Boston Park Plaza Floorplan

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This meeting took place in 2012


Here are the related meetings in 2018:
Uncomplicating Diabetes: Reducing the Burden of Diabetes-Related End-Organ Injury (J7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Complications of Diabetes: Mechanisms of Injury and Failure of Repair (C5)


Organizer(s) Rama Natarajan, Matthias Kretzler and E. Dale Abel
March 11—16, 2012
Boston Park Plaza • Boston, Massachusetts USA
Abstract Deadline: Nov 10, 2011
Late Abstract Deadline: Dec 14, 2011
Scholarship Deadline: Nov 10, 2011
Early Registration Deadline: Jan 12, 2012

Sponsored by Merck & Co., Inc.

Summary of Meeting:
Diabetes is associated with significantly accelerated rates of several microvascular and macrovascular complications including nephropathy, neuropathy, retinopathy and atherosclerosis. Furthermore, results from both clinical trials and animal studies indicate that these complications might progress despite glycemic control, a phenomenon termed metabolic memory. Ongoing studies have identified biochemical and nuclear mechanisms, genetic determinants, epigenetic factors and non-coding RNAs in the pathogenesis of diabetic complications. Thus, the study of the key mechanisms leading to injury in target organs and failure of adaptive processes holds great promise for the identification of mechanism-targeted therapeutic approaches. These experimental approaches have been aided by tremendous advances in high-throughput genomic and epigenomic technologies, integrated systems biology and bioinformatics. Advances in the fields of stem cell therapies, induced pluripotency and regenerative medicine have provided new hope for the treatment of complications. The goal of this interdisciplinary meeting is to integrate these evolving concepts with current knowledge to facilitate a systems-level understanding of diabetic complications.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 11

15:00—19:30
Registration

Imperial Check Room
18:15—19:15
Refreshments

Plaza Ballroom
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* Rama Natarajan, Beckman Research Institute of City of Hope, USA

Kenneth R. Chien, Karolinska Institutet, Sweden
Driving Heart Progenitor Cell Fate and Regeneration in vivo via Chemically Modified mRNA


MONDAY, MARCH 12

07:30—08:30
Breakfast

Plaza Ballroom
07:30—20:30
Poster Setup

Plaza Ballroom
08:30—17:00
Poster Viewing

Plaza Ballroom
08:30—11:45
Mechanisms for Glucotoxicity and Lipotoxicity
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
Paul J. Thornalley, Warwick Medical School, UK
Glycation, Dicarbonyls and Oxidative Stress

George L. King, Joslin Diabetes Center, USA
Characterization of Protective Factors for Diabetic Retinopathy and Nephropathy

Karin E. Bornfeldt, University of Washington School of Medicine, USA
Monocyte/Macrophage Fatty Acid Metabolism is More Important than Glucose Metabolism in Mediating an Inflammatory Phenotype and Atherosclerosis

Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Signal Transduction and the Vascular Complications of Diabetes

Günaj Rakipovski, Novo Nordisk, Denmark
Short Talk: Fluctuating hyperglycemia induces higer levels of oxidative stress relative to sustained hyperglycemia in obese rats – possible role for lack of metabolic adaptation

Adam R. Wende, University of Alabama at Birmingham, USA
Short Talk: Glucose-Mediated Control of Mitochondrial Gene Expression and Oxidative Phosphorylation Protein Function in the Heart

09:40—10:00
Coffee Break

Imperial Foyer
11:45—12:30
Lunch

Plaza Ballroom
12:15—14:30
Poster Session 1

Plaza Ballroom
14:30—16:30
Workshop 1: Techniques and Translational Approaches

Imperial Ballroom
* Simeon Taylor, University of Maryland School of Medicine, USA

Thomas M. Coffman, NUS Duke SIngapore, Singapore
Animal Models and Update on AMDCC

Hans-Joachim Anders, University of Munich, Germany
Chemokine Related Targets in Diabetic Nephropathy

Karin Agnes Maria Jandeleit-Dahm, Monash University, Australia
Drug Targets and Drugs for Diabetic Complications

Matthew D. Breyer, Eli Lilly and Company, USA
Hurdles to the Development of Therapies for Diabetic Nephropathy: Making the Leap from Bench to Bedside

16:30—17:00
Coffee Available

Imperial Foyer
17:00—19:00
Micro- and Macrovascular Damage Mechanisms
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* George L. King, Joslin Diabetes Center, USA

Moshe Levi, University of Colorado Health Sciences Center, USA
Role of LXR in Diabetic Complications

Masaomi Nangaku, University of Tokyo School of Medicine, Japan
Abnormal Oxygen Metabolism and Epigenetic Changes in Diabetic Kidney Disease

Eva L. Feldman, University of Michigan, USA
Dyslipidemia in Diabetic Neuropathy

Nhat-Tu Le, University of Rochester, USA
Short Talk: A Crucial Role of p90RSK-Mediated Reduction of Endothelial ERK5 Transcriptional Activity in Endothelial Inflammation, Dysfunction, and Atherosclerosis Formation

 
On Own for Dinner


TUESDAY, MARCH 13

07:30—08:30
Breakfast

Plaza Ballroom
07:30—08:30
Poster Setup

Plaza Ballroom
08:30—17:00
Poster Viewing

Plaza Ballroom
08:30—11:45
Molecular Mechanisms of Injury and Novel Approaches to Cellular Repair
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* Eva L. Feldman, University of Michigan, USA

Paola Romagnani, University of Florence, Italy
Renal Progenitors for Kidney Regeneration: A 'Renopoietic' System?

Jan Kajstura, Brigham and Women's Hospital, Harvard Medical School, USA
Stem Cell and Diabetic Cardiomyopathy

Maria B. Grant, University of Florida, USA
Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors

Sarah X. Zhang, University of Oklahoma Health Sciences Center, USA
ER Stress, Angiogenesis and Inflammation in Diabetic Retinopathy

Josephine M. Forbes, Mater Medical Research Institute, Australia
Short Talk: Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Accelerates the Progression of Diabetic Nephropathy

Zongwei Wang, Massachusetts General Hospital, USA
Short Talk: Inhibition of inflammatory mediators reverses the bladder dysfunction associated with Type 2 Diabetes

09:40—10:00
Coffee Break

Imperial Foyer
11:45—12:30
Lunch

Plaza Ballroom
12:15—14:30
Poster Session 2

Plaza Ballroom
14:30—16:30
Workshop 2: Extramural Funding Opportunities for Diabetes Complications Research

Imperial Ballroom
* Ann Marie Schmidt, New York University Langone Medical Center, USA

Tamara Darsow, American Diabetes Association, USA

Helen D. Nickerson, Juvenile Diabetes Research Foundation, USA

Teresa Jones, NIDDK, National Institutes of Health, USA

Christian Ketchum, NIDDK, National Institutes of Health, USA
NIDDK Opportunities

Tracy Rankin, NIDDK, National Institutes of Health, USA

16:30—17:00
Coffee Available

Imperial Foyer
17:00—19:00
Oxidative Stress and Mitochondrial Dysfunction
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

Subramaniam Pennathur, University of Michigan, USA
Role of Lipoporotein Oxidation in Atherosclerosis

Irina G. Obrosova, Pennington Biomedical Research Center, Louisiana State University System, USA
Oxidative-Nitrosative Stress in Diabetic Neuropathy

Hanna E. Abboud, University of Texas, USA
Noxes, NADPH Oxidase and Diabetic Complications

Xianwen Yi, University of North Carolina, USA
Short Talk: Antioxidants, Mitochondria and Diabetic Nephropathy

 
On Own for Dinner


WEDNESDAY, MARCH 14

07:30—08:30
Breakfast

Plaza Ballroom
07:30—08:30
Poster Setup

Plaza Ballroom
08:30—17:00
Poster Viewing

Plaza Ballroom
08:30—11:45
Lessons Learned from Animal and Human Models of Diabetic Complications
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* Katalin Susztak, University of Pennsylvania, USA

Frank Chip Brosius III, University of Michigan, USA
How a Systems Approach Using Humans and Mice Can Bring New Insight to Understanding Diabetic Complications

Susan Quaggin, Northwestern University, USA
VEGF Pathway and DN: Insight from Murine Models

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Novel Molecular Mechanisms for Diabetic Cardiomyopathy

Mark Yore, Beth Israel Deaconess Medical Center & Harvard Medical School, USA
Vascular and Neural Dysfunction in Diabetic Models

Charles E. Alpers, University of Washington, USA
Short Talk: The BTBR ob/ob Mouse is a Good Model of Diabetic Complications

Richard C. Davis, University of California, Los Angeles, USA
Short Talk: Genetic Mapping of Genes Contributing to Diabetic Complications

09:40—10:00
Coffee Break

Imperial Foyer
11:45—12:30
Lunch

Plaza Ballroom
12:15—14:30
Poster Session 3

Plaza Ballroom
14:30—15:00
Coffee Available

Imperial Foyer
15:00—17:00
Genetics
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* Matthias Kretzler, University of Michigan, USA

Andrzej S. Krolewski, Joslin Diabetes Center, USA
Genetics of Nephropathy in Type 1 Diabetes: Search for Genes Contributing to Rapid Progression to End Stage Renal Disease (ESRD)

Barry I. Freedman, Wake Forest University Baptist Medical Center, USA
Genetic Factors in Diabetic and Non-Diabetic Nephropathy

Kang Zhang, University of California, San Diego, USA
Genetics of Diabetic Retinopathy

Eoin P. Brennan, Conway Institute, Ireland
Short Talk: New Genetic loci Associated with Kidney Disease in Type 1 Diabetes

 
On Own for Dinner


THURSDAY, MARCH 15

07:30—08:30
Breakfast

Plaza Ballroom
08:30—11:45
Role of Epigenetics and MicroRNAs in Diabetic End-Organ Damage
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* Hanna E. Abboud, University of Texas, USA

Katalin Susztak, University of Pennsylvania, USA
Epigenetics in Human Diabetic Kidney Disease

Rama Natarajan, Beckman Research Institute of City of Hope, USA
Role of Epigenetic Mechanisms and microRNAs Underlying Inflammation in Diabetic Vascular Complications and Metabolic Memory

Farhad Danesh, University of Texas MD Anderson Cancer Center, USA
The Emerging Role of MicroRNAs in Diabetic Nephropathy

Assam El-Osta, Baker IDI Heart Research Institute, Australia
Epigenetic Changes in Hyperglycemic Memory of Endothelial Dysfunction in Diabetes

Mary R. Loeken, Joslin Diabetes Center, USA
Short Talk: Inhibition of Differentiation-Induced DNA Methylation Patterns Explains Disturbed Embryo Gene Expression during Diabetic Embryopathy

Nancy E. Castro, City of Hope, USA
Short Talk: miR-30 and miR-130 Family Inhibition by Transforming Growth Factor beta1 Leads to Enhanced Pro-Fibrotic Genes in Mouse Kidney Mesangial Cells

09:40—10:00
Coffee Break

Imperial Foyer
11:45
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Imperial Foyer
17:00—19:00
Integrative Biology Approaches to Diabetic Complications
Meeting has ended...abstracts no longer viewable online.

Imperial Ballroom
* Frank Chip Brosius III, University of Michigan, USA

Aldons J. Lusis, University of California, Los Angeles, USA
Systems-Based Approaches to Cardiovascular and Metabolic Diseases

Matthias Kretzler, University of Michigan, USA
Integration of Large-Scale Data Sets in Diabetic Nephropathy: Defining Networks of Repair, Progression and Response to Therapy

Edward P. Feener, Joslin Diabetes Center, USA
Proteomic Networks in Diabetic Complications

Wenjun Ju, University of Michigan, USA
Short Talk: A Novel Approach for Discovering Chronic Kidney Disease Associated Human Podocyte-Specific Genes

19:00—20:00
Social Hour with Lite Bites

Plaza Ballroom
20:00—23:00
Entertainment

Plaza Ballroom

FRIDAY, MARCH 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-03

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Aastrom Biosciences, Inc. Biogen Idec
JDRF
 

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