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This meeting took place in 2012



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Cardiovascular Development and Regeneration (A6)


Organizer(s) Katherine E. Yutzey and Deepak Srivastava
January 22—27, 2012
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 21, 2011
Late Abstract Deadline: Oct 24, 2011
Scholarship Deadline: Sep 21, 2011
Early Registration Deadline: Nov 22, 2011

Supported by the Directors’ Fund

Summary of Meeting:
Cardiovascular disease is the leading cause of death worldwide, affecting both children and adults. There is increasing evidence that developmental mechanisms of cardiac cell lineage differentiation and organogenesis contribute to cardiovascular disease throughout life and could be leveraged for regenerative therapies. This meeting will emphasize shared molecular mechanisms in cardiovascular development and disease. Sessions on cardiovascular lineage specification and stem cell biology will emphasize common molecular mechanisms with therapeutic potential in heart regeneration. Discussion of bioengineering and tissue-based therapies will complement these sessions, with the aim of facilitating translational approaches. Recent advances in cardiac organogenesis and the genetics of human congenital heart disease will be presented in order to promote mechanistic connections in heart development and disease. Overall, the goal of the meeting is to bring together researchers with expertise in cardiac embryology, molecular biology, stem cell biology, human genetics and tissue engineering to facilitate new scientific directions and therapeutic approaches in the management and treatment of cardiovascular disease in children and adults.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 22

15:00—19:30
Registration

Chamisa Lobby
18:15—19:15
Refreshments

Chamisa Ballroom 2
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan
Induction of Pluripotency by Defined Factors


MONDAY, JANUARY 23

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Cardiovascular Lineage Development I
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA

Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia
Defining the Cardiac Gene Regulatory Network through Large Scale Transcription Factor Target Site Profiling using DamID

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Cellular Reprogramming Approaches for Human Heart Disease

Deborah L. Yelon, University of California, San Diego, USA
Signaling Pathways in Zebrafish Cardiogenesis

Margaret E. Buckingham, Institut Pasteur, France
A Cell Lineage Tree for the Heart

Wenqing Cai, Boston Children's Hospital, USA
Short Talk: Cerberus-1 Commits Cardiac-Specification of Flk1+ Progenitor through Transient Inhibition of Nodal and BMP

Alexandra Klaus, Max-Delbrueck-Center, Germany
Short Talk: Wnt/beta-catenin and Bmp Signals Control Distinct Sets of Transcription Factors in Cardiac Progenitor Cells

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: Cell Signaling/Transcriptional Mechanisms in Cardiovascular Development

Chamisa Ballroom 1
* Brian L. Black, University of California, San Francisco, USA

Nuno Camboa, University of California, San Diego, USA
Genetic Pathways Required for Maintenance of Vascular Smooth Muscle Phenotype

Ivan P. Moskowitz, University of Chicago, USA
A Tbx5-Scn5a Molecular Network Modulates Function of the Adult Cardiac Conduction System

Caitlin Braitsch, University of Texas Southwestern Medical Center, USA
Pod1/Tcf21 is Regulated by Retinoic Acid Signaling and is Required to Inhibit Smooth Muscle Differentiation in Epicardium-Derived Cells

Sean Xue Li, Boston Children's Hospital, Harvard Medical School, USA
Six-Eya Functional Unit and Behavior of the Second Heart Field Progenitors

Stacey L. Rentschler, Washington University School of Medicine, USA
Myocardial Notch Signaling Reprograms Cardiomyoctes to a Conduction-Like Phenotype

Marine Roux, Aix-Marseille Université, France
Anterior Hox Genes are Required for Second Heart Field Development

Nadia A. Rosenthal, The Jackson Laboratory, USA
PW1 Marks a Novel Class of Cardiac Progenitor Cells Responsive to Physiological Stress

Paul Cheng, University of California San Francisco, USA
Fibronectin Mediates Mesendodermal Cell Fate Decisions

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Cardiovascular Lineage Development II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Eric N. Olson, University of Texas Southwestern Medical Center, USA

Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA
Epigenetic Regulation of Cardiac Lineage Development

Brad Davidson, University of Arizona, USA
Invasive Cell-Matrix Adhesion in Heart Progenitor Induction

Brian L. Black, University of California, San Francisco, USA
Transcriptional Pathways in Endothelial Cell Specification and Sub-Specification

Kazuko Koshiba-Takeuchi, University of Tokyo, Japan
Short Talk: Chromatin Formation is Necessary for Cardiomyocyte Regeneration in Mammal/Amphibian Models

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, JANUARY 24

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Translational Approaches to Congenital Heart Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jonathan A. Epstein, University of Pennsylvania, USA

Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, USA
Genetic Mechanisms of Marfan Syndrome

Bruce D. Gelb, Mount Sinai Medical Center, USA
Noonan Syndrome and Related Disorders: A RAS-pY Tale

Jonathan G. Seidman, Harvard Medical School, USA
Genomic Approaches to Congenital Heart Disease

Gail D. Pearson, NHLBI, National Institutes of Health, USA
NHLBI’s Bench to Bassinet Program: The View from the Bassinet

Stephanie M. Ware, Cincinnati Children's Hospital, USA
Short Talk: The Genetic Basis of Heterotaxy Spectrum Cardiovascular Malformations

Vidu Garg, Ohio State University/Nationwide Children's Hospital, USA
Short Talk: Endothelial Nitric Oxide Signaling Regulates Notch1 in Aortic Valve Development and Disease

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Organogenesis of the Heart
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Deborah L. Yelon, University of California, San Diego, USA

Eric N. Olson, University of Texas Southwestern Medical Center, USA
MicroRNA Mediators of Heart Development, Disease and Regeneration

Jonathan A. Epstein, University of Pennsylvania, USA
Regulatory Pathways in Cardiac Neural Crest Development

Vincent M. Christoffels, Academic Medical Center, Netherlands
Maturation of Specialized Cardiac Conduction System Lineages

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: A Genetic Network Involving Cdc42 Required for Heart Lumen Formation and Morphogenesis in Drosophila

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, JANUARY 25

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Epicardial Cell Lineage Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA

James F. Martin, Baylor College of Medicine, USA
Hippo Signaling in Cardiomyocyte Proliferation

William T. Pu, Children's Hospital, Harvard Medical School, USA
Regulation of Heart Growth by YAP1, a Nuclear Effector of Hippo Signaling

Paul R. Riley, University of Oxford, UK
Epicardial Cell Activation and Myocardial Repair

David M. Ornitz, Washington University School of Medicine, USA
Mechanisms of Cardioprotection and Hypertrophy Mediated by Fibroblast Growth Factor Signaling

Konstantinos Malliaras, Cedars Sinai Medical Center, USA
Short Talk: Induction of Cardiomyocyte Cell-Cycle Re-Entry by Cell Therapy in Fate-Mapped Bitransgenic Mice

Yosuke Mukoyama, National Heart, Lung, and Blood Institute, USA
Short Talk: Coordinated Branching Morphogenesis of Coronary Vessels and Peripheral Nerves in the Developing Heart

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 2: Cardiac Stem Cells and Reprogramming

Chamisa Ballroom 1
* Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute, Australia

Daniel Aberdam, INSERM Unité 976, France
p63, Member of the p53 Family, is Essential for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

Nicolas Christoforou, Duke University, USA
Engineering the Reprogramming of Human and Mouse Cells Towards the Cardiac Cell Lineage

Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Identification of miRNAs Involved in the Initiation of Cardiogenesis

Mark P. White, Gladstone Institute of Cardiovascular Disease (GICD), USA
The Role of NOTCH1 Haploinsufficiency in Human Aortic Valve Disease

Cynthia N. Perry, University of California, San Diego, USA
Induced Pluripotent Stem Cell Derived Cardiomyocytes as a Model of Danon Disease and Impaired Autophagy

W. Patrick Devine, University of California, San Francisco, USA
Identification and Characterization of a Multipotent Cardiac Precursor

Ina Gruh, Hannover Medical School, Germany
Generation of Human Bioartificial Cardiac Tissue based on Pluripotent Stem Cell-derived Cardiomyocytes

Kimberly R. Cordes, Gladstone Institute, USA
Reprogramming Patient-specific Fibroblasts to Model Smooth Muscle Vascular Disease

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Valve Development and Engineering
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Vidu Garg, Ohio State University/Nationwide Children's Hospital, USA

Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Endocardial Cushions, Valve Development and Disease

Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Molecular Mechanisms of Heart Valve Development and Disease

Frank Baaijens, Eindhoven University of Technology, Netherlands
Heart Valve Tissue Engineering

H. Scott Baldwin, Vanderbilt University, USA
Short Talk: Tie1 Regulates Semilunar Valve Form and Function

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, JANUARY 26

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Cardiovascular Stem Cell Biology and Regeneration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA

Lior Zangi, Icahn School of Medicine at Mount Sinai, USA
Driving Heart Progenitor Cell Fate and Cardiovascular Regeneration in vivo via Chemically Modified mRNA

Kenneth D. Poss, Duke University Medical Center, USA
Cardiac Regeneration in Zebrafish

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Cardiovascular Development from Human Pluripotent Stem Cells

Christine L. Mummery, Leiden University Medical Center, Netherlands
Pluripotent Stem Cells and Differentiation to Cardiovascular Cells: Potential Use in Cardiovascular Pharmacology

Hesham A. Sadek, University of Texas Southwestern Medical Center, USA
Short Talk: Inhibition of the Post-Natal Cell Cycle Arrest in Cardiomyocytes

Tilanthi M. Jayawardena, Duke University, USA
Short Talk: MicroRNA-Mediated in vitro and in vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

09:00—09:20
Coffee Break

Chamisa Lobby
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Bioengineering and Tissue Repair
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Christine L. Mummery, Leiden University Medical Center, Netherlands

Peter W. Zandstra, University of Toronto, Canada
Engineering Heart Tissue for Discovery and Repair

Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Myocardial Tissue Engineering

Richard T. Lee, Harvard University, USA
Circulating Systemic Factors from Young Mice Reverse Age-Related Cardiac Hypertrophy

Jennifer L. Young, University of California, San Diego, USA
Short Talk: In vivo Application of Dynamic Hyaluronic Acid Material for Myocardial Infarction Therapy

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

FRIDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL110472-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation
American Heart Association's Council on Basic Cardiovascular Sciences


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Cardiology

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676