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This meeting took place in 2011



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Obesity (J2)


Organizer(s) Steven R. Smith and Jacqueline M. Stephens
January 12—17, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 17, 2010
Late Abstract Deadline: Oct 15, 2010
Scholarship Deadline: Sep 17, 2010
Early Registration Deadline: Nov 12, 2010

Sponsored by Takeda Pharmaceutical Company Limited


Summary of Meeting:
An obesity epidemic is sweeping across the Westernized world. More than ever, there is an acknowledgement that the regulation of body weight regulation is more complicated than ever imagined. The last decade has seen rapid progress in our understanding of how body weight is regulated; multiple organs are involved adding to the complexity. These exciting discoveries are leading us in new directions in therapeutics and helping us to better understand of mechanisms underlying the successes of obesity surgery. The goal of this meeting is to bring to light recent advances in the molecular and cellular aspects of these inter-related systems controlling body weight. It is becoming increasingly clear that there are multiple interlocking and redundant systems controlling energy intake, energy expenditure, substrate selection and ultimately body weight. This meeting will assemble international leaders from each of these thematic areas. The program highlights recent advances in the molecular etiology in the major peripheral organs that orchestrate energy balance: adipose tissue, the brain and the gut. Emphasis will be placed on the role of the gut in the regulation of energy metabolism, how the peripheral tissues signal to the brain, and adipose tissue as an orchestrator of metabolism. A major goal of the meeting is to provide a forum that encourages interactions between basic and translational scientists at all career levels to critically evaluate new developments and current controversies. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on “Diabetes”, which will share two Keynote Speakers and three joint plenary sessions with this meeting. The joint sessions will cover mitochondrial energetics, how adipose tissue causes insulin resistance and the epigenetic control of metabolism concluding with a workshop / panel discussion on mechanisms of insulin resistance in obesity.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JANUARY 12

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Deborah M. Muoio, Duke University Medical Center, USA

* Steven R. Smith, Florida Hospital, USA

Stephen O'Rahilly, University of Cambridge, UK
Common Metabolic Disorders: Lessons from Human Genetics

David A. Sinclair, Harvard Medical School, USA
Genetic and Pharmacological Interventions to Treat Age-Related Diseases


THURSDAY, JANUARY 13

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
Mitochondrial Bioenergetics in Health and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* P. Darrell Neufer, East Carolina University, USA

Daniel P. Kelly, University of Pennsylvania, USA
Networks Controlling Muscle Mitochondrial Function

Mary-Ellen Harper, University of Ottawa, Canada
Mitochondrial Uncoupling: Energy Costs and ROS Control Benefits

Xianwen Yi, University of North Carolina, USA
Short Talk: Does Alpha-Lipoic Acid Retain Body Energy by Regulating Nitric Oxide and Reversing Mitochondrial Dysfunction?

Iain Scott, University of Pittsburgh, USA
Short Talk: A Prokaryote-Derived Mitochondrial Acetyltransferase Counteracts the Respiratory Effects of SIRT3

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Regulation of Adipogenesis and Energy Homeostasis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—12:00
NIH Sponsored Workshop: NIH Loan-Repayment Program (Joint)

Columbine Ballroom
Milton Hernandez, NIAID, National Institutes of Health, USA

11:15—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Hot Topics in Obesity Mechanisms

Quandry Peak
* Antonio J. Vidal-Puig, University of Cambridge, UK

Parth Patwari, Brigham and Women's Hospital, USA
The Alpha-Arrestin ARRDC3 Regulates Obesity in Mice and Humans

Shwetha Ramachandrappa, Cambridge University, UK
Single Minded 1 (SIM1) in Severe Early Onset Obesity

Peter K. Jackson, Stanford University, USA
Ciliopathies and Monogenic Obesity Disorders: Bardet-Biedl Syndrome (BBS) and Tubby Family Proteins Direct GPCR Traffic to the Primary Cilium

Clemence Blouet, University of Cambridge, UK
Nutrient Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice

Nicole Ehrhardt, Cedars-Sinai Medical Center, USA
Lmf1 Deficiency Causes Lipodystrophy

Rebecca E. Mercer, University of Alberta, Canada
Leptin Resistance in the Magel2-null Mouse Model of Prader-Willi Syndrome Precedes the Development of Obesity and is Associated with Increased Melanocortin Responsiveness

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
The Adipose-Brain Axis
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Karine Clément, INSER/Sorbonne universite, France

Randy J. Seeley, University of Michigan, USA
A Role for CNS PPARgamma in the Regulation of Energy Balance

Steven R. Smith, Florida Hospital, USA
Adipose Tissue Hypoxia in Obesity

17:00—19:00
Sirtuins, NAD Biology and Circadian Control of Metabolism
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* David A. Sinclair, Harvard Medical School, USA

Shin-ichiro Imai, Washington University School of Medicine, USA
SIRT1 and NAMPT-Mediated NAD Biosynthesis: Systemic Control of Metabolism and Aging in Mammals

Matthew D. Hirschey, Duke University, USA
Short Talk: SIRT3 Deficiency Accelerates the Development of the Metabolic Syndrome

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Epigenomic Regulation of Circadian Rhythm and Metabolism by Nuclear Receptors

Ueli Schibler, University of Geneva, Switzerland
The Synchronization of Peripheral Circadian Clocks

19:00—20:00
Social Hour with Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

FRIDAY, JANUARY 14

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
Gut Nutrient Sensing in the Regulation of Body Weight
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Randy J. Seeley, University of Michigan, USA

Elaine Holmes, Imperial College London, UK
The Gut Microbiome in Obesity

Philip Schauer, Cleveland Clinic Foundation, USA
Obesity Surgery: State-of-the-Art?

Robert F. Margolskee, Monell Chemical Senses Center, USA
Taste Receptors in Gut Regulate Endocrine Function

Vincent Aguirre, University of Texas, Southwestern Medical Center, USA
Short Talk: MC4Rs in Autonomic Neurons of the Brainstem Mediate Effects of Gastric Bypass on Diabetes but not Energy Expenditure or Body Weight

Hua V. Lin, Eli Lilly & Co., USA
Short Talk: Short-Chain Fatty Acids Regulate Incretin Secretion & Energy Metabolism and Protect Against Diet Induced Obesity

08:00—11:15
Insulin Resistance, Mitochondrial Dysfunction and Lipotoxicity in Humans
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Mary-Elizabeth Patti, Joslin Diabetes Center, USA

Christoph Handschin, University of Basel, Switzerland
Coordination of Anabolic and Catabolic Pathways in Skeletal Muscle by PGC1Ą

K. Sreekumaran Nair, Mayo Clinic, USA
Muscle Mitochondrial Dysfunction and Muscle Insulin Resistance in Diabetes

P. Darrell Neufer, East Carolina University, USA
Mitochondrial Bioenergetics, Redox Imbalance and Insulin Resistance

Elizabeth J. Parks, University of Missouri, USA
Alterations in Fatty Acid Partitioning during Feeding

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Novel Actions of Insulin in Control of Brain and Body Metabolism

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
13:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
How Adipose Tissue Causes Insulin Resistance (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
Anthony W. Ferrante, Columbia University, USA
Immunology and Metabolism in Adipose Tissue

Karine Clément, INSER/Sorbonne universite, France
Human Adipose Tissue Remodelling and Metabolic Complications

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipose Tissue Factors: Modulators of Insulin Sensitivity, Inflammation and Apoptosis

Timo D. Müller, Institute for Diabetes and Obesity, Germany
Short Talk: Sequestosome 1 (P62) Deficiency in Adipose Tissue Leads to Obesity and Glucose Intolerance by Impairing BAT Function in Mice

19:00—20:00
Social Hour with Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

SATURDAY, JANUARY 15

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:15
Adipose Tissue Architecture
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Jacqueline M. Stephens, Louisiana State University, USA

James G. Granneman, Wayne State University School of Medicine, USA
Imaging the Organization and Trafficking of Lipolytic Proteins

David E. James, University of Sydney, Australia
Mapping the Insulin Signalling Network in Adipocytes

Matthew J. Brady, University of Chicago, USA
Stranger in a Strange Land: Glycogen Metabolism in Adipose Tissue

Justin J. Rochford, University of Aberdeen, UK
Short Talk: The Human Lipodystrophy Protein BSCL2/Seipin Binds the Key Lipogenic Enzyme Lipin 1

Xunshan Ding, University of Texas Southwestern Medical Center, USA
Short Talk: beta-Klotho in Adipose Tissue Is Required for the Anti-Obesity Effect of Fibroblast Growth Factor 21 in Mice

08:00—11:00
Mechanisms of Metabolic Failure
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

David A. Bernlohr, University of Minnesota, USA
Oxidative Stress and Adipocyte Mitochondrial Dysfunction

Seung-Hoi Koo, Sungkyunkwan University, South Korea
Regulation of Hepatic Glucose Output by TORC2/CRTC2

Roberta Leonardi, St. Jude Children's Hospital, USA
Short Talk: Gluconeogenesis is Controlled by CoA Levels and PanK1

Reuben J. Shaw, The Salk Institute for Biological Studies, USA
Class IIa Histone Deacetylases are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

Deborah M. Muoio, Duke University Medical Center, USA
Mitochondrial Stress and Metabolic Dysfunction in Skeletal Muscle

Romain Barres, NNF Center for Basic Metabolic Research, Denmark
Short Talk: Exercise Induces Transient DNA Hypomethylation in Human Skeletal Muscle

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom
13:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Hot Topics in Obesity Therapy

Quandary Peak
Chenguang Ouyang, Indiana University, USA
Discovery of Peptides Balanced In Glucagon Receptor Antagonism and GLP-1 Agonism. A Search for the Molecular Basis in the Inversion of Activity at Homologous Receptors

* Thomas E. Hughes, Zafgen, Inc, USA
Methionine Aminopeptidase 2 (MetAP2) Inhibition Improves Metabolic Control and Causes Loss of Excess Body Weight in Mice, Dogs, and Humans

Shirly Pinto, Merck & Co., Inc., USA
Pharmacological Inhibition of Diacylglycerol Acyltransferase 1 Leads to Weight Loss and Prolongation of GLP-1 Release

* Claire M. Steppan, Pfizer, USA
Pharmacological Inhibition to Examine the Role of DGAT1 in Dietary Lipid Absorption in Mice and Man

Jennifer L. Lachey, Ember Therapeutics, USA
Characterization of the Thermogenic Program Induced in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB

Yong Qi, Sirtris, A GlaxoSmithKline Company, USA
Activation of Sirtuin1 (SIRT1) by the Novel Small Molecule SRT2104 Protects against Diet-Induced Obesity and Improves Glucose Homeostasis by Increasing Fatty Acid and Carbohydrate Oxidation in Mice

Andrea R. Nawrocki, Janssen Pharmaceutical, USA
The Metabotropic Glutamate Receptor mGluR8 Modulates Energy Metabolism and Amphetamine Induced Hyperactivity in Mice

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Enhanced Metabolic Benefits of Single Peptides with Nuclear Hormone Pharmacology

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
JAK-STAT Signaling in Obesity
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Stephen R. Farmer, Boston University School of Medicine, USA

Jacqueline M. Stephens, Louisiana State University, USA
STATs in Adipocyte Development and Function

Martin G. Myers, Jr., University of Michigan, USA
Molecular and Neural Mechanisms of Leptin Action

Allison W. Xu, University of California, San Francisco, USA
Regulation of Energy Balance and Hepatic Lipid Metabolism by Central Stat3 and PI3K Signaling

Tamara L. Allen, Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Modified IC7, a Designer gp130 Receptor Ligand that improves obesity, Improves High Fat Diet-Induced Insulin Resistance

17:00—19:00
Lipid Trafficking and Signaling
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* David A. Bernlohr, University of Minnesota, USA

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
ACSL1 and Lipid Partitioning

Rudolf Zechner, University of Graz, Austria
Lipolysis and the Lipid Droplet Signaling to the PPARs/PGC1á

Hei Sook Sul, University of California, Berkeley, USA
Regulation of Adipocyte Lipolysis

Saswata Talukdar, Merck, USA
Short Talk: GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects

19:00—20:00
Social Hour with Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

SUNDAY, JANUARY 16

07:00—08:00
Breakfast

Colorado Rockies Ballroom
07:30—08:00
Poster Setup

Colorado Rockies Ballroom
08:00—17:00
Poster Viewing

Colorado Rockies Ballroom
08:00—11:15
New Players in the Old Game - Adipogenesis
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Matthew J. Brady, University of Chicago, USA

Antonio J. Vidal-Puig, University of Cambridge, UK
Allostatic Load and Over-Load in the Context of PPARgamma Ablation

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Comparative Epigenomic Analysis of Human and Murine Adipogenesis

Stephen R. Farmer, Boston University School of Medicine, USA
Repression of Gene Programs during the Conversion of Mesenchymal Stem Cells to Adipocytes

Merlin Crossley, University of New South Wales, Australia
The Transcriptional Regulators: KLF3, C-Terminal Binding Protein Co-Repressor (Ctbp), and Friend of Gata in the Regulation of Adipogenesis

Kai Ge, NIDDK, National Institutes of Health, USA
Short Talk: Epigenetic Regulation of Adipogenesis by Histone Methylation

Juliane G. Bogner-Strauss, Graz University of Technology, Austria
Short Talk: Adipocyte Plasma Membrane-Associated Protein (APMAP): A Transmembrane Protein Required for Adipogenesis and Targeted by PPARgamma

08:00—11:15
Insulin Signaling, Action and Secretion
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Elizabeth J. Parks, University of Missouri, USA

Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise-Induced Enhancement of Insulin Action

Jorge L. Ruas, Karolinska Institutet, Sweden
Short Talk: Hypertrophic Effects of the PGC1a4 Isoform on Skeletal Muscle

* Christopher B. Newgard, Duke University Medical Center, USA
In Search of Targets for Restoring beta-Cell Function in Diabetes

Angela M. Hall, Washington University School of Medicine, USA
Short Talk: Suppression of Monoacylglycerol Acyltransferase-1 (Mogat1) Improves Glucose Tolerance in Diet-Induced Obese Mice

Andrew Butler, St. Louis University, USA
Short Talk: Adropin-Deficient Mice Exhibit a Pre-Diabetic Condition and Increased Metabolic Distress with Diet-Induced Obesity

Vijay K. Yechoor, University of Pittsburgh, USA
Short Talk: Bmal1 and beta-Cell Clock are Required for Mitochondrial Function and GSIS

Markus Stoffel, ETH Zürich, Switzerland
MicroRNAs and Regulation of Glucose and Lipid Metabolism

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—12:15
Lunch

12:00—14:30
Poster Session 4

Colorado Rockies Ballroom
14:30—16:30
Workshop: Mechanisms of Insulin Resistance: Recent Advances and Current Controversies (Joint)

Columbine Ballroom
* Christopher B. Newgard, Duke University Medical Center, USA

Deborah M. Muoio, Duke University Medical Center, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA

Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA

P. Darrell Neufer, East Carolina University, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Epigenetic Control of Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Steven R. Smith, Florida Hospital, USA

Mary-Elizabeth Patti, Joslin Diabetes Center, USA
Developmental Origins of Obesity and Type 2 Diabetes

Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA
Programming Metabolic Disease: Effects of Maternal Obesity and Diet

Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease

19:00—20:00
Social Hour with Lite Bites

Colorado Rockies Ballroom
20:00—23:00
Entertainment

Colorado Rockies Ballroom

MONDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-02




We gratefully acknowledge additional support for this conference from:

AdipoGen International Takeda Pharmaceutical Company Limited

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676