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This meeting took place in 2012


Here are the related meetings in 2018:
HIV and Co-Infections: Pathogenesis, Inflammation and Persistence (X8)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Frontiers in HIV Pathogenesis, Therapy and Eradication (X8)


Organizer(s) Alan N. Engelman, Eric O. Freed and John M. Coffin
March 26—31, 2012
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 29, 2011
Late Abstract Deadline: Jan 4, 2012
Scholarship Deadline: Nov 29, 2011
Early Registration Deadline: Jan 26, 2012

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation. Sponsored by Sangamo BioSciences, Inc.


Summary of Meeting:
AIDS is incurable because cells latently infected with HIV resist antiviral therapy. Topical to the discussion of HIV eradication is the biology behind latent infection as well as models for the study of latency and pharmacological approaches to stimulate proviral gene expression. The Keystone Symposia meeting on Frontiers in HIV Pathogenesis, Therapy and Eradication will create an environment for free exchange of ideas and cutting-edge results from a range of scientists in academia and industry in the fields of HIV pathogenesis, pharmacology and eradication. Joint plenary sessions with the concurrent meeting on Cell Biology of Virus Entry, Replication and Pathogenesis will highlight common topics of interest including mechanisms of virus entry and inhibition, and will significantly enhance opportunities for interdisciplinary interactions. Leaders from the HIV replication and drug resistance fields will critically examine the state of antiviral therapy, novel inhibitors and important virus-host interactions. Speakers selected from submitted abstracts will fill out workshops on pharmacological approaches and the cell biology of HIV infection.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 26

14:55—15:10
Coffee Break

Fitzsimmons
15:00—19:30
Registration

Grand Foyer
18:15—19:15
Refreshments

Grand Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Alan N. Engelman, Dana-Farber Cancer Institute, USA

* Michael Farzan, The Scripps Research Institute, USA

Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Understanding How Antiretroviral Therapy for HIV Infection Really Works

Stephen C. Harrison, Harvard Medical School, USA
Mechanisms of Virus Entry


TUESDAY, MARCH 27

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:15
Retroviral Entry Mechanisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Peter D. Kwong, NIAID, National Institutes of Health, USA

Sriram Subramaniam, National Institutes of Health, USA
Structure of HIV and SIV Envelope Glycoproteins and Mechanisms of Viral Entry

Kelly K. Lee, University of Washington, USA
Short Talk: Solution Structure and Conformational Dynamics in Full-Length, Glycosylated HIV Gp120

Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
HIV in the Cytoplasm: How Can Early Events Influence Late Outcomes?

Michael J. Root, Thomas Jefferson University, USA
HIV-1 gp41 Structural Changes Associated with Viral Membrane Fusion

Clare Jolly, University College London, UK
Cell-Cell Transfer of HIV-1

Kelechi C. Chikere, University of California, Los Angeles, USA
Short Talk: High Throughput Receptor Affinity Profiling Reveals Distinct Entry Efficiency Patterns amongst HIV-1 Isolates that Correlate with Pathogenic and Biological Phenotypes

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky A
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sea to Sky A
14:30—16:30
Workshop 1: New Approaches to the Study of Treatment of Viral Infections

Sea to Sky C
* Benhur Lee, University of California, Los Angeles, USA

Aaron J. Arvey, Gilead, USA
Profiling the Genome-Wide Regulatory Network of a Tumor Virus and Its Human Host

Benjamin K. Chen, Mount Sinai School of Medicine, USA
Coupled HIV-1 Endocytosis and Maturation-Induced Viral Fusion during Cell-Cell Infection

Daniel C. DiMaio, Yale University School of Medicine, USA
Artificial Transmembrane Proteins that Inhibit CCR5 Expression and HIV Co-Receptor Activity

J. Nicholas Francis, University of Utah, USA
Membrane Localization of D-Peptide HIV Entry Inhibitors

Tijana Ivanovic, Harvard Medical School, USA
Dissecting Conformational Rearrangements in Influenza-Virus Hemagglutinin through a Single-Virion Membrane-Fusion Assay

Jason Kindrachuk, National Institutes of Health, USA
Temporal Systems Kinomics Analysis of Host Cell Responses to Ebola

Emma-Kate Loveday, University of British Columbia, Canada
Temporal and Strain-Specific Host MicroRNA Molecular Signatures Associated with Swine-Origin H1N1 and Avian-Origin H7N7 Influenza A Virus Infection

Jason A. Wojcechowskyj, University of Pennsylvania, USA
How HIV Reprograms Cells - Quantitative Phosphoproteomics during HIV Entry

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Inhibition of Virus Entry (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Amy Jacobs, State University of New York at Buffalo, USA

Peter D. Kwong, NIAID, National Institutes of Health, USA
Effective Antibody-Mediated Inhibition of HIV-1 Entry

Peter S. Kim, Stanford University, USA
Vaccine Candidates that Mimic the HIV-1 gp41 Pre-Hairpin Intermediate

Michael Farzan, The Scripps Research Institute, USA
The Sulfotyrosine-Binding Pockets of gp120 as a Therapeutic Target

Jie Xue, Stanford University, USA
Short Talk: Biochemical Investigation of the Mechanism of Griffithsin: Dimer Structure Plays an Essential Role in Griffithsin Function

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

WEDNESDAY, MARCH 28

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:15
Mechanisms of HIV Latency
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* David M. Margolis, University of North Carolina at Chapel Hill, USA

Eric M. Verdin, University of California, San Francisco, USA
Roles of Proviral Integration Sites

Melanie M. Ott, University of California, San Francisco, USA
Regulation of HIV-1 Transcription by Tat Posttranslational Modifications

Matthew J. Pace, University of Oxford, UK
Short Talk: Direct Infection of Resting CD4+ T Cells with HIV Leads to Not Only Integration but also Expression of Gag Proteins without Efficient Viral Spread in a Model of HIV Latency

Jonathan Karn, Case Western Reserve University, USA
Control of HIV Latency by Epigenetic and Non-Epigenetic Silencing

Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA
Tissue Analysis of Viral Reservoirs in Patients on ART

Sharon Schlesinger, Columbia University, College of Physicians and Surgeons, USA
Short Talk: Proviral Silencing in Embryonic Cells: Why YY1?

08:00—11:00
Anti-Viral Therapeutics: New and Old Paradigms
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Kartik Chandran, Albert Einstein College of Medicine, USA

Benhur Lee, University of California, Los Angeles, USA
Mechanistic Basis of Broad Spectrum Antivirals that Target Virus-Cell Fusion

Benjamin R. tenOever, Icahn School of Medicine at Mount Sinai, USA
miRNA-Mediated Control of Virus Infection

JoAnn A. Suzich, MedImmune, USA
Treating Respiratory Syncytial Virus Infections

Phoebe L. Stewart, Case Western Reserve University, USA
Defensin Neutralization of Adenovirus

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky A
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sea to Sky A
14:30—16:30
Workshop 1: New Pharmacologies/Intervention

Sea to Sky B
* Andrew J. Henderson, Boston University School of Medicine, USA

Ramesh K. Akkina, Colorado State University, USA
Topical Gel Formulation of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 Protects against HIV-1 Vaginal Challenge in a Humanized Mouse Model

Li Liu, NIAID, National Institutes of Health, USA
Neutralization Epitope Masking within the Native HIV-1 Env Trimer: Intraprotomer Rather than Interprotomer Masking of V3 Epitopes by V1V2

Eugenio Montini, San Raffaele Scientific Institute, Italy
Assessing the Impact of Lentiviral Vector Integration on Splicing of Cellular Genes at the Genome-Wide Level

Webster L. Santos, Virginia Tech, USA
Inhibiting RNA-Protein Interactions: Cell Permeable Branched Peptide Boronic Acids Inhibit Tat-TAR and Rev-RRE Interactions

Kayoko Waki, NCI, National Institutes of Health, USA
A Tale of Two HIV-1 Maturation Inhibitors – Bevirimat (BVM) and PF-46396: Insights into Gag Assembly and Virion Maturation

Keith R. Jerome, Fred Hutchinson Cancer Research Center, USA
Pharmacodynamic Considerations in Targeted Endonuclease Therapy for HIV

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
HIV Therapy: State of the Art
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Celia A. Schiffer, University of Massachusetts Medical School, USA

Douglas D. Richman, University of California, San Diego, USA
Measuring the Latent Reservoir

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
TCR Clonotypes Modulate the Protective Effect of HLA Class I Alleles in HIV-1 Infection

Tae-Wook Chun, NIAID, National Institutes of Health, USA
Cellular Reservoirs of HIV: Perspectives for Eradication and Development of Therapeutic Strategies

Mathias Lichterfeld, Massachusetts General Hospital, USA
Short Talk: Treatment of Early HIV-1 Infection Reduces Viral Reservoirs in CD4 T Cells to Levels Found in Elite Controllers

17:00—19:00
Viral Entry Processes
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Sean P. Whelan, Harvard Medical School, USA

Judith M. White, University of Virginia Health Sciences Center, USA
Roles for Cathepsin Priming of the Ebola Virus Glycoprotein for Cellular Entry

Lucas Pelkmans, University of Zürich, Switzerland
Cell-to-Cell Variability Modeling of Virus Infection Reveals Complex Population-Determined RNAi Phenotypes

Roselyn J. Eisenberg, University of Pennsylvania, USA
Herpes Virus Fusion and Entry: A Story with Many Characters

Mathieu Mateo, Mayo Clinic, USA
Short Talk: Nectin-4 is the Measles Virus Host Exit Receptor

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 2

Sea to Sky A

THURSDAY, MARCH 29

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:15
Targeting Latency for Eradication
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Carol D. Weiss, US Food and Drug Administration, USA

David M. Margolis, University of North Carolina at Chapel Hill, USA
Targeting Latency for Eradication: State of the Art

Daria J. Hazuda, Merck Research Laboratories, USA
The HIV-1 Eradication Pipeline: Challenges and Opportunities

Jan Chemnitz, Heinrich Pette Institute, Germany
Short Talk: Excision of Proviral DNA by Tre-Recombinase in HIV-Infected Humanized Mice

John W. Mellors, University of Pittsburgh School of Medicine, USA
Clinical Trials of Strategies to Cure HIV-1 Infection

Sharon R. Lewin, University of Melbourne, Australia
Understanding Infection of Resting T-Cells and Maintenance of Latency: The Role of Myeloid Dendritic Cells

Kathryn Miller-Jensen, Yale University, USA
Short Talk: Chromatin Accessibility at the HIV-1 LTR Promoter Sets a Threshold for NF-kappaB-Mediated Viral Gene Expression

08:00—11:00
Structural Approaches to Virology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Stephen C. Harrison, Harvard Medical School, USA

Z. Hong Zhou, University of California, Los Angeles, USA
Atomic Structures by cryoEM Suggest Divergent Mechanisms of Entry by dsRNA Viruses

Glen R. Nemerow, The Scripps Research Institute, USA
Adenovirus Structure

Félix Rey, Institut Pasteur, France
The First Snapshot of a Cell-Cell Fusion Protein Reveals Unanticipated Links with Viruses

Timothy F. Booth, Public Health Agency of Canada, Canada
Short Talk: Three-Dimensional Structure of Ebola Virus Determined by Cryo-Electron Microscopy and Cryo-Electron Tomography

Kai Xu, National Institutes of Health, USA
Short Talk: Crystal Structure of the Nipah Virus Fusion Glycoprotein Reveals a Functionally Essential Hexameric Assembly

Robin Löving, Karolinska Institutet, Sweden
Short Talk: Maturation Cleavage of the Retrovirus Mo-MLV Spike Precursor Splays the Transmembrane Subunits to Prime it for Receptor Triggering

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky A
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sea to Sky A
14:30—16:30
Workshop 2: Cell Biology of HIV Infection

Sea to Sky B
* Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA

Lars-Anders Carlson, NIDDK, National Institutes of Health, USA
Towards an in vitro Reconstitution of HIV-1 Assembly and Release

Tonya Kueck, King's College London, UK
A Trafficking Determinant in HIV-1 VPU is Essential to Counteract Type 1 Interferon-Induced Levels of Tetherin in CD4+ T Cells

Kyeongeun Lee, NCI, National Institutes of Health, USA
CPSF6 and TNPO3 Interactions Regulate HIV-1 Infection

Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Efficient Macrophage Infection by Uptake of Dying HIV-1-Infected T Cells

Nicholas Francella, University of Pennsylvania, USA
Emergence of CD4-Independent SIV Variants during in vivo SIV Adaptation to a Lack of CD4

Anna Christina Kajaste-Rudnitski, San Raffaele Scientific Institute, Italy
Molecular Insights Into TRIM22-Mediated HIV-1 Transcriptional Repression

Felipe Diaz-Griffero, Albert Einstein College of Medicine, USA
RING Domain Mutations Uncouple TRIM5alpha Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating

Angela M. Gronenborn, University of Pittsburgh, USA
Structures of Vpr and Vpx in DDB1-DCAF1 Complexes - Unique Surfaces for Substrate Recruitment

14:30—16:30
Workshop 2: Virus Host Interactions

Sea to Sky C
* Judith M. White, University of Virginia Health Sciences Center, USA

Susanna Ruth Bidgood, MRC Laboratory of Molecular Biology, UK
Mechanism of Antibody-Dependent Intracellular Neutralization Mediated by TRIM21

Chengyu Liang, University of Southern California, USA
Autophagic Tumor Suppressor UVRAG Controls Viral Endosomal Transport and Release

Emily Happy Miller, Albert Einstein College of Medicine, USA
Host-Programmed Recognition of an Intracellular Entry Receptor by Ebola Virus

Frank Neipel, Universitaet Erlangen, Germany
The Ephrin Receptor Tyrosine Kinase A2 is a Cellular Receptor for Kaposi’s Sarcoma-Associated Herpesvirus

Ryan S. Noyce, Dalhousie University, Canada
Tumor Cell Marker PVRL4 (NECTIN 4) is an Epithelial Cell Receptor for Measles Virus

Christopher M. Robinson, University of Texas Southwestern Medical Center, USA
Virus-Microbiota Interactions in the Gut: The Role of Bacterial Polysaccharides

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
New Approaches to Antiviral Treatment
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Douglas D. Richman, University of California, San Diego, USA

Zeger Debyser, KU Leuven, Belgium
LEDGINs Potently Inhibit HIV Replication and Block Multiple Functions during Integration

Paula M. Cannon, University of Southern California, Keck School of Medicine, USA
Engineering Cells to Resist HIV Infection by CCR5 Knockout

Sarah E. Palmer, University of Sydney, Australia
Characterizing and Targeting Latent HIV Reservoirs

Patrick M. Younan, Fred Hutchinson Cancer Research Center, USA
Short Talk: Immune Response Promotes Recovery of Unmodified CD4+ T-Cells in the SHIV-Macaque Model after Hematopoietic Stem Cell Gene Therapy

17:00—19:00
Systems Approaches to Virology
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Nir Hacohen, Massachusetts General Hospital, USA

Andrew Fire, Stanford University, USA
Evolution of Effector Repertoire in Response to Viral Infection

Abraham L. Brass, University of Massachusetts Medical School, USA
Genetic Strategies to Investigate Host-Virus Interactions

Bruce M. McManus, University of British Columbia, Canada
Host Signaling Response to Coxsackievirus B3

Gilad Sivan, NIAID, National Institutes of Health, USA
Short Talk: Human Genome-Wide siRNA Screen Reveals the Importance of the Nuclear Pores for the Cytoplasmic Life Cycle of Vaccinia Virus

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 3

Sea to Sky A

FRIDAY, MARCH 30

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:00
Models for Therapy and Eradication
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Melanie M. Ott, University of California, San Francisco, USA

J. Victor Garcia-Martinez, University of North Carolina at Chapel Hill, USA
The Humanized BLT Mouse Model

Zandrea Ambrose, University of Pittsburgh, USA
Using Macaque Models to Study HIV Persistence and Eradication Strategies

Binhua Ling, Tulane National Primate Research Center, USA
Short Talk: The Effect of Antiretroviral Therapy on SIV Gut Mucosal Reservoirs in Chinese Rhesus macaques of SIV Infection – New Non-Human Primate Model for Identification and Eradication of HIV Tissue Reservoirs

Kathleen L. Collins, University of Michigan Medical Center, USA
HIV-1 Infection of Hematopoietic Progenitor Cells

Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Short Talk: Strategies for Evaluation of Residual Virus and Viral Eradication Approaches in Antiretroviral Drug Suppressed, SIV-Infected Rhesus macaques

08:00—11:00
Immunity and Viral Evasion
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Michael Farzan, The Scripps Research Institute, USA

Dan R. Littman, HHMI/New York University School of Medicine, USA
Dendritic Cell Sensing

Jonathan C. Kagan, Boston Children's Hospital, USA
Peroxisomes, MAVS and Innate Immunity

Diane E. Griffin, Johns Hopkins Bloomberg School of Public Health, USA
Measles: Determinants of Virus Clearance and Protective Immunity

Nir Hacohen, Massachusetts General Hospital, USA
Innate Responses to Influenza A Virus

09:20—09:40
Coffee Break

Grand Foyer
11:15—13:00
Poster Setup

Sea to Sky A
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sea to Sky A
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Host Factors and HIV Replication
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Angela M. Gronenborn, University of Pittsburgh, USA

Alan N. Engelman, Dana-Farber Cancer Institute, USA
HIV-Host Interactions in Nuclear Import and Integration

Eric O. Freed, NCI, National Institutes of Health, USA
Host Cell Factors in Retrovirus Assembly and Release

Jonathan P. Stoye, National Institute for Medical Research, UK
SAMHD1 and HIV-1 Replication

Schuyler Van Engelenburg, NICHD, National Institutes of Health, USA
Short Talk: Characterization of HIV-1 Gag Assembly and Particle Production

Schuyler Van Engelenburg, NICHD, National Institutes of Health, USA
Short Talk: Characterization of HIV-1 Gag Assembly and Particle Production

17:00—19:00
Viral Assembly and Replication
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Andrew Mehle, University of Wisconsin, Madison, USA

Sean P. Whelan, Harvard Medical School, USA
Control of Polymerase Activity during Replication and Assembly of Negative-Sense RNA Viruses

Barbara Müller, Heidelberg University Hospital, Germany
HIV Assembly and Maturation

Emily Bruce, University of Cambridge, UK
Short Talk: Rab11 and its Effector Myosin Vb are Involved in Late Stages of Influenza Virus Assembly and Budding

Mickey J. Pentecost, David Geffen School of Medicine at University of California, Los Angeles, USA
Short Talk: SUMO and Ubiquitin Modifications in the Subnuclear Trafficking and Function of Nipah Virus Matrix

Roland Schwarzer, Humboldt University, Germany
Short Talk: The Role of Lipid Rafts in Virus Assembly

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
20:00—23:00
Entertainment

Sea to Sky A

SATURDAY, MARCH 31

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation Sangamo BioSciences, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI098442-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Biogen Idec Office of AIDS Research, NIH

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck Research Laboratories


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