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This meeting took place in 2012



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Angiogenesis: Advances in Basic Science and Therapeutic Applications (A3)


Organizer(s) Napoleone Ferrara, Anne C. Eichmann and Kenneth Walsh
January 16—21, 2012
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 19, 2011
Late Abstract Deadline: Oct 19, 2011
Scholarship Deadline: Sep 19, 2011
Early Registration Deadline: Nov 16, 2011

Sponsored by Bayer USA Foundation and Genentech, Inc.

Summary of Meeting:
Much progress has been made in the identification of key signaling pathways regulating blood vessel development. There is also evidence that various stromal cell types participate in normal and pathological angiogenesis in a tissue- or context-specific fashion. However, many important molecular and biological questions regarding these processes remain unanswered. In addition, several angiogenesis inhibitors have been approved by the FDA as therapy for cancer or intraocular neovascular disorders. Perhaps some of the most successful applications of anti-angiogenic therapy are in age-related macular degeneration and other intraocular neovascular diseases, although such findings have been rarely presented outside specialized meetings. The Keystone Symposia meeting on Angiogenesis: Advances in Basic Science and Therapeutic Applications will critically examine the latest basic science on the regulation of angiogenesis in health and disease, discuss the lessons from clinical trials in cancer and intraocular neovascular disorders and identify novel therapeutic targets. Additional discussion will focus on a renewed interest in therapeutic angiogenesis by tissue engineering or stem cell-based approaches.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 16

15:00—19:30
Registration

Ballroom Lobby
18:15—19:15
Refreshments

Ballroom Lobby
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Kari K. Alitalo, University of Helsinki, Finland
Biological Functions and Therapeutic Potential of Vascular Endothelial Growth Factors

Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Vascular Responses to Ischemia Mediated by Hypoxia-Inducible Factor 1


TUESDAY, JANUARY 17

07:00—08:00
Breakfast

Superior/Superior Lobby
08:00—11:15
Vascular Development
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Anne C. Eichmann, Yale University School of Medicine, USA
Mechanisms of Vascular Patterning

Ralf H. Adams, Max Planck Institute for Molecular Biomedicine, Germany
Notch and Ephrin-B2 in Vascular Development

Richard A. Lang, Cincinnati Children's Hospital Medical Center, USA
Inhibitory Role of Flt-1 in Development of Retinal Vasculature

Konstantin Gaengel, Karolinska Institutet, Sweden
S1P Signaling through S1P1 Controls Vascular Stabilization by Limiting Sprouting Angiogenesis

Rong Wang, University of California, San Francisco, USA
Short Talk: Endothelial Notch Signaling Regulates Arterial Venous Programming in Health and Disease

Florian P. Limbourg, Medizinische Hochschule Hannover, Germany
Short Talk: Tip Cell Selection by Notch Ligand Delta-Like 1 Regulates Vascular Branching Morphogenesis

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Ballroom 1
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Ballroom 1
14:30—16:15
Workshop 1: Novel Mechanisms / Pathways in Developmental Angiogenesis

Ballroom 2-3
* Luisa Iruela-Arispe, University of California, Los Angeles, USA

Karin Albrecht Schgoer, Medical University Hospital Innsbruck, Austria
The Angiogenic Factor Secretoneurin Activates VEGF-Receptors in Coronary Endothelial Cells by Operating as Endogenous Stimulator of VEGF Binding to Heparansulfate Proteoglycans

Maria Georgiadou, Vesalius Research Center, K.U.Leuven, Belgium
Dll4/Notch Induces Endothelial Cell Quiescence through p53-Mediated Metabolic Reprogramming

Sophie Paquet-Fifield, Peter MacCallum Cancer Centre, Australia
VEGF-D Modulates Cutaneous Blood Vessels and Lymphatics during Skin Development and Wound Healing

Ivan B. Lobov, Regeneron Pharmaceuticals, Inc., USA
Effects of Selective or Combined Inhibition of PlGF and VEGF-A on Pathological Neovascularization and Retinal Revascularization in the Murine Model of Oxygen Induced Ischemic Retinopathy (OIR)

Akiyoshi Uemura, Nagoya City University, Japan
RhoJ Mediates Sema3E-Induced Contraction of Endothelial Cells

Travis I. Moore, Seoul National University, South Korea
Angiogenesis on a Chip: Microfluidic Platform for Studies in Vessel Morphogenesis, Trans-Endothelium Regulation and High-Throughput Drug Screening

Jianrong Lu, University of Florida College of Medicine, USA
Restraint of Angiogenesis by CTCF-Mediated Chromatin Insulation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:50
VEGF and VEGF Receptors
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Masabumi Shibuya, University of Tokyo, Japan
Dual Role of VEGFR-1 in Angiogenesis: Its Positive Function in Carcinogenesis

Luisa Iruela-Arispe, University of California, Los Angeles, USA
Ins and Outs of VEGFR2

Eli Keshet, Hebrew University, Israel
"Non-Traditional" Functions of VEGF and the Vasculature

Michael E. Boulton, University of Florida, USA
Short Talk: Secretase-Dependent Cleavage of VEGFR1 Regulates VEGF-Induced Angiogenesis

19:00—20:00
Social Hour with Lite Bites

Ballroom 1
19:30—22:00
Poster Session 1

Ballroom 1

WEDNESDAY, JANUARY 18

07:00—08:00
Breakfast

Superior/Superior Lobby
08:00—11:05
Role of Inflammation in Tumor Angiogenesis/Lymphangiogenesis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Amato J. Giaccia, Stanford University, USA
Hypoxia and Cancer

Tatiana V. Byzova, Cleveland Clinic Foundation, USA
TLR2 and Angiogenesis

Roberta Mazzieri, San Raffaele Telethon Institute for, Italy
Macrophage Regulation of Tumor Angiogenesis

Viviane Tabar, Memorial Sloan Kettering Cancer Center, USA
Cancer Stem Cells and Angiogenesis

Lee M. Ellis, University of Texas MD Anderson Cancer Center, USA
Angiocrine Signaling and Induction of the Cancer Stem Cell Phenotype

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Ballroom 1
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Ballroom 1
14:30—16:30
Workshop 2: New Mechanisms and Therapeutic Targets for Tumor Angiogenesis

Ballroom 2-3
* Robert S. Kerbel, Sunnybrook Research Institute, Canada

Christian Kupatt, Technical University Munich, Germany
Angiopoietin-2-Induced Pericyte Loss Partially Mediates Systemic Inflammatory Response Syndrome (SIRS)

David O. Bates, Queen's Medical Centre, UK
SRPK1 Is a Novel Angiogenesis Target through Alteration of VEGF Splicing

Mikhail G. Kolonin, University of Texas, USA
Pro-Angiogenic Adipocyte Progenitors Contribute to Obesity-Associated Cancer Progression

Anja C. Runge, German Cancer Research Center, Germany
Hepatocellular Carcinoma Angiogenesis Utilizing a Novel Conditional Model of Multi-Stage Liver Tumor Progression

Mark Thomas Uhlik, Eli Lilly and Company, USA
Discovering a Novel Anti-Angiogenesis Inhibitor, from "Phenotypic" to "Mechanistic"

Tsuyoshi Osawa, University of Tokyo, Japan
Inhibition of Histone Demethylase JHDM2A Expressed under Hypoxia and Nutrient Starvation Suppresses Tumor Growth and Enhances Anti-Angiogenic Therapy

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Tumor Angiogenesis and Translational Studies
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David A. Cheresh, University of California, San Diego, USA
A MEK-Independent Role for CRAF in Mitosis, Angiogenesis and Tumor Progression

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Cancer Cell Autonomous Changes Cooperate with Stromal Changes to Facilitate Cancer Progression and Metastasis

Gou Young Koh, Institute of Basic Science, South Korea
Targeting Angiopoietin-2 and VEGF-A for Anti-Angiogenesis and Anti-Vascular Leakage

Mallika Singh, Genentech, Inc., USA
Short Talk: Anti-VEGF Monoclonal Antibody Therapy in Genetically Engineered Mouse Tumor Models: Efficacy, Survival and Metastasis

19:00—20:00
Social Hour with Lite Bites

Ballroom 1
19:30—22:00
Poster Session 2

Ballroom 1

THURSDAY, JANUARY 19

07:00—08:00
Breakfast

Superior/Superior Lobby
08:00—11:00
Metabolism, Hypoxia and Angiogenesis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* M. Celeste Simon, University of Pennsylvania, USA
Hypoxia and Angiogenesis

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Metabolism: A Target in Angiogenesis

Ulf P.E. Eriksson, Karolinska Institutet, Sweden
Role of VEGF-B in Lipid and Glucose Metabolism

Masataka Majima, Kitasato University School of Medicine, Japan
Roles of Prostaglandins in Enhancement of Angiogenesis and Lymphangiogenesis in Pathological Conditions

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Ballroom 1
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Ballroom 1
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Ocular Angiogenesis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Michael E. Boulton, University of Florida, USA

Jayakrishna Ambati, University of Kentucky College of Medicine, USA
CCR3 in Choroidal Neovascularization

Eric Ng, University College London, UK
Model Systems for Studying Vascular Growth and Barrier Function

Weilan Ye, Genentech, Inc., USA
Subtype Specification and Patterning of the Retinal Vasculature

Chatarina A. Löfqvist, Harvard Medical School, USA
Short Talk: Adiponectin May Play a Role in Retinopathy of Prematurity

19:00—20:00
Social Hour with Lite Bites

Ballroom 1
19:30—22:00
Poster Session 3

Ballroom 1

FRIDAY, JANUARY 20

07:00—08:00
Breakfast

Superior/Superior Lobby
08:00—11:00
Anti-Angiogenesis: Insights from Clinical Trials
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Napoleone Ferrara, University of California, San Diego, USA
Tumor Microenvironment and VEGF-Independent Angiogenesis

Robert S. Kerbel, Sunnybrook Research Institute, Canada
Preclinical Translational Approach to Improving the Predictive Potential of Anti-Angiogenic Treatments for Early or Late Stage Metastatic Disease

Brian I. Rini, Cleveland Clinc, USA
Anti-Angiogenic Therapy in the Clinic: Where We are, Where We Are Going and How We Will Get There

Aarif Y. Khakoo, Amgen, USA
Short Talk: Exploration of Cardiotoxicity due to Sunitinib Reveals a Novel Role for Microvascular Pericytes in the Heart

Anna I. Dimberg, Uppsala University Hospital, Sweden
Short Talk: Distinct Gene Expression Signature of Vessels in Human Glioblastoma

09:00—09:20
Coffee Break

Ballroom Lobby
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Therapeutic Angiogenesis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Kenneth Walsh, Boston University School of Medicine, USA
Mechanisms That Coordinate Angiogenesis with Physiological Tissue Growth

Shahin Rafii, Weill Cornell Medical College, USA
Vascular Niche-Derived Angiocrine Factors Initiate and Sustain Organ Regeneration

William C. Sessa, Yale University School of Medicine, USA
MicroRNA/Therapeutic Angiogenesis

Puneet Opal, Northwestern University, USA
Short Talk: VEGF Ameliorates the Ataxic Phenotype in Spinocerebellar Ataxia Type 1 (SCA1) Mice

19:00—20:00
Social Hour with Lite Bites

Ballroom 1-2
20:00—23:00
Entertainment

Ballroom 1-2

SATURDAY, JANUARY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bayer USA Foundation Genentech, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL110545-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.
American Heart Association's Council on Basic Cardiovascular Sciences


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676