Beaver Run Resort Floorplan

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This meeting took place in 2012



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Chemokines and Leukocyte Trafficking in Homeostasis and Inflammation (A1)


Organizer(s) William W. Agace, Sirpa Jalkanen and Sergio A. Lira
January 8—13, 2012
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 15, 2011
Late Abstract Deadline: Oct 11, 2011
Scholarship Deadline: Sep 15, 2011
Early Registration Deadline: Nov 8, 2011

Sponsored by Biogen Idec, Novo Nordisk A/S and Vertex Pharmaceuticals Incorporated

Summary of Meeting:
The organized trafficking of leukocyte subsets through the tissue compartments of the body is critical to the generation of innate and adaptive immune responses and for normal organ immuno-surveillance; however, when misguided, such processes can promote uncontrolled inflammation resulting in tissue pathology. It is now well established that cellular adhesion and chemokine receptors play a central role in regulating tissue-specific leukocyte migration. Recent studies have started to unravel the complex mechanisms underlying the expression of these receptors on lymphocytes and highlight the importance of the local lymph node environments and migratory dendritic cells in the induction of peripheral tissue homing receptors. While immunologists have traditionally tended to focus on primary and secondary lymphoid compartments to study immunological processes and immune cell interactions, there is a growing realization that many, if not most, of our immune cells are located in peripheral tissues and that each of these sites possess unique immunological characteristics. This Keystone Symposia meeting on Chemokines and Leukocyte Trafficking in Homeostasis and Inflammation will bring together scientists and clinicians with expertise in immune cell migration, cellular adhesion/chemokine receptor regulation and tissue-specific leukocyte trafficking with a focus on the peripheral tissue compartments in health and disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 8

15:00—19:30
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
William W. Agace, Lund University, Sweden
Welcoming Remarks

Philip M. Murphy, NIAID, National Institutes of Health, USA
Chemokines: Tales from the Clinic

* Sirpa T. Jalkanen, University of Turku, Finland

* Sergio A. Lira, Mount Sinai School of Medicine, USA

Eugene C. Butcher, Stanford University, USA
Trafficking Programs in Tolerance and Immunity


MONDAY, JANUARY 9

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Leukocyte Interactions with Vascular/Lymphatic Endothelium
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Sirpa T. Jalkanen, University of Turku, Finland

Ronen Alon, Weizmann Institute of Science, Israel
Distinct Modalities of Chemokine Promoted Transendothelial Migration of Lymphocytes

Paul Kubes, University of Calgary, Canada
Imaging Intravascular Immunity

Sussan Nourshargh, Barts and The London Medical School, UK
Leukocyte Motility through Venular Walls

Cornelia Halin, ETH Zürich, Switzerland
Dendritic Cell Interactions with Lymphatic Endothelium

Caname Iwata, University of Tokyo, Japan
Short Talk: Podoplanin-Bound CCL21 Regulates Adhesive Migration of T Lymphocytes on the Cell Surfaces of Lymphatic Endothelium

Trupti D. Vardam, Roswell Park Cancer Institute, USA
Short Talk: Immunoprotective Role of an IL-6/sIL-6R/gp130/STAT3 Signaling Axis Controlling Lymphocyte Trafficking during Fever

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
 
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Workshop 1: Modulators of Immune Cell Migration

Colorado Ballroom
* Reina E. Mebius, Vrije Universiteit, Netherlands

Craig T. Lefort, La Jolla Institute for Allergy and Immunology, USA
Distinct Roles for Talin-1 and Kindlin-3 in LFA-1-Dependent Neutrophil Rolling and Arrest

Stefano Angiari, University of Verona, Italy
Metabolic Intervention with Pantethine Inhibits T Cell Trafficking and Autoimmune Disease

Masayuki Miyasaka, Osaka University, Japan
The Autotaxin/Lysophosphatidic Acid Axis Regulates Lymphocyte Extravasation at Lymph Node High Endothelial Venules

Xuguang Chen, Dana-Farber Cancer Institute, USA
Distinct Roles for CCL2/MCP-1 and CCR2 in Mammary Cancer Development and Tumor Neovascularization

Cecilia Jädert, Karolinska Institutet, Sweden
Decreased Leukocyte Recruitment by Inorganic Nitrate and Nitrite in Microvascular Inflammation and NSAID-Induced Intestinal Injury

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Migratory Pathways of Monocyte/Dendritic Cell Subsets
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* William R. Heath, University of Melbourne, Australia

Miriam Merad, Mount Sinai School of Medicine, USA
Migratory Potential of Dendritic Cell Precursors

Steffen Jung, Weizmann Institute of Science, Israel
The CX3CR1 / CX3CL1 Chemokine Axis

Gwendalyn J. Randolph, Washington University, USA
A Look at Dendritic Cells and Macrophages in Perinodal Adipose Tissue

Michael Y. Gerner, NIAID, National Institutes of Health, USA
Short Talk: Distinct Spatial Localization and Function of Resident Dendritic Cell Subsets in Lymph Nodes

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

TUESDAY, JANUARY 10

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Intra-Organ Leukocyte Migration
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Sussan Nourshargh, Barts and The London Medical School, UK

Michael Sixt, Institute of Science and Technology Austria, Austria
Intestitial Leukocyte Mobility: Chemotactic Guidance of Dendritic Cells in vivo

Ulrich H. Von Andrian, Harvard Medical School, USA
Innate Immunity-Adaptive Immunity: What's the Difference?

Ellen A. Robey, University of California, Berkeley, USA
Visualizing Immune Responses to Toxoplasma gondii in situ

Paul S. Frenette, Albert Einstein College of Medicine, USA
Circadian Influences on Leukocyte Migration

Wolfgang K. Kastenmuller, NIAID, National Institutes of Health, USA
Short Talk: Selectively Prepositioned Effector Cells in the Lymph Node Provide Optimal Defense against Systemic Spread of Lymph Node Pathogens

Irah King, McGill University, Canada
Short Talk: Visualization the iNKT Cell Activation in vivo

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
 
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Breckenridge Ballroom
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Leukocyte Trafficking to the Inflamed CNS
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Ronen Alon, Weizmann Institute of Science, Israel

Richard M. Ransohoff, Biogen, USA
Microglia: What's in a Name?

Gabriela Constantin, University of Verona, Italy
New Insights into Leukocyte Trafficking in CNS Diseases

Jian Song, Muenster University, Germany
Short Talk: A Pivotal Role for Cytokine-Regulated MMP-2 and MMP-9 Activity in Leukocyte Chemotaxis into the Brain

Shahani Noor, University of California, Riverside, USA
Short Talk: Impact of CCR7-Dependent T Cell Migration in Memory Responses to Toxoplasma Infection in the Brain

Marco Prinz, University of Freiburg, Germany
Short Talk: Cytosolic Rig-I-Like Helicases Act as Negative Regulators of Sterile Inflammation in the CNS

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

WEDNESDAY, JANUARY 11

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Generation of Tissue Tropic Lymphocyte Subset
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Oliver Pabst, Hannover Medical School, Germany

Bart N. Lambrecht, VIB, Ghent University, Belgium
Lung Dendritic Cell Subsets and the Initiation of Allergic Airway Inflammation

Reina E. Mebius, Vrije Universiteit, Netherlands
Vitamin A and the Mucosal Immune System

Carola G. Vinuesa, Australian National University, Australia
FoxP3+ Regulatory T Cells and NKT Cells Co-Opt the Tfh Differentiation Pathway to Upregulate CXCR5 and Participate in Antibody Responses

Reinhold Förster, Hannover Medical School, Germany
Lymph Node Homing of Immune Cells via Afferent Lymphatics

Beatriz León, University of Alabama at Birmingham, USA
Short Talk: B Cell-Dependent Positioning of CXCR5-Expressing Dendritic Cells Drives Th2 Development

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
 
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Breckenridge Ballroom
14:30—16:30
Workshop 2: Leukocyte Migration to and within Peripheral Tissues

Colorado Ballroom
* Thorsten R. Mempel, Massachusetts General Hospital, USA

* Gwendalyn J. Randolph, Washington University, USA

Javier Rangel-Moreno, University of Rochester, USA
Early Induction of iBALT Enhances T Follicular Cell Recruitment to Influenza-Infected Lungs, Promotes Rapid Viral Clearance and Prevents Immuno-Pathology

Livija Deban, Oxford BioTherapeutics, UK
RGS-1 in Intestinal T Cell Trafficking and Responsiveness

Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
CCL19-Cre BAC Transgenic Mice: Targeting Lymph Node Fibroblastic Reticular Cells in vivo

Jeffrey C. Nolz, University of Iowa, USA
Dynamic Expression of Selectin Ligands Directs Memory CD8 T Cells to Inflamed Tissues Independent of Antigenic Stimulation

Michael G. Overstreet, University of Rochester Medical Center, USA
Interstitial Migration of CD4+ T Cells is Dependent on alpha5beta1 Integrin

Calum C. Bain, University of Edinburgh, Scotland
Ly6Chigh Monocytes Give Rise to Resident and Inflammatory Intestinal Macrophages in a Context-Dependent Manner

Kathryn A. Fraser, University of Minnesota, USA
Effector Memory CD8 T Cells are not as Dependent on IL-15 for Homeostatic Maintenance

William R. Heath, University of Melbourne, Australia
Different Patterns of Peripheral Migration by Memory CD4 and CD8 T Cells

Silvia Ariotti, Netherlands Cancer Institute, Netherlands
Skin Patrol by Tissue-Resident Memory CD8+ T Cells

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Chemokines and Leukocyte Trafficking at Epithelial Surfaces: Lung/Skin
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Reinhold Förster, Hannover Medical School, Germany

Andrew D. Luster, Massachusetts General Hospital, USA
Lymphocyte Trafficking to Inflamed Airways

William W. Agace, Lund University, Sweden
Intestinal Dendritic Cell Subsets and the Generation of Gut Tropic Effector T Cells

Thomas S. Kupper, Brigham and Women's Hospital, USA
T Cell Trafficking and Skin-Resident T Cells

Jason M. Schenkel, University of Minnesota, USA
Short Talk: Dynamics and Function of CD8 T Cell Responses within the Female Reproductive Tract

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

THURSDAY, JANUARY 12

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Chemokines and Leukocyte Trafficking at Mucosal Surfaces: The Gut
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* William W. Agace, Lund University, Sweden

Sergio A. Lira, Mount Sinai School of Medicine, USA
Chemokines and the Intestinal Mucosa

Oliver Pabst, Hannover Medical School, Germany
Coordinated Migration of Regulatory T Cells Enables Intestinal Tolerance

Enric Esplugues, Mount Sinai School of Medicine, USA
How TH17 Cells are Controlled in the Gut

David H. Adams, University of Birmingham, UK
Modulating Lymphocyte Migration for the Treatment of Liver Disease

Junjie Mei, Children's Hospital of Philadelphia, USA
Short Talk: CXCR2 and CXCL5 Regulate IL-17/G-CSF Axis and Neutrophil Homeostasis

Guy Shakhar, Weizmann Institute of Science, Israel
Short Talk: CD103+ DCs Mobilize to the Intestinal Epithelium to Sample Bacteria from the Lumen

09:00—09:20
Coffee Break

Foyer
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cell Migration in Cancer
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Sergio A. Lira, Mount Sinai School of Medicine, USA

Alberto Mantovani, Humanitas University, Italy
Chemokines as Key Components of Cancer-Related Inflammation

Thorsten R. Mempel, Massachusetts General Hospital, USA
In vivo Dynamics of NFAT Activation in Cytotoxic T Cells

Sirpa T. Jalkanen, University of Turku, Finland
Homing-Associated Molecules as Potential Therapeutic Targets in Cancer

Steven T. Pals, University of Amsterdam, Netherlands
Short Talk: A Clinically Active BTK Inhibitor Targets Adhesion and Migration in Chronic Lymphocytic Leukemia

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

FRIDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Biogen Idec Novo Nordisk A/S
Vertex Pharmaceuticals Incorporated
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI096755-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

ChemoCentryx, Inc. R&D Systems, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676