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This meeting took place in 2010


Here are the related meetings in 2018:
Emerging Technologies in Vaccine Discovery and Development (J5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Immunological Mechanisms of Vaccination (S1)


Organizer(s) Bali Pulendran, Rino Rappuoli and Bruce A. Beutler
October 27—November 1, 2010
Sheraton Seattle Hotel • Seattle, Washington USA
Abstract Deadline: Jun 28, 2010
Late Abstract Deadline: Jul 30, 2010
Scholarship Deadline: Jun 28, 2010
Early Registration Deadline: Aug 27, 2010

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Vaccines have been described as one of the most cost effective public health tools in history. Despite their success, most vaccines have been made empirically, and we understand little about the mechanisms by which they stimulate protective immunity. Indeed, immunologists and vaccinologists have until recently, occupied parallel universes! Understanding the immunology of vaccines and infections is of paramount importance in the rational design of future vaccines against pandemics such as HIV, malaria and tuberculosis, and against emerging infections such as swine influenza and dengue. Recent advances in immunology, human genetics, and systems biology are beginning to offer a deeper understanding of the molecular and cellular mechanisms of host immunity, and the pivotal role played by the innate immune system in shaping the adaptive immune response. Such insights are enhancing our understanding of the correlates of protective immunities, of the early innate immune signatures of vaccine efficacy, and guiding the rational design of novel and safer vaccines and adjuvants. Immunological Mechanisms of Vaccination will bring together an interdisciplinary group of scientists in immunology, virology, systems biology and vaccinology, to address critical advances in these fields and their implications for vaccinology. • The importance of the innate immune system in sensing vaccines and shaping the vaccine immunity • Modulating immune memory to vaccines with innate immunity • Novel approaches to understanding host-pathogen interactions • Deconstructing the mode of action of successful vaccines, vectors adjuvants with innate immunity • Constructing new vaccines and adjuvants with innate immunity • Application of systems biology to predicting vaccine efficacy, and discovering novel immune mechanisms of protection

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, OCTOBER 27

13:00—17:00
Registration

Grand Ballroom Foyer
17:00—17:30
Coffee Available, Joint with GCGH

Grand Ballroom Foyer
17:30—19:00
Keynote Session (Joint Session with Grand Challenges in Global Health)
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C-D
* Chris Wilson, Bill & Melinda Gates Foundation, USA

Tadataka Yamada, Mountain Field LLC, USA
Innovation in Vaccine Research for Global Health

Anthony S. Fauci, NIAID, National Institutes of Health, USA
Challenges in Vaccinology: A Tale of Three Diseases

19:00—21:00
Joint Reception with GCGH

Sweeney F, Main Level Breakout Rooms

THURSDAY, OCTOBER 28

07:30—08:30
Breakfast

Sweeney F, Main Level Breakout Rooms
08:30—09:00
Orientation

Grand Ballroom C-D
09:00—12:45
Innate Sensing of Pathogens and Vaccines
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
Dissecting Innate Sensing with Forward Genetics

* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Mechanisms Underlying the Sensing of Microbial DNA

Dana Philpott, University of Toronto, Canada
Innate Sensing of Microbes by NOD Proteins

Philippa C. Marrack, HHMI/National Jewish Health, USA
The Adjuvant and Other Activities of Alum

Stephanie C. Eisenbarth, Yale University, USA
Short Talk: The Nlrp3 Inflammasome Regulates Th17 but not Th2 Differentiation Following Immunization

* Ken J. Ishii, National Institute of Biomedical Innovation, Health and Nutrition, Japan
Short Talk: Innate Immune Signaling Pathways Essential for DNA and Viral Vaccines

09:40—10:00
Coffee Break

Grand Ballroom Foyer
12:45—13:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Understanding T and B Cell Memory to Vaccines
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Rafi Ahmed, Emory University School of Medicine, USA
Vaccination and Immune Memory

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Essential Roles of Follicular Helper CD4 T Cells (Tfh) in Antibody Responses to Vaccination

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Dissecting the Human T and B Cell Response to Pathogens

Hana Golding, US Food and Drug Administration, USA
Short Talk: Shift in Antibody Repertoire and Greater Focus on Protective Epitopes in Hemagglutinin after Vaccination with Oil-in-water Adjuvanted Pandemic Influenza Vaccines

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakout Rooms

FRIDAY, OCTOBER 29

07:30—08:30
Breakfast

Sweeney F, Main Level Breakout Rooms
08:30—11:45
Systems Biological Approaches to Vaccination and Infections
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Bali Pulendran, Emory University, USA
Learning Immunology from Successful Vaccines: Innate Immunity to Systems Vaccinology

Ronald N. Germain, NIAID, National Institutes of Health, USA
A Systems Approach to Immunology

Alan Aderem, Center for Infectious Disease Research, USA
Systems Vaccinology: Using the Tools of Systems Biology to Enable Rational Vaccine Design

Rafick-Pierre Sékaly, Case Western Reserve University, USA
Systems Biology Approaches to Dissecting Protective Immune Responses

I-Ming Wang, Merck Research Lab, USA
Short Talk: Blood Profiling of Vaccines and Adjuvants in Non-Human Primates to Study Mode of Action, Immunogenicity and Predict Adverse Events

Surojit Sarkar, Pennsylvania State University, USA
Short Talk: Functional and Genomic Profiling of CD8 T Cell Memory Responses Elicited by Adenovirus 5 Vectored Immunogens

09:40—10:00
Coffee Break

Grand Ballroom Foyer
11:45—13:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
14:30—16:30
Workshop 1: Tuning the Immune Response

Grand Ballroom C-D
* Shane Crotty, La Jolla Institute for Allergy and Immunology, USA

Michael W. Munks, Oregon Health & Science University, USA
Aluminum Adjuvants Induce Fibrin-Dependent Extracellular Traps In Vivo

Santhakumar Manicassamy, Emory University, USA
Activation of beta-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

Carrie Arnold, Johnson & Johnson, USA
Forward Genetic Analysis of the Humoral Immune Response

Claudia Giesecke, Charité University Medicine Berlin, Germany
Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells

Yang Zhang, University of Birmingham, UK
Manipulating Affinity Maturation in the Germinal Centre

Stefan Riebel, Max Planck Institute for Infection Biology, Germany
Single Cell Analysis of a Polyclonal Germinal Center Reaction

Wendy G. H. Tan, Emory University, USA
Rapamycin Treatment Improves The Quality And Quantity Of Ad5 Vaccine Induced CD8 T Cell Responses

Francis M. Ndungu, KEMRI, Wellcome Research Collaborative Programme, Kenya
Maintenance of Antibody and B Cell Memory to Plasmodium falciparum Antigens (in children) in the Absence of Persistent Exposure to Parasites

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Novel Approaches to Understanding Host-Microbe Interactions
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
* Rafick-Pierre Sékaly, Case Western Reserve University, USA

Lalita Ramakrishnan, University of Cambridge, UK
The Goldilocks Principle: Modulating Inflammation to Prevent and Treat Tuberculosis

Daniel A. Portnoy, University of California, Berkeley, USA
Forward Microbial Genetics and the Discovery of cyclic-di-AMP: An Essential and Conserved Bacterial Signaling Molecule that Triggers the Type 1 Interferon Response

Harlan Robins, Fred Hutchinson Cancer Research Center, USA
Short Talk: Overlap and Effective Size of the Human CD8+ T-Cell Receptor Repertoir

Eva Harris, University of California, Berkeley, USA
Short Talk: Investigating the Human Antibody and B Cell Repertoire in Dengue Virus Infection

Sarah E. Henrickson, Children's Hospital of Philadelphia, USA
Short Talk: Low Dose, Short Duration Antigenic Constellation Fosters CD8+ T Cell Effector Function without Stable Contacts with DCs, Yielding Immunological Amnesia

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakout Rooms

SATURDAY, OCTOBER 30

07:30—08:30
Breakfast

Sweeney F, Main Level Breakout Rooms
08:30—11:45
Translating Immunity to Vaccines
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
Ralph M. Steinman, Rockefeller University, USA
Dendritic Cell-Based Protein Vaccines Against AIDS

Christine Trumpfheller, Roche Glycart, Switzerland
Immunization of Rhesus Macaques with HIV Proteins and Adjuvant Followed by Recombinant NYVAC

* Robert L. Coffman, Dynavax Technologies, USA
Harnessing TLR9 Ligands for Immune Modulation

Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Immunology of TB: Impact on Vaccine Development

Sudhir Pai Kasturi, Emory University, USA
Short Talk: Programming the Quality and Persistence of Antibody Responses with Innate Immunity

Ofer Levy, Children's Hospital Boston, USA
Short Talk: Accounting for Innate Immune Ontogeny in Pre-Clinical Development of Pediatric Vaccines: Imidazoquinoline TLR8 Agonists Trigger Adenosine- & cAMP-Refractory Pathways for Robust Activation of Newborn and Infant Antigen-Presenting Cells

09:40—10:00
Coffee Break

Grand Ballroom Foyer
11:45—13:00
Poster Setup

Sweeney F, Main Level Breakout Rooms
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakout Rooms
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:15
Immunity and Vaccines Against Pandemics and Emerging Pathogens I
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
* Kanta Subbarao, NIAID, National Institutes of Health, USA

Rino Rappuoli, GlaxoSmithKline Vaccines, Italy
Reverse Vaccinology

Joe D. Cohen, GlaxoSmithKline Biologicals, Belgium
The RTS/S Malaria Vaccine: Lessons Learned

M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Innate and Adaptive Immunity Against HIV Vaccines

Pia Dosenovic, Rockefeller University, USA
Short Talk: Manipulation of the Naïve B Cell Repertoire by Transient BLyS Treatment as a Means to Alter Vaccine-Elicited Ab Responses to HIV-1 Env

19:15—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakout Rooms

SUNDAY, OCTOBER 31

07:30—08:30
Breakfast

Sweeney F, Main Level Breakout Rooms
08:30—11:45
Immunity and Vaccines Against Pandemics and Emerging Pathogens II
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
* Patrick E. Duffy, NIAID, National Institutes for Health, USA

Stephen L. Hoffman, Sanaria, USA
Development of an Attenuated Sporozoite Vaccine to Prevent and Eliminate Plasmodium falciparum Malaria

Supachai Rerks-Ngarm, Prime-Boost HIV Vaccine Trial Phase III, Thailand
Phase III, Efficacy Trial of HIV Prime-Boost Vaccine Combination in Thailand: Immunological Studies and Future Plan

Kanta Subbarao, NIAID, National Institutes of Health, USA
Scientific Obstacles to Developing Vaccines Against Pandemic Influenza

Firdausi Qadri, International Centre for Diarrhoeal Disease Research, Bangladesh
Immunity to Vibrio cholerae and Other Enteric Pathogens: Studies in Patients and Vaccines

Junbao Yang, Benaroya Research Institute, USA
Short Talk: The Dynamics of CD4+ T Cell Mediated Immunity to 2009 H1N1/Influenza A Virus

Bonnie B. Blomberg, University of Miami School of Medicine, USA
Short Talk: Intrinsic Defects in B Cell Response to both Seasonal Influenza and H1N1 Vaccination in Elderly Humans

09:40—10:00
Coffee Break

Grand Ballroom Foyer
13:30—15:30
Workshop 2: Innate Control of Vaccine Immunity

Grand Ballroom C-D
* Cevayir Coban, WPI Immunology Frontier Research Center, Osaka University, Japan

Kevin Shenderov, NIAID, National Institutes of Health, USA
Inflammasome-dependent IL-1beta Production is Critical for Complete Freund’s Adjuvant-induced Helper T Cell Polarization

Meghan E. Turnis, St. Jude Children's Research Hospital, USA
IRAK-M Removal Counteracts DC Vaccine Deficits in Migration and Longevity

Ali H. Ellebedy, Washington University School of Medicine, USA
Critical Role for ASC in the Adjuvant Effect of MF59

Arnaud Didierlaurent, GlaxoSmithKline Vaccines, Italy
Link between Innate Responses and the Enhanced Adaptive Response: Insights into AS04 and AS03 Mechanism of Action

Anke Huckriede, Molecular Virology, Netherlands
Vaccine-Triggered Innate Reactions of Dendritic Cells Correlate with the Immune Response Evoked by Vaccination

Elena Caproni, Novartis Vaccines & Diagnostics, Italy
Distinctive Innate Immune Signatures at Injection Site Boost the Adaptive Response to Flu Subunit Vaccine

Susanna R. Brauner, Karolinska Institutet, Sweden
Vaccination of Patients with the Autoimmune Disease Sjögren’s Syndrome Induces IL-7 and Skewed B Cell Maturation with Increased Levels of Plasmablasts Resulting in Higher Titers of Vaccine-Specific IgG Antibodies

15:30—16:00
Coffee Available

Grand Foyer
16:00—18:00
Immunology of Adjuvants
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C/D
* Hana Golding, US Food and Drug Administration, USA

Ennio De Gregorio, GlaxoSmithKline Vaccines, Italy
Molecular and Cellular Signatures of Vaccine Adjuvants

Steven Reed, Infectious Disease Research Institute, USA
Rational Design of New Adjuvants

Eugene Maraskovsky, CSL Limited, Australia
Short Talk: Mechanisms of Action of ISCOMATRIX® adjuvant

Norman Baylor, Biologics Consulting Group, Inc., USA
Adjuvant Development: The View from the FDA

18:00—19:00
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom C-D
Peter C. Doherty, University of Melbourne, Australia

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakout Rooms
20:00—23:00
Entertainment

Sweeney F, Main Level Breakout Rooms

MONDAY, NOVEMBER 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI091178-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Landes Bioscience

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



CSL Limited


Dynavax Technologies Corporation


GlaxoSmithKline Biologicals


Novartis Vaccines and Diagnostics


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