Big Sky Resort Floorplan

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This meeting took place in 2012


Here are the related meetings in 2018:
Atherosclerosis: Lessons Learned and Concepts Challenged (B2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Basis of Vascular Inflammation and Atherosclerosis (C7)


Organizer(s) Edward A. Fisher, Catherine C. Hedrick and MacRae F. Linton
March 25—30, 2012
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Nov 22, 2011
Late Abstract Deadline: Jan 3, 2012
Scholarship Deadline: Nov 22, 2011
Early Registration Deadline: Jan 25, 2012

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc. and Merck & Co., Inc.

Summary of Meeting:
Inflammation is inextricably woven into the natural history of atherosclerosis. The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic. Consequently, macrophage biology will be a major focus of the Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis. The critical contributions of innate and adaptive immunities to atherosclerosis will also be reviewed, and a session on fundamental features of the inflammatory process, including its resolution, will introduce concepts likely to influence future paradigms in the atherosclerosis field. Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented. Other highlights include progress in genomic approaches to discover risk factors for coronary artery disease, as well as advances in imaging techniques to detect atherosclerotic plaques, cellular composition of plaques and trafficking of immune cells in vivo. The keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 25

15:00—19:30
Registration

Lower Atrium
18:15—19:15
Refreshments

Lower Atrium
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Edward A. Fisher, New York University School of Medicine, USA

Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptor Regulation of Lipid Metabolism and Inflammation


MONDAY, MARCH 26

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:00
Macrophage Biology
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Catherine (Lynn) Hedrick, La Jolla Institute for Allergy and Immunology, USA

Kathryn J. Moore, New York University Medical Center, USA
Role of Retention Molecules in Macrophage Accumulation in Atherosclerosis

Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Multiphoton Live Cell Imaging Reveals Productive Antigen-Specific Interactions between CD4 T Cells and Dendritic Cells in the Aortic Wall of Apoe-/- Mice

Edward A. Fisher, New York University School of Medicine, USA
Macrophage Diversity in Mouse Atherosclerotic Plaques

MacRae F. Linton, Vanderbilt University Medical Center, USA
Macrophage JNK Signaling in Apoptosis and Atherosclerosis

Richard N. Hanna, MedImmune, USA
Short Talk: NR4A1 (Nur77) Deficiency Increases Inflammatory Macrophage Activity and Atherosclerosis Development

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Madison/Gallatin
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Madison/Gallatin
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Adaptive Immunity in Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Elena Galkina, Eastern Virginia Medical School, USA

Amy S. Major, Vanderbilt University, USA
T Lymphocytes Are Important Mediators of Autoimmune-Associated Atherosclerosis

Andrew H. Lichtman, Brigham and Women's Hospital, USA
Regulation of T Cell Responses in Atherosclerosis

Mary G. Sorci-Thomas, Wake Forest School of Medicine, USA
HDL-Mediated Regulation of Lymphocyte Function

Claudia Monaco, University of Oxford, UK
Short Talk: B Regulatory Cells Mediate Atheroprotection via IL-10

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
19:30—22:00
Poster Session 1

Madison/Gallatin

TUESDAY, MARCH 27

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:15
Innate Immunity in Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* MacRae F. Linton, Vanderbilt University Medical Center, USA

Ira Tabas, Columbia University, USA
The Role of MyD88 Signaling in CD11chi Cells in Atherosclerosis

Myron I. Cybulsky, University of Toronto, Canada
Role of Intimal Dendritic Cells in the Initiation of Atherosclerosis

Peter S. Tobias, The Scripps Research Institute, USA
Toll-Like Receptors in Atherosclerosis

Catherine (Lynn) Hedrick, La Jolla Institute for Allergy and Immunology, USA
Role of Cholesterol in Modulating Innate Immune Responses

Yvonne Döring, Institute for Cardiovascular Prevention Ludwig-Maximilians University Munich, Germany
Short Talk: CCL17-Expressing Dendritic Cells Drive Atherosclerosis by Restraining Regulatory T Cell Homeostasis in Mice

Ebru Erbay, Bilkent University, Turkey
Short Talk: Macrophage Lipid Chaperones Link Host, Pathogen and Metabolism

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Madison/Gallatin
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Madison/Gallatin
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Inflammation Biology Relevant to Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Kathryn J. Moore, New York University Medical Center, USA

Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Formins and New Insights into RAGE Signal Transduction

Kenneth L. Rock, University of Massachusetts Medical School, USA
The Sterile Inflammatory Response and Atherosclerosis

Charles N. Serhan, Brigham and Women's Hospital, USA
Functional Decoding Lipid Mediator-Metabolomics in Resolving Inflammation

Prabhakara Redd Nagareddy, Columbia University, USA
Short Talk: Hyperglycemia Enhances Myeloid Cell Proliferation and Impairs Atherosclerosis Regression in Diabetes

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
19:30—22:00
Poster Session 2

Madison/Gallatin

WEDNESDAY, MARCH 28

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:15
Genetics of Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Klaus Ley, La Jolla Institute for Allergy and Immunology, USA

Robert Hegele, Robarts Research Institute, Canada
Genetic Architecture of Plasma Triglyceride Metabolism

Norman E. Sharpless, University of North Carolina School of Medicine, USA
The 9p21.3 CDKN2a/b Locus and the Risk of Atherosclerosis

Muredach P. Reilly, Columbia University, USA
Translational Studies of ADAMTS7 a Novel GWAS Locus for Coronary Atherosclerosis

Kiran Musunuru, University of Pennsylvania, USA
Genetic and Functional Studies of SORT1, a Cholesterol and Myocardial Infarction Gene

Jonathan E. Feig, New York University School of Medicine, USA
Short Talk: Regression of Atherosclerosis is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

Naif A. M. Almontashiri, University of Ottawa Heart Institute, Canada
Short Talk: Serum Interferon alpha-21 is a Biomarker that Predicts Coronary Artery Disease in Individuals Homozygous for the 9p21.3 Risk Locus

09:20—09:40
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Madison/Gallatin
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Madison/Gallatin
16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Non-Immune Cells in Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Ann Marie Schmidt, New York University Langone Medical Center, USA

Wayne Orr, Lousiana State University Health Sciences Center, Shreveport, USA
EphA2 Activation Promotes the Endothelial Cell Inflammatory Response: A Potential Role in Atherosclerosis

Nigel Mackman, University of North Carolina at Chapel Hill, USA
Tissue Factor and Atherothrombosis

Joseph M. Miano, University of Rochester, USA
Genomic Regulation of Vascular Smooth Muscle Cell Phenotype

Richard C. Austin, McMaster University, Canada
Short Talk: Deficiency of TDAG51 Reduces Atherosclerotic Lesion Growth and Necrosis by Modulating Apoptosis, Cholesterol Efflux and Peroxiredoxin-1 Expression

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
19:30—22:00
Poster Session 3

Madison/Gallatin

THURSDAY, MARCH 29

07:00—08:00
Breakfast

Madison/Gallatin
08:00—11:00
Lipoprotein Metabolism and Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Mary G. Sorci-Thomas, Wake Forest School of Medicine, USA

Sergio Fazio, Vanderbilt University Medical Center, USA
A Novel Domain Interaction Regulates PCSK9 Secretion and Function

Viktoria Gusarova, Regeneron Pharmaceuticals, USA
Fully Human Antibody That Blocks PCSK9 Demonstrates Reduction in LDL-C Preclinically and in Early Clinical Trials

Carlos Fernández-Hernando, New York University School of Medicine, USA
Role of miRNAs in Regulating Macrophage and Hepatic Lipid Metabolism

Theo J. C. Van Berkel, University of Leiden, Netherlands
Lipoproteins, Macrophage Cholesterol Homeostasis and Atherosclerosis

Bernd Hewing, New York University School of Medicine, USA
Short Talk: Impact of Myeloperoxidase-modified ApoA-I on Regression of Atherosclerosis

09:20—09:40
Coffee Break

Lower Atrium
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Molecular Imaging
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Edward A. Fisher, New York University School of Medicine, USA

Zahi A. Fayad, Mount Sinai Medical School, USA
Translational Bleeding Edge Imaging and Therapy of Atherosclersosis

Matthias Nahrendorf, Harvard Medical School, USA
In vivo Imaging of Plaque Composition

Eric Ahrens, Carnegie Mellon University, USA
In vivo Cytometry: An MRI-Based Approach to Quantitatively Study Inflammation and Cell Trafficking

Bohumil Bednar, Merck Research Laboratories, USA
Short Talk: Quantitative Longitudinal Imaging of Vascular Inflammation and Angiogenesis in Atherosclerotic Mice Using Newly Developed Optical Imaging Biomarkers of Cathepsin Activity and alphavbeta3 Integrin

19:00—20:00
Social Hour with Lite Bites

Madison/Gallatin
20:00—23:00
Entertainment

Madison/Gallatin

FRIDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc. Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL112449-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Aastrom Biosciences, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Regeneron Pharmaceuticals, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676