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This meeting took place in 2011



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New Frontiers at the Interface of Immunity and Glycobiology (C5)


Organizer(s) Brian A. Cobb, Gabriel A. Rabinovich and Yvette van Kooyk
March 6—11, 2011
Fairmont Chateau Lake Louise • Lake Louise, AB Canada
Abstract Deadline: Nov 15, 2010
Late Abstract Deadline: Dec 9, 2010
Scholarship Deadline: Nov 15, 2010
Early Registration Deadline: Jan 6, 2011

Supported by the Directors’ Fund

Summary of Meeting:
Carbohydrates are often overlooked in the study of the immune system, yet mounting data show that glycans, whether microbial or host in origin, play central roles in essentially all immune response pathways. Changes in glycosylation of host proteins can lead to autoimmunity, indicate oncogenic transformation, or even promote metastasis. Inflammation can be strongly influenced by carbohydrate binding proteins on immune cells. Selectins play critical roles in cell homing to the site of infection, while glycosylation directly influences cellular development and differentiation. Recent advances also highlight how glycan-mediated antigen recognition by dendritic cells impacts our understanding of the innate immune response, while other findings reveal that glycolipids and bacterial polysaccharides can lead to NKT and T cell activation. The goal of this meeting is to bring together the international “glycoimmunology” community to foster interactions and promote the latest insights into the role of glycans in the immune system.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 6

15:00—19:30
Registration

Alpine Gallery
18:15—19:15
Refreshments

Heritage Hall
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
James C. Paulson, The Scripps Research Institute, USA
Modulating Innate and Adaptive Immune Responses with Glycan Ligands of Siglecs


MONDAY, MARCH 7

07:00—08:00
Breakfast

Tom Wilson Dining Room
08:00—11:15
B and T Cell Responses and Recognition
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Brian A. Cobb, Case Western Reserve University School of Medicine, USA
MHCII-Mediated T cell Activation by Bacterial Carbohydrate Antigens

Michael B. Brenner, Harvard Medical School, USA
Glycan-Driven Innate Mechanisms Activate CD1d Restricted iNKT Cell Responses to Fungi and Other Microbes

Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
Recognition of Glycolipids from Pathogenic Microbes by Natural Killer T Cells

Linda G. Baum, University of California, Los Angeles, USA
CD45 and CD43 Glycosylation during T Cell Maturation, Activation and Survival

María Belén Prados, Universidad Nacional de Río Negro, Argentina
Short Talk: Progesterone Induces a Switch in Oligosaccharyltransferase Isoform Expression: Consequences on IgG N-Glycosylation

Nina Salinger, Emory University School of Medicine, USA
Short Talk: Anti-Glycan Responses in Mice to Glycan Antigens from the Parasitic Trematode Schistosoma mansoni

09:20—09:40
Coffee Break

Heritage Hall
11:15—13:00
Poster Setup

Mt Temple C
13:00—22:00
Poster Viewing

Mt Temple C
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Heritage Hall
17:00—19:00
Innate Immune Responses and Recognition
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Paul R. Crocker, University of Dundee, UK
CD33-Related Siglecs in Modulation of Inflammatory Responses

Jamey D. Marth, Sanford-Burnham Medical Research Institute, USA
Exposure and Sensing of Dangerous Glycans in the Prevention and Pathogenesis of Disease

Caetano Reis e Sousa, Francis Crick Institute, UK
Syk-Coupled C-Type Lectins at the Crossroads of Innate and Adaptive Immunity

Smanla Tundup, University of Georgia, USA
Short Talk: Immune Regulation in Response to Schistosoma Antigen

19:00—20:00
Social Hour with Lite Bites

Mt Temple C
19:30—22:00
Poster Session 1

Mt Temple C

TUESDAY, MARCH 8

07:00—08:00
Breakfast

Tom Wilson Dining Room
08:00—11:15
Cell Communication, Homing and Inflammation
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Yvette van Kooyk, Vrije University Medical Center, Netherlands
Carbohydrate Recognition by Dendritic Cells and Cell Communication

Rodger P. McEver, Oklahoma Medical Research Foundation, USA
Selectin-Glycoconjugate Interactions in Cell Communication

Sachiko Sato, Laval University, Canada
Cytosolic Lectin, Galectin-3 and Innate Immune Response during Infections

Fu-Tong Liu, Institute of Biomedical Sciences, Academia Sinica, Taiwan
Galectins in Allergic Inflammation

Hiroto Kawashima, University of Shizuoka, Japan
Short Talk: Essential Role of Peripheral Node Addressin in Lymphocyte Homing to Nasal-Associated Lymphoid Tissues and Allergic Immune Responses

Jeffrey C. Nolz, University of Iowa, USA
Short Talk: Memory CD8 Tcell Recruitment through Regulation of Selectin Ligand

09:20—09:40
Coffee Break

Heritage Hall
11:15—13:00
Poster Setup

Mt Temple C
13:00—22:00
Poster Viewing

Mt Temple C
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Heritage Hall
17:00—19:00
Workshop and Panel: High-Throughput Screening in Glycomics of the Immune Response
This workshop and panel will discuss new technologies and techniques to study glycobiology at the "glycomic" scale. After the invited talks, the audience will join in a roundtable interactive session designed to promote glycomics to understand the immune response and to foster potential collaborations.

Mt Temple A/B
* Anne Dell, Imperial College London, UK
High Sensitivity Mass Spectrometric Analysis of Glycosylation Patterns

Michael Pierce, CCRC, USA
Application of Glycomic Technologies to Identify Potential Cellular Markers and Investigate Glycan Function

Ten Feizi, Imperial College London, UK
Ligand Discovery for Carbohydrate Recognition Systems

19:00—20:00
Social Hour with Lite Bites

Mt Temple C
19:30—22:00
Poster Session 2

Mt Temple C

WEDNESDAY, MARCH 9

07:00—08:00
Breakfast

Tom Wilson Dining Room
08:00—11:15
Host-Pathogen Interactions
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Richard Cummings, Emory University, USA
O- and N-Glycosylation Pathways in Host-Pathogen Interactions

Stephen M. Beverley, Washington University School of Medicine, USA
The Role of Glycoconjugates in Infectivity and Immune Reponses Against the Protozoan Parasite Leishmania major

Gerardo R. Vasta, University of Maryland School of Medicine, USA
C- and F-Type Lectins, and Galectins in Host-Pathogen Interactions

Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
C-type lectin signaling in immunity and infection

Bronwyn M. Gunn, Massachusetts General Hospital, USA
Short Talk: Alphavirus N-Linked Glycan Activation of the Host Complement System Contributes to Virus-Induced Inflammatory Disease

Chun-Hung Hans Lin, Academia Sinica, Taiwan
Short Talk: Role for alpha-L-Fucosidase in the Control of Helicobacter pylori-Infected Gastric Cancer Cells

09:20—09:40
Coffee Break

Heritage Hall
11:15—12:00
Lunch

12:00—14:00
Workshop: Glycobiology and Its Implications for HIV-1 Vaccine Design

Mt Temple A/B
James Arthos, NIAID, National Institutes of Health, USA
N-Linked Glycosylation Patterns in the gp120 Envelope Protein Impact HIV-1 Transmission

Heather Desaire, University of Kansas, USA
Comparative Analysis of Recombinant gp140's, using a Glycosylation Site Specific Approach

Chris N. Scanlan, University of Oxford, UK
Antibody Recognition of HIV Carbohydrates as a Template for Vaccine Design

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
Differential Antibody Glycosylation as a Mechanism for Longterm Control of HIV

14:00—14:30
Coffee Available

Heritage Hall
15:00—17:00
Hematopoiesis and Lymphocyte Development
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Pamela Stanley, Albert Einstein College of Medicine, USA
O-Fucose Glycans in Notch Signaling and T Cell Development

John B. Lowe, Genentech, Inc., USA
Fucosylation-Dependent Control of Leukocyte Biology

Siew Cheng Wong, Singapore Immunology Network, Singapore
Short Talk: Gene Expression Profiling Reveals Differential Expression of Carbohydrate Binding Receptor Proteins by the Three Human Monocyte Subsets

Martin K. Wild, Max Planck Institute of Molecular Biomedicine, Germany
Short Talk: A Human Defect in alpha2,3-Sialylation Causing Thrombocytopenia and Reduced Selectin Binding

17:00
On Own for Dinner

17:30
Evening Out in Banff
Optional bus trip for those interested in dining and shopping in the town of Banff. Approximate departure time from Banff is 9:00 PM.


THURSDAY, MARCH 10

07:00—08:00
Breakfast

Tom Wilson Dining Room
08:00—11:00
Autoimmunity and Chronic Inflammation
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Gabriel A. Rabinovich, Instituto de Biologia y Medicina Experimental, Argentina
Tolerogenic Circuits Mediated by Galectin-Glycan Interactions in the Resolution of Autoimmune Inflammation

Rikard Holmdahl, Karolinska Institutet, Sweden
Glycosylation Alterations of Autoantigens in Arthritis

Michael Demetriou, University of California, Irvine, USA
N-Glycan Branching, T Cells and Autoimmunity

Hugh J. Willison, University of Glasgow, UK
Antibody-Glycan Interactions in Neuronal Autoimmunity

George Buchlis, University of Pennsylvania and Children's Hospital of Philadelphia, USA
Short Talk: Intrinsically Hyperactive and Hyperproliferative T Cells in Cmah-/- Mice

09:20—09:40
Coffee Break

Heritage Hall
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Heritage Hall
17:00—19:00
Tumor Immunity
Meeting has ended...abstracts no longer viewable online.

Mt Temple A/B
* Minoru Fukuda, Sanford-Burnham Medical Research Institute, USA
Endothelial Heparan Sulfate Controls Chemokine Presentation in the Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes and Inflammatory Tissues

Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Differential Glycosylation of Self and Abnormal Self Antigens for Immunosurveillance of Premalignant and Malignant Lesions

James W. Dennis, Mount Sinai Hospital, Canada
N-glycan, Metabolism and Tumor Progression

Pierre van der Bruggen, Ludwig Institute for Cancer Research, Belgium
Short Talk: Is it Possible to Correct the Impaired Function of Human Infiltrating Lymphocytes?

19:00—20:00
Social Hour with Lite Bites

Victoria
20:00—23:00
Entertainment

Victoria

FRIDAY, MARCH 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI094888-01




We gratefully acknowledge additional support for this conference from:

Alberta Innovates - Health Solutions, Funded by the Alberta Heritage Foundation for Medical Research Endowment Fund BioMarin Pharmaceutical Inc.

Genentech, Inc.

Genentech, Inc.

Mizutani Foundation for Glycoscience

 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676