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This meeting took place in 2012



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Epigenomics (J3)


Organizer(s) Steven E. Jacobsen and Steven Henikoff
January 17—22, 2012
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 20, 2011
Late Abstract Deadline: Oct 20, 2011
Scholarship Deadline: Sep 20, 2011
Early Registration Deadline: Nov 17, 2011

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc., Novartis Institutes for BioMedical Research and Takeda Pharmaceutical Company Limited

Joint Meeting: Chromatin Dynamics (J4)

Summary of Meeting:
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs. Although these processes are beginning to be understood at a mechanistic level, less is known of their dynamic nature within genomes. This meeting will highlight recent advances in the application of genomics techniques to the study of epigenetics. Research in a variety of model systems will be presented, which will highlight the conservation and divergence of patterns in different eukaryotic kingdoms. Session topics emphasize integration between epigenomic patterning and developmental regulation, as well as cross-talk between different epigenetic processes. This meeting will also highlight cutting-edge, high-throughput technology being developed and applied to understand epigenomes. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Chromatin Dynamics, which will share a keynote address and two plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 17

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—20:30
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Chromatin and the Control of Cell State


WEDNESDAY, JANUARY 18

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Epigenomics of DNA Methylation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
Steven E. Jacobsen, University of California, Los Angeles, USA
Genetics and Genomics of DNA Methylation in Arabidopsis

Daniel Zilberman, University of California, Berkeley, USA
Evolution of DNA Methylation in Eukaryotes

Deborah Bourc'his, Institut Curie, France
Short Talk: The Fates of Oocyte-Inherited Methylation during Early Mammalian Development

* Joseph R. Ecker, The Salk Institute for Biological Studies, USA
DNA Methylation Dynamics in Plants and People

Keji Zhao, NHLBI, National Institutes of Health, USA
Intragenic DNA Methylation Facilitates Exon Recognition


Following Session is for Chromatin Dynamics (J4)

08:00—11:00
Chromatin Assembly
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Epigenetic Challenges in Centromere Inheritance during the Cell Cycle

Karolin Luger, Colorado State University, USA
Nucleosome Interacting Proteins

Yamini Dalal, NCI, National Institutes of Health, USA
Short Talk: Structural Transitions in the CENP-A Nucleosome are Accompanied by Novel Histone Modifications in vivo

Jakob Mejlvang, UiT The Arctic University of Norway, Norway
Short Talk: New Histone Supply Controls Replication Fork Speed

James T. Kadonaga, University of California, San Diego, USA
The Prenucleosome, a Novel Histone-DNA Complex that Is an Intermediate in the Assembly of Chromatin

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Pluripotency and Differentiation (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Kathrin Plath, University of California, Los Angeles, USA
Chromatin Changes during Reprogramming to Pluripotency 



Bradley E. Bernstein, Massachusetts General Hospital, USA
Systematic Analysis of Genome Regulatory Elements and their Regulation

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
DNA Methylation Dynamics in Development

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Short Talk: Polycomb Repression Co-Associates with Non-Productive RNA Polymerase II in ES Cells

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

THURSDAY, JANUARY 19

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Epigenetics of Disease
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetic Basis of Common Human Disease

Timothy H. Bestor, Columbia University College of Physicians and Surgeons, USA
Abnormalities of Genomic Methylation Patterns in Disease

Asaf Hellman, Hebrew University-Hadassah Medical School, Israel
Short Talk: An Innovative Research Approach for the Elucidation of Epigenetic Risk Factors in Common Human Diseases was Successfully Applied in Type-2 Diabetes

Peter A. Jones, Van Andel Research Institute, USA
The Cancer Epigenome

Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
New Functions for Histone Modifying Enzymes


Following Session is for Chromatin Dynamics (J4)

08:00—11:00
Chromatin Remodeling
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Bradley R. Cairns, HHMI/University of Utah, USA
Regulation of Chromatin Remodeling by Novel Domains Intrinsic to the Motor Subunit of ISWI and SWI/SNF Remodelers

Timothy J. Richmond, ETH Zürich, Switzerland
Structure and Mechanism of the ISW1a Remodeler

Blaine Bartholomew, University of Texas MD Anderson Cancer Center, USA
Short Talk: Dynamics of Nucleosome Remodeling and the Roles of Various Domains in Mobilizing Nucleosomes

Robert E. Kingston, Massachusetts General Hospital, USA
Structural Basis of Silencing: Sir3p BAH Domain in Complex with a Nucleosome at 3.0 Å Resolution

Gerald R. Crabtree, Stanford University, USA
Conversion of Fibroblasts to Neurons with a micro-RNA Chromatin Switch: Instructive Roles of ATP-Dependent Chromatin Remodeling in Early Development

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Demethylation and Hydroxymethylcytosine
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Nathaniel Heintz, HHMI, The Rockefeller University, USA
Cell Specific Profiling of 5-Hydroxymethylcytosine in Neural Cell Types

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Profiling and Function of Hydroxymethylcytosine

Robert L. Fischer, University of California, Berkeley, USA
Regulation of Arabidopsis Gene Imprinting and Transposon Silencing by DNA Demethylation

Thomas G. Fazzio, University of Massachusetts Medical School, USA
Short Talk: Regulation of Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells


Following Session is for Chromatin Dynamics (J4)

17:00—19:00
Dosage Compensation
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Peter B. Becker, University of Munich, Germany
Dosage Compensation – Complexities of Genome-Wide Tuning of Transcription

Jessica Chery, Brown University, USA
Short Talk: A Novel Zinc Finger Protein is a Key Regulator of Drosophila Dosage Compensation

Edith Heard, Institut Curie, France
Spatio-Temporal Regulation of X-Chromosome Inactivation

Barbara J. Meyer, University of California, Berkeley, USA
Functioning and Targeting of Chromosome Condensation Proteins in C. elegans X-Chromosome Dosage Compensation

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

FRIDAY, JANUARY 20

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Epigenomics of the Nucleus
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Job Dekker, University of Massachusetts Medical School, USA
Three-Dimensional Organization of Gene Expression

Wendy A. Bickmore, University of Edinburgh, UK
Integrating Chromosome Structure and Function during Development

Shalini Oberdoerffer, NCI, National Institutes of Health, USA
Journal of Biological Chemistry, Herb Tabor Young Investigator Short Talk: Intragenic CTCF Promotes RNA Polymerase II Pausing and Links DNA Methylation to Alternative Pre-mRNA Splicing

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Architecture and Dynamics of Nuclear Lamina – Genome Interactions

Matthias Merkenschlager, Imperial College London, UK
Short Talk: The Impact of Cohesin on Gene Regulation and Chromatin Organization in Non-Dividing Mammalian Cells


Following Session is for Chromatin Dynamics (J4)

08:00—11:15
Histone Modification
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Shelley L. Berger, University of Pennsylvania, USA
Regulation of Chromatin Modification in Germ Cells

Jerry L. Workman, Stowers Institute for Medical Research, USA
Co-Transcriptional Histone Acetylation is a Consequence of Histone Exchange

Ernesto Guccione, Institute of Molecular and Cell Biology, IMCB, Singapore
Short Talk: The Role of Symmetric vs Asymmetric Arginine Dimethylation in Transcription Regulation and Development

Ali Shilatifard, Northwestern University, USA
Transcription, Chromatin, Epigenetics and Cancer

Joanna Wysocka, Stanford University School of Medicine, USA
Enhancer Mediated Gene Regulation in Development

Rena Levin-Klein, Hebrew University of Jerusalem, Israel
Short Talk: Epigenetic Control of Ig Allelic Exclusion

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Small RNA Biology (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by Heterochromatin Machinery and Non-Coding RNAs

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Gregory J. Hannon, University of Cambridge, UK
Small RNA Biology

Yunsun Nam, University of Texas Southwestern Medical Center, USA
Short Talk: Regulation of let-7 microRNA Biogenesis by Lin28

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

SATURDAY, JANUARY 21

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Epigenomic Landscapes and Dynamics
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
High-Resolution Mapping of Epigenome Dynamics

Oliver J. Rando, University of Massachusetts Medical School, USA
Systematic Dissection of Histone Modification Pathways in Yeast

Lucas Kaaij, Hubrecht Institute, Netherlands
Short Talk: Global Release of DNA Methylation Maintenance in Differentiating Small Intestinal Stem Cells

* Bing Ren, Ludwig Institute for Cancer Research, USA
Base-Resolution Analyses of Parent-of-Origin and Sequence Dependent Allele Specific DNA Methylation in the Mouse Genome

Paul D. Soloway, Cornell University, USA
Short Talk: Next Generation Epigenomic Methods

Inkyung Jung, University of California, San Diego, USA
Short Talk: Global Mapping of the Regulatory Interactions of Histone Residues


Following Session is for Chromatin Dynamics (J4)

08:00—11:00
Replication, Repair, Recombination
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Gary Karpen, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
Heterochromatin Proteins Regulate the Spatial and Temporal Dynamics of Recombination Repair among Repeated DNAs

David M. Gilbert, Florida State University, USA
Replication Timing Maps Define a Discrete Unit of Large-Scale Chromosome Organization

Gerald M. Pao, The Salk Institute, USA
Short Talk: BRCA1 Mediated Tumor Suppresion Occurs via Mono-ubiquitylation of Histone H2A and Heterochromatin Integrity

Toshio Tsukiyama, Fred Hutchinson Cancer Research Center, USA
ATR-Like Kinase Mec1 Regulates Chromatin Accessibility at DNA Replication Forks

Jesper Q. Svejstrup, Francis Crick Institute, UK
The Interface between Transcription, Chromatin, and Mechanisms Maintaining Genome Integrity

09:00—09:20
Coffee Break

Longs Peak Foyer
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Epigenetic Reprogramming
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Wolf Reik, Babraham Institute, UK
Epigenetic Reprogramming in Mammalian Development

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
RNA Interference, Heterochromatin Reprogramming and Germ Cell Fate

Amanda G. Fisher, MRC Clinical Sciences Centre, Imperial College London, UK
Epigenetic Reprogramming of Somatic Cells toward Pluripotency

David J. Katz, Emory University, USA
Short Talk: The Histone Demethylase LSD1/KDM1 Maintains Stem Cell Fates by Reprogramming Epigenetic Memory


Following Session is for Chromatin Dynamics (J4)

17:00—19:00
Transcription Initiation/Elongation
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
* Stephen Buratowski, Harvard Medical School, USA
Co-Transcriptional Histone Modification and RNA Processing

Julie Ahringer, University of Cambridge, UK
Chromatin Regulation in Transcription and Splicing

John T. Lis, Cornell University, USA
Activator Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70

Raul Mostoslavsky, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Regulates Transcriptional Elongation in Metabolism

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

SUNDAY, JANUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Boehringer Ingelheim Pharmaceuticals, Inc. Novartis Institutes for BioMedical Research
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HG006396-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

BioVentures, Inc. Gordon and Betty Moore Foundation
Integrated DNA Technologies March of Dimes Foundation
New England Biolabs, Inc. Novus Biologicals, Inc.
Zymo Research Corporation
Journal of Biological Chemistry


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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