van Etten, Tufts Medical Center, USA

Ting Zhou, Univrsity of Texas Health Science Center at San Antonio, USA
MDS but not AML can be Transferred by Transplanting Crebbp+/- Hematopoietic Stem Cells

Cheng Cheng Alec Zhang, University of Texas Southwestern Medical Center, USA
IGF Binding Protein 2 Supports the Activity of Acute Myeloid Leukemia Stem Cells

Kristian Reckzeh, Institute of Laboratory Medicine, Lund University, Sweden
The Role of Biallelic C/EBPalpha Mutations and FLT-3 ITD in Initiation and Maintenance of AML

Bryan J. Zimdahl, Eureka Therapeutics, USA
Loss of Lis1 Impairs the Self-Renewal of Normal and Malignant Hematopoietic Stem Cells

Yi-Fen Lu, Regeneron Pharmaceuticals, USA
Timing of Donor Leukocyte Infusion Affects the Mechanism of Graft-vs-Leukemic Stem Cells in a Mouse Chronic Myeloid Leukemia Model

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Systems Approaches to Hematopoiesis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Hanna K.A. Mikkola, University of California, Los Angeles, USA

Ihor R. Lemischka, Icahn School of Medicine at Mount Sinai, USA
Network Models of Stem Cell Fate

Trista E. North, Beth Israel Deaconess Medical Center, USA
Metabolic Activity Determines the Timing and Localization of HSC Induction

Michael P. Cooke, Genomics Institute of the Novartis Research Foundation, USA
Aryl Hydrocarbon Receptor Antagonists Promote Human Hematopoietic Stem Cell Expansion

Hsuan-Ting Huang, Children's Hospital Boston, USA
Short Talk: A Screen for Epigenetic Regulators of Hematopoiesis Reveals chd7 is a Cell Autonomous Regulator of Hematopoietic Stem Cells

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
19:30—22:00
Poster Session 3

Madison/Gallatin

THURSDAY, MARCH 31

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:15
Leukomogenesis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Daniel G. Tenen, Cancer Science Institute, Singapore

Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA
Mechanisms Controlling Oncogene Cooperativity in Leukemia Stem Cells

James R. Downing, St. Jude Children's Research Hospital, USA
Molecular Pathology of Acute Leukemia

Iannis Aifantis, New York University School of Medicine, USA
Switching an Oncogene to a Tumor Suppressor: Diverse Functions of Notch Signaling in Hematopoiesis and Leukemia

Romain Aucagne, INSERM U866, France
Short Talk: Transcription Intermediary Factor 1 gamma is an Epigenetically-Regulated Tumor Suppressor Gene in Human Chronic Myelomonocytic Leukemia

Katelyn Andrzejewski, Roswell Park Cancer Institute, USA
Short Talk: Mitochondrial Dysfunction Leads to Ineffective Erythropoiesis

Rong Lu, Stanford University, USA
Tracing Single Hematopoietic Stem Cell Differentiation in vivo using High-Throughput Sequencing

09:20—09:40
Coffee Break

Lower Atrium
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Aging of the Blood System. Session Sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Deepta Bhattacharya, Washington University School of Medicine, USA

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Lkb1 Regulates Energy Metabolism and Cell Cycle in Hematopoietic Stem Cells

Richard L. Boyd, Monash University, Australia
Drug and Stem Cell Based Rejuvenation of Haemopoiesis and Lymphopoiesis

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Regulation of the Fanconi Anemia Pathway

Christos Gekas, Center for Genomic Regulation, Spain
Short Talk: Integrin alphaIIb (CD41) is Required for the Survival and Competitive Repopulation Ability of Hematopoietic Stem Cells

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
20:00—23:00
Entertainment

Madison/Gallatin

FRIDAY, APRIL 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL108493-01




We gratefully acknowledge additional support for this conference from:

BD Biosciences Onyx Pharmaceuticals, Inc.
The Ellison Medical Foundation
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



The Genomics Institute of the Novartis Research Foundation


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Hematopoiesis News

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676