Portola Hotel & Spa Floorplan

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This meeting took place in 2012


Here are the related meetings in 2018:
Frontiers in Islet Biology and Diabetes (B3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Advances in Islet Biology (C8)


Organizer(s) Lori Sussel, Jorge Ferrer and Andrew F. Stewart
March 25—30, 2012
Portola Hotel & Spa • Monterey, California USA
Abstract Deadline: Nov 22, 2011
Late Abstract Deadline: Jan 3, 2012
Scholarship Deadline: Nov 22, 2011
Early Registration Deadline: Jan 25, 2012

Sponsored by Merck & Co., Inc. and Sanofi US

Summary of Meeting:
During the past 10 to 15 years, there has been significant progress in our understanding of pancreatic islet development and islet biology. This knowledge has been complemented and accelerated by major advances in diverse fields including islet transplantation, stem cells, small molecule screening, high-throughput sequencing, epigenetics and human genetics. The integration of these divergent disciplines has allowed us to develop a clearer definition of a functional b cell and has elucidated many of the mechanisms underlying the differentiation, survival and death of the b cell. Furthermore, these studies have revealed the potential to generate new b cells through replication or neogenesis. Improvements in differentiation and transdifferentiation protocols have also illustrated the potential of using stem cells and some somatic cell types as sources of islet cells, but these studies have also revealed the challenges associated with generating functional b cells. The purpose of this Keystone Symposia meeting is to highlight the areas of islet biology that have seen the most remarkable advances and to address some of the controversies that still exist in the field, especially with regards to the generation and maintenance of functionally mature b cells for therapeutic purposes. In addition, where it is possible, comparative mouse and human studies will be discussed to illustrate if and when mouse studies can be applied to the human situation.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 25

15:00—19:30
Registration

De Anza Foyer
18:15—19:15
Refreshments

De Anza Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Jorge Ferrer, Imperial College London, UK

Andrew Hattersley, Peninsula Medical School, UK
The Genetics of Diabetes: Understanding Inherited Beta Cell Defects


MONDAY, MARCH 26

07:30—08:30
Breakfast

De Anza 1-3
08:30—11:45
Stem Cells as a Source of Islet Cells
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Matthias Hebrok, University of California, San Francisco, USA

Ludovic Vallier, Wellcome Trust Sanger Institute, UK
Signaling Pathways Controlling Differentiation of Human Endoderm Cells

Paul Gadue, Children's Hospital of Philadelphia, USA
Generation of Self-Renewing Endodermal Stem Cells with the Potential to Produce Functional Beta Cells in vitro

M. Cristina Nostro, University Health Network, Canada
Short Talk: Human Embryonic Stem Cell-derived INSULIN-expressing Cells Generate alpha-like Cells in vivo

Kevin A. D'Amour, ViaCyte, Inc., USA
Development of an Encapsulated Stem-Cell Therapy for Insulin-Dependent Diabetes

Raphael Scharfmann, INSERM, France
Pancreatic Beta Cell Development: Experimental Models to Transfer Data from Rodent to Human

Diego Balboa Alonso, University of Helsinki, Finland
Short Talk: Directed Differentiation of Patient-Specific iPS Cells to Model Permanent Neonatal Diabetes Mellitus

09:40—10:00
Coffee Break

De Anza Foyer
11:45—13:00
Poster Setup

De Anza 1-3
11:45
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

De Anza 1-3
16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:15
Mechanisms of Beta Cell Replication
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Anil Bhushan, University of California, San Francisco, USA

Andrew F. Stewart, Mount Sinai School of Medicine, USA
Induction of Proliferation in Human beta Cells for Diabetes

Seung K. Kim, Stanford University, USA
Regulation of Pancreatic Beta Cell Growth and Maturation

Jean-Sébastien Annicotte, EGID CNRS UMR 8199, France
Short Talk: An E2F1-CDK4-CDKN2A Pathway Controlling beta-Cell Proliferation and Function

Ernesto Bernal-Mizrachi, University of Miami Miller School of Medicine, USA
Integration of PI3K, mTor and GSK3beta Signaling with Pancreatic Beta Cell Replication

Jeffery S. Tessem, Duke University Medical Center, USA
Short Talk: Nkx6.1 Mediated beta Cell Proliferation Pathways

19:15—20:15
Social Hour with Lite Bites

De Anza 1-3
19:30—22:00
Poster Session 1

De Anza 1-3

TUESDAY, MARCH 27

07:30—08:30
Breakfast

De Anza 1-3
07:30—20:30
Poster Setup

De Anza 1-3
08:30—17:00
Poster Viewing

De Anza 1-3
08:30—11:45
Reprogramming
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Lori Sussel, University of Colorado, USA

Domenico Accili, Columbia University, USA
Generation of Functional Insulin-Producing Cells in the Gut by Foxo1 Ablation

Matthias Hebrok, University of California, San Francisco, USA
Cellular Plasticity in the Pancreas

Chris Wright, Vanderbilt University Medical Center, USA
Lineage Interconversion between Pancreas Cell Types in Combined Injury and Pdx1 Overexpression Models

Judsen D. Schneider, Vanderbilt University Medical Center, USA
Short Talk: Ngn3 Reprograms Acinar Cells into Endocrine Cells

Christine A. Beamish, Lawson Health Research Institute, Canada
Short Talk: Rare Transition of Mouse beta-Cells to Duct-Like Cells in vitro: beta-Cell Differentiation or Activation of Insulin+ Precursors?

Luc Baeyens, Free University Brussels, Belgium
Cytokines that Protect and Regenerate Functional Beta Cells to Normalize Hyperglycemia in Mice

09:40—10:00
Coffee Break

De Anza Foyer
11:45—12:30
Lunch

De Anza 1-3
12:00—14:30
Poster Session 2

De Anza 1-3
14:30—16:30
Workshop 1: Signaling Pathways Influencing the Adult Islet

Steinbeck Forum
* George K. Gittes, Children's Hospital of Pittsburgh of UPMC, USA

Zhiguang Guo, Sanford Research/USD, USA
Targeting GPR119 to Stimulate beta-Cell Regeneration

Elina Hakonen, University of Helsinki, Finland
Conditional Expression of a Constitutively Active EGF-R in beta Cells Protects Against Streptozotocin-Induced Diabetes

Tatsuyoshi M. Kono, Indiana University School of Medicine, USA
Rescue of SERCA2B Expression Improves Pancreatic beta Cell Proliferation and Survival in Type 2 Diabetes Mellitus

Mette V. Jensen, Duke University Medical Center, USA
Pyruvate-Isocitrate Cycling Regulates Expression of Kv2.2 and Glucose-Stimulated Insulin Secretion

Alan Schneyer, University of Massachusetts, Amherst, USA
Role of Activin and FSTL3 in alpha- and beta-Cell Expansion/TransDifferentiation

Yousef El-Gohary, Children's Hospital of Pittsburgh, USA
Smad Signaling Plays a Key Role in Regulating Islet Cell Proliferation and Development


Jens Høiriis Nielsen, University of Copenhagen, Denmark
Identification of Circulating Factors that may be Involved in Beta Cell Adaptation to Pregnancy

Patricia Ducy, Columbia University, USA
Regulation of Perinatal beta-Cell Proliferation by Osteocalcin Signaling

16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:15
Epigenetics of the Islet Cell
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Yuval Dor, Hebrew University-Hadassah Medical School, Israel

Jorge Ferrer, Imperial College London, UK
Long Non-Coding Transcripts in Human Islet Cells

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Global Epigenetic Analysis of Pancreatic Islet Cells

Anil Bhushan, University of California, San Francisco, USA
Epigenetic Mechanisms that Regulate Pancreatic beta Cell Identity

Michael L. Stitzel, The Jackson Laboratory for Genomic Medicine, USA
Short Talk: Cis-Regulatory Variation in Islet Dysfunction and Diabetes

Philippe Ravassard, Institut du Cerveau et de la Moelle, France
Short Talk: A Long-Range Cell Type-Specific Enhancer of Neurog3 Acts as a Polycomb Response Element in vivo

 
On Own for Dinner


WEDNESDAY, MARCH 28

07:30—08:30
Breakfast

De Anza 1-3
08:30—11:45
Immunopathology of Type 1 Diabetes
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Fred Levine, Sanford-Burnham Medical Research Institute, USA

Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Novel Insights into the Immunopathogenesis of Human Type 1 Diabetes

Gerald T. Nepom, Benaroya Research Institute, USA
Therapeutic Options in Type 1 Diabetic Patients

Dale L. Greiner, University of Massachusetts Medical School, USA
Humanized Mice for the Study of Diabetes

Pere Santamaria, University of Calgary, Canada
The beta-Cell Regenerative Capacity of the Diabetic NOD Pancreas Upon Reversal of Autoimmunity

Midhat H. Abdulreda, Diabetes Research Institute, USA
Short Talk: In vivo Non-Invasive Imaging of the Immunopathology of Type 1 Diabetes in NOD Mice

Scott A. Soleimanpour, University of Michigan Medical School, USA
Short Talk: Clec16a, a T1DM Susceptibility Gene and Novel Pdx1 Target, Regulates Endosomal and Mitochondrial Function in Min6 beta-Cells

09:40—10:00
Coffee Break

De Anza Foyer
11:45—13:00
Poster Setup

De Anza 1-3
11:45
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

De Anza 1-3
16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:15
Cell-Cell Communications Influencing the Endocrine Pancreas
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
Ondine Cleaver, University of Texas Southwestern Medical Center, USA
The Role of Vasculature in Regulation of Islet Cell Differentiation

Vincenzo Cirulli, University of Washington, USA
Cell-Cell and Cell-Matrix Interactions as Instructive Cues for Developing Islet Progenitors

Peter W. Zandstra, University of Toronto, Canada
Synthetic Stem Cell Niche Engineering to Control Endoderm Development and Pancreatic Maturation

Rachel B. Reinert, Vanderbilt University Medical Center, USA
Short Talk: VEGF-A Directs Autonomic Innervation of the Pancreatic Islet

David A. Cano, Institute of Biomedicine of Seville, Spain
Short Talk: Role of Glial Cell Line-Derived Neurotrophic Factor in Embryonic Pancreas Colonization by Neural Precursors

19:15—20:15
Social Hour with Lite Bites

De Anza 1-3
19:30—22:00
Poster Session 3

De Anza 1-3

THURSDAY, MARCH 29

07:30—08:30
Breakfast

De Anza 1-3
08:30—11:45
Novel Therapeutic Targets
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Andrew F. Stewart, Mount Sinai School of Medicine, USA

Bridget Wagner, Broad Institute, USA
High-Throughput Screening for Small Molecules to Increase Beta-Cell Mass

Bryan A. Laffitte, Genomics Institute of the Novartis Research Foundation, USA
Approaches to Beta Cell Regeneration and Survival in Type-1 Diabetes

Yuval Dor, Hebrew University-Hadassah Medical School, Israel
Mechanisms of Pancreatic Beta Cell Regeneration

David J. Hill, St. Joseph's Hospital, Canada
Pathways to Regeneration: Statins, Augurin and Immunization with Myobacterial Adjuvant

Fred Levine, Sanford-Burnham Medical Research Institute, USA
Short Talk: Induction of beta-Cell Replication by an HNF4a Antagonist

Olov Andersson, Karolinska Institutet, Sweden
Short Talk: A Chemical Screen in Zebrafish Identifies Adenosine Signaling as a Promoter of Pancreatic Beta-Cell Regeneration

09:40—10:00
Coffee Break

De Anza Foyer
11:45
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Survival and Functional Maintenance of the beta Cell

Steinbeck Forum
* Catherine Lee May, University of Pennsylvania, USA

Brandon L. Taylor, Genomics Institute of the Novartis Research Foundation, USA
Nkx6.1 is Required for Maintenance of beta Cells and beta Cell Function

Ja-Young Kim-Muller, Merck & Co., USA
Triple FoxO Knockout (1, 3a, and 4) in beta-Cells Impairs Glucose-Induced Insulin Secretion and Causes Hyperglycemia

Arun Sharma, MedImmune, USA
MafA Expression is Sufficient to Overcome beta-Cell Dysfunction in Pdx1 Haplo-Insufficient Mice

Bryan O'Sullivan-Murphy, Fumi Urano/LRB-522 - University of Massachusetts Medical School, USA
WFS1 Allelic Variants Enhance beta Cell Viability and Function

Lukas Adrian Berchtold, University of Copenhagen, Denmark
An Integrative Network-Based Approach Identifies Pannexin2 as an Anti-Apoptotic Protein in Pancreatic beta Cells

Young-mi Song, Yonsei University, South Korea
Inhibition of Autophagy by Increase of ER Stress through Glycated Albumin(GA)-Induced ROS Increases Apoptosis

Mark O. Huising, University of California, Davis, USA
Urocortins Promote beta Cell Survival and can Prevent Streptozotocin-Induced Hyperglycaemia

Hye Seung Jung, Seoul National University Hospital, South Korea
Suppression of Perk Improved Insulin Secretion and Hyperglycemia in beta Cell-Specific Atg7 Knockout Mice

16:30—17:00
Coffee Available

De Anza Foyer
17:00—19:00
Maturation and Maintenance of Beta Cell Function
Meeting has ended...abstracts no longer viewable online.

Steinbeck Forum
* Chris Wright, Vanderbilt University Medical Center, USA

Lori Sussel, University of Colorado, USA
Specification and Maintenance of Beta Cell Fate, Identity and Function

Roland W. Stein, Vanderbilt University Medical Center, USA
The Effect of Oxidative Stress on Islet beta-Cell-Enriched Transcription Factors

Susan Bonner-Weir, Joslin Diabetes Center, USA
Physiological Factors Influence beta Cell Maturation during Early Postnatal Period

Barak Blum, Harvard University, USA
Short Talk: Functional Maturation of beta-Cells is Marked by Expression of Urocortin 3

19:00—20:00
Social Hour with Lite Bites

De Anza 1-3
20:00—23:00
Entertainment

De Anza 1-3

FRIDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Merck & Co., Inc. Sanofi US

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-03

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

ALPCO Diagnostics JDRF
Mercodia, Inc.
ViaCyte, Inc.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genomics Institute of the Novartis Research Foundation


ViaCyte, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676