Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2012



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Chemical Biology and Novel Tools in Pharmacology (B3)


Organizer(s) Laura L. Kiessling, Kevan M. Shokat and Jason E. Gestwicki
February 12—16, 2012
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 12, 2011
Late Abstract Deadline: Nov 11, 2011
Scholarship Deadline: Oct 12, 2011
Early Registration Deadline: Dec 12, 2011

Sponsored by Infinity Pharmaceuticals, Novartis Institutes for BioMedical Research and Onyx Pharmaceuticals, Inc.

Summary of Meeting:
The best solutions to the most important problems in biomedical science have come from multi-disciplinary research. The discovery of new chemical probes and therapeutics requires cross-cutting expertise and the innovative application of new technologies. Scientific forums have become increasingly specialized and narrow in their scope. The specific purpose of the Keystone Symposia meeting on Chemical Biology and Novel Tools in Pharmacology is to initiate and foster active discussions between academic and industrial researchers in the broader area of pharmacological tools. Rather than focus on a specific disease, model system or technical method, this meeting will bring together a variety of experts whose primary, common trait is their innovative use of chemical and biological approaches to solve important problems in biology. From this organizing principle, the specific aims of this meeting are: (a) to assemble chemists and biologists who may not normally interact with each other; (b) to make new connections between chemists and biologists, academics and industrial scientists; and (c) to provide a forum for an open discourse of modern, cross-platform ideas. An unintended consequence of increasingly specialized forums for scientific discussion is the lack of mechanisms for dissemination of novel ideas, platforms and methodologies. The major innovation of this meeting is that it is designed to encourage and inspire researchers to explore and implement inter-disciplinary, emerging methods in chemical biology and pharmacology to their specific biological questions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 12

15:00—19:30
Registration

Promenade
18:15—19:15
Refreshments

Promenade
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Christopher T. Walsh, Harvard Medical School, USA
Biosynthetic Morphing of Peptide Backbones and Side Chains into Heterocyclic Scaffolds


MONDAY, FEBRUARY 13

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
Chemical Microbiology
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Ronald W. Woodard, University of Michigan, USA

Nathan A. Magarvey, McMaster University, Canada
Mining Microbiomes for Genetically Encoded Bioactive Natural Products

Stephen B. del Cardayre, LS9, Inc., USA
Engineering Microbial Fatty Acid Metabolism for Sustainable Fuel and Chemical Production

Suzanne Walker, Harvard Medical School, USA
Cell Biology and Enzymology of Cell Wall Biosynthesis

Laura L. Kiessling, University of Wisconsin, Madison, USA
The Chemistry and Biology of Mycobacterial Polysaccharide Assembly

Douglas B. Weibel, Amazon.com, Inc., USA
Short Talk: Bacteria Control Intracellular Organization by Straining Their Cytoplasmic Membrane

Howard C. Hang, Rockefeller University, USA
Short Talk: Chemical Reporters for Dissecting Host-Pathogen Interactions

09:20—09:40
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Promenade
17:00—18:25
Chemical Communication I
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Susan L. Clugston, Cubist Pharmaceuticals, USA

Sean Cutler, University of California, Riverside, USA
Sidestepping Genetic Redundancy with Small Molecules

Cameron R. Currie, University of Wisconsin-Madison, USA
Drugs from Bugs of Bugs

Erin E. Carlson, Indiana University, USA
Short Talk: Chemical Probes to Explore Histidine Kinase Signaling

18:25—19:00
Probing and Perturbing Cell Signaling I
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Timothy J. Mitchison, Harvard Medical School, USA
How Does Taxol Work as a Medicine?

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 1

Mesa C

TUESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
Probing and Perturbing Cell Signaling II
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Sharon Xiaoning Zhao, Amgen Inc, USA

Carsten Schultz, European Molecular Biology Laboratory Heidelberg, Germany
Tools for Visualizing Cell Biology

Jing Huang, University of California, Los Angeles, USA
Small Molecule Regulators of Aging

Tom W. Muir, Princeton University, USA
Protein Ligation: An Enabling Technology for Studying Protein Post-Translational Modifications

Kevan M. Shokat, University of California, San Francisco, USA
Chemical-Genetic Investigations of Protein and Lipid Kinase Signaling

Matthew R. Pratt, University of Southern California, USA
Short Talk: O-GlcNAc as a Link Between Metabolism and Survival in Cancer

Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Short Talk: A Photochemical Approach to Lymphocyte Signaling Dynamics

09:20—09:40
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Promenade
17:00—19:00
Protein Quality Control
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Susan Wiedner, Pacific Northwest National Laboratory, USA

Jason E. Gestwicki, University of California, San Francisco, USA
Molecular Chaperones and Protein Folding: Chemical Tools for Probing Quality Control

Julian Adams, Vedantra Pharmaceuticals, Inc., USA
Natural Product-Derived Inhibitor of the Hedgehog Pathway and Clinical Development to Treat Cancer

Raquel L. Lieberman, Georgia Institute of Technology, USA
Short Talk: Pharmacological Chaperone Development for the Glaucoma-Associated Olfactomedin Domain of Myocilin

Kurt Dwaine Deshayes, Genentech, Inc., USA
Short Talk: Peptide Sensors of Angiogenesis

Eric R. Strieter, University of Wisconsin, USA
Short Talk: Non-Enzymatic Synthesis of Polyubiquitin Chains

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
20:00—22:00
Poster Session 2

Mesa C

WEDNESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—10:25
Probing and Perturbing Cell Signaling III
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Alison N. Hulme, University of Edinburgh, UK

Ulrike S. Eggert, King's College London, UK
A Chemical Approach to Understanding Cell Division

Rebecca W. Heald, University of California, Berkeley, USA
Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-beta

Luke D. Lavis, HHMI/Janelia Farm Research Campus, USA
Short Talk: Targeting Small Molecules with Cellular Specificity using Enzyme–Substrate Pairs

E. James Petersson, University of Pennsylvania, USA
Short Talk: Thioamides: Minimalist Chromophores for Monitoring Protein Dynamics In Vitro and In Vivo

10:25—11:00
Chemical Communication II
Meeting has ended...abstracts no longer viewable online.

John W. Kozarich, ActivX Biosciences, Inc., USA
Toward a Functional, Chemoproteomic Interrogation of Kinome and Nucleotide Binding Space

09:20—09:40
Coffee Break

Promenade
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Promenade
17:00—19:15
Chemical Biology in Model Organisms
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Jeffrey P. Henderson, Center for Women's Infectious Diseases Research, Washington University, USA

Charlie M. Boone, University of Toronto, Canada
Linking Bioactive Compounds to Cellular Targets by High-Throughput Chemical-Genetic Profiling in Yeast

Frank C. Schroeder, Boyce Thompson Institute at Cornell University, USA
C. elegans Ascarosides, a Modular Library of Small Molecule Signals

Carolyn R. Bertozzi, Stanford University, USA
Bioorthogonal Chemistry for Glycoprofiling and Beyond

Jeffery W. Kelly, The Scripps Research Institute, USA
Adapting Proteostasis to Ameliorate Aggregation-Associated Gain-of-Toxic Function Diseases and Developing Folding and Aggregation Sensors of these Maladies

20:15—21:15
Social Hour with Lite Bites

Mesa Ballroom
20:15—23:00
Entertainment

Mesa Ballroom

THURSDAY, FEBRUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Infinity Pharmaceuticals Novartis Institutes for BioMedical Research
Onyx Pharmaceuticals, Inc.
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13GM100628-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

ActivX Biosciences
ACS Chemical Biology

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


ACS Chemical Biology


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676