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This meeting took place in 2012


Here are the related meetings in 2018:
Lymphocytes and their Roles in Cancer (R1)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Regulation of Lymphocyte Signaling (C4)


Organizer(s) Arthur Weiss and Bernard Malissen
March 11—16, 2012
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 10, 2011
Late Abstract Deadline: Dec 13, 2011
Scholarship Deadline: Nov 10, 2011
Early Registration Deadline: Jan 12, 2012

Sponsored by Abbott Laboratories, Novo Nordisk A/S and Takeda Pharmaceutical Company Limited

Summary of Meeting:
Key individual components of signaling pathways that control lymphocyte activation have been identified. However, their specific regulation, integration within pathways and regulation are still the subject of intense investigation. Currently, they are being probed through biochemical, chemical-genetic, modeling and imaging methods. Major hurdles still reflect our very simplistic understanding of both the kinetic parameters of the molecules involved as well as the complexity of the regulatory circuits of these signaling pathways. Moreover, it is still quite difficult to translate such information into downstream biologically important information. The fact that therapeutics targeting these signaling pathways are still lagging is not surprising. The Keystone Symposia meeting on Regulation of Lymphocyte Signaling will highlight different methodologies and approaches aimed at developing a better integration of complex information about signaling. This information will lead to better understanding of how the normal immune system functions and where interventions in signaling pathways can be used in diseases of the immune system.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 11

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Arthur Weiss, University of California, San Francisco, USA

Joseph Schlessinger, Yale University School of Medicine, USA
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy


MONDAY, MARCH 12

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Biochemistry and Systems Biology of TCR Signaling
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France

Arthur Weiss, University of California, San Francisco, USA
Regulation of Tyrosine Kinases by the TCR

Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Signaling Mutants Uncover Rare Populations of Innate-Like Lymphocytes

Katharina Gaus, University of New South Wales, Australia
Short Talk: The Role of LAT Vesicles in T Cell Activation

Mira Barda-Saad, Bar Ilan University, Israel
Short Talk: Molecular Characterization of the WIP;WASp Complex Essential for Actin Polymerization: Insights from Triple-Color FRET Imaging Technology

Arup K. Chakraborty, Massachusetts Institute of Technology, USA
Role of the Membrane Environment in Regulating Early Events in TCR Signaling

Garry P. Nolan, Stanford University, USA
Single Cell "Phosphoflow" Analysis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Longs/Quandary Peaks
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
BCR Signaling and Regulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* John C. Cambier, University of Colorado SOM, USA

Michael Reth, Albert-Ludwigs University Freiburg, Germany
Nanoscale Analysis of B Cell Antigen Receptor Activation

Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Dysregulation of Self-Tolerance Checkpoints by Mutations in the Antigen Receptor - NF-kappaB Signaling Pathway

Pavel Tolar, Francis Crick Institute, UK
Coordination of Signaling and Endocytosis in the B Cell Synapse

Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: The B Cell Antigen Receptor Transduces Signals from the BAFF Receptor Required for B Cell Survival

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, MARCH 13

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Imaging Signaling in Cells and in vivo
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan

Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Responses in Vivo

Stephen C. Bunnell, Tufts University School of Medicine, USA
Ubiquitin-Dependent Recruitment of IKKgamma/NEMO to TCR Microclusters during T Cell Activation

Jay T. Groves, University of California, Berkeley, USA
Patterned Spatial Segregation of Interacting Receptors

Eilon Sherman, NCI, National Institutes of Health, USA
Short Talk: Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

Sarah Russell, Swinburne University of Technology, Australia
How Important is Asymmetric Cell Division in the Control of Immune Cell Fate Decisions

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Longs/Quandary Peaks
14:30—16:30
Workshop 1

Grays Peak
* Eric S. Huseby, University of Massachusetts Medical School, USA

María Almena, National Center of Biotechnology, Spain
Diacylglycerol Metabolism Controls the Strength of Signaling during T Cell Development

Matthew L. Bettini, Baylor College of Medicine, USA
Basic Residues in the CD3epsilon Lipid Binding Region are Required for Normal TCR Signaling and T Cell Development

Mark R. Boothby, Vanderbilt University Medical Center, USA
Cell-Intrinsic Roles of mTOR Complex 2 in Development, Survival, and Functional Capacity of Mature B Cells and the Memory Response

Rebecca J. Brownlie, Edinburgh University, UK
Loss of the Cytoplasmic Phosphatase, PTPN22, Activates Regulatory T Cells that Control Effector T Cell Expansion

Nicole M. Chapman, St. Jude Children's Research Hospital, USA
Pyk2 Controls Distinct TCR-Induced Signaling Pathways Leading to PI3K Activation and T Cell Spreading in Human T Cells

Clifford S. Guy, St. Jude Children's Research Hospital, USA
Distinct T Cell Receptor Signaling Pathways Drive Proliferation and Cytokine Production in T Cells

John A. Hammer, NHLBI, National Institutes of Health, USA
Actin Retrograde Flow and Acto-Myosin II Arc Contraction Drive Receptor Cluster Dynamics at the Immunological Synapse in Jurkat T Cells

Jinsung Hong, Georgia Institute of Technology, USA
2D Kinetics of 3.L2 TCR-pMHC Binding Determine T Cell Function

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Ubiquitination and Proteolytic Control of Signaling
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Sarah Russell, Swinburne University of Technology, Australia

Marc-Werner Dobenecker, Rockefeller University, USA

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Innate Immune Signaling

Leonard L. Dragone, National Jewish Health, USA
Short Talk: The Regulation of TCR Complex Signaling by Cullin-RING Ubiquitin Ligases

Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and Innate Immune Signaling

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, MARCH 14

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Signaling to Control Developmental Transitions
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA

Kristin A. Hogquist, University of Minnesota, USA
TCR Signal Strength in Thymic Selection

Benedict Seddon, University College London, UK
Short Talk: Regulation of Thymocyte Development and T Cell Homeostasis by Zap70 Signaling

Oreste Acuto, University of Oxford, UK
Themis: An Enigmatic Protein Required for Positive Selection

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Signals Controlling B Cell Development, Maintenance and Transformation

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Contribution of Transcription Factors to Rapid Responsiveness of IgG Type Memory B Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Longs/Quandary Peaks
14:30—16:30
Workshop 2

Grays Peak
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Li-Heng Hsu, University of Glasgow, UK
Analysing the Role of ERK MAPK Signaling in Tolerance and Priming of Antigen-Specific CD4+ T Cells in vitro

Robert L. Kortum, National Cancer Institute, National Institutes of Health, USA
Signaling through the RasGEFs Sos1 and RasGRP1 is Required at Multiple Stages of Thymocyte Development

Baoyu Liu, Georgia Institute of Technology, USA
Force-Regulated Interactions between T Cell and its Antigen

Daniel Marshall, IP Group Plc, UK
The Role of TCR and Cytokine Signaling in the Development of Regulatory T-Cells

Miguel E. Moreno-Garcia, Seattle Children's Research Institute, USA
Kinase-Independent Feedback Signaling of the TAK1/TAB1 Complex on BCL10 Turnover and NF-kappaB Activation in Lymphocytes

Kole Thomas Roybal, University of California, San Francisco, USA
Systems-Scale Quantification of the Spatiotemporal Dynamics of Actin Regulation during T Cell Activation

Wenqing Li, National Cancer Institute, USA
IL-7–Independent IL-7Ralpha Signaling in Childhood Acute Lymphoblastic Leukemia

Martin J. Richer, University of Iowa, USA
Inflammatory Cytokines Regulate Functional Avidity Maturation of CD8 T Cells by Enhancing T Cell Receptor Proximal Signaling

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Signaling in Tolerance and Selection
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kristin A. Hogquist, University of Minnesota, USA

Nicholas R. J. Gascoigne, National University of Singapore, Singapore
Short Talk: Themis Sets the Thymocyte Signaling Threshold between Positive and Negative/Agonist Selection

Ed Palmer, University of Basel Hospital, Switzerland
Signaling Thresholds in Tolerance: Changing over Time

Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Signals Involved in Anergy

John C. Cambier, University of Colorado SOM, USA
B Cell Anergy: Molecular Underpinning, Translation to Human Disease and Exploitation for Therapy

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, MARCH 15

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Pathology Resulting from Signaling Aberrations
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Averil I. Ma, University of California, San Francisco, USA

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
LAT Signaling Pathology: An "Autoimmune" Condition without T Cell Self-Reactivity

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Mechanisms of Cell Death Control Critical for a Functioning Immune System

Silvia Bolland, NIAID, National Institutes of Health, USA
TLR Signaling Abnormalities Leading to Autoimmunity

Michael Mingueneau, Biogen Idec, USA
Short Talk: Impact of NOD (Non-Obese Diabetic) Genetic Variation on Thymic Decision Checkpoints and TCR Signaling Networks

Louis M. Staudt, National Cancer Institute, NIH, USA
Therapeutic Strategies in Lymphoma Based on Oncogenic B Receptor and MYD88 Signaling

Jeroen Roose, University of California, San Francisco, USA
Short Talk: Effective Cooperation between Cytokine Receptor-Input and the Rasgrp1 Oncogene in T Cell Leukemogenesis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

14:30—16:30
Workshop 3

Grays Peak
* Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada

Karsten Sauer, Pfizer, USA
Feedback Regulation of TCR Signaling via PI3K by Soluble Inositol Tetrakisphosphate

Alexandra Schrader, University Medicine, Germany
New Pathway Activities in Aggressive Non-Hodgkin Lymphomas Identified via Guided Clustering

Rut Valdor, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy Regulates T Cell Function

Feng Wang, Stanford University School of Medicine, USA
T Cell Receptor and Membrane Dynamics Analyzed with Super-Resolution Imaging Secondary Ion Mass Spectrometry

Ruobing Wang, Seattle Biomedical Research Institute, USA
Fueling Immunity: Dissecting the Dynamic Interplay between Metabolic Pathways and Lymphocyte Signaling Cascades

Christoph Wülfing, University of Texas Southwestern Medical Center, USA
Itk Regulates the Spatiotemporal Organization of T Cell Signaling

Jun Zhong, Johns Hopkins University, USA
TSLP Signaling Revealed by Quantitative Phosphoproteomics

Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Negative Regulation of TCR Signaling by PD-1 Microcluster

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Therapeutic Targeting of Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Louis M. Staudt, National Cancer Institute, NIH, USA

John J. O'Shea, NIAMS, National Institutes of Health, USA
Jak Kinases as Targets

Andrew C. Chan, Genentech, Inc., USA
Transforming Clinical Medicine into Molecular Medicine

Stuart S. Winter, Children's Minnesota, USA
Short Talk: Macrophage and NK-Mediated Killing of Precursor-B Acute Lymphoblastic Leukemia Cell Lines and Primary Patient Samples Targeted with a-Fucosylated Anti-CD19 Humanized Antibodies

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
20:00—23:00
Entertainment

Longs/Quandary Peaks

FRIDAY, MARCH 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Abbott Laboratories Novo Nordisk A/S
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI098289-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676