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This meeting took place in 2012



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The Role of Inflammation during Carcinogenesis (E2)


Organizer(s) Jeffrey W. Pollard and Laurence Egan
May 20—25, 2012
Royal Dublin Society • Dublin, Ireland
Abstract Deadline: Jan 20, 2012
Late Abstract Deadline: Feb 21, 2012
Scholarship Deadline: Jan 20, 2012
Early Registration Deadline: Mar 20, 2012

Organized in Collaboration with Science Foundation Ireland. Sponsored by Hoffmann-La Roche, Inc. and Pfizer Inc.

Summary of Meeting:
There is a growing appreciation that inflammation is the root cause of many cancers. Epidemiological and infectious disease literature supports this hypothesis. In addition, there is a growing body of experimental support confirming the role of inflammation in cancer initiation. However, once tumors are established, this inflammatory response changes and a set of immune cells are recruited that are immunomodulatory and not inflammatory. These types of immune cells, particularly those of the innate system, are also recruited to tumors in which there is no evidence for inflammation as a cause of tumorigenesis. This phenomenon has sometimes been called sterile inflammation. These immune cells enhance tumor progression and metastasis by promoting angiogenesis, enhancing tumor cell migration, invasion and intravasation and suppressing anti-tumor immunity. The conference will address the mechanisms behind the recruitment of the immune cells and their function, the switches in type of inflammatory responses during tumor progression and the actions of these cells in tumor promotion both at the primary and metastatic sites.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MAY 20

15:00—19:30
Registration

Concert Hall Foyer
18:15—19:15
Refreshments

Hall 4
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Jeffrey W. Pollard, Queen's Medical Research Institute, UK

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
New Adventures of an Old Flame


MONDAY, MAY 21

07:30—08:30
Breakfast

Your Lodging Location
08:30—11:30
The Microbiome and Cancer
Meeting has ended...abstracts no longer viewable online.

Concert Hall
Lita M. Proctor, National Human Genome Research Institute, USA
The Human Microbiome Project: An Update

Mathias Chamaillard, Inserm Nord-Quest, France
Remote Control of Intestinal Tumorigenesis in Response to Commensals

Christian Jobin, University of Florida, USA
Role of Bacteria in Colitis-Associated Colorectal Cancer

* Sergio A. Lira, Mount Sinai School of Medicine, USA
A Role for Inflammation in the Development of Intestinal Serrated Lesions?

Eduardo Bonavita, Cancer Research UK Manchester Institute, University of Manchester, UK
Short Talk: Dual Role of Toll Interleukin-1 Receptor (IL-1R) 8 / TIR8 in Cancer

Pratyusha Mandal, Emory University, USA
Short Talk: Latent gammaherpesvirus Infection Induces Widespread, Interferon-Dependent DNA Damage that Synergizes with Environmental Carcinogens to Promote Aggressive Lymphoma

09:40—10:10
Coffee Break

Hall 4
11:30—13:00
Poster Setup

Hall 4
11:30
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Hall 4
16:30—17:00
Coffee Available

Hall 4
17:00—19:00
Regulation of Inflammation in Cancer
Meeting has ended...abstracts no longer viewable online.

Concert Hall
Grace Yi Chen, University of Michigan, USA
Nod1, A Bacterial Sensor that Regulates Inflammation and Cancer in the Gut

Michael Girardi, Yale University School of Medicine, USA
Lessons from Langerhans Cells: Cooperative Carcinogenesis

* Ian A. Blair, University of Pennsylvania, USA
Cyclooxygenases and Lipoxygenases in Cancer

Sabine Gruber, Institute for Genetics, University of Cologne, Germany
Short Talk: Obesity Abrogates IL-6 Receptor alpha Dependency of Liver Carcinogenesis via GSK-3beta Inhibition

19:00—20:00
Social Hour with Lite Bites

Hall 4
19:30—22:00
Poster Session 1

Hall 4

TUESDAY, MAY 22

07:30—08:30
Breakfast

Your Lodging Location
07:30—08:00
Poster Setup

Hall 4
08:00—17:00
Poster Viewing

Hall 4
08:30—11:30
Mechanism of Inflammation-Induced Cancer
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Manipulations of the Immune Microenvironment of Cancer

Rinat Abramovitch, Hadassah Hebrew University Hospital, Israel
Double Strand DNA Breaks, Chronic Inflammation and Liver Cancer

Kevin Struhl, Harvard Medical School, USA
An Epigenetic Switch that Links Inflammation to Cancer

Christopher K. Glass, University of California, San Diego, USA
Activation and Repression Mechanisms that Regulated Inflammatory Responses of Macrophages

Masataka Majima, Kitasato University School of Medicine, Japan
Short Talk: Roles of Prostaglandins in Enhancement of Angiogenesis and Lymphangiogenesis during the Developments of Cancers and Inflammation

Aideen E. Ryan, National University of Ireland Galway, Ireland
Short Talk: Targeting Colon Cancer Cell NF-kappaB Regulates Tumor-Associated Macrophage Polarization and Enhances Anti-Tumor Immune Response

09:40—10:10
Coffee Break

Hall 4
11:30—12:30
Lunch

Hall 4
12:00—14:30
Poster Session 2

Hall 4
14:30—16:30
Workshop: Imaging of Immune Cells

Concert Hall
* Claire E. Lewis, University of Sheffield Medical School, UK
Visualising Tumor-Associated Macrophages in Zebrafish: Effects of Chemotherapy and Vasculature-Damaging Agents

Paul Martin, University of Bristol, UK
Live Imaging of Early Interactions between Leukocytes and Transformed Cells in Zebrafish Larvae

Tim S. Kees, Cold Spring Harbor Laboratory, USA
A Nanoparticle-Based Approach to Activate Macrophage Tumoricidal Activities in vivo

Damya Laoui, Vrije Universiteit Brussel-VIB, Belgium
Macrophage Mannose Receptor-Specific Nanobody-Based Targeting and in vivo Imaging of Tumor-Associated Macrophages

Stavros Melemenidis, Gray Institute for Radiation Biology and Oncology, UK
Development of a Combined Molecularly-Targeted and Hyperpolarized Gas Imaging Approach for Early in vivo Detection of Lung Metastasis

16:30—17:00
Coffee Available

Hall 4
17:00—19:00
Cancer Inflammation: Mucosal Immunity as a Cause of Cancer
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Laurence Egan, National University of Ireland, Galway, Ireland
Inflammation, DNA Methylation and Colitis-Associated Cancer

Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
NF-kappaB and Stat3 Signaling in the Initiation and Progression of Colon Cancer

Cynthia L. Sears, Johns Hopkins University School of Medicine, USA
Gut Flora and Colon Cancer

Sergei Grivennikov, Fox Chase Cancer Center, USA
Short Talk: Cytokine Signaling Controls Tumor-Elicited Inflammation and Promotes Colorectal Cancer

19:00
On Own for Dinner


WEDNESDAY, MAY 23

07:30—08:30
Breakfast

Your Lodging Location
08:30—11:30
Tumor Promotion by Inflammatory Cells
Meeting has ended...abstracts no longer viewable online.

Concert Hall
Michele De Palma, École Polytechnique Fédérale de Lausanne, Switzerland
A MicroRNA Switch Modulates Genetic Programmes of TAMs

Steven M. Albelda, University of Pennsylvania, USA
Role of Tumor-Associated Neutrophils in Cancer

Johanna A. Joyce, University of Lausanne, Switzerland
Tumor-Associated Macrophages Regulate Cancer Progression and Response to Therapy

Neta Erez, Tel Aviv University, Israel
Cancer-Associated Fibroblasts Mediate Tumor Promoting Inflammation

09:40—10:10
Coffee Break

Hall 4
11:30—13:00
Poster Setup

Hall 4
11:30
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Hall 4
16:30—17:00
Coffee Available

Hall 4
17:00—19:00
The Evolving Inflammatory Response
Meeting has ended...abstracts no longer viewable online.

Concert Hall
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Monocyte and Macrophage Diversity Promotes Tumor Progression and Metastasis

Suzanne Ostrand-Rosenberg, University of Maryland, USA
Inflammation-Amplified Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Drives Tumor Progression

* Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Reprogramming the Immune Microenvironment as an Anti-Cancer Therapeutic Strategy

Metamia Ciampricotti, Netherlands Cancer Institute, Netherlands
Short Talk: Chemotherapy Response of Spontaneous Mammary Tumors is Independent of the Adaptive Immune System

19:00—20:00
Social Hour with Lite Bites

Hall 4
19:30—22:00
Poster Session 3

Hall 4

THURSDAY, MAY 24

07:30—08:30
Breakfast

Your Lodging Location
08:30—11:30
Clinical Correlation and Susceptibility to Cancer
Meeting has ended...abstracts no longer viewable online.

Concert Hall
Douglas McClain Noonan, Università degli Studi dell'Insubria, Italy
Diet Derivatives and Phytochemicals in Cancer Prevention

* Judith Campisi, Buck Institute for Research on Aging, USA
Aging, Inflammation and Cancer

Tyler J. Curiel, University of Texas Health Science Center, USA
Regulatory T Cells in Cancer: Immunopathology and Therapeutic Potential

Randy D. Gascoyne, British Columbia Cancer Agency, Canada
Mechanisms of Immune Escape in Lymphoid Cancers

Nancy J. Boudreau, NCI, National Institutes of Health, USA
Short Talk: Inhibition of Tumor Progression by HoxA5

09:40—10:10
Coffee Break

Hall 4
11:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Hall 4
17:00—18:10
Inflammation as Therapy
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
Mechanisms of Protective Tumor Immunity

18:10—19:15
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Concert Hall
* Laurence Egan, National University of Ireland, Galway, Ireland
Closing Remarks

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
TLRs as Therapeutic Targets in Inflammation and Cancer

19:15—20:15
Social Hour with Lite Bites

Hall 4
20:00—23:00
Entertainment

Hall 4

FRIDAY, MAY 25

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Hoffmann-La Roche, Inc. Pfizer Inc.
Science Foundation Ireland
 

We gratefully acknowledge additional support for this conference from:

Biogen Idec Fáilte Ireland

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676