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This meeting took place in 2011



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Genetics, Immunology and Repair in Multiple Sclerosis (B8)


Organizer(s) Wendy B. Macklin, Gavin Giovannoni and Stephen L. Hauser
February 15—20, 2011
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 18, 2010
Late Abstract Deadline: Nov 19, 2010
Scholarship Deadline: Oct 18, 2010
Early Registration Deadline: Dec 15, 2010

Sponsored by National Multiple Sclerosis Society and Teva Pharmaceuticals

Summary of Meeting:
Although the specific etiology of Multiple Sclerosis (MS) remains unknown, important insights into the genetics and environmental triggers underlying the disease have been made. This conference will discuss advances in MS genetics, epigenetics and the interaction of genetics with the environment, particularly with vitamin D metabolism and Epstein Barr Virus. There will be a focus on the immunopathogenesis of MS, including pre-active MS lesions, mechanisms of lymphocyte activation, the B cell and trafficking of cells across the blood brain barrier. The application of new imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. The challenge of integrating emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science will he discussed. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 15

15:00—19:30
Registration

Chamisa Lobby
18:15—19:15
Refreshments

Chamisa Ballroom 2
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Stephen Sawcer, University of Cambridge, UK
Whole Genome Studies in MS: Past, Present and Future


WEDNESDAY, FEBRUARY 16

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Genetic Susceptibility in MS
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Stephen L. Hauser, University of California, San Francisco, USA

Trevor J. Kilpatrick, University of Melbourne, Australia
Approaches to Identifying and Studying Genes Relevant to Multiple Sclerosis

Lars Fugger, University of Oxford, UK
Humanized Animal Models for Mutiple Sclerosis

Linda Ottoboni, Harvard University, USA
Short Talk: Pathways Convergence of Transcriptomic Signatures from Multiple Sclerosis Susceptibility Alleles

Justin Spanier, University of Minnesota, USA
Short Talk: 1,25-Dihydroxyvitamin D3 Suppresses Fatal Progressive Experimental Autoimmune Encephalomyelitis in Interferon-gamma-Null Mice

Pierre-Antoine Gourraud, University of California, San Francisco, USA
Aggregation of Genetic Risk Variants in Multiple Sclerosis

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Epidemiology of MS
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK

Francesca Aloisi, Instituto Superior de Sanita, Italy
Epstein Barr Virus Infection in MS Pathogenesis

Ute C. Meier, ICMS London, UK
Short Talk: Innate Immune Responses is Innate Immune Activation as a Hallmark of the Active Multiple Sclerosis Lesion

Anne-Louise Ponsonby, Murdoch Children's Research Institute, Australia
The Hygiene Hypothesis and the Development of Multiple Sclerosis

Bruce Hollis, Medical University of South Carolina, USA
Achieving Adequate Vitamin D Status and its Role in Multiple Sclerosis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, FEBRUARY 17

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Updates on Current Therapeutics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Bibianna Bielekova, NIH, USA

Gavin Giovannoni, Barts and The London School of Medicine and Dentistry, UK
Emerging Therapies for Multiple Sclerosis

Alasdair Coles, University of Cambridge, UK
Autoimmunity - Good and Bad - After Alemtuzumab Treatment of Muliple Sclerosis

Kenneth L. Tyler, University of Colorado School of Medicine, USA
Association of PML with Immunomodulatory MS Therapeutics

Susan Goelz, , USA
JC Virus Pathobiology and PML in Multiple Sclerosis Patients

Sybil Rose Stacpoole, University of Cambridge, UK
Short Talk: Human Oligodendrocytes from Embyronic Stem Cells – A Valuable Tool and Potential Therapy for Multiple Sclerosis

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:30
Role of B Cells in MS
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Colleen E. Hayes, University of Wisconsin-Madison, USA

Stephen L. Hauser, University of California, San Francisco, USA
Multiple Sclerosis: Current B Cell Therapies in MS

Peter K. Gregersen, Feinstein Institute for Medical Research, USA
Linking Genotype to Phenotype: Examples from Human Autoimmunity

Kevin C. O'Connor, Yale School of Medicine, USA
B Cells and Antibodies in the MS CNS

Jeffrey Bennett, University of Colorado Denver, USA
The Targets of Cerebrospinal Fluid Oligoclonal Bands in Multiple Sclerosis

Emily Pierson, University of Washington, USA
Short Talk: B Cells are Important for the Expansion of T Cells in the CNS during the Induction of EAE

19:30—20:30
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, FEBRUARY 18

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Events at the Blood-Brain Barrier
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Raymond A. Sobel, Stanford University School of Medicine, USA

Richard Daneman, University of California, San Diego, USA
Cellular and Molecular Regulation of Blood-Brain Barrier Regulation during Health and Disease

Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
T Cell Migration into the CNS during Health and Disease: Different Molecular Keys Allow Access to Different CNS Compartments

Piet Stinissen, Hasselt University, Belgium
Short Talk: CX3CR1 Drives CD4+CD28null Cytotoxic T Cells into the Central Nervous System of Patients with MS

Ann M. Ranger, Biogen Idec, USA
Short Talk: The Level of CXCL13 Correlates with a B Cell and Plasma Cell Transcriptionl Signature in the Cerebrospinal Fluid of Secondary Progressive Multiple Sclerosis Patients

Stephen McQuaid, Queen's University Belfast, UK
Tight Junction Abnormalities at Blood Brain Barrier in Multiple Sclerosis

Paula Dore-Duffy, Wayne State University, USA
Microvascular Pericytes: A Source of Adult Stem Cells

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop: MS Research: Prospects for Funding and Training

Stephen L. Hauser, University of California, San Francisco, USA

Richard A. Rudick, Cleveland Clinic Foundation, USA

Henry McFarland, NINDS, National Institutes of Health, USA

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Imaging in MS Diagnosis and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Henry McFarland, NINDS, National Institutes of Health, USA

Sergio E. Baranzini, University of California, San Francisco, USA
Linking Voxel-Based Morphometry with Genetic Variation in MS

Elizabeth Fisher, Cleveland Clinic, USA
Short Talk: A Four-Year Longitudinal Study of Cortical Thickness in Multiple Sclerosis

Douglas Arnold, Montreal Neurological Hospital and Institute, Canada
Magnetization Transfer Ratio as a Marker of Demyelination and Remyelination in MS

Laura J. Balcer, University of Pennsylvania, USA
Optical Coherence Tomography as a Measure of Axonal and Neuronal Loss in MS

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, FEBRUARY 19

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Mechanisms of MS Progression
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Richard A. Rudick, Cleveland Clinic Foundation, USA

Amit Bar-Or, University of Pennsylvania, USA
Pediatric-Onset MS: A Window into the MS Spectrum

Selva Baltan, University of Washington, USA
Excitotoxicity and Mitochondrial Dysfunction Lead to Axonal Degeneration

Bruce D. Trapp, Cleveland Clinic Foundation, Lerner Research Institute, USA
Cortical Remyelination in Multiple Sclerosis: Environment, Not Age, Modulates Cell Replacement in Human Brain

David Baker, Blizard Institute, Queen Mary University of London, UK
Control of Spasticity using Central Nervous System-Excluded Cannabinoid Receptor Agonists

Nicole Schaeren-Wiemers, University Hospital Basel, Switzerland
Short Talk: Remyelinated Lesions Express a Distinct Pattern of Genes Involved in Oligodendrocyte Proliferation and Differentiation

Ranjan Dutta, Lerner Research Institute, Cleveland Clinic, USA
Short Talk: Loss of Myelin Leads to Alteration of a Neuronal MicroRNA in Multiple Sclerosis Hippocampus

09:20—09:40
Coffee Break

Chamisa Lobby
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Regulation of Remyelination
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Robyn S. Klein, Washington University School of Medicine, USA

Wendy B. Macklin, University of Colorado Denver, USA
Signaling Mechanisms Regulating CNS Myelination

V. Wee Yong, University of Calgary, Canada
Promoting Remyelination by Reducing an Inhibitory Microenvironment

Steve Fancy, University of California, San Francisco, USA
A Therapeutic Target for Repair in Human Newborn Brain Injury and Multiple Sclerosis

Danette Nicolay, University of Colorado Denver, USA
Short Talk: Promoting Remyelination of MS Lesions: Where do Fish Fit in?

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, FEBRUARY 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS073227-01




We gratefully acknowledge additional support for this conference from:

Biogen Idec Boehringer Ingelheim Pharmaceuticals, Inc.
National Multiple Sclerosis Society Teva Pharmaceuticals

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Biogen Idec


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676