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This meeting took place in 2011



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Metabolic Responses to Extreme Conditions (D4)


Organizer(s) John R. Speakman, Jan Nedergaard and Sandra L. Martin
April 1—5, 2011
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Dec 1, 2010
Late Abstract Deadline: Jan 31, 2011
Scholarship Deadline: Dec 1, 2010
Early Registration Deadline: Feb 18, 2011

Supported by the Directors’ Fund

Summary of Meeting:
Animals face a number of extreme stressors to which they must respond. Generally researchers have focused on responses to particular stressful situations, and hence research communities have grown up around these specialized areas. The aim of this meeting is to draw together several of these research communities in a unique interdisciplinary meeting. The aim of bringing such communities together is to allow researchers to explore parallel responses of animals to rather different ‘extremes’. We anticipate this will allow the emergence of common themes and provide an opportunity for researchers to interact with others outside their main areas of interest.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 1

15:00—19:30
Registration

Lower Atrium
18:15—19:15
Refreshments

Lower Atrium
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson
Yvon Le Maho, Université de Strasbourg and Centre National de la Recherche Scientifique, France
How Antarctic Penguins Cope with Extreme Conditions and How They May Fail Due to Climate Change


SATURDAY, APRIL 2

07:00—08:00
Breakfast

Madison
08:00—11:15
Caloric Restriction and Starvation
Meeting has ended...abstracts no longer viewable online.
Responses of animals and humans to profound restriction over chronic time scales.

Jefferson
* Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA

Susan B. Racette, Washington University School of Medicine, USA
Human Responses to CR: The "CALERIE" Project

Carlos M. Isales, Georgia Regents University, USA
Bone Turnover Under Conditions of Caloric Restriction or Selective Nutrient Deprivation

John Speakman, Institute of Genetics and Developmental Biology, CAS, China
The Effects of Graded Caloric Restriction on Metabolomic Profiles in Mice

Deborah M. Kristan, California State University San Marcos, USA
Calorie Restriction Produces a Strong Immune Response but does not Protect against Parasite Infection

Kevork Hagopian, University of California, Davis, USA
Short Talk: The Influence of Calorie Restriction on H2O2 Production in Mitochondrial Subpopulations from Mouse Liver

Jennifer H. Stern, University of Arizona Cancer Center, USA
Short Talk: The Impact of Calorie Restriction on Whole Body Energy Metabolism in p66Shc(-/-) Mice

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Madison
13:00—22:00
Poster Viewing

Madison
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Over-Nutrition
Meeting has ended...abstracts no longer viewable online.
Responses of animals and humans to prolonged excess calorie intake.

Jefferson
* Susan B. Racette, Washington University School of Medicine, USA

Jan Nedergaard, Stockholm University, Sweden
Are we Protected Against Overnutrition?

Hongwei Gao, Brigham and Women's Hospital and Harvard Medical School, USA
Obesity, Bone Metabolism and Inflammation

Donald A. McClain, University of Utah School of Medicine, USA
Short Talk: Metabolic Consequences of Genetic Adaptation to High Altitude in Tibetans

Banumathi K. Cole, Eastern Virginia Medical School, USA
Short Talk: Nutritional Status Regulates Expression of the Pro-Inflammatory 12/15-Lipoxygenase in Mouse Adipose Tissue

19:00—20:00
Social Hour with Lite Bites

Madison
19:30—22:00
Poster Session 1

Madison

SUNDAY, APRIL 3

07:00—08:00
Breakfast

Madison
08:00—11:15
Hibernation
Meeting has ended...abstracts no longer viewable online.
Responses of animals to winter that include prolonged torpor and/or body freezing.

Jefferson
* John Speakman, Institute of Genetics and Developmental Biology, CAS, China

Sandra L. Martin, University of Colorado Denver, Anschutz Medical Campus, USA
Poly-Omics of Mammalian Hibernation

Seth W. Donahue, Michigan Technological University, USA
Effects of Hibernation on Bone

Kelly L. Drew, University of Alaska, Fairbanks, USA
Seasonal Sensitization in Purinergic Signaling Permits Adenosine A1 Receptor Activation to Induce Torpor in Hibernating Arctic Ground Squirrels

Matthew T. Andrews, University of Minnesota, USA
Molecules Regulating Hibernation in Mammals

Hannah V. Carey, University of Wisconsin-Madison, USA
Short Talk: Immune Function in Mammalian Hibernation

Marshall Hampton, University of Minnesota, Duluth, USA
Short Talk: Deep Sequencing the Transcriptome of the 13-Lined Ground Squirrel: An Emerging Model Organism for Mammalian Hibernation

09:20—09:40
Coffee Break

Lower Atrium
13:00—22:00
Poster Viewing

Madison
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Molecular Mediators of Extreme Metabolic States
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Jan Nedergaard, Stockholm University, Sweden

Thomas S. Scanlan, Oregon Health & Science University, USA
3-Iodothyronamine: A Novel Bioactive Metabolite of Thyroid Hormone

Steven J. Swoap, Williams College, USA
AMP vs. Adenosine as a Mediator of Fasting Induced Torpor

Mark B. Roth, Fred Hutchinson Cancer Research Center, USA
Physiologic Response to Hydrogen Sulfide

Kevin J. Phillips, Methodist Hospital Research Institute, USA
Short Talk: The Thyroid Hormone Analogue GC-1 Restores Cold Tolerance in Obese (ob/ob) Mice by Rescuing Defects in Adaptive Thermogenesis

19:00—20:00
Social Hour with Lite Bites

Madison
19:30—22:00
Poster Session 2

Madison

MONDAY, APRIL 4

07:00—08:00
Breakfast

Madison
08:00—11:15
Space
Meeting has ended...abstracts no longer viewable online.
Responses to space flight and microgravity simulation.

Jefferson
* Seth W. Donahue, Michigan Technological University, USA

Michael J. Pecaut, Loma Linda University, USA
Impact of the Spaceflight Environment on the Immune System

Maria-Teresa Giardi, National Council of Research-CNR, Italy
Radiation Pressure on D1 Protein Evolution: Space Research and in silico Studies on Chlamydomonas reinhardtii

Adrian LeBlanc, Universities Space Research Association, USA
The Effects of Microgravity on Bone

Marco V. Narici, Manchester Metropolitan University, UK
Muscle Loss in Space

Tulasi R. Jinka, University of Alaska Fairbanks, USA
Short Talk: Inhibition of NMDA Type Glutamate Receptors Induces Arousal from Torpor in Hibernating Arctic Ground Squirrels

Scott T. Cooper, University of Wisconsin, La Crosse, USA
Short Talk: Effects of Hibernation on Hemostasis and Fibrinolysis in 13-Lined Ground Squirrels Why Blood Clotting in Hibernators is Cool

09:20—09:40
Coffee Break

Lower Atrium
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Hypoxia
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Kelly L. Drew, University of Alaska, Fairbanks, USA

Vincent Pialoux, Université Claude Bernard Lyon 1, France
Hypoxia and Oxidative Stress in Humans: From Physiology to Pathology

Robert S. Mazzeo, University of Colorado, USA
Altitude and Immune Function

Zachary A. Cheviron, University of Nebraska, USA
Ecological Genomics of High-Altitude Adaptation

Dana L. Miller, University of Washington, USA
Short Talk: Hydrogen Sulfide Protects Against Hypoxia in C. elegans

19:00—20:00
Social Hour with Lite Bites

Madison
20:00—23:00
Entertainment

Madison

TUESDAY, APRIL 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-02




We gratefully acknowledge additional support for this conference from:

Seahorse Bioscience, Inc.

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Phone:+1 970-262-2690

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