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Sheraton Miyako Hotel Tokyo Floorplan
This meeting took place in 2013
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Meeting Details
Aging and Diseases of Aging (S2)
Organizer(s) Takashi Kadowaki, Leonard P. Guarente, Judith Campisi and Sean M. Oldham
October 22 - October 27, 2012
Sheraton Miyako Hotel Tokyo • Tokyo, Japan
Abstract Deadline: June 21, 2012
Late Abstract Deadline: July 25, 2012
Scholarship Deadline: June 21, 2012
Early Registration Deadline: August 22, 2012
Sponsored by Novartis Pharma K.K., Takeda Pharmaceutical Company Limited and Astellas Pharma Inc. Special scholarship support provided by the Japanese Society of Anti-Aging Medicine.
CME Information
Summary of Meeting:
Age-related diseases and disabilities, such as cancer, diabetes and neuronal degeneration, pose an ever-increasing social and economic burden worldwide. Fortunately, the last decades have witnessed dramatic progress in our understanding of the aging process. Genetic studies in particular have helped elucidate some of the molecular pathways that regulate aging and have offered new insights into the treatment of age-related diseases. However, there is still much to be learned and further progress in addressing the unique challenges of the aging population will require new insights and novel approaches. In order to accelerate the discovery process, this Keystone Symposia meeting will cover essential aspects of the aging processes, including cell signaling pathways, DNA stability, protein homeostasis, stem cells and cellular senescence. Each plenary session will emphasize innovative findings from a variety of models in basic research areas and link them to age-related disease and frailty. The ultimate goal is to provide an opportunity for attendees to communicate and promote an integrated understanding of aging and age-related diseases. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.
CME Information
Age-related diseases and disabilities, such as cancer, diabetes and neuronal degeneration, pose an ever-increasing social and economic burden worldwide. Fortunately, the last decades have witnessed dramatic progress in our understanding of the aging process. Genetic studies in particular have helped elucidate some of the molecular pathways that regulate aging and have offered new insights into the treatment of age-related diseases. However, there is still much to be learned and further progress in addressing the unique challenges of the aging population will require new insights and novel approaches. In order to accelerate the discovery process, this Keystone Symposia meeting will cover essential aspects of the aging processes, including cell signaling pathways, DNA stability, protein homeostasis, stem cells and cellular senescence. Each plenary session will emphasize innovative findings from a variety of models in basic research areas and link them to age-related disease and frailty. The ultimate goal is to provide an opportunity for attendees to communicate and promote an integrated understanding of aging and age-related diseases. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.
Conference Program Print | View meeting in 12 hr (am/pm) time
MONDAY, OCTOBER 22
16:00—20:00
Arrival and Registration
Daigo Foyer
06:30—08:30
Breakfast
NOTE: Breakfast at Individual Hotel
Individual Hotel
07:30—08:30
Poster Setup
Daigo
08:30—15:00
Poster Viewing
Daigo
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Takashi Kadowaki,
University of Tokyo, Japan
Welcome Speech
Welcome Speech
*
Leonard P. Guarente,
Massachusetts Institute of Technology, USA
Introduction of Keynote Address
Introduction of Keynote Address
David A. Sinclair,
Harvard Medical School, USA
Using Sirtuins to Identify Fundamental Causes of Aging and Age-Related Diseases
Using Sirtuins to Identify Fundamental Causes of Aging and Age-Related Diseases
09:30—12:15
Cell Signaling I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Eric M. Verdin,
University of California, San Francisco, USA
Leonard P. Guarente,
Massachusetts Institute of Technology, USA
Aging and Disease: Connections to Sirtuins
Aging and Disease: Connections to Sirtuins
*
Marcia C. Haigis,
Harvard Medical School, USA
Role of Mitochondrial Metabolism in Diseases of Aging
Role of Mitochondrial Metabolism in Diseases of Aging
Eisuke Nishida,
Kyoto University, Japan
A Fasting-Responsive Signaling Network That Extends Life-Span in C. elegans
A Fasting-Responsive Signaling Network That Extends Life-Span in C. elegans
Laura Bordone,
Genomics Institute of the Novartis Research Foundation, USA
Regulation of Glucose and Nitrogen Metabolism by SIRT4
Regulation of Glucose and Nitrogen Metabolism by SIRT4
Martin S. Denzel,
Max Planck Institute for Biology of Aging, Germany
Short Talk: Enhancing N-Glycosylation via Activation of the Hexosamine Pathway Improves ER Protein Folding Capacity and Slows Aging
Short Talk: Enhancing N-Glycosylation via Activation of the Hexosamine Pathway Improves ER Protein Folding Capacity and Slows Aging
10:10—10:30
Coffee Break
Foyer
12:15—12:45
Lunch
Foyer/Saga
12:30—15:00
Poster Session 1
Daigo
14:30—15:00
Coffee Available
Foyer
15:00—17:00
Cell Signaling II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
David A. Sinclair,
Harvard Medical School, USA
*
Hiroshi Itoh,
Keio University School of Medicine, Japan
Sean M. Oldham,
Sanford-Burnham Medical Research Institute, USA
Role of Nutrient Sensing TOR Pathway in Obesity and Aging
Role of Nutrient Sensing TOR Pathway in Obesity and Aging
Shin-ichiro Imai,
Washington University School of Medicine, USA
The Systemic Regulatory Network for Mammalian Aging and Longevity: The Importance of SIRT1 and NAMPT in the Hypothalamus and Adipose Tissue
The Systemic Regulatory Network for Mammalian Aging and Longevity: The Importance of SIRT1 and NAMPT in the Hypothalamus and Adipose Tissue
Yousin Suh,
Albert Einstein College of Medicine - Price Center 450, USA
Functional Genomic Approaches to Human Aging
Functional Genomic Approaches to Human Aging
Caroline Kumsta,
Sanford-Burnham Medical Research Institute, USA
Short Talk: The Integrin-Signaling Complex Regulates Longevity and Thermo-Tolerance via HSF-1 in C. elegans
Short Talk: The Integrin-Signaling Complex Regulates Longevity and Thermo-Tolerance via HSF-1 in C. elegans
17:00—
On Own for Dinner
06:30—08:30
Breakfast
NOTE: Breakfast at Individual Hotel
Individual Hotel
08:30—11:45
Stem Cells and Aging. Session Sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: Support for these organizer-selected speakers generously provided by this foundation.
Daigo
*
Kazuo Tsubota,
Keio University School of Medicine, Japan
Thomas A. Rando,
Stanford University School of Medicine, USA
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation
Heinrich Jasper,
Buck Institute for Research on Aging, USA
Proliferative Homeostasis and Aging of the Adult Intestine of Drosophila
Proliferative Homeostasis and Aging of the Adult Intestine of Drosophila
Mineo Kurokawa,
Graduate School of Medicine, University of Tokyo, Japan
Short Talk: Regulation of Stem Cells in Normal and Malignant Hematopoiesis
Short Talk: Regulation of Stem Cells in Normal and Malignant Hematopoiesis
Anne H. H. Tseng,
Academia Sinica and National Yang Ming University, Taiwan
Short Talk: SIRT3 Crosstalks with FOXO3 Acetylation-Phosphorylation-Ubiquitination to Mediate Hypoxic Adaptation
Short Talk: SIRT3 Crosstalks with FOXO3 Acetylation-Phosphorylation-Ubiquitination to Mediate Hypoxic Adaptation
09:50—10:10
Coffee Break
Foyer
11:45—12:45
Poster Setup
Daigo
11:45—16:00
Poster Viewing
Daigo
11:45—15:30
On Own for Lunch and Recreation
15:30—16:00
Coffee Available
Foyer
16:00—18:00
Cell Signaling III
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
*
Yo-ichi Nabeshima,
Foundation for Biomedical Research and Innovation, Japan
alpha-Klotho in Health and Diseases
alpha-Klotho in Health and Diseases
Noboru Mizushima,
University of Tokyo, Graduate School of Medicine, Japan
Autophagy: Its Regulation Mechanism and Selective Substrates
Autophagy: Its Regulation Mechanism and Selective Substrates
Raul Mostoslavsky,
Massachusetts General Hospital, Harvard Medical School, USA
The Chromatin Deacetylase SIRT6 is a Critical Modulator of Cancer Metabolism
The Chromatin Deacetylase SIRT6 is a Critical Modulator of Cancer Metabolism
Bernadette Zwaans,
University of Michigan, USA
Short Talk: SIRT6 Promotes Repetitive Element Silencing
Short Talk: SIRT6 Promotes Repetitive Element Silencing
18:00—19:00
Social Hour w/ Lite Bites
Foyer/Saga/Daigo
19:00—22:00
Poster Session 2
Daigo
06:30—08:30
Breakfast
NOTE: Breakfast at Individual Hotel
Individual Hotel
07:30—08:30
Poster Setup
Daigo
08:30—15:00
Poster Viewing
Daigo
08:30—11:45
DNA Damage Response, Telomeres and Cellular Senescence
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Heinrich Jasper,
Buck Institute for Research on Aging, USA
*
Raul Mostoslavsky,
Massachusetts General Hospital, Harvard Medical School, USA
Judith Campisi,
Buck Institute for Research on Aging, USA
The DNA Damage Response, Inflammation, and Aging
The DNA Damage Response, Inflammation, and Aging
Manuel Serrano,
Spanish National Cancer Center (CNIO), Spain
Tumor Suppressors at the Interface between Cancer and Aging
Tumor Suppressors at the Interface between Cancer and Aging
Naoko Ohtani,
Cancer Institute of JFCR, Japan
Short Talk: Senescence-Associated Secretory Phenotypes (SASPs) Promote Obesity-Associated Hepatocarcinogenesis
Short Talk: Senescence-Associated Secretory Phenotypes (SASPs) Promote Obesity-Associated Hepatocarcinogenesis
Fuyuki Ishikawa,
Kyoto University, Japan
CST Complex in Telomere DNA Replication
CST Complex in Telomere DNA Replication
Cynthia T. McMurray,
Lawrence Berkeley National Laboratory, USA
Age-Related Instability and Metabolic Status Contribute to Onset of Huntington’s Disease: A Toxic Oxidation Cycle
Age-Related Instability and Metabolic Status Contribute to Onset of Huntington’s Disease: A Toxic Oxidation Cycle
Victoria P. Belancio,
Tulane University, USA
Short Talk: Circadian Dynamics of L1 Expression in Cancer
Short Talk: Circadian Dynamics of L1 Expression in Cancer
09:50—10:10
Coffee Break
Foyer
12:00—12:45
Lunch
Foyer/Saga/Daigo
12:30—15:00
Poster Session 3
Daigo
14:30—15:00
Coffee Available
Foyer
15:00—17:00
Age-Related Neurodegenerative Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Cynthia T. McMurray,
Lawrence Berkeley National Laboratory, USA
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Role of Autophagy in Neurodegenerative Diseases
Role of Autophagy in Neurodegenerative Diseases
*
Andrew G. Dillin,
University of California, Berkeley, USA
Humoral Control of Proteostasis and Aging
Humoral Control of Proteostasis and Aging
Dale E. Bredesen,
Buck Institute for Research on Aging, USA
Role of Cell Death Signaling in Alzheimer's Disease
Role of Cell Death Signaling in Alzheimer's Disease
Baohua Liu,
University of Hong Kong, Hong Kong
Short Talk: Depleting Suv39h1 Methyltransferase Rescues Defective DNA Repair and Extends Lifespan in Progeria Mouse Model
Short Talk: Depleting Suv39h1 Methyltransferase Rescues Defective DNA Repair and Extends Lifespan in Progeria Mouse Model
17:00—
On Own for Dinner
06:30—08:30
Breakfast
NOTE: Breakfast at Individual Hotel
Individual Hotel
08:30—11:45
Aging and Metabolic Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Leonard P. Guarente,
Massachusetts Institute of Technology, USA
Takashi Kadowaki,
University of Tokyo, Japan
AdipoRs Activation Increases Ca2+ and AMPK/SIRT/PGC-1, thereby Regulating Metabolic Stress and Mitochondria, Leading to Anti-Aging and Amelioration of Diseases of Aging
AdipoRs Activation Increases Ca2+ and AMPK/SIRT/PGC-1, thereby Regulating Metabolic Stress and Mitochondria, Leading to Anti-Aging and Amelioration of Diseases of Aging
*
Juleen R. Zierath,
Karolinska Institutet, Sweden
Nature or Nurture? Gene/Environment Influence in Skeletal Muscle Insulin Sensitivity in Type 2 Diabetes Patients
Nature or Nurture? Gene/Environment Influence in Skeletal Muscle Insulin Sensitivity in Type 2 Diabetes Patients
Carles Cantó,
Nestlé Institute of Health Sciences, Switzerland
Modulating NAD+ Levels for Targeting Metabolic Disorders and Age-Related Physiological Decline
Modulating NAD+ Levels for Targeting Metabolic Disorders and Age-Related Physiological Decline
Eric M. Verdin,
University of California, San Francisco, USA
Mitochondrial Sirtuins: Regulators of Protein Acylation and Metabolism
Mitochondrial Sirtuins: Regulators of Protein Acylation and Metabolism
Yoshito Takeda,
Osaka University Graduate School of Medicine, Japan
Short Talk: Double Deletion of CD9 and CD81 in Mice Leads to a Syndrome Resembling Aging
Short Talk: Double Deletion of CD9 and CD81 in Mice Leads to a Syndrome Resembling Aging
Takashi Ito,
Chiba University, Japan
Short Talk: CDC42 and NFkB Signaling Contribute to Pro-Inflammatory Phenotype of Senescent Endothelial Cells
Short Talk: CDC42 and NFkB Signaling Contribute to Pro-Inflammatory Phenotype of Senescent Endothelial Cells
09:50—10:10
Coffee Break
Foyer
11:45—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
Foyer
17:00—19:00
Aging and Cardiovascular Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
*
Yasuyoshi Ouchi,
Graduate School of Medicine, University of Tokyo, Japan
*
Sean M. Oldham,
Sanford-Burnham Medical Research Institute, USA
Edward G. Lakatta,
NIA, National Institutes of Health, USA
The Stress of Aging Viewed from the Arterial Wall
The Stress of Aging Viewed from the Arterial Wall
Rolf Bodmer,
Sanford-Burnham Medical Research Institute, USA
Genetics of Cardiac Aging and Dysfunction
Genetics of Cardiac Aging and Dysfunction
Hiroshi Itoh,
Keio University School of Medicine, Japan
Significance of Renal Tubular Sirt1 in Diabetic Nephrophaty through Epigenetic Modulation of Claudin-1 Gene Expression in Podocytes—Possible Existence of Renal Tubules-Podocytes Communication
Significance of Renal Tubular Sirt1 in Diabetic Nephrophaty through Epigenetic Modulation of Claudin-1 Gene Expression in Podocytes—Possible Existence of Renal Tubules-Podocytes Communication
Ken Shinmura,
Keio University School of Medicine, Japan
Short Talk: Cardiac Sirt1 Is Essential for Caloric Restriction-Induced Cardioprotection against Ischemia/Reperfusion
Short Talk: Cardiac Sirt1 Is Essential for Caloric Restriction-Induced Cardioprotection against Ischemia/Reperfusion
19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Daigo
Judith Campisi,
Buck Institute for Research on Aging, USA
19:00—20:00
Social Hour w/ Lite Bites
Foyer/Saga/Daigo
Departure
*Session Chair †Speaker invited, not yet responded.
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