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This meeting took place in 2011



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Mechanism and Biology of Silencing (C7)


Organizer(s) Elisa Izaurralde, Victor Ambros and V. Narry Kim
March 20—25, 2011
Portola Hotel & Spa • Monterey, California USA
Abstract Deadline: Nov 18, 2010
Late Abstract Deadline: Dec 21, 2010
Scholarship Deadline: Nov 18, 2010
Early Registration Deadline: Jan 20, 2011

Sponsored by Alnylam Pharmaceuticals, Inc.

Summary of Meeting:
Mechanisms of gene regulation mediated by small RNAs, including microRNAs, siRNAs and piRNAs, play critical roles in processes central to the growth and metabolism of eukaryotic cells and to the development and homeostasis of tissues and organs in humans. Genetic, molecular and biochemical research into RNA silencing, employing model organisms and/or human cells and tissues, continues to reveal new insights and understanding of processes fundamental to human development and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 20

15:00—19:30
Registration

De Anza Foyer
18:15—19:15
Refreshments

De Anza Foyer
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Introductory Remarks

* V. Narry Kim, Seoul National University, South Korea

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structural Insights into Mechanisms of RNA Silencing

* Victor R. Ambros, University of Massachusetts, USA

Eric N. Olson, University of Texas Southwestern Medical Center, USA
MicroRNA Control of Cardiovascular Disease


MONDAY, MARCH 21

07:00—08:00
Breakfast

De Anza 1-3
08:00—11:30
Evolution and Conservation of Silencing Mechanisms
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Rachel Green, Johns Hopkins University School of Medicine, USA

David C. Baulcombe, University of Cambridge, UK
RNA Silencing in Arabidopsis and Tomato

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
RNA Silencing in Mammals and Yeast

Eric C. Lai, Sloan-Kettering Institute, USA
miRNA Biogenesis and Function in Drosophila

Kathleen Collins, University of California, Berkeley, USA
RNA Silencing in Tetrahymena

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Post-Transcriptional Gene Regulation by Small RNAs and RNA Binding Proteins

09:20—09:40
Coffee Break

De Anza Foyer
11:30—13:00
Poster Setup

De Anza 1-3
13:00—22:00
Poster Viewing

De Anza 1-3
11:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:00
miRNAs Biogenesis and Target Identification
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Thomas F. Duchaine, McGill University, Canada

V. Narry Kim, Seoul National University, South Korea
Posttranscriptional Regulation of MicroRNA

Eric A. Miska, University of Cambridge, UK
EMBO Young Investigator Lecture: miRNAs & piRNAs C. elegans

Brian D. Brown, Mount Sinai School of Medicine, USA
Short Talk: Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells

Ian MacRae, The Scripps Research Institute, USA
Short Talk: Target RNAs Promote Release of Guide RNAs from Human Ago2

Filipp Frank, McGill University, Canada
Short Talk: Structural Analysis of 5’-mRNA-Cap Interactions with the Human AGO2 MID Domain

19:00—20:00
Social Hour with Lite Bites

De Anza 1-3
19:30—22:00
Poster Session 1

De Anza 1-3

TUESDAY, MARCH 22

07:00—08:00
Breakfast

De Anza 1-3
08:00—11:15
Mechanisms of miRNA Mediated Gene-Silencing
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* David P. Bartel, HHMI, MIT and Whitehead Institute, USA

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Structural & Mechanistic Insights into Silencing Pathways

Thomas F. Duchaine, McGill University, Canada
Cooperative and Synergistic Interactions between miRNA-Binding Sites Potentiate Deadenylation by the miRNA Machinery

Yukihide Tomari, University of Tokyo, Japan
How are piRNAs Made? A Classical Biochemical Approach

Benjamin A. Hurschler, FMI, Switzerland
Short Talk: The GW182 Proteins AIN-1 and AIN-2 Act Mechanistically Distinct in miRNA-Mediated Gene Silencing in C. elegans

Corinna Speth, University of Tübingen, Germany
Short Talk: A Core Component of the Ribosome Functions in miRNA Mediated Gene Regulation in Arabidopsis thaliana

Anastasios Vourekas, University of Pennsylvania, USA
Short Talk: Target RNA Repertoire of Piwi and Vasa Proteins in the Mouse Male Germline

Brenda L. Bass, University of Utah, USA
Short Talk: What is the Function of Dicer’s Helicase Domain?

09:20—09:40
Coffee Break

De Anza Foyer
11:15—13:00
Poster Setup

De Anza 1-3
13:00—22:00
Poster Viewing

De Anza 1-3
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:15
Transcriptional Gene Silencing
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Heterochromatin and RNA Quality Control Factors Cooperate to Trigger RNAi and Suppress Antisense RNA

Nicholas J. Proudfoot, University of Oxford, UK
Convergent Gene Transcription and Gene Silencing

Rachel Green, Johns Hopkins University School of Medicine, USA
Argonaute Protein Function & miRNA Mediated Silencing

Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
EMBO Young Investigator Short Talk: RNAi-Mediated Co-Transcriptional Gene Silencing (CTGS)

Thomas Schalch, University of Geneva, Switzerland
Short Talk: Coupling RNAi to Heterochromatin

19:15—20:15
Social Hour with Lite Bites

De Anza 1-3
19:30—22:00
Poster Session 2

De Anza 1-3

WEDNESDAY, MARCH 23

07:00—08:00
Breakfast

De Anza 1-3
08:00—11:15
piRNAs and Endo-siRNAs Biogenesis and Function
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Antonio J. Giraldez, Yale University School of Medicine, USA

Kuniaki Saito, Keio University School of Medicine, Japan
piRNA Pathways in Insects

Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
Genetic Approaches to Dissect the piRNA Pathway in Drosophila

Toshie Kai, Temasek Life Sciences Laboratory, Singapore
Nuage: A Potential Site for Processing of Germline piRNA

Vasilii V. Vagin, Cold Spring Harbor Laboratory, USA
Short Talk: Genetic Screen for New Primary piRNA Components in Flies

René F. Ketting, Institute for Molecular Biology, Germany
EMBO Young Investigator Short Talk: Functional Analysis of Tdrd1 in the Zebrafish Germline

P. Jeremy Wang, University of Pennsylvania, USA
Short Talk: Mouse MOV10L1 is Essential for Primary Processing of piRNAs

Chi Zhang, Massachusetts General Hospital, USA
Short Talk: RDE-10 and RDE-11 form a Novel Protein Complex Essential for Efficient RNAi in C. elegans

09:20—09:40
Coffee Break

De Anza Foyer
11:15—13:00
Poster Setup

De Anza 1-3
13:00—22:00
Poster Viewing

De Anza 1-3
11:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 1

Steinbeck Forum
* Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Peter W. Atkinson, University of California, Riverside, USA
Characterization of the piRNA and Endo-siRNA Pathway in the Mosquito, Aedes aegypti - an Insect with a Large and Diverse Transposable Element Load

Alexander S. Raikhel, University of California Riverside, USA
miR-275 is Indispensable for Blood Digestion and Egg Development in the Mosquito Aedes aegypti

David W. Salzman, Yale University, USA
DNA Damage-Induces a Novel Mechanism for the Regulation of MicroRNA Activity

Gabriel D. Bossé, Laval University Cancer Research Centre, Canada
A New Regulator of the microRNAs Level in C. elegans

Taiowa A. Montgomery, Massachusetts General Hospital, USA
Mechanisms and Genetic Requirements of Endogenous siRNA Pathways in C. elegans

Germano Cecere, Columbia University, USA
A Conserved Motif Affecting Nucleosome Occupancy is Required for 21U-RNA Production in C. elegans

Kirk B. Burkhart, University of Wisconsin, USA
A Novel Chromatin Associated Protein is Required for Nuclear RNAi and Germ Cell Immortality

Qinghua Liu, University of Texas Southwestern Medical Center, USA
Structure of C3PO and Mechanism of Human RISC Activation

16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:00
Late Breaking Topics
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Kathleen Collins, University of California, Berkeley, USA

Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
A 'Novel' GW-Motif Protein Binds Argonaute and Promotes Assembly of RNA Silencing Effector Complexes

Martine Simonelig, Insitut de Génétique Humaine, France
Maternal mRNA Regulation by the piRNA Pathway in Drosophila

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Kirsten A. Hagstrom, University of Massachusetts Medical School, USA
Short Talk: Condensin is Required for RNAi-Mediated Transcriptional Gene Silencing Downstream of siRNA Production in C. elegans

19:00—20:00
Social Hour with Lite Bites

De Anza 1-3
19:30—22:00
Poster Session 3

De Anza 1-3

THURSDAY, MARCH 24

07:00—08:00
Breakfast

De Anza 1-2
08:00—11:15
miRNAs in Development and Disease
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Nicholas J. Proudfoot, University of Oxford, UK

Kenneth S. Kosik, University of California, Santa Barbara, USA
miRNAs and the Diversification of Cellular Phenotypes

Victor R. Ambros, University of Massachusetts, USA
MicroRNA Pathways in C. elegans

Tariq M. Rana, University of California, San Diego, USA
Small RNA-Mediated Regulation of iPS Cell Reprogramming

Antonio J. Giraldez, Yale University School of Medicine, USA
miRNAs in Vertebrate Development: Mechanism & Function

Maria-Carla Saleh, Institut Pasteur, France
RNAi-mediated Antiviral Immunity in Insects

Oliver Bischof, Institut Pasteur, France
Short Talk: Senescence is an Endogenous Trigger for microRNA-Directed Transcriptional Gene Silencing in Human Cells

Karen Bulock, RXi Pharmaceuticals, USA
Short Talk: Development of an sd-rxRNATM Based Therapy for Treatment of Fibrosis: Preclinical Development

09:20—09:40
Coffee Break

De Anza Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 2

Steinbeck Forum
* Eric C. Lai, Sloan-Kettering Institute, USA

Hailing Jin, University of California, Riverside, USA
Arabidopsis Argonaute 2 Regulates Innate Immunity via miRNA393b*

Kenji S. Nakahara, Hokkaido University, Japan
Counterdefense against Viral RNAi Suppressors in Tobacco

Maxim V.C. Greenberg, University of California, Los Angeles, USA
Chromatin Effectors and RNA-Directed DNA Methylation in Arabidopsis

Jianbin Wang, University of Colorado School of Medicine, USA
Small RNAs from the Germline and Embryos of Ascaris Reveal their Conservation, Divergence, and Surprising Early Expression in Nematodes

Davide De Pietri Tonelli, Fondazione Istituto Italiano Di Tecnologia, Italy
MicroRNA-9 Controls the Migration of Cortical Neurons in Developing Mouse Neocortex

Stephen M. Eacker, Johns Hopkins School of Medicine, USA
Sensory Experience Regulates Neuronal microRNA Expression by Disrupting Precursor Processing

Eva H. Gottwein, Northwestern University, USA
microRNA Targetome Analysis of Primary Effusion Lymphoma Cell Lines Using PAR-CLIP

16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:15
Novel Classes of Non-Coding RNAs
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* V. Narry Kim, Seoul National University, South Korea

Geir Skogerbø, Chinese Academy of Sciences, China
Interactions between MicroRNAs and Long Noncoding RNAs

Yi Liu, University of Texas Southwestern Medical Center, USA
Diverse Small RNA Production Pathways in Fungi

Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Eukaryotic Transcriptomes: Complex, Multifunctional, Compartimentalized & Elegant

Charles E. Rogler, Albert Einstein College of Medicine, USA
Short Talk: Long non-Coding RNAs Associated with Molecular Machines are Major Targets of Argonaute-Ribonucleoprotein Complexes

Sibum Sung, University of Texas at Austin, USA
Short Talk: Vernalization-Mediated Epigenetic Silencing by a Long Intronic Noncoding RNA

* V. Narry Kim, Seoul National University, South Korea
Concluding Remarks

19:15—20:15
Social Hour with Lite Bites

De Anza 1-3
20:00—23:00
Entertainment

De Anza 1-3

FRIDAY, MARCH 25

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD069083-01




We gratefully acknowledge additional support for this conference from:

Alnylam Pharmaceuticals, Inc. Found Animals' Michelson Prize & Grants in Reproductive Biology
Integrated DNA Technologies
 

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