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This meeting took place in 2011



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Adult Neurogenesis (A5)


Organizer(s) Jenny Hsieh, Fred H. Gage, Alejandro Fabian Schinder and Pierre-Marie Lledo
January 9—14, 2011
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 16, 2010
Late Abstract Deadline: Oct 13, 2010
Scholarship Deadline: Sep 16, 2010
Early Registration Deadline: Nov 10, 2010

Sponsored by Abbott Laboratories

Summary of Meeting:
The ability to generate new neurons in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus provides the adult mammalian brain an important level of plasticity for maintaining cellular homeostasis under physiological conditions, and potentially underlies an injury response under pathological contexts. Yet a full understanding of the neural stem cell niche, basic molecular mechanisms that ultimately dictate the fate of neural stem/progenitor cells, and intrinsic properties that guide the functional integration of newborn neurons in the existing circuitry is still in its infancy. The goal of this Keystone symposium is, by presenting novel mechanistic insights into the regulation and functional implications of adult neurogenesis, both the speakers and audience will gain further understanding, initiate extensive discussion, and promote scientific collaboration regarding the control of self-renewal, survival, and fate specification of neural stem cells in the adult mammalian brain.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 9

15:00—19:30
Registration

Chamisa Lobby
18:15—19:15
Refreshments

Chamisa Ballroom 2
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jenny Hsieh, University of Texas Southwestern Medical Center, USA

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Adult Neurogenesis: Significant Answers and Significant Questions


MONDAY, JANUARY 10

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Neural Stem Cells, Niches and Fate Decision
Meeting has ended...abstracts no longer viewable online.
Self-renewal and neuronal fate determination are the earliest steps of adult neurogenesis. Neurogenic niches provide instructional signals that control proliferation and differentiation of the stem cell pool to ensure that neurogenesis continues throughout life. Current knowledge regarding the mechanisms that control the undifferentiated state and fate determination of adult neural stem cells in the hippocampus and olfactory bulb will be discussed.

Chamisa Ballroom 1
* Arturo Alvarez-Buylla, University of California, San Francisco, USA
Specification and Plasticity of Adult Neural Stem Cells

Jonas Frisén, Karolinska Institutet, Sweden
Stem Cells and Neurogenesis in the Adult Central Nervous System

D. Chichung Lie, University of Erlangen, Germany
Stem Cell Maintenance and Differentiation in the Adult Hippocampus

Grigori Enikolopov, Cold Spring Harbor Laboratory, USA
Division-Coupled Differentiation of Adult Neural Stem Cells

Michael A. Bonaguidi, University of Southern California, USA
Short Talk: Clonal Analysis of Radial Glia-Like Cells Reveals Self-Renewal and Multipotential Properties in the Adult Hippocampus

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Regulation
Meeting has ended...abstracts no longer viewable online.
This topic covers the molecular pathways important for adult neurogenesis, including transcriptional and epigenetic regulatory factors, and signaling mechanisms, during physiological and pathological contexts.

Chamisa Ballroom 1
* Jenny Hsieh, University of Texas Southwestern Medical Center, USA
Master Transcriptional and Epigenetic Regulators in Adult Neurogenesis

Yanhong Shi, Beckman Research Institute of City of Hope, USA
Short Talk: Nuclear Receptor TLX and microRNA Regulatory Cascade in Neural Stem Cells

Chun-Li Zhang, University of Texas Southwestern Medical Center, USA
Short Talk: Molecular Mechanism Controlling Adult Neural Stem Cell Activation

Angélique Bordey, Yale University School of Medicine, USA
Activity-Neurogenesis Coupling: How do Subventricular Cells Respond to Neuronal Activity?

Gerd Kempermann, German Center for Neurodegenerative Diseases, Germany
Physical Activity and Enriched Environments: Regulation of Adult Neurogenesis and Functional Consequences

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, JANUARY 11

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Functional Integration
Meeting has ended...abstracts no longer viewable online.
Newborn neuron in the adult hippocampus and olfactory bulb differentiate and integrate within the existing neuronal circuitry. This topic will address how the impact of adult-born neurons in the hippocampal and olfactory bulb network is dictated by the extent that newborn neurons participate as part of the network and how their intrinsic properties compare to those of existing neurons generated during development.

Chamisa Ballroom 1
* Alejandro F. Schinder, Fundación Instituto Leloir, Argentina
From Neural Stem Cells to Functional Neurons in the Adult Hippocampus

Hongjun Song, University of Pennsylvania, USA
Activity-Dependent Regulation of Adult Hippocampal Neurogenesis

Adi Mizrahi, Hebrew University of Jerusalem, Israel
Imaging Development and Plasticity of Adult-Born Neurons in the Mouse Olfactory Bulb

Amelia J. Eisch, University of Texas Southwestern Medical Center, USA
Cell-Intrinsic Regulation of Adult Neurogenesis and Behavior

Shaoyu Ge, SUNY Stony Brook, USA
Short Talk: Developing Adult-born Neuronal Migration and Output Neural Circuitry Formation

Erno Vreugdenhil, LACDR/University Leiden, Netherlands
Short Talk: Knockdown of the Glucocorticoid Receptor Accelerates Functional Integration of Newborn Neurons in the Adult Hippocampus

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Functional Significance Olfactory Bulb
Meeting has ended...abstracts no longer viewable online.
Newly formed neurons incorporate into functional networks of the olfactory bulb suggesting important roles for adult neurogenesis in the olfactory sensory organ. This topic presents the current evidence regarding the functional roles that newborn granule neurons play in the olfactory bulb.

Chamisa Ballroom 1
* Pierre-Marie Lledo, Pasteur Institute, France
The Flexible Olfactory Brain

Ryoichiro Kageyama, Kyoto University, Japan
Functional Significance of Neurogenesis in the Olfactory Bulb

Carlos Lois, University of Massachusetts, USA
Integration of Neurons into Functional Brain Circuits

Wolfgang Kelsch, University Heidelberg, Germany
Short Talk: N2B-Containing NMDA-Receptors are Required for Functional Integration of Adult-Born Neurons into the Excitatory Olfactory Bulb Circuit

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, JANUARY 12

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Functional Significance Hippocampus
Meeting has ended...abstracts no longer viewable online.
The discovery of adult neurogenesis has fundamentally changed our idea of how our brain can adapt to physiological and environmental stimuli. This topic describes our current understanding of neurogenesis, along with other forms of brain plasticity, which may help us fully understand learning and memory function in the hippocampus.

Chamisa Ballroom 1
* D. Nora Abrous, INSERM U862, France
Spatial Learning: A Sculptor of Neo-Networks

Paul W. Frankland, University of Toronto, Canada
Adult Neurogenesis and Hippocampal Memory

Martin Wojtowicz, University of Toronto, Canada
Adult Neurogenesis and Memory Interference

Janet Wiles, University of Queensland, Australia
Computational Influence of Adult Neurogenesis on Memory

Amanda Sierra, Achucarro Basque Center for Neuroscience, Spain
Short Talk: Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

09:20—09:40
Coffee Break

Chamisa Lobby
11:00
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Comparative Neurogenesis
Meeting has ended...abstracts no longer viewable online.
To fully understand adult neurogenesis, it is important to consider the functional and adaptive significance, and evaluate the comparative nature of neurogenesis across diverse species and in natural populations. This topic will cover recent data regarding adult neurogenesis in songbirds, zebrafish, and in natural populations of mammals.

Chamisa Ballroom 1
* Steven Goldman, University of Rochester Medical Center, USA
Lessons from the Canary: Induced Neurogenesis for the Treatment of Neurologic Disease

Hans-Peter Lipp, University of Zürich, Switzerland
Adult Neurogenesis in Natural Populations of Mammals: Is there a Common Function?

Günther K.H. Zupanc, Northeastern University, USA
Adult Neurogenesis in Teleost Fish

Tatyana Beverly Dias, University of Edinburgh, UK
Short Talk: Spatial and Temporal Expression of Delta-Notch Signaling during Spinal Cord Regeneration in Adult Zebrafish

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, JANUARY 13

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Neurological Disorders and Repair
Meeting has ended...abstracts no longer viewable online.
Recent studies have shown that a wide variety of stimuli, including seizures, stress, stroke, and chronic antidepressant treatment, can profoundly affect adult neurogenesis. Moreover, neurodegenerative disease states are often associated with diminished neurogenesis. This topic will address whether failure of a normal reparative process, i.e., adult neurogenesis, contributes to the development of disease, and/or whether enhancing neurogenesis could be used as a therapeutic strategy in some of these disorders.

Chamisa Ballroom 1
* Olle Lindvall, University of Lund, Sweden
Adult Neurogenesis After Stroke

Frank M. La Ferla, University of California, Irvine, USA
Neural Stem Cells in Alzheimer’s Disease

Jürgen Winkler, University Hospital Erlangen, Germany
Adult Neurogenesis in Parkinson’s Disease

Rene Hen, Columbia University, USA
Hippocampal Neurogenesis: Impact on Mood and Cognition

Amar Sahay, Harvard Medical School, USA
Short Talk: Impact of Increasing Adult Hippocampal Neurogenesis on Cognition and Mood

Mi-Hyeon Jang, Mayo Clinic, USA
Short Talk: Secreted Frizzled-Related Protein 3 (sFRP3) Regulates Activity-Dependent Adult Hippocampal Neurogenesis and Antidepressant Actions

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Future of Neural Repair
Meeting has ended...abstracts no longer viewable online.
Neural stem cell differentiation and reprogramming has many potential therapeutic applications in the treatment of neurological disease. This topic will cover new strategies and technologies in translating neural stem/progenitor cells towards the clinic.

Chamisa Ballroom 1
* Pierre Vanderhaeghen, University of Brussels, Belgium
From Pluripotent Stem Cells to Cortical Circuits: Mechanisms and Implications for Neural Diseases

Carrolee Barlow, Brain Cells Inc., USA
Profiling Neurogenic Compounds to Treat CNS Disorders

Anders Haegerstrand, NeuroNova AB, Sweden
Identification and Clinical Application of Neural Progenitor Cell Proliferating Drugs

Sebastian Jessberger, University of Zürich, Switzerland
Short Talk: Metabolic Control of Neural Stem Cells

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

FRIDAY, JANUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS071629-01




We gratefully acknowledge additional support for this conference from:

Abbott Laboratories Cell Signaling Technology, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Brain Cells Inc.


NeuroNova AB


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676