Sagebrush Inn & Suites Floorplan

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This meeting took place in 2011


Here are the related meetings in 2018:
Advances in Neurodegenerative Disease Research and Therapy (Z3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Neurodegenerative Diseases: The Molecular and Cellular Basis for Neurodegeneration (F2)


Organizer(s) Ted M. Dawson, Virginia M.-Y. Lee and Stephen M. Strittmatter
February 21—26, 2011
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 20, 2010
Late Abstract Deadline: Nov 22, 2010
Scholarship Deadline: Oct 20, 2010
Early Registration Deadline: Dec 21, 2010

Sponsored by AstraZeneca Pharmaceuticals, L.P., Genentech, Inc. and Isis Pharmaceuticals, Inc.

Summary of Meeting:
Neurodegenerative diseases are chronic age-dependent progressive disorders that are substantial and growing health problems, which exert a tremendous toll on the patient, family, health system and society as a whole. Accordingly, there is an urgent need to identify therapies that slow and/or reverse the progression of these disorders. Research in neurodegenerative disorders is providing tremendous advances in the molecular understanding of these disorders. New insights in cell biology, biochemistry, genomics and proteomics into these illnesses are leading to mechanism based therapies and new tools and biomarkers to study disease progression and therapeutic efficacy. In this meeting an emphasis will be placed on understanding new molecular and common mechanisms of disease in Alzheimer’s disease (AD), Parkinson’s disease (PD), triple repeat diseases, frontotemporal lobar dementia and others.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, FEBRUARY 21

15:00—19:30
Registration

Chamisa Lobby
18:15—19:15
Refreshments

Chamisa Ballroom 2
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Thomas C. Südhof, Stanford School of Medicine, USA
Neurotransmitter Release and Neurodegeneration: The SNARE Connection


TUESDAY, FEBRUARY 22

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Cognitive and Emotional Deficits in Neurodegenerative Disorders: From Molecules to Phenotypes
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Holly Soares, Bristol-Myers Squibb, USA

Akira Sawa, Johns Hopkins University, USA
Molecular Link of Huntingtin-PDE4-DISC1: Potential Impact on Emotional and Cognitive Deficits in Huntington’s Disease

Dezhi Liao, University of Minnesota, USA
Tau Mislocalization in Neurodegenerative Diseases

Tracy L. Young-Pearse, Brigham and Women's Hospital and Harvard Medical School, USA
Bidirectional Signal Crosstalk between APP and DISC1 in Neurodevelopment and Aging

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Epigenetics in Cognitive Performance and Alzheimer’s Disease

Sreeganga S. Chandra, Yale University, USA
Short Talk: alphabetagamma-Synuclein Triple Knockout Mice Reveal Age-Dependent Neuronal Dysfunction

Amantha Thathiah, Catholic University of Leuven, Belgium
Short Talk: GPR3 Modulation the gamma-secretase Complex and Abeta Generation in Alzheimer's Disease

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Monitoring Neurodegenerative Disease Progression
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lennart Mucke, Gladstone Institutes and University of California, San Francisco, USA

David M. Holtzman, Washington University, USA
CSF Biomarkers: Correlations with Imaging and Value in Diagnosis and Prognosis

John Q. Trojanowski, University of Pennsylvania, USA
Progress in Alzheimer's Disease (AD) Biomarkers from the AD Neuroimaging Initiative (ADNI)

Holly Soares, Bristol-Myers Squibb, USA
Utility of Multiplexed Panels as Screening Tools for Early Detection of Neurodegeneration

Erik Musiek, Washington University, USA
Short Talk: Direct Comparison of ASL-MRI and FDG-PET in the Diagnosis of Alzheimer’s Disease

Joel C. Watts, University of California San Francisco, USA
Short Talk: Bioluminescence Imaging of Abeta Deposition in Transgenic Mouse Models of Alzheimer’s Disease

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 23

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Anatomical and Functional Basis of Dementia and Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Li-Huei Tsai, Massachusetts Institute of Technology, USA

Lennart Mucke, Gladstone Institutes and University of California, San Francisco, USA
Key Roles of Tyrosine Kinases and Tau in Abeta-Induced Neuronal Dysfunction

Brian J. Bacskai, Massachusetts General Hospital, USA
Imaging Structural and Functional Alterations in AD Models

Lynn A. Raymond, University of British Columbia, Canada
The Role of Excitotoxicity in Neurodegeneration in Huntington Disease

James Surmeier, Northwestern University, USA
Phenotypic Determinants of Neuronal Vulnerability in Parkinson's Disease

Joshua M. Shulman, Baylor College of Medicine, USA
Short Talk: Enhancing Power for Gene Discovery in Alzheimer’s Disease: Intermediate Phenotypes and Functional Validation in Drosophila

Todd J. Cohen, University of Pennsylvania, USA
Short Talk: Tau Acetylation Inhibits Function and Promotes Tau Pathology in Alzheimer’s Disease

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Mitochondria and Protein Quality Control Dysfunction in Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Ted M. Dawson, Johns Hopkins University School of Medicine, USA

Ming Guo, University of California, Los Angeles, USA
Mitochondrial Fission and Fusion in Parkinson's Disease

Richard J. Youle, NINDS, National Institutes of Health, USA
Damage Control - How the Pink1/Parkin Pathway can Regulate Removal of Impaired Mitochondria by Autophagy

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy in Neurodegeneration

Jin-Mi Heo, Harvard Medical School, USA
Short Talk: Identification of Vms1 as a Novel Mitochondrial Stress Responsive Protein Involved in Mitochondrial Protein Quality Control

Thomas M. Durcan, Montreal Neurological Institute, Canada
Short Talk: The Machado-Joseph Disease Associated Mutant Form of Ataxin-3 Promotes Clearance of Parkin Through the Autophagy Pathway

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

THURSDAY, FEBRUARY 24

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Neurodegeneration Due to RNA and DNA Regulatory Proteins
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Stephen M. Strittmatter, Yale University, USA

Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
TDP-43 Proteinopathies

Don W. Cleveland, University of California, San Diego, USA
Rethinking ALS: What's All the FUS?

Aaron D. Gitler, Stanford University School of Medicine, USA
Novel RNA Binding Proteins in ALS

Ted M. Dawson, Johns Hopkins University School of Medicine, USA
Parkin, Paris and PGC-1alpha: A Novel Neurodegenerative Pathway in Parkinson's Disease

Miriam E. Bucheli, Harvard University, Harvard Medical School, USA
Short Talk: A Combinatorial Approach to Identify Common Regulatory Targets for FUS/TLS, TDP-43 and SETX

Thomas L. Kukar, Emory University, USA
Short Talk: Somatic Brain Transgenic FUS Mice

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Bridging Biology to Therapeutics in Neurodegenerative Disorders
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* John Q. Trojanowski, University of Pennsylvania, USA

Per I. Arvidsson, AstraZeneca R&D, Sweden
Beyond Abeta Based Therapies: Developing Novel Modulators of Synaptic Transmission

Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Inhibitors of LRRK2 Kinase: Mechanism-Based Therapy for Parkinson's Disease

Anatoly Nikolaev, Genentech, USA
Short Talk: APP-Death Receptor Signaling Pathway as a Drug Target in Neurodegenerative Disease

Giovanna R. Mallucci, University of Leicester, UK
Short Talk: Mechanisms of Neurotoxicity in Prion Disease

Harald Neumann, University Bonn, Germany
Short Talk: Human Induced Pluripotent Stem Cell-Derived Microglia (iPSdM) as Tool to Study Neurodegenerative Diseases

Lindsay N. Hayes, Johns Hopkins University, USA
Short Talk: The Timing of Sonic Hedgehog and Gli1 Expression Segregates Midbrain Dopamine Neurons

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

FRIDAY, FEBRUARY 25

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Prion and Prion-Like Contributions to Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA

Lary C. Walker, Emory University, USA
Prion-Like Seeding of Cerebral Abeta Deposition in Transgenic Models of Alzheimer-Type Proteopathy

Markus Tolnay, Basel University Hospital, Switzerland
Transmission and Spreading of Tauopathy in Transgenic Mouse Brain

Eliezer Masliah, University of California, San Diego, USA
Prion-Like Protein Propagation in Synucleonopathies: Prospects for Therapeutical Interventions

Stephen M. Strittmatter, Yale University, USA
Abeta Oligomer Initiate Alzheimer’s Disease Process by Binding to Neuronal Surface

Jeppe Pedersen Falsig, IRBM Promidis, Italy
Short Talk: Microglia - A Crucial Regulator of Prion Turnover and Neurotoxicity

Jorg Tatzelt, Ruhr University Bochum, Germany
Short Talk: The Cellular Prion Protein Mediates Neurotoxic Signaling of beta-Sheet-Rich Conformers Independent of Prion Replication

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—18:45
Inducible Pluripotent Stem Cells to Model and Treat Neurodegenerative Disorders
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Valina L. Dawson, Johns Hopkins University School of Medicine, USA

Guo-li Ming, University of Pennsylvania, USA
Modeling Neurodegenerative and Neurodevelopment Disorders with iPS Cells

Lorenz Studer, Memorial Sloan Kettering Cancer Center, USA
Modeling Pathogenesis and Treatment of Familial Dysautonomic Using Patient-Specific iPSCs

18:45—19:45
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Leroy E. Hood, Institute for Systems Biology, USA
Systems Medicine and Emerging Technology: From Reactive to Proactive (P4) Medicine

20:00—21:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SATURDAY, FEBRUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 3R13NS073140-01S1




We gratefully acknowledge additional support for this conference from:

Alzheimer's Drug Discovery Foundation AstraZeneca Pharmaceuticals, L.P.

Genentech, Inc.
iPierian, Inc.
Isis Pharmaceuticals, Inc.
Genentech, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



AstraZeneca R&D


Genentech, Inc.


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Neural Cell News

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676