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This meeting took place in 2011



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DNA Replication and Recombination (C2)


Organizer(s) Peter M. Burgers, Lorraine S. Symington and Johannes Walter
February 27—March 4, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 27, 2010
Late Abstract Deadline: Nov 30, 2010
Scholarship Deadline: Oct 27, 2010
Early Registration Deadline: Dec 29, 2010

Supported by the Directors’ Fund

Summary of Meeting:
As the pathways that govern DNA replication and DNA recombination are better defined, there is exciting progress in our understanding of the basic mechanisms of these processes. There is also growing evidence that replication and recombination are intimately connected in order to resolve problems arising during DNA replication, and to define outcomes with respect to chromosome integrity. This meeting will integrate mechanistic insights from biochemical studies with cellular pathways that control DNA replication initiation and progression, DNA recombination, and responses to DNA damage. Specific plenary sessions will focus on DNA replication mechanisms in prokaryotes and eukaryotes. Recombination sessions will present progress in our understanding of the mechanisms underlying mitotic recombination, and on recombination-based responses to replication stress and DNA damage. Sessions will also address cell cycle checkpoint and chromatin structural responses to DNA damage. The plenary sessions will be conducted by invited speakers and speakers selected from submitted abstracts. In addition, four related workshops will be conducted, with short talks selected from submitted abstracts.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 27

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
Stephen C. Kowalczykowski, University of California, Davis, USA
Mechanics and Visualization of Recombinational DNA Repair


MONDAY, FEBRUARY 28

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Replication Fidelity and Mutagenesis
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Thomas A. Kunkel, NIEHS, National Institutes of Health, USA
Generating and Correcting Leading- and Lagging-Strand DNA Replication Errors

Peggy Hsieh, NIDDK, National Institutes of Health, USA
DNA Mismatch Excision Repair and Damage Signaling

Erik Johansson, Umeå University, Sweden
Short Talk: Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of Pol epsilon

Karen M. Vasquez, University of Texas, Austin, USA
DNA Structure and Mutagenesis

Susan T. Lovett, Brandeis University, USA
A Template-Switch Mechanism for Muational Hotspots

Andrei Chabes, Umeå University, Sweden
Short Talk: Mechanisms of Mutagenesis in vivo Due to Imbalanced dNTP Pools

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Nucleic Acid Enzymes

Longs/Grays Peak
Roxana Georgescu, Rockefeller University, USA
Filling the Gaps … at the Replication Fork

Christopher D. Downey, University of Colorado, Boulder, USA
Chaperoning of a Replicative Polymerase by its Clamp Loader Plays an Integral Role in Initiation Complex Formation

Aimee H. Marceau, University of Wisconsin-Madison, USA
Structural Identification of the E. coli SSB Binding Site on the Chi/Psi Subassembly of the Clamp-Loader Complex

* Sergey Korolev, St. Louis University Medical School, USA
RecOR Alter Conformation of SSB-Bound ssDNA

Jeehae Park, University of Illinois at Urbana Champaign, USA
Reeling in DNA One Nucleotide at a Time: Repetitive Looping Coupled with PcrA Translocation Dismantles RecA Filaments

Richard U. Rymer, University of California Berkeley, USA
The Structural Basis for Nucleotide Binding by Bacterial Primase

Susan E. Tsutakawa, Lawrence Berkeley National Laboratory, USA
Recognition of 5’ Flaps by Flap Endonuclease, hFEN1

Lorena S. Beese, Duke University Medical Center, USA
Human Exonuclease I Complexes with DNA: Implications for the Nucleolytic Step in DNA Repair

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Homologous Recombination Mechanisms
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Wolf-Dietrich Heyer, University of California, Davis, USA
Formation and Disassembly of the Rad51-ssDNA Filament is Controlled by a Balance of the Rad51 Paralogs Rad55-Rad57 and the Anti-Recombinase Srs2

Lorraine S. Symington, Columbia University, USA
The Mus81-Mms4 and Yen1 Nucleases Promote Reciprocal Exchange during Mitotic Recombination

Cees Dekker, Delft University of Technology, Netherlands
Single Molecule Studies of Recombinase Proteins

Ilya Finkelstein, University of Texas at Austin, USA
Short Talk: Single-Molecule Imaging Reveals Mechanisms of how RecBCD Strips DNA-Bound Obstacles

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, MARCH 1

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Replication Origins and Replisome Assembly
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* John F.X. Diffley, Francis Crick Institute, UK
Early Events in Eukaryotic DNA Replication

Johannes C. Walter, Harvard Medical School, USA
Mechanism of the MCM2-7 DNA Helicase

Stephen P. Bell, Massachusetts Institute of Technology, USA
Short Talk: S. Cerevisiae Origin-Dependent Replication Initiation in vitro: Insights into Kinase Function and Polymerase Loading

Michael Botchan, University of California, Berkeley, USA
Regulation and Activation of the MCM Helicase

Bruce W. Stillman, Cold Spring Harbor Laboratory, USA
Multiple Activities For The Origin Recognition Complex (ORC) During The Chromosome Duplication And Segregation Cycle

Jean J. Gautier, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Regulation of DNA Replication by Myc

Andrew Jackson, University of Edinburgh, UK
Short Talk:

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: DNA Replication Mechanisms

Longs/Grays Peak
* Anja Groth, University of Copenhagen, Denmark
New Histone Supply Controls Replication Fork Speed in Human Cells

Giuseppe Lia, Centre National de la Recherche Scientifique, France
Probing Lagging-Strand Synthesis in Real Time. An in vivo Single Bacteria Study

Houra Merrikh, University of Washington, USA
Co-Directional Conflicts between Replication and Transcription at rRNA Genes Lead to Replication Fork Stalling and Restart in vivo

Nick Rhind, University of Massachusetts Medical School, USA
Replication Timing is Regulated by the Number of MCMs Loaded at Origins

Christian Speck, MRC-CSC London, UK
Stepwise Assembly of a Double-Hexameric MCM2-7 Complex during Licensing of Eukaryotic DNA Replication

Philipp Kaldis, Institute of Molecular and Cell Biology, Singapore
Cdk1 is Not Required for S Phase Progression but is Essential for Repression of DNA Re-Replication

Paulina Hannele Wanrooij, University of Gothenburg, Sweden
G-Quadruplex RNA Structures Stimulate Transcription Termination and Priming of Mitochondrial DNA Replication

Nicholas E. Dixon, University of Wollongong, Australia
A Structural Model of the E. coli Pol III Replicase Complex in the Polymerization Mode

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Telomeres and Mitochondria
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Titia de Lange, Rockefeller University, USA
How Telomeres Solve the End-Protection Problem

Maria A. Falkenberg, Göteborgs University, Sweden
Mechanisms of Initiation of DNA Replication in Human Mitochondria

Bruce Demple, Stony Brook University Medical School, USA
Oxidative DNA Damage and Mitochondrial DNA Repair in Cellular Maintenance

Lisa Hang, Weill Cornell / Memorial Sloan-Kettering Cancer Center, USA
Short Talk: SUMO's Influence at the Ends of Chromosomes

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, MARCH 2

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Replication Fork Structure
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Stephen D. Bell, Indiana University, USA
Mechanisms of Archaeal DNA Replication

Michael E. O'Donnell, Rockefeller University, USA
The E. coli Replisome and Use of Clamps to Bypass Replication Barriers

Hiroyuki Araki, National Institute of Genetics, Japan
Short Talk: Essential Function of Pol Epsilon at the Initiation Step of Chromosomal DNA Replication in Budding Yeast

James M. Berger, Johns Hopkins University School of Medicine, USA
Molecular Mechanisms for Initiating DNA Replication

Antoine M. van Oijen, University of Wollongong, Australia
Single-Molecule Studies of the Replisome

Brian A. Kelch, University of California Berkeley, USA
Short Talk: Crystal Structures Provide Snapshots of the Clamp Loading Mechanism

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: DNA Recombination Mechanisms

Longs/Grays Peak
* Anna Malkova, University of Iowa, USA
Break-Induced Replication Is Highly Mutagenic

Angela J. Gruber, University of Wisconsin-Madison, USA
Role of Escherichia coli RecA in Activation of DNA Polymerase V

Gurushankar Chandramouly, Beth Israel Deaconess Medical Center, USA
A BRCA1/CtIP-Independent Long Tract Gene Conversion Pathway of Homologous Recombination

Kevin Brick, NIDDK, National Institutes of Health, USA
Genome-Wide Analysis Reveals Novel Molecular Features of Mouse Recombination Hotspots

Ravindra Amunugama, Harvard Medical School, USA
RAD51 Turnover is Regulated by the ATP Cap during Homologous Recombinational Repair

Thomas Wechsler, Stanford School of Medicine, USA
Alternative Pathways of Holliday-Junction Resolution

Barnabas Szakal, Istituto FIRC di Oncologia Molecolare, Italy
Alternate Pathways Promoting the Resolution of Template Switch Derivatives throughout Cell Cycle

Sandeep Burma, University of Texas Southwestern Medical Center, USA
DNA Resection by Exo1 Dictates Critical DNA Repair and Damage Signaling Decisions in Response to DNA Double-Strand Breaks

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Recombination and DNA Repair
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* James E. Haber, Brandeis University, USA
Control of Gene Conversion and Break-Induced Replication

Akira Shinohara, Osaka University, Japan
The Psy3-Csm2-Shu1-Shu2 (PCSS) Complex, a New Rad51 Mediator, in Homologous Recombination

Catherine H. Freudenreich, Tufts University, USA
Trinucleotide Repeat Instability: Links to Replication and Recombination

Katharina Schlacher, MD Anderson Cancer Center, USA
Short Talk: Homologous Recombination Independent Role For BRCA2 In Blocking Stalled Replication Fork Degradation By MRE11

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 3

Quandary Peak

THURSDAY, MARCH 3

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Alterations in DNA and Chromatin
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Patrick M. Sung, Yale University, USA
Mechanism and Regulation of the Helicase-Driven Path of DNA End Resection in Saccharomyces cerevisiae

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Variation on the Theme of Chromatin Assembly

Michael M. Cox, University of Wisconsin-Madison, USA
Short Talk: Oligonucleotide-Directed DNA Cleavage with a Novel RecA-Dependent Nuclease

Taekjip Ha, University of Illinois at Urbana Champaign, USA
Single Molecule Fluorescence-Force Analysis of Protein Dynamics on Single Stranded DNA

Ian D. Hickson, University of Copenhagen, Denmark
Roles of BLM in Recombination and Replication

Mara G. Prentiss, Harvard University, USA
Short Talk: Mechanical Stress is a Stringency Factor for RecA-Mediated Homology Searching

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 4: DNA Damage Response Mechanisms

Longs/Grays Peak
* Francesca Storici, Georgia Institute of Technology, USA
Resolution of RNA/DNA Mispairs Results from Interplay between Mismatch Repair and RNase H Functions

David Thomas Long, Medical University of South Carolina, USA
Homology-Directed DNA Interstrand Cross-Link Repair in S Phase

Arnab Ray Chaudhuri, National Institutes of Health, USA
Replication Fork Regression Precedes Double Strand Break Formation Upon Topoisomerase I Inhibition

Mitch McVey, Tufts University, USA
The Bloom Syndrome Helicase Prevents Spontaneous Genome Rearrangements and Tumorigenesis during Aging in Drosophila

Grant W. Brown, University of Toronto, Canada
Genomic Instability Results in an Unscheduled Expansion of dNTP Pools

Vincent Dion, University of Lausanne, Switzerland
Live Imaging of Chromatin Mobility during DNA Repair

M. Todd Washington, University of Iowa, USA
Crystal Structures of Ubiquitin-Modified and SUMO-Modified PCNA

Kirill S. Lobachev, Georgia Institute of Technology, USA
The Role of Structure-Specific Nucleases and Helicases in Cell Cycle Regulated Palindrome Fragility in Yeast

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
DNA Damage Response
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Helle D. Ulrich, Institute of Molecular Biology, Germany
Timing and Spacing of Ubiquitin-Dependent DNA Damage Bypass

Peter M. Burgers, Washington University School of Medicine, USA
Metal Binding Clusters in Eukaryotic B-Family DNA Polymerases Mediate Subunit Interactions and Replication Processivity

Lee Zou, Harvard Medical School, USA
New Insights into the Mechanisms of ATR Activation in Human Cells

Anindya Dutta, University of Virginia, USA
Short Talk: The Effect of the Intra-S-Phase Checkpoint on Origins of Replication in Human Cells

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

FRIDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676