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This meeting took place in 2011



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Lipid Biology and Lipotoxicity (E2)


Organizer(s) Scott A. Summers and Rudolf Zechner
May 15—20, 2011
INEC-Ireland's National Events Centre • Killarney, Co. Kerry Ireland
Abstract Deadline: Jan 13, 2011
Late Abstract Deadline: Feb 15, 2011
Scholarship Deadline: Jan 13, 2011
Early Registration Deadline: Mar 15, 2011

Organized in Collaboration with Science Foundation Ireland

Summary of Meeting:
The accumulation of fat in tissues not suited for lipid storage has deleterious consequences on organ function, leading to cellular damage that underlies diabetes, heart disease, and hypertension. Illustrating the relationship is the fact that numerous effective therapeutics ameliorate metabolic disease symptoms by limiting the inappropriate deposition of fat in peripheral tissues (e.g. thiazolidinediones, metformin, or statins). Recent advances in genomics and lipidomics offer researchers an opportunity to make a substantial leap in the understanding and treatment of pathogenic conditions resulting from the excessive production and/or underutilization of fat. This meeting reviews these areas, placing specific emphasis on the following: (a) relationships between ectopic lipid deposition and metabolic disease; (b) mechanisms through which lipid excess alter tissue function; (c) regulatory processes that control lipid storage and metabolism; and (d) technological advances in the area of lipid analysis (i.e. lipidomics).

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MAY 15

15:00—19:30
Registration

INEC Conference Centre Foyer
18:15—19:15
Refreshments

INEC Conference Centre Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Scott A. Summers, Duke-NUS Graduate Medical School, Singapore

Roger H. Unger, University of Texas Southwestern Medical Center, USA
Origins of the Lipotoxicity Hypothesis: Implications for Human Disease


MONDAY, MAY 16

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Ectopic Lipid Accumulation and Disease
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Gregory J. Cooney, University of Sydney, Australia

Antonio J. Vidal-Puig, University of Cambridge, UK
Adipose tissue expandability, lipotoxicity and the Metabolic syndrome

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Tissue-Specific Deficiencies of Acyl-CoA Synthetase-1 in Mice

Matej Orešič, Steno Diabetes Center, Denmark
Lipidomic Analysis of Metabolic Disease

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Role of FTO in Obesity

Gos Micklem, University of Cambridge, UK
Short Talk: metabolicMine: An Integrated Web Resource of Data & Tools to Support the Common Metabolic Disease Research Community

10:20—10:40
Coffee Break

INEC Confenece Centre Foyer
12:00—13:00
Poster Setup

INEC Conference Centre Foyer
13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
12:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:15
Fatty Liver/NASH
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Michael Trauner, Medical University of Vienna, Austria

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipokines, Mitochondrial Function and Fatty Liver

Catherine Postic, Institut Cochin, France
The Transcription Factor ChREBP and Hepatic Steatosis

Anil K. Agarwal, University of Texas Southwestern Medical Center, USA
Lipodystrophy and Hepatic Steatosis Due to Agpat2 Deficiency

Jared Rutter, University of Utah, USA
Short Talk: Signal Integration to Control Lipid Metabolism

Patricia C. Chui, Beth Israel Deaconess Medical Center, USA
Short Talk: Fibroblast Growth Factor 21 Plays a Critical and Protective Role in the Development of Steatohepatitis

19:15—20:15
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 1

INEC Conference Centre Foyer

TUESDAY, MAY 17

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Lipid-Induced Insulin Resistance
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Carsten Schmitz-Peiffer, Garvan Institute of Medical Research, Australia

Deborah M. Muoio, Duke University Medical Center, USA
Incomplete Lipid Oxidation and Insulin Resistance in Skeletal Muscle

Mark A. Febbraio, Garvan Institute of Medical Research, Australia
Regulation of Lipid-Induced Inflammation in Macrophages: Role in Obesity-Induced Insulin Resistance

Karen Reue, University of California, Los Angeles, USA
Lipin-1 and Protection from Muscle Lipotoxicity

Scott A. Summers, Duke-NUS Graduate Medical School, Singapore
A Role for Ceramides at the Nexus of Inflammation and Metabolic Diseases

Caleb Lord, University of Texas Southwestern Medical Center, USA
Short Talk: CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action

10:20—10:40
Coffee Break

INEC Confenece Centre Foyer
12:00—13:00
Poster Setup

INEC Conference Centre Foyer
13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
12:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:15
Lipid Hydrolysis and Oxidation
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Richard Lehner, University of Alberta, Canada

Rudolf Zechner, University of Graz, Austria
ATGL (PNPLA2) and Adiponutrin (PNPLA3): Closely Related Enzymes with Different Functions

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy and Lipid Catabolism

Richard Roy, McGill University, Canada
Genes that Affect Lipid Storage and Hydrolysis in Response to Energy/Environmental Stress

Thomas Scherer, Mount Sinai School of Medicine, USA
Short Talk: Short–Term Overfeeding Disrupts Brain Insulin Control of Liver and Adipose Tissue Function

Takashi Osumi, University of Hyogo, Japan
Short Talk: Physiological Significance of Micro-Lipid Droplets and Intracellular Traffic of Lipid Droplet-Associated Proteins in Adipocyte Lipolysis

19:15—20:15
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 2

INEC Conference Centre Foyer

WEDNESDAY, MAY 18

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Physiology of Lipid Droplet Formation
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* David B. Savage, University of Cambridge, UK

Dawn L. Brasaemle, Rutgers University, USA
Perilipin Control of Lipolysis

Robert G. Parton, University of Queensland, Australia
Cav-/- Mice are Resistant to Diet-induced Obesity

Michael P. Czech, University of Massachusetts Medical School, USA
Lipid Droplet Proteins in the Control of Peripheral Insulin Sensitivity

Ronald P. Kühnlein, Max-Planck-Institut für Biophysikalische Chemie, Germany
Lipid Droplet Proteins and Fat Storage in Flies

Sheetal Gandotra, University of Cambridge, UK
Short Talk: Human Perilipin Deficiency is Associated with Partial Lipodystrophy, Hypertriglyceridaemia and Insulin Resistant Diabetes

10:20—10:40
Coffee Break

INEC Confenece Centre Foyer
12:00—13:00
Poster Setup

INEC Conference Centre Foyer
13:00—22:00
Poster Viewing

INEC Conference Centre Foyer
12:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:30
Lipid Synthesis and Storage
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Jacqueline M. Stephens, Louisiana State University, USA

Ira J. Goldberg, New York University, USA
Introduction to the Journal of Lipid Research Lectureship

Robert V. Farese Jr., Harvard School of Public Health, USA
Journal of Lipid Research Lecture: How Cells Fatten Up: Fat Synthesis and Lipid Droplets

Juleen R. Zierath, Karolinska Institutet, Sweden
Role of Diacylglycerol Kinase delta in Insulin Sensitivity and Energy

Morris J. Birnbaum, Pfizer Inc., USA
The Regulation of Hepatic Lipid Metabolism by Insulin

Ajay Chawla, University of California, San Francisco, USA
Short Talk: Macrophages and Brown Fat Metabolism

Joerg Heeren, University Medical Center Hamburg-Eppendorf, Germany
Short Talk: Activation of Brown Adipose Tissue is a Master Regulator of Systemic Triglyceride Metabolism

19:30—20:30
Social Hour with Lite Bites

INEC Conference Centre Foyer
19:30—22:00
Poster Session 3

INEC Conference Centre Foyer

THURSDAY, MAY 19

08:00—09:00
Breakfast

INEC Conference Centre Foyer
09:00—12:00
Cardiovascular Complications of Lipotoxicity
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Sander Kersten, Wageningen University, Netherlands

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Lipid-Induced Mitochondrial Dysfunction in the Heart

Ira J. Goldberg, New York University, USA
Lipotoxicity in the Heart

Jean E. Schaffer, Washington University School of Medicine, USA
Unexpected Regulators of Metabolic Stress

Gary D. Lopaschuk, University of Alberta, Canada
Contribution of Fatty Acid Oxidation to Lipotoxicity in the Heart

Ebru Erbay, Bilkent University, Turkey
Short Talk: Nutritional Modification of Lipotoxic Endoplasmic Reticulum Stress and Inflammation by a Bioactive Lipokine Prevents Atherosclerosis

10:20—10:40
Coffee Break

INEC Confenece Centre Foyer
12:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

INEC Conference Centre Foyer
17:00—19:00
Lipid Handling of Beta Cells
Meeting has ended...abstracts no longer viewable online.

INEC Main Auditorium
* Kyle Hoehn, University of Virginia, USA

Marc Prentki, , Canada
Glycerolipid/Fatty Acid Cycling and beta-Cell Signal Transduction in Health and Diabetes

Vincent Poitout, Montreal Diabetes Research Center, Canada
Glucolipodysfunction of the Pancreatic Beta Cell

Ernesto Bernal-Mizrachi, University of Miami Miller School of Medicine, USA
Nutrient Regulation of beta-Cell Mass

Trevor J. Biden, Garvan Institute of Medical Research, Australia
Short Talk: A Lipidomic Screen Links Ceramide with ER Stress in Pancreatic beta-Cell Lipotoxicity

19:00—20:00
Social Hour with Lite Bites

INEC Conference Centre Foyer
20:00—23:00
Entertainment

INEC Conference Centre Foyer

FRIDAY, MAY 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL108500-01




We gratefully acknowledge additional support for this conference from:

Avanti Polar Lipids, Inc. Fáilte Ireland
Science Foundation Ireland
Journal of Lipid Research

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