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This meeting took place in 2011



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Immunity in the Respiratory Tract: Challenges of the Lung Environment (X6)


Organizer(s) David L. Woodland, Liise-anne Pirofski and Allen G. Harmsen
February 26—March 3, 2011
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Oct 26, 2010
Late Abstract Deadline: Nov 29, 2010
Scholarship Deadline: Oct 26, 2010
Early Registration Deadline: Dec 27, 2010

Sponsored by Hoffmann-La Roche, Inc.


Summary of Meeting:
Recently, there has been an explosion in information about the regulation of inflammation, immunity, and immunopathology in the lung. Despite these advances, we still have only a rudimentary understanding of how these responses relate to the lung environment or how and why they translate into beneficial or detrimental effects, health or disease. The goals of this meeting are to (i) bring together allergists, immunologists, microbiologists and vaccinologists to discuss pulmonary inflammation and immunity in the context of lung biology and (ii) to build on this understanding to develop improved vaccines and therapeutic interventions for inflammatory conditions and infectious diseases that affect the lungs. Expert talks in plenary sessions will present the latest research in the field. Workshops and additional talks will add late-breaking cutting-edge results. The meeting will considerably advance our understanding of respiratory immunity.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 26

15:00—19:30
Registration

BC Foyer
18:15—19:15
Refreshments

BC Foyer
19:15—20:30
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Joanne L. Viney, JLV Biotech Consulting, USA

Patrick G. Holt, University of Western Australia, Australia
Immunity and Inflammation in the Lung – Bridging Innate and Adaptive Immunity


SUNDAY, FEBRUARY 27

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Innate Immunity at Mucosal Surfaces: The Players (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
Alice Prince, Columbia University, USA
Participation of Airway Epithelial Signalling in the Response to Bacterial Infection

Cedar J. Fowler, National Institutes of Infectious Diseases, USA
Short Talk: Exploring Pattern-Recognition Receptors and Ciliary Function Utilizing Primary Respiratory Epithelial Cell Cultures

* Marco Colonna, Washington University School of Medicine, USA
Functional Plasticity of Human NK-22 Cells

* Bana Jabri, University of Chicago, USA
IL-15, a Checkpoint in Tissue Immunity

Shipra Vaishnava, University of Texas Southwestern Medical Center, USA
Short Talk: The Antibacterial C-Type Lectin RegIIIgamma Maintains Spatial Segregation between Microbiota and Host in the Intestine

Dana Philpott, University of Toronto, Canada
Nod1 and Nod2 in Mucosal Defence

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Cytokines, Chemokines and Mucosal Immunoregulation

British Ballroom
* Maria T. Abreu, University of Miami, Miller School of Medicine, USA

* Paul Garside, University of Glasgow, UK

Thomas A. Wynn, Pfizer, USA
The IL-13 Decoy Receptor Tightly Controls Pathogenic Th17 and Th2 Responses in the Mucosa

Tomohiro Yoshimoto, Hyogo College of Medicine, Japan
Role of IL-33 in Experimental Allergic Conjunctivitis

Donald N. Cook, NIEHS, National Institutes of Health, USA
LPS Promotes IL-35-Dependent Suppression of Allergen-Induced Airway Disease

Anthony Cao, University of Texas Medical Branch, USA
Th17 Cells Contribute to Intestinal Homeostasis by Inducing Intestinal IgA and pIgR Expression

Alexander F. Heiseke, Technical University Munich, Germany
CCL17 Drives Intestinal Inflammation and Counteracts Foxp3-Mediated Protection from Colitis

Pim J. Koelink, Utrecht University, Netherlands
Proline-Glycine-Proline, a Chemotactic Collagen Breakdown Product, is Involved in Inflammatory Bowel Diseases: Future Target?

Rose Szabady, University of Massachusetts Medical School, USA
A Novel Pathogenic Role for IL-22 in Chronic Intestinal Inflammation

Jennifer H. Cox, Novo Nordisk Research Center, USA
Dichotomous Consequences of IL-23 Signaling in Chemically Induced Colitis in Mice

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Lung Innate Immunity and Disease: First Line of Defense to Disease
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Innate Immune Responses to Influenza Viruses

* Shawn J. Skerrett, University of Washington, USA
Innate Immunity to Bacterial Pneumonia

Uwe Koppe, Charité University Medicine Berlin, Germany
Short Talk: Streptococcus pneumoniae Activates a Type I Interferon Response Depending on Pneumolysin as Well as the Host Cell Molecules STING and IRF3

* Patricia W. Finn, University of Illinois, USA
Innate Immune Responses in Asthma

17:00—19:00
Mechanisms for Protection from Intestinal Inflammation
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Protecting the Border with a Fake ID: CD4 T Cells Stretch Beyond Plasticity

* Joanne L. Viney, JLV Biotech Consulting, USA
Butyrophilins: Complexity in Costimulation at the Mucosal Surface

Vanessa Beatriz Freitas Alves, Federal University of Triângulo Mineiro, Brazil
Short Talk: Human Mesenchymal Stromal Cells (Msc) Modulate Gut Inflammation and Th17 Responses In Experimental Inflammatory Bowel Disease

Maria T. Abreu, University of Miami, Miller School of Medicine, USA
Recent Advances in IBD Therapy

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

MONDAY, FEBRUARY 28

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:00
Navigating the Lung - The Ins and Outs of Adaptive Immune Responses
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
Thomas J. Braciale, University of Virginia, USA
Regulating Inflammation during the Host Response to Respiratory Virus Infection: It's about Self Control

* Andrew D. Luster, Massachusetts General Hospital, USA
Chemokine Control of Effector and Regulatory T Cell Trafficking into the Lung

David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Regulation of T Cell Immunity to Respiratory Virus Infections

Emily E. Thornton, University of Oxford, UK
Short Talk: Lung Surveillance Revealed by Two-Photon Live Imaging

Berber Piet, Academic Medical Center, Netherlands
Short Talk: Lymphocytes in the Frontline; Human Lung CD8+ T Cells Recognizing Influenza Virus Reside in Airway Epithelium

08:00—11:15
Viruses in Health and Disease
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Thaddeus S. Stappenbeck, Washington University School of Medicine, USA
Chronic Viral Infection, Autophagy and IBD

* Genoveffa Franchini, NCI, National Institutes of Health, USA
Is the Direct Targeting of the Mucosa Necessary for an HIV Vaccine?

Yong Jun Sui, National Cancer Institute, National Institutes of Health, USA
Short Talk: TLR Agonists and/or IL-15 Adjuvanted Mucosal SIV-Vaccine Prevented Gut CD4+ Memory T Cell Loss After SIVmac251-Challenge in Macaques

Jo-Ann S. Passmore, University of Cape Town, South Africa
An African Perspective on Inflammation and Activation in the Female Genital Tract during HIV Infection

Elisabeth Menu, Institut Pasteur, France
Short Talk: Mucosal Innate Immunity and Natural Control of HIV-1 Transmission during Human Pregnancy

Haina Shin, Washington University, USA
Prime and Pull: Protection against Genital HSV Infection

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Dendritic Cells, Macrophages and Mucosal Immunoregulation

British Ballroom
* Joanne L. Viney, JLV Biotech Consulting, USA

* Cherié L. Butts, Biogen, USA

Katherine Arias, McMaster University, Canada
Evolution of Immune-Suppressive and Immune-Responsive Capacities in the Lung during Development in Mice

Pejman Soroosh, Janssen R&D, USA
Essential Role of Lung Resident Macrophages in Regulating Airway Tolerance in Response to Innocuous Inhaled Antigen

Dorothée Duluc, Baylor Institute for Immunology Research, USA
Characterization of Dendritic Cell Subsets in Human Vaginal Mucosa

Barbara Cassani, Massachusetts General Hospital, USA
Gut-Specific Lymphocyte Homing as a Key Player in Oral Immunological Tolerance

Usriansyah Hadis, Hannover Medical School, Germany
Cooperation of Lymph Nodes and Intestinal Lamina Propria in Foxp3+ Regulatory T Cell Mediated Intestinal Tolerance

Oscar Medina-Contreras, Georgia State University, USA
CX3CR1 Regulates Intestinal Macrophage Homeostasis, Bacterial Translocation and Colitis

Rajesh (Nair) Ravindran, Emory University, USA
Oral Delivery of TLR Ligands Programs Splenic Dendritic Cells to Induce T Regulatory Responses

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Inflammatory Aspects of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Graham S. Le Gros, Malaghan Institute of Medical Research, New Zealand
Anti-Helminth Immunity in the Airways

Yui-Hsi Wang, Cincinnati Childrens' Hospital, USA
Short Talk: A Novel Subset of TH2 Memory/Effector Cells that Produce Inflammatory IL-17 Cytokine and Promote the Exacerbation of Allergic Asthma

* Nicholas W. Lukacs, University of Michigan, USA
Chemokines and Respiratory Immune Responses

Clifford V. Harding, Case Western Reserve University, USA
Toll-Like Receptor Regulation of Antigen-Presenting Cells and Responses to Mycobacterium tuberculosis

17:00—19:00
Control of Immune Responses in the Skin, Eye and Genital Tract
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Shannon J. Turley, Genentech, Inc., USA
Regulation of Dendritic Cell and T Cell Function by Lymphoid Stroma

* Rachel R. Caspi, NEI, National Institutes of Health, USA
Ocular Immune Privilege, T Regulatory Cells and Autoimmunity

Thomas J. Hannan, Washington University, USA
Short Talk: Innate and Adaptive Mucosal Immune Checkpoints in Chronic and Recurrent Bacterial Cystitis

Sarah Howie, University of Edinburgh, UK
Immunoregulation in the Female Reproductive Tract

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

TUESDAY, MARCH 1

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Immunoregulatory Mechanisms (Joint)
Meeting has ended...abstracts no longer viewable online.

British Columbia Ballroom
* Dominique Kaiserlian, INSERM-U851, France
Oral tolerance: Respective Roles of Liver, MLN and the Gut Flora

Eduardo J. Villablanca, Karolinska Institute, Sweden
Short Talk: MyD88-Dependent Signals Synergize with Retinoic Acid to Educate Gut-Associated Dendritic Cells

Kayla A. Weiss, University of Iowa, USA
Short Talk: Multiple CD4+ T Cell Subsets Produce Immunomodulatory IL-10 during Acute Respiratory Syncytial Virus Infection

* Yasmine Belkaid, NIAID, National Institutes of Health, USA
Roles of Retinoic Acid in Immunity

Cherié L. Butts, Biogen, USA
Short Talk: Immunomodulatory Role of Progesterone on Immune Cell Function in Uterine and Other Tissues

De' Broski R. Herbert, University of Pennsylvania, USA
Short Talk: Epithelial Cells Promote Th2 Immunity Against Parasitic Helminths

Wenjun Ouyang, Amgen, Inc., USA
The Functions of IL-22 in Mucosal Immunity

09:20—09:40
Coffee Break

BC Foyer
11:15—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: NODS/TLRs and Innate Immunity

British Ballroom
* Dana Philpott, University of Toronto, Canada

* Gérard Eberl, Institut Pasteur, France

Soumita Das, University of California San Diego, USA
Recognition of Enteric Bacteria by a New Pattern Recognition Receptor BAI1 (Brain Angiogenesis Inhibitor 1)

R. William DePaolo, University of Washington, USA
Regulation of Anti-Microbial Peptides and IL-17 by TLR1 during Oral Yersinia Enterocolitica Infection

Akhilesh Singh, Seattle Children's Research Institute, USA
TLR5 Ligand Stimulates Colonic IL-22 Production by LTi-like Cells in an IL-23R Independent Fashion

Melissa A. Kinnebrew, Memorial Sloan-Kettering Cancer Center, USA
Mediators of Flagellin Induced IL-22 Expression at the Intestinal Mucosa

Irene Jarchum, Sloan-Kettering Institute, USA
Toll-Like Receptor 5 Stimulation Protects Mice from Clostridium Difficile Colitis

Naohiro Inohara, University of Michigan Medical School, USA
Nod1 Prevents Systemic Inflammation by Recruiting Neutrophils to Clear Translocated Commensals after Clostridium Difficile Infection

Kaoru Geddes, University of Toronto, Canada
Nod Proteins Regulate Intestinal Inflammation

Jooeun Lee, University of Toronto, Canada
The Interplay between Nod1 and PGLYRP2 in Mucosal Immunity

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Damage Control
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Liise-anne Pirofski, Albert Einstein College of Medicine, USA
Antibody-Mediated Damage Control

Marianne L. Boes, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Netherlands
Short Talk: Defective BCR Internalization and Calcium Mobilization in Common Variable Immunodeficiency (CVID)

* Joseph P. Mizgerd, Boston University School of Medicine, USA
Signaling Hubs Balancing Host Defense and Lung Injury during Pneumonia

Cherilyn M. Sirois, Universidad de las Americas, Ecuador
Short Talk: RAGE Promotes Inflammatory Responses to DNA in the Lung

Catherine J. Sanders, St. Jude Children's Research Hospital, USA
Short Talk: IL-1 Signaling in Lung Recovery from Influenza-Induced Damage

17:00—19:00
Mucosal B Cells and Lymphoid Organogenesis
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Jo Spencer, King's College London, UK
Generation and Diversification of Human IgA Responses in Gut-Associated Lymphoid Tissue

Duane R. Wesemann, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Extramedullary V(D)J Recombination in Gut Lamina Propria B Lineage Cells

* Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation of Splenic Marginal Zone B Cell Responses by Mucosal Signals

Gérard Eberl, Institut Pasteur, France
Symbiotic Bacteria and Proinflammatory Immunity

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

WEDNESDAY, MARCH 2

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:15
Immunotherapy: Helping the Host
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Allen G. Harmsen, Montana State University, USA
Nonspecific Enhancement of Resistance to Lung Viruses by Nanoparticle-Induction of BALT

Troy D. Randall, University of Alabama at Birmingham, USA
Lung Lymphoid Tissue and Regulation of Local Immune Responses

* Arturo Casadevall, Albert Einstein College of Medicine, USA
Antibody-Based Therapies: Promise and Complexity

Scott E. Evans, University of Texas MD Anderson Cancer Center, USA
Short Talk: Epithelial Resistance to Pneumonia Induced by TLR Synergy

Jory R. Baldridge, GlaxoSmithKline, USA
TLR4 Agonists Facilitate “Rapid Acting Vaccine” Against the Respiratory Tract Pathogen, Influenza A

François Coulombe, Laval University, Canada
Short Talk: Muramyl Dipeptide Induces NOD2-Dependent Modulation of Protective Host Response Against Influenza Virus

08:00—11:15
Innovative Approaches in Modern Medicine and Vaccine Development
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* Paul Garside, University of Glasgow, UK
Visualizing Tolerance vs. Priming in vivo Using Novel Imaging, Labeling and Tracking Technologies

* Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA
Protein Domains, Signaling Networks, and Immunity

Xiaoxiao Li, University of California, Los Angeles, USA
Short Talk: Detecting Disease-Related Biologic Neighborhoods by Metaproteomic Analysis at Mucosal-Luminal Interface

Andrew J. Yates, University of Glasgow, UK
Cytotoxic T Lymphocytes, Virus Strategies and Sterilizing Immunity

Robert M. Hershberg, VentiRx Pharmaceuticals, USA
Novel TLR Therapies for Treating Allergic Rhinitis and Asthma

09:20—09:40
Coffee Break

BC Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 4: Epithelial Barrier Function and Bugs

British Ballroom
* Bana Jabri, University of Chicago, USA

* De' Broski R. Herbert, University of Pennsylvania, USA

Paria Mirmonsef, Rush University Medical Center, USA
Activation of Mucosal Innate Immune Responses by Short Chain Fatty Acids and Toll-Like Receptor Ligands

Yuko Akiyama, University of Tokyo, Japan
Dual Role of Epithelial Fucosylation in the Small Intestine: Co-Habitation and Defense Niches for Commensal and Pathogenic Bacteria

Sin-Hyeog Im, POSTECH, South Korea
IRT5 Probiotics as an Immune Modulator for Diverse Immune Disorders

Gwo-Tzer Ho, University of Edinburgh, UK
Epithelial Multidrug Resistance-1 (MDR1) Gene Modulates Specific NF-kappaB-Response to Bacterial Flagellin and Promotes a Pro-Inflammatory Response in the Intestinal Epithelium

Mahima Swamy, London Research Institute, Cancer Research UK, UK
Understanding IEL Epithelium Interactions in the Gut

Lionel Le Bourhis, Institut Curie, France
Mucosal Associated Invariant T Cells Function in the Intestine

Bjoern Ole Schroeder, University of Gothenburg, Sweden
Reduced to Action: Human beta defensin-1 in the Intestine

16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Vaccines Inducing Pathogen-Specific Lung Immunity
Meeting has ended...abstracts no longer viewable online.

Columbia Ballroom
* Kanta Subbarao, NIAID, National Institutes of Health, USA
Local Immunity Induced by Live Attenuated Pandemic Influenza Vaccines

Maytal Bivas-Benita, Beth Israel Deaconess Medical Center/Harvard Medical school, USA
Short Talk: Pulmonary DNA Immunization Generates Antigen-Specific CD8+T Cells in the Lung Airways that Protect Against Respiratory Lethal Viral Challenge

Catharine M. Bosio, NIAID, National Institutes of Health, USA
Requirements for Immunity Against Pneumonic Tularemia

* Jay K. Kolls, Tulane School of Medicin, USA
Balancing Mucosal Immunity in a Vaccine Context

17:00—19:00
Genetic and Molecular Basis of Intestinal Inflammation and Allergy
Meeting has ended...abstracts no longer viewable online.

British Ballroom
* John D. Rioux, Montreal Heart Institute and Université de Montréal, Canada
What Genetic Studies Are Teaching Us about Mucosal Biology and Intestinal Inflammation

* Ludvig M. Sollid, Institute of Immunology, Norway
Autoimmune Dysregulation in Celiac Disease

Valerie Abadie, University of Montreal-Research Center CHU Sainte-Justine, Canada
Short Talk: Co-Adjuvant Effects of Retinoic Acid and IL-15 Induce Inflammatory Immunity to Dietary Antigens

Hugh A. Sampson, Mount Sinai School of Medicine, USA
Treating Food Allergy

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

THURSDAY, MARCH 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI092849-01




We gratefully acknowledge additional support for this conference from:

Burroughs Wellcome Fund Hoffmann-La Roche, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline Biologicals


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Respiration

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676