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This meeting took place in 2011



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Pathogenesis of Influenza: Virus-Host Interactions (E3)


Organizer(s) Siamon Gordon, Malik Peiris and Kanta Subbarao
May 23—28, 2011
Sheraton Hong Kong Hotel & Towers • Kowloon, Hong Kong China
Abstract Deadline: Jan 21, 2011
Late Abstract Deadline: Feb 22, 2011
Scholarship Deadline: Jan 21, 2011
Early Registration Deadline: Mar 22, 2011

Organized in Collaboration with The University of Hong Kong as part of its Centenary Celebrations;
also made possible by an Area of Excellence in Influenza grant
funded by the University Grants Committee of Hong Kong

Summary of Meeting:
The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in “seasonal,” zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. The current symposium brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense, to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and ex vivo / in vitro human experimental models as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong would be particularly appropriate.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MAY 23

15:00—19:30
Registration

Ballroom A, Foyer
18:15—19:15
Refreshments

Ballroom A, Foyer
19:15—22:00
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Ballroom B,C
* Malik Peiris, University of Hong Kong, Hong Kong
Introduction

Sir John J. Skehel, MRC National Institute of Medical Research, UK
Structure Function of HA

Robert G. Webster, St. Jude Children's Research Hospital, USA
The Ecology of Influenza Viruses

Peter C. Doherty, University of Melbourne, Australia
T Cells


TUESDAY, MAY 24

08:00—09:00
Breakfast

Celestial Court
08:00—09:00
Poster Setup

Ballroom A
09:00—12:00
Virology
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Andrew S. Pekosz, Johns Hopkins University, USA

Ron A.M. Fouchier, Erasmus Medical Center Rotterdam, Netherlands
Viral Virulence

Yoshihiro Kawaoka, University of Wisconsin/University of Tokyo, USA
Influenza Pathogenesis

Yi Guan, Hong Kong University, China
The Emergence of the H1N1/2009 Pandemic Influenza virus

Nadia Naffakh, Institut Pasteur, France
Influenza Ribonucleoproteins - Host Cell Interactions

Jim-Tong Horng, Chang Gung University, Taiwan
Short Talk: Identification of BPR3P0128 as an Inhibitor against Cap Snatching Activity of Influenza Virus

10:20—10:40
Coffee Break

Ballroom A, Foyer
12:00—13:00
Lunch

Ballroom A, Tang Rooms
12:00—17:00
Poster Viewing

Ballroom A
12:00—14:30
Poster Session 1

Ballroom A
14:00—14:30
Coffee Available

Ballroom A, Foyer
14:30—17:00
Virus Receptors/Glycans/Structure
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Sir John J. Skehel, MRC National Institute of Medical Research, UK

John Nicholls, University of Hong Kong, China
Receptors in the Human Respiratory Tract - Making and Breaking the links

Ram Sasisekharan, Massachusetts Institute of Technology, USA
Glycans and HA

Ian A. Wilson, The Scripps Research Institute, USA
New Insights into Broad Neutralization of Influenza Virus and Implications for a Universal Flu Vaccine

Patrick C. Reading, University of Melbourne, Australia
Short Talk: Specific Sites of N-linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to C-Type Lectins of the Innate Immune System

Gillian M. Air, University of Oklahoma Health Sciences Center, USA
Binding and Cleavage of Sialylated Glycans by H3N2 and H1N1 Influenza Viruses


WEDNESDAY, MAY 25

08:00—09:00
Breakfast

Celestial Court
09:00—12:00
Human Disease, Lung Injury and Human-Cell Experimental Models
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Yoshihiro Kawaoka, University of Wisconsin/University of Tokyo, USA

Sherif R. Zaki, Centers for Disease Control and Prevention, USA
Influenza Pathogenesis in Humans: Revisited

Arthur Slutsky, University of Toronto, Canada
Lung Injury and ARDS

Paul G. Thomas, St. Jude Children's Research Hospital, USA
Short Talk: Elucidating Early Site-of-Infection Immune Responses to Influenza A in Young Children

Sagi Shapira, Broad Institute, USA
Host-Influenza Interactions

Malik Peiris, University of Hong Kong, Hong Kong
Human ex-vivo and in-vitro Experimental Models for Studying Influenza Pathogenesis

10:20—10:40
Coffee Break

Ballroom A, Foyer
12:00—13:00
Lunch

Ballroom A, Tang Rooms
13:00—14:30
Workshop 1: Pathogen-Host Interaction

Ballroom B-C
* Nadia Naffakh, Institut Pasteur, France

Marciela DeGrace, Harvard University, USA
Dissecting the Role of Trafficking Machinery in the Influenza a Life Cycle Reveals Novel Restriction Factors

Gregory A. Boivin, McGill University, Canada
Combining Clinical and Expression QTLs in the Context of Infection: New Insights into Susceptibility to Influenza

Michael C.W. Chan, University of Hong Kong, China
Impaired Alveolar Edema Fluid Clearance in Human Alveolar Epithelial Cells Injured by Severe Influenza A Virus Infection

Rafael A. Medina, Pontificia Universidad Catolica de Chile, Chile
Effects of Glycosylations in the Globular Head of the 2009 H1N1 Influenza Virus Hemagglutinin: Modulation of Virulence and Antigenicity

Iris K. Pang, Chinese University of Hong Kong, Hong Kong
Mechanism of IL-1- Dependent Protective Immunity Against Influenza Virus

14:00—14:30
Coffee Available

Ballroom A, Foyer
14:30—16:45
Experimental Models
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Adolfo García-Sastre, Mount Sinai School of Medicine, USA

Andrew S. Pekosz, Johns Hopkins University, USA
Influenza A Virus Infection of Primary, Differentiated Respiratory Epithelial Cell Cultures

Jacqueline M. Katz, Centers for Disease Control and Prevention, USA
Small Animal Models for the Study of Influenza Virus Pathogenesis

Kanta Subbarao, NIAID, National Institutes of Health, USA
Replication of Influenza Viruses in Non-Human Primates

16:45—17:00
European Research Activities on Influenza
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
Christian Desaintes, European Commission, Belgium
Short Talk: Research Activities Supported by the European Commission on Influenza


THURSDAY, MAY 26

08:00—09:00
Breakfast

Celestial Court
08:00—09:00
Poster Setup

Ballroom A
09:00—12:00
Immunity
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Jacqueline M. Katz, Centers for Disease Control and Prevention, USA

Gunther Hartmann, Universitätsklinikum Bonn, Germany
Mechanisms of RNA Recognition through RIG-I and TLR7

Hui-Ling Yen, University of Hong Kong, Hong Kong
Short Talk: Gene Constellation Determines the Transmissibility of the 2009 Pandemic H1N1 Influenza Viruses in a Ferret Model

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs and Viral Infection

Seema Lakdawala, NIAID, National Institutes of Health, USA
Short Talk: Aerosol Transmission of the Pandemic H1N1 Influenza Virus

Toshihiro Ito, Okayama University, Japan
Short Talk: The Critical Role of Notch Ligand Delta-like 1 in Influenza A Virus Infection

Ken J. Ishii, National Institute of Biomedical Innovation, Health and Nutrition, Japan
Endo- and Exogenous Adjuvant for Influenza Vaccination

10:20—10:40
Coffee Break

Ballroom A, Foyer
12:00—13:00
Lunch

Ballroom A, Tang Rooms
12:00—17:00
Poster Viewing

Ballroom A
12:00—14:30
Poster Session 2

Ballroom A
14:00—14:30
Coffee Available

Ballroom A, Foyer
14:30—17:00
Immunity, Systems Biology, Gender and Susceptibility
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Peter C. Doherty, University of Melbourne, Australia

Tao Dong, MRC Human Immunology Unit, University of Oxford, UK
Antigen Specific T Cells in Human Influenza A Virus Infection

Jack R. Bennink, NIAID, National Institutes of Health, USA
Antigenic Drift: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape

Thomas C. Friedrich, University of Wisconsin, USA
Short Talk: Cross-Reactive T Cells are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus Infection by Nonhuman Primates

Ronald N. Germain, NIAID, National Institutes of Health, USA
A Systems Approach to Influenza Infection and Vaccine Responses

Sabra L. Klein, Johns Hopkins University, USA
Sex Differences in Response to Influenza Virus Infection and Vaccination


FRIDAY, MAY 27

08:00—09:00
Breakfast

Celestial Court
09:00—12:00
Pathogenesis and Transmission
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Ron A.M. Fouchier, Erasmus Medical Center Rotterdam, Netherlands

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
In vivo Dynamics of Influenza Virus Infection

Connie Y.H. Leung, University of Hong Kong, Hong Kong
Short Talk: Toll-like Receptor (TLR)3 Signaling Contributes to Enhanced Disease Severity in H5N1 but not Pandemic H1N1 Infection in Mice

Christopher J. O'Donnell, NHLBI, National Institutes of Health, USA
Short Talk: Antibody Pressure by a Human Monoclonal Antibody (hMAb) Targeting the Sa Region of 2009 Pandemic H1N1 Virus Hemagglutinin can Drive the Development of a More Virulent Virus

Alexandra Godlee, Imperial College London, UK
Influenza-Induced Immunological Alterations in the Respiratory Tract

Daniel R. Perez, University of Maryland, USA
Challenges in Understanding Influenza Transmission

10:20—10:40
Coffee Break

Ballroom A, Foyer
12:00—13:00
Lunch

Ballroom A, Tang Rooms
13:00—14:30
Workshop 2: Modulation of Infection

Ballroom B-C
* Paul G. Thomas, St. Jude Children's Research Hospital, USA

Kobporn Boonnak, Mahidol University, Thailand
Treatment of Influenza Virus Infection with Viral Peptides Linked to Dendritic Cells

Huailiang Ma, Emory University, USA
Human Annexin A6 Interacts with the Influenza A Virus M2 Protein and Negatively Modulates Infection

Wenwei Tu, University of Hong Kong, China
Pamidronate Boosts gammadelta-T-Cell Immunity and Controls Influenza A Infection: A Novel Therapeutic Option for Influenza

Susanne Herold, University of Giessen Lung Center, Germany
Alveolar Epithelial Cells Shape Pulmonary Dendritic Cell Antiviral Responses in Severe Influenza Virus Pneumonia by Expression of GM-CSF

Michael Schotsaert, MSSM, USA
M2e-Based Universal Vaccine Protects against Influenza A Virus Challenge and Enhances Heterosubtypic Immunity during Subsequent Infections

14:00—14:30
Coffee Available

Ballroom A, Foyer
14:30—17:00
Interventions
Meeting has ended...abstracts no longer viewable online.

Ballroom B-C
* Kanta Subbarao, NIAID, National Institutes of Health, USA

Philip Dormitzer, Pfizer Vaccine Research and Development, USA
Advances in Vaccines Against Seasonal and Pandemic Influenza

YanChun Peng, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Short Talk: Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with NP and M1 Containing MVA Vaccine

Chi-Huey Wong, Academia Sinica, Taiwan
Toward the Design of Universal Glycoprotein Vaccines against Influenza and other Viral Diseases

Stephan Ludwig, University of Münster, Germany
Intracellular Signal Transduction and Influenza Virus Infection – Identifying Novel Targets for Antiviral Therapy

17:30—17:35
Depart hotel lobby and transfer to cruise

20:00—21:15
Dragon Pearl Cruise with dinner

21:00—21:15
Disembark Dragon Pearl Cruise and transfer back to hotel


SATURDAY, MAY 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI094917-01




We gratefully acknowledge additional support for this conference from:

Landes Bioscience

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