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This meeting took place in 2012



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Viral Immunity and Host Gene Influence (X6)


Organizer(s) Laurence C. Eisenlohr, Connie C. Bergmann, Stephen J. Turner and Andrea Lynn Cox
March 21—26, 2012
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 21, 2011
Late Abstract Deadline: Dec 22, 2011
Scholarship Deadline: Nov 21, 2011
Early Registration Deadline: Jan 20, 2012

Supported by the Directors’ Fund

Joint Meeting: HIV Vaccines (X5)

Summary of Meeting:
This meeting will focus on recent advances in viral immunity and host gene influence that have most excited the scientific community. Systems biology approaches are being increasingly applied to the exploration of host-pathogen interactions, including the impact of viral infection on innate and adaptive immunity. Accordingly, the keynote talk will be on this topic. The first full session on the next day will focus on innate immunity, a field that continues to evolve rapidly and hold great interest in the field. In the evening the audience will hear from others who have successfully applied a systems biology approach to examine virus-host interactions. The second day explores adaptive immunity, a topic that historically has been a centerpiece for this meeting, and an area that continues to move forward rapidly. On the third day, the morning session will focus on immune evasion and subversion and will illustrate how formidable the opposition can be and why vaccine development for a number of important human diseases is so challenging. Talks on persistent and chronic viral infections, a topic with clear relevance to a number of human diseases, will be covered in the evening session. The morning session of the final day will cover immune tailoring in non-lymphoid tissues; talks will illustrate how different host responses can and must be, depending upon anatomical location of the infection. The final session will cover the latest advances in the development of vaccines and therapeutics, the traditional ending for this meeting series and a reminder to attendees of the ultimate objectives. Overall, the objective of the Keystone Symposia meeting on Viral Immunity and Host Gene Influence is to accelerate progress in understanding and manipulating anti-viral immunity to improve human health. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on HIV Vaccines, which will share a keynote address and three plenary sessions with this meeting. We anticipate this pairing will facilitate a wider cross-fertilization of ideas and foster innovative collaborations among scientists working in vaccinology and those studying innate immune mechanisms and other viral diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, MARCH 21

15:00—19:30
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—19:30
Welcome Address by the Organizers (Joint)

Columbine Ballroom
Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA

19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Naglaa Shoukry, University of Montreal Hospital Research Center, Canada

* Andrew J. McMichael, Oxford University, UK

Stanley M. Lemon, University of North Carolina at Chapel Hill, USA
Divergent Infection Outcomes Marked by Similarities and Differences in Induction and Evasion of Interferon Responses by Hepatotropic RNA Viruses

Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Structure of the Membrane-Anchored HIV-1 Envelope Glycoprotein Trimer Complex by Cryoelectron Microscopy


THURSDAY, MARCH 22

07:00—08:00
Breakfast

Torreys Peak
08:00—11:15
Innate Immune Responses to Virus Infection
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
IFITM-Mediated Intracellular Anti-Viral Restriction

* Mariapia A. Degli-Esposti, LEI, University of Western Australia, Australia
NK Cell Immune Mechanisms in a Natural Host-Pathogen System

Andrew G. Brooks, University of Melbourne, Australia
Killer Immunoglobulin Receptor 3DL1-Mediated Recognition of HLA-A and –B Allotypes

Luis J. Sigal, Fox Chase Cancer Center, USA
Innate Immunity to Ectromelia Virus

Michael A. Schmid, University of California, Berkeley, USA
Short Talk: Dendritic Cells and the Immune Response to Dengue Virus Infection in the Skin

Béhazine Combadière, INSERM, France
Short Talk: Neutrophils Drag and Drop Antigen from the Dermis to the Bone Marrow Initiating an Alternative Source of Long-Lived Memory CD8+ T Cells


Following Session is for HIV Vaccines (X5)

08:00—11:00
HIV-1/SIV Transmission
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* Daniel C. Douek, NIAID, National Institutes of Health, USA

* Barbara L. Shacklett, University of California, Davis, USA

Beatrice H. Hahn, University of Pennsylvania, USA
Biology of Transmitted/Founder Viruses

Damien Tully, Ragon Institute of MGH, MIT and Harvard, USA
A Deeper View of Transmitted/Founder Viruses during Acute HIV-1 Infection using 454 Whole Genome Deep Sequencing

Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
Defining the Mechanisms of Heterosexual HIV Transmission

Christopher J. Miller, University of California, Davis, USA
Lessons Learned from Recapitulating the Step Trial in NHP

Kamini Gounder, Doris Duke Medical Research Institute, University of KwaZulu Natal, South Africa
Short Talk: Viral Evolution and Immune Escape in Gag during Acute HIV-1 Subtype C Infection

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Torreys Peak

Following Session is for HIV Vaccines (X5)

11:00—12:30
Hands On Computer Workshop on Los Alamos SEQUENCE DATABASE and Tools
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Bette Korber and Carla Kuiken.

Castle Peaks
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Torreys Peak

Following Session is for HIV Vaccines (X5)

14:30—16:30
Workshop 1: HIV-1/SIV Transmission and NHP Protection Studies

Longs/Grays Peaks
* Eric Hunter, Emory University, USA

* Christopher J. Miller, University of California, Davis, USA

Debby Basu, Emory University, USA
Intra-Subtype C HIV-1 Superinfection Occurs Prior to Robust Neutralizing Antibody Responses in the Newly Infected Partner

Katja Pfafferott, Weatherall Institute of Molecular Medicine, UK
Analysis of Two Clade A Transmission Pairs with Contrasting Clinical Outcomes Suggests Contributions of the Founder Virus and Host CD8 T Cell Response to Set-Point Viremia

Rama Rao Amara, Emory University, USA
GM-CSF Expressed by DNA but Not MVA Enhances Prevention of Acquisition by a Heterologous Mucosal Challenge

Shari N. Gordon, NCI, National Institutes of Health, USA
Human Papillomavirus Pseudovirion Vaccines Delivering SIV DNA Partially Protects from Mucosal SIVmac251 Infection

Brian Moldt, The Scripps Research Institute, USA
Non-Fucosylated b12 has Enhanced FcyRIIIa-Mediated Antiviral Activity in vitro but Not Improved Protection against Mucosal SHIV Challenge in Macaques

Amarendra Pegu, NIAID, National Institutes of Health, USA
VRC01 Provides Sterilizing Protection to Non Human Primates from Mucosal SHIV Challenges

Adrienne E. Swanstrom, University of Pennsylvania, USA
In vitro and in vivo Characterization of a Novel Variant of SIVmac239 Lacking CD4 Tropism

Liang Shang, University of Minnesota, USA
Natural Killer Cells Are Critical to Control Viral Infection in the Female Genital Tract of Rhesus Macaque after SIV Vaginal Challenge

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Systems Approaches to Virus-Host Interactions
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

* Ralph S. Baric, University of North Carolina at Chapel Hill, USA
Systems Genetics and Respiratory Virus Pathogenomics

Alison Simmons, Weatherall Institute of Molecular Medicine, UK
Early Host Responses to HIV Infection

Nathan P. Croft, University of Melbourne, Australia
Short Talk: Quantitative Kinetics of Antigen Presentation during Viral Infection


Following Session is for HIV Vaccines (X5)

17:00—19:00
B Cells and Neutralizing Antibodies
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

* Michael B. Zwick, The Scripps Research Institute, USA

David M. Tarlinton, Monash University, Australia
Memory B Cell and Plasma Cell Development in Response to Vaccination

Dennis R. Burton, The Scripps Research Institute, USA
Neutralizing Antibody Targets on the HIV-1 Spike

Gary J. Nabel, Sanofi, USA
Generation of Broadly Neutralizing Antibodies in an AIDS Vaccine: The End of the Beginning

Jinghe Huang, NIAID, National Institutes of Health, USA
Short Talk: Isolation of a Broad, Potent, MPER-Specific Monoclonal Antibody with Novel Binding Characteristics

19:00—20:00
Social Hour with Lite Bites

Torreys Peak
19:30—22:00
Poster Session 1

Torreys Peak

FRIDAY, MARCH 23

07:00—08:00
Breakfast

Torreys Peak
08:00—11:15
Stimulation of Adaptive Immune Responses (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Mark Connors, NIAID, National Institutes of Health, USA

* Kevin L. Legge, University of Iowa Carver College of Medicine, USA

Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA
MHC Class II-Restricted Processing Pathways for Viral Antigens

Chris C. Norbury, Pennsylvania State University Medical School, USA
Short Talk: Assessing the Role of APC Phenotype and Maturation Status upon the Contribution of Direct and Cross Antigen Presentation during a Natural Virus Infection

Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden
Properties of B Cell Responses Elicited By Soluble HIV-1 Env Trimers

Laura E. McCoy, The Scripps Research Institute, USA
Short Talk: Potent Multi-Clade Neutralization of HIV-1 by a Llama VHH Antibody Induced by Immunization

Marc K. Jenkins, University of Minnesota Medical School, USA
Maintenance of Protective CD4+ “Memory” T Cells during Persistent Phagosomal Infection

David Price, Cardiff University School of Medicine, UK
The Clonotypic Basis of Adaptive T Cell Immunity

09:20—09:40
Coffee Break

Longs Peak Foyer
11:45—13:00
Poster Setup

Torreys Peak

Following Session is for HIV Vaccines (X5)

11:15—12:45
Hands On Computer Workshop on Los Alamos IMMUNOLOGY DATABASE and Tools
Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructors: Brian Foley, Bette Korber and Carla Kuiken.

Castle Peaks
11:45
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Torreys Peak
14:30—16:30
Workshop 1

Quandary Peak
Sophie Hambleton, Newcastle University, UK
A Defect in Type I Interferon Signaling Causes Severe Susceptibility to Some, but Not All, Viral Infections in Humans

Tao Peng, University of Washington, USA
System Biology Approaches to Dissect Immune-Surveillance Roles of CD8+ Cells at Mucosal Surface during HSV-2 Reactivation

Daniela Weiskopf, La Jolla Institute for Allergy & Immunology, USA
Proteome Wide Mapping of Dengue Virus-Specific T Cell Responses in Human Donors Reveals Antigenic Hot Spots and a Dominance of HLA B Restricted Responses

* Michelle L. Baker, CSIRO Livestock Industries, Australia
Immunology of an Important Viral Reservoir, the Australian Black Flying Fox

* Andrew J. Yates, University of Glasgow, UK
The Race for the Prize – Surveillance Strategies for the Efficient Induction of T Cell Responses

Allison M. W. Malloy, Uniformed Services University of the Health Sciences, USA
CD8+ T Cell Epitope Hierarchy is Established during the Neonatal Period in Respiratory Syncytial Virus-Infected Mice

Christopher Lupfer, St. Jude Children's Research Hospital, USA
T Cell Intrinsic Role of Nod2 in Cellular Immunity to Virus Infection

Shiki Takamura, Kinki University Faculty of Medicine, Japan
CD69 Controls a Balance between S1P- and CXCL16-Induced Chemotaxes during the Process of Memory CD8+ T Cell Recruitment to the Lung Airways


Following Session is for HIV Vaccines (X5)

14:30—16:30
Workshop 2: B Cells and Neutralizing Antibodies

* Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA

* James A. Hoxie, University of Pennsylvania, USA

Torben Schiffner, The Scripps Research Institute, USA
Modulating Immunogenicity by Chemical Modification of gp140

Mattias Forsell, Umeå University, Sweden
Targeted Immunosilencing Reveals Independent Regulation of Epitope Specific B Cell Responses to HIV-1 Env

Elise Landais, International AIDS Vaccine Initiative, USA
Development of Broadly Neutralizing Antibody Responses in a Large Sub-Saharan HIV Primary Infection Cohorts

Jason S. McLellan, University of Texas at Austin, USA
Structural and Biophysical Studies of Antibodies Isolated from RV144 Vaccinees

Lawrence S. Shapiro, Columbia University, USA
Deep Sequencing with Longitudinal Sampling of a VRC01-Like-Antibody Response in a Chronically Infected Individual

Jordan R. Willis, Vanderbilt University, USA
Structure Analysis of Healthy Donor Repertoire Confers Sequences that Match Long Complementary Determining Regions of Broadly Neutralizing Antibodies

Samantha J. Hoot, Seattle Biomedical Research Institute, USA
Interaction of Germline Precursors to Broadly Neutralizing Anti-CD4 Binding Site Antibodies with HIV-1 Envelope Glycoproteins

M. Gordon Joyce, U.S. Military HIV Research Program, USA
Structures of Reverted Germline VRC01-Like Antibodies Guide HIV-1 Immunogen Design

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Adaptive Immunity: Regulating T Cell Function at the Levels of Epigenetics and TCR Activation
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Pedro R. Lowenstein, University of Michigan School of Medicine, USA
CD8 TcR Synapses in vitro and in vivo

Heather D. Hickman, NIAID, National Institutes of Health, USA
Intravital Imaging of CD8+ T Cell Activation after Viral Infection

* Stephen J. Turner, University of Melbourne, Australia
Epigenetic Regulation of Virus-Specific CD8+ T Cell Responses

J. Scott Hale, University of Utah, USA
Short Talk: Distinct Memory CD4 T Cells with Commitment to the T Follicular Helper and Th1 Lineages


Following Session is for HIV Vaccines (X5)

17:00—19:00
Cellular Immunity against HIV/SIV - Messages for Vaccines
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* Nilu Goonetilleke, University of North Carolina at Chapel Hill, USA

* Guido Ferrari, Duke University Medical Center, USA

Marcus Altfeld, Heinrich-Pette-Institute, Germany
NK Cell Mediated Immune Pressure in HIV-1 Infection

Stephen J. Kent, University of Melbourne, Australia
ADCC Activity against HIV

David I. Watkins, University of Miami, Miller School of Medicine, USA
SIV-Specific T Cell Responses

Alessandra Noto, Lausanne University Hospital, Switzerland
Short Talk: Loss of Id2 during Chronic HIV Infection is Mediated by PD-1 Triggering and is Responsible for HIV-Specific CD8+ T Cell Exhaustion

19:00—20:00
Social Hour with Lite Bites

Torreys Peak
19:30—22:00
Poster Session 2

Torreys Peak

SATURDAY, MARCH 24

07:00—08:00
Breakfast

Torreys Peak
08:00—11:15
Immune Evasion and Subversion (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA

Ted C. Pierson, NIAID, National Institutes of Health, USA
A Dynamic Landscape for Antibody-Mediated Neutralization and Enhancement of Flavivirus Infection

* Klaus Früh, Oregon Health & Science University, USA
Evasion of T Cell Responses by Cytomegalovirus

Hanneke Schuitemaker, Janssen Vaccines & Prevention B.V., Netherlands
HIV-1 Dynamics in Relation to Cross-Reactive Neutralizing Humoral Immunity

Nilu Goonetilleke, University of North Carolina at Chapel Hill, USA
Short Talk: T Cell Immunodominance, Breadth and Epitope Entropy are the Major Determinants of Virus Escape in Acute HIV-1 Infection

Andrew J. McMichael, Oxford University, UK
HIV-1 Escape from CD8+ T Cell Recognition

Timothy E. Dudek, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Accurate Recapitulation of Human Acute-Phase HIV-Specific CD8+ T-Cell Responses and Viral Evolution in Humanized BLT Mice

Kia Katchar, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Adaptation of Hepatitis C Virus (HCV) to KIR-Associated Immune Pressures

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—11:45
The Grant Submission Process at NIH/NIAID (Joint)
The presentation will introduce the NIH/NIAID grant submission process and describe some grants available to new investigators.

Columbine Ballroom
Cheryl Lapham, NIAID, DHHS, National Institutes of Health, USA

11:15—13:00
Poster Setup

Torreys Peak
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Torreys Peak
14:30—16:30
Workshop 2

Quandary Peak
Christopher Brooke, NIAID, National Institutes of Health, USA
Nine Out of Ten Influenza A Virions Can Be Wrong: The Cost of Segmentation

Michael E. Wortzman, University of Toronto, Canada
Role of CD8 T Cell Intrinsic TNF in Enhancing the Contraction of Short-Lived Effector Cells during Respiratory Influenza Virus Infection

Matthieu Daugan, INRS-Institut Armand-Frappier, Canada
Mechanisms Implicated in the Late Appearance of Neutralizing Antibodies against Lymphocytic Choriomeningitis Virus

* Mario L. Santiago, University of Colorado Denver, USA
A Single Nucleotide Polymorphism in Tetherin Promotes Retrovirus Restriction in vivo

Deepak Mittal, University of Queensland Diamantina Institute, Australia
Mechanisms of Local Immune Suppression in HPV E7 Expressing Skin

* Pinghui Feng, University of Southern California, USA
A Herpesvirus Selectively Hijacks an Innate Immune Signal Pathway to Enable Viral Transcriptional Activation and Disable Host Antiviral Cytokine Production

Amy Haseley, Ohio State University, USA
Secreted ECM Protein CCN1 Limits Oncolytic HSV-1 Efficacy for Glioma

Patrick C. Rämer, University of Zürich, Switzerland
Identification of Viral Tumor-Suppressor Using a Humanized Mouse Model of EBV Infection


Following Session is for HIV Vaccines (X5)

14:30—16:30
Workshop 3: Cellular Immunity against SIV/HIV

Longs/Grays Peaks
* Richard A. Koup, NIAID, National Institutes of Health, USA

* Bette Tina Marie Korber, Los Alamos National Laboratory, USA
A Comparison of Conserved Region versus Full-Length Protein T Cell Vaccines in Rhesus Monkeys Reveals No Evidence for Immunofocusing

Karthik Shekhar, Massachusetts Institute of Technology, USA
Collective Evolution in HIV Proteins Reveals Strategies for Rational HIV Vaccine Design

Tomas Hanke, University of Oxford, UK
Immunogenicity of a Universal HIV-1 Vaccine Vectored by DNA, MVA and ChAdV-63 in a Phase I/IIa Clinical Trial

Daniel Claiborne, Ragon Institute of MGH, MIT, and Harvard, USA
Rare HLA-Associated Gag Polymorphisms Dramatically Reduce Replicative Capacity of Transmitted Founder Viruses and Modulate Set Point Viral Load

Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
Sequence Signatures Define HIV Antigen Processing Mutations Leading to Immune Escape at the Population Level

Lydie Trautmann, US Military HIV Research Program, USA
Dissecting Function, Memory Generation, and TCR Repertoire of Effector CD8 T cells in Primary HIV Infection and other Acute Viral Infections

Srinika R. F. Ranasinghe, Ragon Institute of MGH, MIT and Harvard, USA
Promiscuity in Peptide-HLA Class II Interactions Impact HIV Immune Control

LaTonya D. Williams, Duke University Medical Center, USA
CD4-Like Immunologic Function by IL-21-Producing CD8 T Cells in HIV-Infected Individuals

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Immunity to Chronic and Persistent Viral Infections
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Mehrdad Matloubian, University of California, San Francisco, USA
Role of Innate Sensing Pathways in Chronic Viral Infections

Barbara Rehermann, NIDDK, National Institutes of Health, USA
Natural Killer Cell Function in Hepatitis C Virus Infection

Christopher M. Snyder, Thomas Jefferson University, USA
Short Talk: Small Populations of Memory-Like CD8+ T Cells Undergo Memory Inflation during MCMV Infection

* Andrea Lynn Cox, Johns Hopkins University, USA
The Missing Link between Inflammasome Complex Activation and Adaptive Immune Responses in the Transition from Acute to Chronic HCV Infection


Following Session is for HIV Vaccines (X5)

17:00—19:00
Update from Clinical Trials of HIV-1 Vaccines
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* Lawrence Corey, Fred Hutchinson Cancer Research Center, USA

* Amapola Manrique, Global HIV Vaccine Enterprise, USA

Nicole Frahm, Fred Hutchinson Cancer Research Center, USA
The HIV Vaccine Landscape after Step and RV144

Nelson L. Michael, Walter Reed Army Institute of Research, USA
Thai Phase III Update. RV144 Follow-up: Antigenicity, Correlates, and Sieve Analysis

Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
Antibodies, Variable Regions, and the RV144 Vaccine Trial Results

Amy W. Chung, Ragon Institute of MGH, MIT & Harvard, USA
Short Talk: RV144 Vaccine Induces a Differential Antibody Effector Function Profile in Comparison to VAX003

19:00—20:00
Social Hour with Lite Bites

Torreys Peak
19:30—22:00
Poster Session 3

Torreys Peak

SUNDAY, MARCH 25

07:00—08:00
Breakfast

Torreys Peak
08:00—11:15
Immune Tailoring in Non-Lymphoid Tissues
Meeting has ended...abstracts no longer viewable online.

Quandary Peak
Mark T. Heise, University of North Carolina at Chapel Hill, USA
Systems Genetics and Regulation of Virus-Induced Inflammatory Responses

David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Lung Specific Recruitment of Virus-Specific T Cells during Acute Respiratory Infection

Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan
Short Talk: Memory B Cells in the Lung Participate in Protective Humoral Immune Responses to Pulmonary Influenza Virus Reinfection

* Cornelia C. Bergmann, Cleveland Clinic Foundation, USA
Cell Type-Specific Immune Regulation during Viral Encephalomyelitis

Jasmin Herz, NINDS, National Institutes of Health, USA
Short Talk: Dynamics of Memory T Cells Clearing a Persistent Infection in the Absence of Severe Tissue Injury

Robert L. Hendricks, University of Pittsburgh, USA
Manipulating HSV-Specific CD8+ T Cell Function to Control Latent Infections in Sensory Gangli


Following Session is for HIV Vaccines (X5)

08:00—11:00
Effective Immune Responses in Animal Models
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peaks
* James E. Robinson, Tulane University Health Sciences Center, USA

* Nancy R. Miller, NIAID, National Institutes of Health, USA

Jason M. Brenchley, NIAID, National Institutes of Health, USA
Microbial Translocation, Immune Activation, and Disease Progression

Poonam Pegu, NCI, National Institutes of Health, USA
Short Talk: Mucosal Transmission of a Limited Number of SIVmac251 Variants in Macaques Recapitulates HIV Vaccine Efficacy in Humans

Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA
Analysis of HIV-1 Env and Elicited Antibody Responses for Improved Immunogen Design

Nancy L. Haigwood, Oregon Health & Science University, USA
Clues to Understanding the Role and Impact of Eliciting Neutralizing Antibodies

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
New Concepts Guiding Vaccine Development (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Gunilla B. Karlsson Hedestam, Karolinska Institutet, Sweden

* Laurence C. Eisenlohr, Children's Hospital of Philadelphia and University of Pennsylvania, USA

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Designing Vaccines: Follicular Helper CD4 T Cells and their Roles in Generating Neutralizing Antibody Responses

Robert A. Seder, NIAID, National Institutes of Health, USA
Impact of Adjuvants on HIV-Specific Immune Responses

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Human Antibodies to HIV

19:00—20:00
Social Hour with Lite Bites

Torreys Peak
20:00—23:00
Entertainment

Torreys Peak

MONDAY, MARCH 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI098254-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Biogen Idec

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Crucell


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676