Beaver Run Resort Floorplan

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This meeting took place in 2011


Here are the related meetings in 2018:
T Cell Dysfunction, Cancer and Infection (A3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Immunoregulatory Networks (D5)


Organizer(s) Dario A.A. Vignali, Steven F. Ziegler and Hilde Cheroutre
April 1—6, 2011
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Dec 1, 2010
Late Abstract Deadline: Jan 3, 2011
Scholarship Deadline: Dec 1, 2010
Early Registration Deadline: Jan 31, 2011

Sponsored by Amgen Inc. and Novo Nordisk A/S

Summary of Meeting:
Immunoregulatory networks play a pivotal role in preventing autoimmunity, but also restrict anti-tumor immunity and modulate immune responses to pathogens. While regulatory T cells (Tregs) are a central component of this network, there is now the growing realization that there are many other cellular and molecular components that contribute to this network. While this will be is a Treg-centric meeting, it will also focus on how Tregs integrate with other cellular and molecular components to prevent autoimmunity and control immune responses. This meeting will dissect our current understanding of four key areas: development and homeostasis of regulatory populations, molecular control of immunoregulatory networks, mechanisms of regulatory function and regulatory T cell plasticity. A second goal will be to discuss how Tregs interact with different cells types or utilize different cytokines that modulate or indirectly mediate their activity. A third goal will be to assess how the advances presented can be utilized to develop novel therapies for autoimmune disease and cancer.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 1

15:00—19:30
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Introductory Remarks

Diane Mathis, Harvard Medical School, USA
Tissular Tregs


SATURDAY, APRIL 2

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
Transcriptional Control of Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
FOXP3 and the Control of Regulatory T Cell Generation and Function

Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Transcriptional Modulation of Treg Development and Function

Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Novel Transcription Factors that Control Treg Development and Function

Daniel Campbell, Benaroya Research Institute, USA
Functional Specialization of Foxp3+ Regulatory T Cells

Yisong Wan, University of North Carolina at Chapel Hill, USA
Short Talk: A Role of GATA-3 in Regulating Treg Function

Jonathan S. Bromberg, University of Maryland School of Medicine, USA
Induction, Migration, and Function of Treg

10:00—10:20
Coffee Break

Foyer
11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:30
On Own for Lunch and Recreation

17:00—17:30
Coffee Available

Foyer
17:00—19:00
Molecular Mechanics of Regulation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA

Douglas R. Green, St. Jude Children's Research Hospital, USA
Metabolic Perturbation, Apoptotic Drive and Regulatory Lineage Commitment

Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
The Mammalian Target of Rapamycin (mTOR) Provides a Critical Link between T Cell Differentiation, Function and Metabolism

Ryan D. Michalek, Duke University Medical Center, USA
Short Talk: Distinct Glycolytic and Lipid Oxidative Metabolic Programs of Effector and Regulatory T Cells Regulated by Estrogen Related Receptor-alpha

Mark S. Anderson, University of California, San Francisco, USA
Control of Immune Tolerance by Peripheral Aire

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

SUNDAY, APRIL 3

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Treg Development and Immunomodulation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Chyi-Song Hsieh, Washington University, USA
The Role of TCR Specificity in Thymic and Peripheral Regulatory T Cell Development

Hongbo Chi, St. Jude Children's Research Hospital, USA
Short Talk: Intrinsic and Extrinsic Controls of Peripheral Induction of Regulatory T Cells

Michal Kuczma, Georgia Regents University, USA
Short Talk: Connexin 43 Signaling is Necessary for the Generation of Foxp3+ Regulatory T Cells

Michael Croft, La Jolla Institute for Allergy and Immunology, USA
TNFR Family Members and the Induction of Treg

Peter B. Ernst, University of California, San Diego, USA
Immune Modulation by Adenosine

David Artis, Cornell University, USA
Immuno-Regulatory Mechanisms at Barrier Surfaces

10:00—10:20
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:15
On Own for Lunch and Recreation

17:00—17:30
Coffee Available

Foyer
17:00—19:30
Workshop 1: Molecular Immunoregulatory Networks

Peak 5
* Diane Mathis, Harvard Medical School, USA

Anna Cebula, Georgia Regents University, USA
Origin and TCR Diversity of Intestinal Foxp3+ Regulatory T Cells

Wenxian Fu, Harvard Medical School, USA
Synergistic Effects of Foxp3 and Other Cofactors in Transcriptional Regulation of Regulatory T Cells

Li-Fan Lu, University of California, San Diego, USA
The Role of SOCS1 Repression by miR-155 in Regulation of the Immune Responsiveness

Lukas Jeker, University Hospital and University of Basel, Switzerland
microRNAs Induced by CD28 are Required for Optimal T Cell Co-Stimulation and Essential for Treg Function in vivo

Marc Beyer, German Center for Neurodegenerative Diseases, Germany
Repression of SATB1 in Regulatory T Cells is Required for Suppressive Function and Inhibition of Effector Differentiation

Fabio Grassi, Institute for Research in Biomedicine, Switzerland
Inhibition of Regulatory T Cell Function and Generation by Purinergic P2X Receptors

Yu-Hui Huang, Kymab Biotechnology Co. Ltd., Taiwan
Regulatory T Cells Selectively Attenuate TCR Signaling by Disrupting NF-kappaB Nuclear Accumulation in CD4 T Cells

Clifford S. Guy, St. Jude Children's Research Hospital, USA
Distinct T Cell Receptor Signaling Pathways Drive Proliferation and Cytokine Production in T Cells

Yan Zheng, University of Chicago, USA
Early Growth Response Gene 2 (Egr2) is Essential for T Cell Anergy and Control of the Anergy Transcriptional Program

Darshana Poddar, Cleveland State University, USA
Macrophage-Specific Ribosomal Protein L13a-Knockout Mice Reveal an Endogenous Mechanism to Control Inflammation

17:00—19:30
Workshop 2: Cellular Immunoregulatory Networks

Peaks 1-4
* Jeffrey A. Bluestone, University of California, San Francisco, USA

Ofir Goldberger, Fluidigm Corporation, USA
The Cytokine Network in Steady-State and Disease

Li Wang, Medical College of Wisconsin, USA
VISTA, a Novel Ig-Superfamily Ligand that Negatively Regulates T Cell Responses

Christina E. Zielinski, Technical University Munich, Germany
Differential Requirement for IL-1beta for the Generation of Human Microbe-Specific Th17 Cells

Thorsten Buch, University of Z├╝rich, Switzerland
Inducible CD4+ T Cell-Specific Ablation of TGF-beta Signaling Reveals a Role in Homeostasis but not in Tolerance and Treg Cell Function

David A. Schaer, Memorial Sloan-Kettering Cancer Center, USA
Ligation of GITR during Tumor Immunotherapy Induces Foxp3 Loss and Regulatory T Cell Instability

Xin Chen, SAIC-Frederick/NCI-Frederick, National Institutes of Health, USA
TNF by Inducing Co-Stimulatory TNF Receptor Superfamily Members TNFR2, 4-1BB and OX40 Augments the Number and Function of CD4+FoxP3+ Regulatory T Cells

Jenny Louise McGovern, University College London, UK
Anti-TNF Antibody Therapy in Patients with Rheumatoid Arthritis, but not TNF Receptor Blockade, Induces IL-17 Suppressing Regulatory T Cells

Lucas J. Thompson, Agonox, Inc, USA
De Novo Induction of Functional Foxp3+ Regulatory CD4 T Cells in Response to Tissue-Restricted Self Antigen

Ulf Dittmer, University of Duisburg-Essen, Germany
Depletion of Regulatory T Cells Reactivates Virus-Specific CD8+ T Cells and Reduces Chronic Retroviral Setpoints

Allison L. Bayer, University of Miami School of Medicine, USA
Successful Engraftment of Transplanted Donor Treg Cells Leading to Tolerance to Allogeneic Bone Marrow Cells in NOD Mice

19:30—20:30
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—22:30
Poster Session 2

Breckenridge Ballroom

MONDAY, APRIL 4

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
Cytokine Modulation of Regulatory Networks
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
A Regulatory Triad: Tregs, IL-35 and iTr35s

Christopher A. Hunter, University of Pennsylvania, USA
New Insights into the Immunobiology of IL-27

Anne O'Garra, Francis Crick Institute, UK
IL-10 and Immunoregulation

Casey T. Weaver, University of Alabama at Birmingham, USA
Modulation of Regulatory Networks by Cytokines

Paula M. Oliver, University of Pennsylvania, USA
Short Talk: TGF-beta Silences IL-4 Production via an Ndfip1- and Itch-Dependent Mechanism to Provide a Window of Opportunity for iTreg Differentiation

Randolph J. Noelle, Dartmouth College, USA
Retinoic Acid Controls a Critical Checkpoint in the Development of T Cell Mediated Immunity

10:00—10:20
Coffee Break

Foyer
11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:30
On Own for Lunch and Recreation

17:00—17:30
Coffee Available

Foyer
17:00—19:00
Novel Regulators and Other Interesting Regulatory Mechanisms
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Christopher A. Hunter, University of Pennsylvania, USA

Wanjun Chen, NIDCR, National Institutes of Health, USA
TGF-beta is Required for the Development of Foxp3+ Treg Cells and TCRalphabeta+CD8alphaalpha+ IEL

Thomas F. Tedder, Duke University Medical Center, USA
Regulatory B10 B Cells during Health and Disease

Eric F. Tewalt, University of Virginia, USA
Short Talk: Lymphatic Endothelial Cells Mediate CD8 T Cell Peripheral Tolerance via the B7-H1:PD-1 Pathway

Dmitry I. Gabrilovich, Wistar Institute, USA
The Nature of Myeloid-Derived Suppressor Cells in Cancer

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

TUESDAY, APRIL 5

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
Cell Surface Modulators of Regulatory Networks and Immunotherapy
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA

Greg E. Lemke, The Salk Institute for Biological Studies, USA
Immunomodulation by TAM Receptors

Richard M. Maizels, University of Edinburgh, UK
Tregs Induced by Helminths

Bruce R. Blazar, University of Minnesota, USA
Treg-Based Immunotherapy in Hematopoietic Stem Cell Transplantation

Arlene H. Sharpe, Harvard Medical School, USA
Role of PD-1:PD-L1 Interactions in Regulating the Balance between T Cell Activation and Tolerance

Suzanne L. Topalian, Johns Hopkins University School of Medicine, USA
Blockade of Immunologic Checkpoints in Cancer Therapy: the PD-1/B7-H1 Axis

Joe Ponte, Tolerx, Inc., USA
Short Talk: Anti-GITR Combined with anti-CTLA4 and Gemcitabine Eradicates Established Colon Carcinoma in Mice

10:00—10:20
Coffee Break

Foyer
11:30
On Own for Lunch and Recreation

17:00—17:30
Coffee Available

Foyer
17:00—19:00
Plasticity of Regulatory Populations
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Stretching CD4 Effector T Cells Beyond Plasticity

Juan J. Lafaille, New York University School of Medicine, USA
Natural and Adaptive Foxp3+ Regulatory T Cells

Yingzi Cong, University of Texas Medical Branch, USA
Short Talk: IL-12 Promotes Microbiota Antigen-Specific Foxp3+ Regulatory T Cell Conversion to Foxp3+IFN-gamma+ T Cells with Regulatory Function

Jeffrey A. Bluestone, University of California, San Francisco, USA
Modulation of the Treg Phenotype in Autoimmunity

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

WEDNESDAY, APRIL 6

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI094916-01




We gratefully acknowledge additional support for this conference from:

Boehringer Ingelheim Pharmaceuticals, Inc. Educational donation provided by Amgen
JDRF Novo Nordisk A/S
Rigel Pharmaceuticals, Inc.
 

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