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This meeting took place in 2011



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Genomic Instability and DNA Repair (B4)


Organizer(s) Junjie Chen, Karlene A. Cimprich and Michael B. Yaffe
January 30—February 4, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 30, 2010
Late Abstract Deadline: Nov 2, 2010
Scholarship Deadline: Sep 30, 2010
Early Registration Deadline: Nov 30, 2010

Supported by the Directors’ Fund

Summary of Meeting:
The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health. This meeting will present the most recent advances in the field and reveal how a complex network of signaling transduction pathways are involved in DNA damage response. The topics include early detection of DNA lesions, DNA damage checkpoint control, DNA repair, genotoxic damage in cancer stem cells, modulation of DNA damage signaling by microRNAs, systems biology approaches to DNA damage and the use of cutting edge technologies in the study of DNA damage responses.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 30

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Junjie Chen, University of Texas MD Anderson Cancer Center, USA

David M. Livingston, Dana-Farber Cancer Institute, USA
Genomic Instability and Breast Cancer

Stephen J. Elledge, Harvard Medical School, USA
The DNA Damage Response: Making it Safe to Play with Knives


MONDAY, JANUARY 31

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
DNA Damage Signaling: Networks and Systems Approaches
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Stephen J. Elledge, Harvard Medical School, USA

Stephen P. Jackson, University of Cambridge, UK
Early Events in DNA Damage Signaling and DNA Repair

Yosef Shiloh, Tel Aviv University, Israel
The ATM-Mediated DNA Damage Response: The System and the Pathways

Galit Lahav, Harvard Medical School, USA
Temporal Dynamics of Biological Signals

Trey Ideker, University of California, San Diego, USA
Widespread Induction of Genetic Networks in Response to DNA Damage

Claus Storgaard Sørensen, University of Copenhagen, Denmark
Short Talk: Generation of ssDNA at Stalled DNA Replication Forks is Mediated by hFBH1 Helicase

Shunichi Takeda, Kyoto University, Japan
Short Talk: SLX4 Links Fanconi anemia Pathway to Structure Specific Endonucleases, MUS81, SLX1 and XPF in Interstrand Crosslink Repair

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Checkpoint Controls

Longs/Grays Peak
* Karlene A. Cimprich, Stanford University, USA

James A. Borowiec, New York University School of Medicine, USA
Single Molecule Analysis Demonstrates that RPA Phosphorylation is Necessary for Efficient Fork Movement during Replication Stress

Samuel Sidi, Mount Sinai School of Medicine, USA
Chk1 Regulates PIDDosome Assembly and Function after DNA Damage

Nathan A. Ellis, University of Illinois, Chicago, USA
BLM SUMOylation Regulates ssDNA Accumulation at Stalled Forks

Jen-Wei Huang, Fred Hutchinson Cancer Research Center, USA
The microRNAs, miR-103 and miR-107, Target RAD51D and Regulate Homologous Recombination and Sensitivity to DNA Damaging Agents

Susana Gonzalo, Saint Louis University School of Medicine, USA
Nurturing the Genome: Roles for A-type Lamins in Telomere Maintenance and Regulation of Mechanisms of DNA DSBs Repair

Sandy Giuliano, INSERM U895 Equipe 1, France
MITF Controls the DNA Damage Response Signaling Pathway and Cellular Senescence

Kareem N. Mohni, University of Connecticut Health Center, USA
Herpes Simplex Virus Type 1 Infection Disables ATR Signaling

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mechanism of DNA Damage Signaling and DNA Repair
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Yosef Shiloh, Tel Aviv University, Israel

Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK
Regulating Recombination at Telomeres

Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
The Ubiquitous Role of Ubiquitin in DNA Double-Strand Break Signaling and Repair

Junjie Chen, University of Texas MD Anderson Cancer Center, USA
DNA Damage Signaling and DNA Repair

Xiaohua Wu†, The Scripps Research Institute, USA
Short Talk: MRN and CtIP are Important for Processing DNA Ends with Secondary Structures in Mammalian Cells

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, FEBRUARY 1

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Advance in DNA Damage Response
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Stephen P. Jackson, University of Cambridge, UK

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Regulation of the Fanconi Anemia Pathway by Ubiquitin and SUMO

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Signaling in DNA Repair Pathways

Karlene A. Cimprich, Stanford University, USA
Mechanisms for Maintaining Genome Stability at the Replication Fork

John A. Tainer, The Scripps Research Institute, USA
Extreme Allostery, Mre11-Rad50-Nbs1 Conformations, and the Control of Sensing, Signaling, and Effector Responses at DNA Double-Strand Breaks

Zhenkun Lou, Mayo Clinic, USA
Short Talk: Histone Methyltransferase MMSET Regulates Histone H4 Lysine 20 Methylation and 53BP1 Accumulation at DNA Damage Sites

Shaun E. Peterson, Columbia University, USA
Short Talk: Regulation of Chromosomal DSB Resection in Vertebrate S- and M-Phases

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: DNA Repair

Longs/Grays Peak
* Junjie Chen, University of Texas MD Anderson Cancer Center, USA

Sharon B. Cantor, University of Massachusetts Medical School, USA
An Acetylation Switch Modulates BACH1/FANCJ Function in DNA Damage Repair

Jeremy M. Stark, Beckman Research Institute of the City of Hope, USA
The DNA Damage Response is Important for Faithful End Utilization during NHEJ of Multiple Chromosome Breaks

Jianyuan Jack Luo, University of Maryland Baltimore, USA
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

Ali Nowrouzi, NCT, Deutsches Krebsforschungszentrum Heidelberg, Germany
Genome–Wide Detection of DNA Double Strand Breaks (DSB) at Single Nucleotide Resolution

Lisa Postow, Rockefeller University, USA
Ubiquitylation of DNA-Bound Ku80 by the SCF Complex

Ralph Scully, Beth Israel Deaconess Medical Center, USA
Real Time Imaging of the Mammalian Double Strand Break Response

Wojciech Piwko, Swiss Federal Institute of Technology, ETH Zurich, Switzerland
Identification of the Mms22L – Nfkbil2 Complex as a Novel Regulator of DNA Replication in Human Cells

Junran Zhang, Case Western Reserve University, USA
A Dual Role of BRCA1 in Two Distinct Homologous Recombination Mediated Repairs in Response to Replication Arrest

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
DNA Repair, Stem Cells, Senescence and Aging. Session Sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Laura J. Niedernhofer, The Scripps Research Institute, USA

Michael F. Clarke, Stanford University, USA
Effects of Genomic Instability on the Epigenetic and Transcriptional Programs of Breast Cancer Cells

David A. Sinclair, Harvard Medical School, USA
DNA Damage as a Trigger for the Relocalization of Chromatin Factors during Aging and the Role of Fluctuating NAD+

Judith Campisi, Buck Institute for Research on Aging, USA
Genome Maintenance, Aging and Cancer

Joris Pothof, Erasmus MC, Netherlands
Short Talk: MicroRNAs and the DNA Damage Response

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, FEBRUARY 2

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Models of DNA Damage Repair and Therapy
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Michael B. Kastan, St. Jude Children's Research Hospital, USA

André Nussenzweig, NCI, National Institutes of Health, USA
Mechanisms of DNA Damage Detection and Repair in Lymphocytes

Michael T. Hemann, Massachusetts Institute of Technology, USA
A Role for the DNA Damage Response in Tumor Cell Survival and Acquired Chemoresistance

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Homologous Recombination and Chromosomal Translocation

Helen Piwnica-Worms, Washington University School of Medicine, USA
Exploiting Cell Cycle Checkpoint Control in Cancer Therapy

Anindya Dutta, University of Virginia, USA
Short Talk: CRL4-Cdt2 Ubiquitin Ligase Pathway in the Response to DNA Damage and as a Target for Chemotherapy

JoAnn M. Sekiguchi, University of Michigan, USA
Short Talk: Mechanisms Underlying Genome Instability and Aberrant Chromosomal Rearrangements Due to Defective Artemis DNA Nuclease Activity

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Study of DNA Damage Response at Organism Level

Longs/Grays Peak
* André Nussenzweig, NCI, National Institutes of Health, USA

Olivier J. Becherel, University of Queensland, Australia
The First Setx-/- Mouse Model for Ataxia Oculomotor Apraxia Type 2 (AOA2) Uncovers a Novel Role for Senataxin in Meiotic DNA Repair, Recombination and Germ Cell Maturation

Michael S. Y. Huen, University of Hong Kong, Hong Kong
Limiting Histone Ubiquitylation Selectively Promotes Homologous Recombination DNA Repair

Janneke E. Jaspers, Netherlands Cancer Institute, Netherlands
Loss of 53BP1 Causes Resistance to PARP Inhibition in BRCA1-Mutated Mouse Mammary Tumors

Stephen Meyn, Hospital for Sick Children, Canada
The Fanconi anemia Pathway Regulates BLM-Dependent Telomeric Recombination and Telomere DNA Synthesis in ALT Human Cells

Tomasz Skorski, Temple University, School of Medicine, USA
Targeting Phosphotyrosine-315 in RAD51 Recombinase to Prevent BCR-ABL1 Oncogenic Kinase –Mediated Unfaithful Homeologous Recombination Repair

Shan Zha, Columbia University Medical Center, USA
XLF Has Functional Redundancy with ATM and H2AX in V(D)J Recombination and Non-homologous DNA End-joining

Chengming (Ben) Zhu, University of Texas MD Anderson Cancer Center, USA
Interplay of DNA Repair Pathway and Tumor Suppressor p53 and its Role in Preventing Tumorigenesis and Aging

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Expanding Dimensions of Genomic Instability and Cancer Therapy
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Michael B. Yaffe, Massachusetts Institute of Technology, USA

Judy Lieberman, Harvard University, USA
miR-34a Mediates the p53 Response

Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia and University of Pennsylvania, USA
A MicroRNA Component of the Myc-p53 Axis

Laura J. Niedernhofer, The Scripps Research Institute, USA
DNA Repair Protects Against Numerous Age-Related Degenerative Diseases

Xiaochun Yu, University of Michigan, USA
Short Talk: Protein Neddylation Regulates DNA Damage Response

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 3

Quandary Peak

THURSDAY, FEBRUARY 3

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Posttranslational Regulation and Modifications Involved in DNA Damage Response
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Alan D. D'Andrea, Dana-Farber Cancer Institute, USA

Michele Pagano, New York University School of Medicine, USA
Role of SCF Ubiquitin Ligases in the Maintenance of Genomic Stability

Michael B. Yaffe, Massachusetts Institute of Technology, USA
Modular Domains Mediate the Assembly and Function of DNA Damage Signaling Complexes

J. Wade Harper, Harvard Medical School, USA
Genetic and Proteomic Analysis of Damage-Signaling Systems

J. Wade Harper, Harvard Medical School, USA
Genetic and Proteomic Analysis of Damage-Signaling Systems

René H. Medema, Netherlands Cancer Institute, Netherlands
A Phosphoproteomic-Based siRNA Screens Uncovers Novel Regulators of Plk1 and p53 that Control Recovery from a DNA Damage-Induced Arrest

Dipanjan Chowdhury, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: New Approaches to Study Role of Phosphatases in the DNA Damage Response

Lee Zou, Harvard Medical School, USA
Short Talk: Cell Cycle-Regulated and DNA Damage-Induced Chromatin Alterations by CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Genomic Instability, Cancer and Therapy
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Michael T. Hemann, Massachusetts Institute of Technology, USA

Thomas Helleday, Karolinska Institutet, Sweden
Novel Players and Pathways for Restarting Stalled Replication Forks

Michael B. Kastan, St. Jude Children's Research Hospital, USA
Modulation of ATM and p53 for Clinical Benefit

Massimo Squatrito, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: 53bp1 is a Haploinsufficient Tumor Suppressor that Protects Glioma Cells from Response to Therapy

Jac A. Nickoloff, Colorado State University, USA
Short Talk: Neoamphimedine, a Novel Topoisomerase IIalpha Inhibitor, Blocks Metnase-Potentiated DNA Decatenation

Katharina Schlacher, MD Anderson Cancer Center, USA
Short Talk: BRCA2 Protects Stalled Replication Forks from Nucleolytic Degradation Independent of Homologous Recombination

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

FRIDAY, FEBRUARY 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA153403-01




We gratefully acknowledge additional support for this conference from:

BioMarin Pharmaceutical Inc. Integrated DNA Technologies
Landes Bioscience The Ellison Medical Foundation

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