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This meeting took place in 2012



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The Biology of Cytokines (Q1)


Organizer(s) Christopher A. Hunter, John J. O'Shea and Fiona M. Powrie
February 5—10, 2012
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 5, 2011
Late Abstract Deadline: Nov 7, 2011
Scholarship Deadline: Oct 5, 2011
Early Registration Deadline: Dec 5, 2011

Sponsored by Novartis Institutes for BioMedical Research and Novo Nordisk A/S. Supported by an educational donation provided by Amgen.


Summary of Meeting:
In the last decade, cytokine therapies have been included as the standard of care for the treatment of infectious disease and cancer, and cytokine antagonists have been deployed for the management of chronic inflammation. Many researchers in this field are interested in basic principles through which cytokines mediate communication with and between cells of the immune system. Others are interested in the contributions of cytokines and cytokine signaling to the development of, or protection from, a broad range of diseases including allergy, infectious diseases, cancer, atherosclerosis and autoimmunity. With the recognition that many of these pathways impact broadly on multiple conditions, the goal of the Keystone Symposia meeting on The Biology of Cytokines is to promote interaction between scientists who study the molecular mechanisms of cytokine function, signal transduction and gene expression, and scientists who study how cytokines work in vivo. We anticipate that this meeting will foster discussion aimed at translating this knowledge into novel therapies for human disease. Opportunities for interdisciplinary interaction will be significantly enhanced by the concurrent meeting on Th17 Cells in Health and Disease, which will share a keynote address and two plenary sessions with this meeting.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 5

15:00—20:30
Registration

Longs Peak Foyer
19:00—20:00
Refreshments

Longs Peak Foyer
20:00—21:45
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
Diane Mathis, Harvard Medical School, USA
Regulation of Autoimmune Disease by Intestinal Microbes: Good Bugs/Bad Bugs

Tadatsugu Taniguchi, University of Tokyo, Japan
Old and New Cytokines and Immune Regulation


MONDAY, FEBRUARY 6

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* David Artis, Cornell University, USA

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
IL-1 and the Inflammasome

Kevin J. Tracey, Feinstein Institute for Medical Research, USA
Sterile Inflammation and HMGB1

Ming O. Li, Memorial Sloan Kettering Cancer Center, USA
TGF-beta Control of Immune Homeostasis

Brendan J. Jenkins, Hudson Institute of Medical Research, Australia
Cross-Talk between IL-6 Family Cytokines and TLRs in Inflammation and Cancer

Danielle N. Kroetz, University of Michigan, USA
Short Talk: Novel Role for the Th2 Cytokine TSLP in Controlling Intracellular Growth of a Fungal Pathogen

James Harris, Monash University, Australia
Short Talk: Autophagy Regulates Inflammation through the Control of IL-1beta and IL-23


Following Session is for Th17 Cells in Health and Disease (Q2)

08:00—11:00
Molecular Regulation of Th17 Cells
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Dan R. Littman, HHMI/New York University School of Medicine, USA
RORgamma and Th17 Differentiation

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Small Molecule Inhibitors of T Cell Responses in vivo

Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Role of BATF Family Transcription Factors in Immune Cell Type Specificity

Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Regulatory T Cells and Control of Th17 Cells

Elke Glasmacher, , Germany
Short Talk: Regulation of Th17 Cell Differentiation by IRF-4/BATF/JunB Complexes

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Quandary Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Metabolic Disease and Cancer
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Obesity and Inflammation

Ajay Chawla, University of California, San Francisco, USA
Innate Regulation of Adipose Tissue Metabolism

Giorgio Trinchieri, NCI, National Institutes of Health, USA
Cytokines and Cancer

Chia-Lin Hsu, National Yang-Ming University, Taiwan
Short Talk: Antigen-Mediated Skin Inflammation is Dependent on an IL-33/ST2 Pathway


Following Session is for Th17 Cells in Health and Disease (Q2)

17:00—19:15
Innate Source and Function of Th17-Related Cytokines
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Daniel J. Cua, Merck Research Laboratories, USA

Kingston H.G. Mills, Trinity College Dublin, Ireland
Role of the IL-1 Cytokine Family in Activating Th17 and gammadelta T Cells in Infection and Autoimmunity

Bruno Silva-Santos, University of Lisbon, Portugal
EMBO Young Investigator Lecture: In vivo Differentiation and Expansion of gammadelta T Cells

Yueh-hsiu Chien, Stanford School of Medicine, USA
gammadelta T Cell Activation: Antigen Recognition vs. Environmental Cues

Hergen Spits, University of Amsterdam, Netherlands
Regulation of IL-22 Production by Th22 Cells and Innate Lymphoid Cells

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, FEBRUARY 7

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Cytokines and Adaptive Processes
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Fiona M. Powrie, University of Oxford, UK

Thomas F. Tedder, Duke University Medical Center, USA
Regulatory B Cell Production of IL-10 Directs Innate and Adaptive Immunity

Cecile King, Garvan Institute of Medical Research, Australia
IL-21 and Mucosal Autoimmunity

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Th2-Mediated Immunity: Who Does What?

K. Christopher Garcia, Stanford University School of Medicine, USA
Molecular Insight into Signal Initiation by Interleukin-2 and Interleukin-15

Hidehiro Yamane, NIAID, National Institutes of Health, USA
Short Talk: Strong TCR Signal-Mediated Suppression of Th2 Differentiation Requires Presenilin Function Independent of Notch Pathway

Reiko Horai, NEI, National Institutes of Health, USA
Short Talk: IFN-gamma is Critical for Pathogenesis of Autoimmune Uveitis in a Spontaneous Mouse Model


Following Session is for Th17 Cells in Health and Disease (Q2)

08:00—11:15
Th17 Cells and Inflammatory Diseases
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Brigitta Stockinger, Francis Crick Institute, UK

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Th17 Cells in Autoimmunity and Tissue Inflammation

Alison L. Budelsky, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
IL-17RA as a Novel Therapeutic Target for the Treatment of Multiple Autoimmune Diseases

Clare M. Lloyd, Imperial College London, UK
IL-17 in Asthma

Jingwu Zhang Zang, GlaxoSmithKline, China
Role of Neurotrophin Leukemia Inhibitory Factor (LIF) in Th17 Cell Differentiation and Its Association with Neural Progenitor Cell Therapy in Autoimmune Disease

Simona Rolla, University of Turin, Italy
Short Talk: Phenotypical and Functional Characterization of T Helper 22 Cells in Multiple Sclerosis Patients

Akihiko Yoshimura, Keio University, Japan
Short Talk: Effect of Biological and Chemical JAK Inhibitors on Th17 and Inflammatory Disease Models

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Quandary Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
The Interferons
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* John J. O'Shea, NIAMS, National Institutes of Health, USA

Carolina B. López, University of Pennsylvania, USA
Type I IFN Induction: Antagonism vs. Viral Recognition, and the Role of Defective Genomes

Virginia Pascual, Cornell University, USA
Type I IFNs and Autoimmunity

Anne O'Garra, Francis Crick Institute, UK
Cytokines Involved in the Pathogenesis of Tuberculosis

Marco Prinz, University of Freiburg, Germany
Short Talk: Cytosolic RIG-I-Like Helicases Limit TH1/TH17 Mediated Autoimmunity in the CNS


Following Session is for Th17 Cells in Health and Disease (Q2)

17:00—19:00
Th17 Cells and Cancer
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Wenjun Ouyang, Amgen, Inc., USA

Weiping Zou, University of Michigan, USA
Human Th17 Cells have Stem Cell-Like Features

Nicholas P. Restifo, NCI, National Institutes of Health, USA
Self-Renewal and Persistence of T Cell Subsets

Sergei B. Koralov, New York University, USA
STAT3 in T Cells: At the Crossroads of Inflammation and Cancer

Xue-Zhong Yu, Moffitt Cancer Center & Research Institute, USA
Short Talk: Reciprocal Regulation and Distinct Contribution of Th1 and Th17 Cells in Acute Graft-versus-Host Disease

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, FEBRUARY 8

07:00—08:00
Breakfast

Quandary Peak
08:00—11:15
Cytokines and Environmental Interfaces
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jay K. Kolls, Tulane School of Medicin, USA

David Artis, Cornell University, USA
Mechanisms of Immunoregulation at Barrier Surfaces

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
TSLP and Lung Inflammation

Fiona M. Powrie, University of Oxford, UK
IL-23-Driven Cellular and Molecular Pathways that Promote Intestinal Inflammation and Colon Cancer

Michael Croft, La Jolla Institute for Allergy and Immunology, USA
TNFR Family Molecules and Lung Inflammation

Paula M. Oliver, University of Pennsylvania, USA
Short Talk: Preventing IL-4 Production is Required for Appropriate T Cell Differentiation

Mark A. Travis, University of Manchester, UK
Short Talk: Expression of the TGF-beta Activating Integrin alphav beta8 on Dendritic Cells: A Crucial Pathway for the Induction of Oral Tolerance


Following Session is for Th17 Cells in Health and Disease (Q2)

08:00—11:00
Th17 Cell Deficiencies
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Kingston H.G. Mills, Trinity College Dublin, Ireland

Jean-Laurent Casanova, Rockefeller University, USA
Life-Threatening Infectious Diseases of Childhood: Single-Gene Inborn Errors of Immunity?

Manuela Raffatellu, University of California, Irvine, USA
The Role of IL-17 and IL-22 during the Early Phase of Salmonella colitis

Laurence Zitvogel, Institut Gustave Roussy, France
TH17/gammadeltaT17 Differentiation during Immunogenic Cell Death in Cancer

Hongbo Chi, St. Jude Children's Research Hospital, USA
Short Talk: Programming of TH17 Differentiation and Inflammation by Dendritic Cell-Derived Innate Immune Signals

Sophie Cypowyj, Rockefeller University, USA
Short Talk: Gain-of-Function Human STAT1 Mutation Impair IL-17 Immunity and Underlie Chronic Mucocutaneous Candidiasis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Quandary Peak
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Quandary Peak
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
The IL-6 Family
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Giorgio Trinchieri, NCI, National Institutes of Health, USA

Elina I. Zuniga, University of California, San Diego, USA
Gp130 Signaling Cytokines During Chronic Viral Infection

Christopher A. Hunter, University of Pennsylvania, USA
IL-6 and IL-27: Opposing Roles in the Regulation of TFH and B Cell Responses

Lindsay L. Jones, St. Jude Children's Research Hospital, USA
Short Talk: Distinct Heterodimer Pairing Criteria and Subunit Competition within the IL-12 Cytokine Family

Simon A. Jones, Cardiff University School of Medicine, UK
IL-6 in Anti-Microbial Host Defense and associated Inflammation-Induced Tissue Damage


Following Session is for Th17 Cells in Health and Disease (Q2)

17:00—19:00
Th17 Cells and Mucosal Immunity
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Chen Dong, Tsinghua University, China

Jay K. Kolls, Tulane School of Medicin, USA
Th17 Cells and Mucosal Immunity

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Commensal Pathogen Cross Talk at Barrier Surfaces

Shabaana Khader, Washington University School of Medicine, USA
T Helper Subsets in Immunity to Pulmonary Intracellular Pathogens

Stephen Rubino, Brigham and Women's Hospital, USA
Short Talk: Plasticity of IL-17 T-Cell Responses to Enteric Infection

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
19:30—22:00
Poster Session 3

Quandary Peak

THURSDAY, FEBRUARY 9

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
Th17 Cytokines and Regulators (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA

Daniel J. Cua, Merck Research Laboratories, USA
IL-23 Control of Th17 and Treg Cells

John J. O'Shea, NIAMS, National Institutes of Health, USA
STATs and Helper Cell Plasticity

Chen Dong, Tsinghua University, China
Regulation and Function of Th17 Cells

Liang Zhou, Northwestern University, USA
Molecular Regulation of Gut Immunity

Jobert G. Barin, Johns Hopkins University, USA
Short Talk: GM-CSF Control of Macrophage Differentiation is a Critical Effector of Th17 Responses in vivo

09:00—09:20
Coffee Break

Longs Peak Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Regulation and Function of IL-22 (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human T Cell Subsets in Inflammation

Wenjun Ouyang, Amgen, Inc., USA
Regulation and Function of IL-22 in Mucosal Immunity

Brigitta Stockinger, Francis Crick Institute, UK
Beyond Th17 Cells

Jacob S. Lee, Merck, USA
Short Talk: AHR is Required for the Development of Small Intestine Lymphoid Tissues and their Associated IL-22-Producing Lymphoid Cells

19:00—20:00
Social Hour with Lite Bites

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

FRIDAY, FEBRUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen Novartis Institutes for BioMedical Research
Novo Nordisk A/S
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI096545-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.
Cytokine journal

eBioscience, Inc. Janssen Research & Development LLC
Rigel Pharmaceuticals, Inc.
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676